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ZNF141 (zinc finger protein 141)
Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7700
Gene nameGene Name - the full gene name approved by the HGNC.
Zinc finger protein 141
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ZNF141
SynonymsGene synonyms aliases
D4S90, pHZ-44
ChromosomeChromosome number
4
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p16.3
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]
SNPsSNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
SNP ID Visualize variation Clinical significance Consequence
rs587776959 C>T Pathogenic-likely-pathogenic Genic downstream transcript variant, missense variant, coding sequence variant, intron variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT028830 hsa-miR-26b-5p Microarray 19088304
MIRT650461 hsa-miR-6808-5p HITS-CLIP 23824327
MIRT650460 hsa-miR-6893-5p HITS-CLIP 23824327
MIRT650459 hsa-miR-940 HITS-CLIP 23824327
MIRT650458 hsa-miR-3929 HITS-CLIP 23824327
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 7649249
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0005634 Component Nucleus IEA
GO:0006355 Process Regulation of transcription, DNA-templated IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q15928
Protein name Zinc finger protein 141
Protein function May be involved in transcriptional regulation as a repressor. Plays a role in limb development.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB
3 → 44
KRAB box
 Family
PF00096 zf-C2H2
227 → 249
Zinc finger, C2H2 type
 Domain
PF00096 zf-C2H2
255 → 277
Zinc finger, C2H2 type
 Domain
PF00096 zf-C2H2
283 → 305
Zinc finger, C2H2 type
 Domain
PF00096 zf-C2H2
311 → 333
Zinc finger, C2H2 type
 Domain
PF00096 zf-C2H2
339 → 361
Zinc finger, C2H2 type
 Domain
PF13912 zf-C2H2_6
367 → 392
Domain
PF00096 zf-C2H2
395 → 417
Zinc finger, C2H2 type
 Domain
PF00096 zf-C2H2
423 → 445
Zinc finger, C2H2 type
 Domain
PF00096 zf-C2H2
451 → 473
Zinc finger, C2H2 type
 Domain
Sequence 
MELLTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSLGVAISNPDLVTCLEQRK
EPYNVKIHKIVARPPAMCSHFTQDHWPVQGIEDSFHKLILRRYEKCGHDNLQLRKGCKSL
NECKLQKGGYNEFNECLSTTQSKILQCKASVKVVSKFSNSNKRKTRHTGEKHFKECGKSF
QKFSHLTQHKVIHAGEKPYTCEECGKAFKWSLIFNEHKRIHTGEKPFTCEECGSIFTTSS
HFAKHKIIHTGEKPYKCEECGKAFNRFTTLTKHKRIHAGEKPITCEECRKIFTSSSNFAK
HKRIHTGEKPYKCEECGKAFNRSTTLTKHKRIHTGEKPYTCEECGKAFRQSSKLNEHKKV
HTGERPYKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDRSQHKKIHSAD
KPYKCKECDKAFKQFSLLSQHKKIHTVDKPYKCKDCDKAFKRFSHLNKHKKIHT
Sequence length 474
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
Reactome
    Generic Transcription Pathway
Associated diseases
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Polydactyly Polydactyly, POLYDACTYLY, POSTAXIAL, TYPE A6, Postaxial polydactyly type A rs1583729398, rs121917709, rs1583734240, rs121917714, rs397507422, rs398122899, rs587776959, rs386833752, rs1057518698, rs1060499558, rs755938967, rs1375768446, rs1309855392, rs1565601979, rs748321474, rs368652620, rs1562587032, rs760694987 23160277, 26394607, 23160277
Unknown
Disease name Disease term dbSNP ID References
Postaxial hand polydactyly Ulnar polydactyly of fingers

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