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ZKSCAN1 (zinc finger with KRAB and SCAN domains 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7586
Gene nameGene Name - the full gene name approved by the HGNC.
Zinc finger with KRAB and SCAN domains 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ZKSCAN1
SynonymsGene synonyms aliases
KOX18, PHZ-37, ZNF139, ZNF36, ZSCAN33
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q22.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT665264 hsa-miR-6513-3p HITS-CLIP 23824327
MIRT639834 hsa-miR-4716-5p HITS-CLIP 23824327
MIRT639833 hsa-miR-4485-5p HITS-CLIP 23824327
MIRT639832 hsa-miR-1281 HITS-CLIP 23824327
MIRT639830 hsa-miR-2116-3p HITS-CLIP 23824327
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0005515 Function Protein binding IPI 25416956, 28514442, 31515488, 32296183, 32814053
GO:0005634 Component Nucleus IEA
GO:0006357 Process Regulation of transcription by RNA polymerase II IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P17029
Protein name Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18)
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02023 SCAN
52 141
SCAN domain
Domain
PF01352 KRAB
226 266
KRAB box
Family
PF00096 zf-C2H2
377 399
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
405 427
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
433 455
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
461 483
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
489 511
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
517 539
Zinc finger, C2H2 type
Domain
Sequence
MMTAESREATGLSPQAAQEKDGIVIVKVEEEDEEDHMWGQDSTLQDTPPPDPEIFRQRFR
RFCYQNTFGPREALSRLKELCHQWLRPEINTKEQILELLVLEQFLSILPKELQVWLQEYR
PDSGEEAVTLLEDLELDLSGQ
QVPGQVHGPEMLARGMVPLDPVQESSSFDLHHEATQSHF
KHSSRKPRLLQSRALPAAHIPAPPHEGSPRDQAMASALFTADSQAMVKIEDMAVSLILEE
WGCQNLARRNLSRDNRQENYGSAFPQ
GGENRNENEESTSKAETSEDSASRGETTGRSQKE
FGEKRDQEGKTGERQQKNPEEKTRKEKRDSGPAIGKDKKTITGERGPREKGKGLGRSFSL
SSNFTTPEEVPTGTKSHRCDECGKCFTRSSSLIRHKIIHTGEKPYECSECGKAFSLNSNL
VLHQRIH
TGEKPHECNECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQ
RIH
TGEKPYECSECGKAFNRNSYLILHRRIHTREKPYKCTKCGKAFTRSSTLTLHHRIHA
RERASEYSPASLDAFGAFLKSCV
Sequence length 563
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Generic Transcription Pathway
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928 30804561
Unknown
Disease name Disease term dbSNP ID References
Lung diseases Lung Diseases, Interstitial 23583980

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