ZNF22 (zinc finger protein 22)

Gene

• Entrez ID: 7570
• Gene name: Zinc finger protein 22
• Gene symbol: ZNF22
• Synonyms: HKR-T1, KOX15, ZNF422, Zfp422
• Chromosome: 10
• Chromosome location: 10q11.21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT648393	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT648394	hsa-miR-4469	HITS-CLIP	23824327
MIRT648392	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT648391	hsa-miR-4287	HITS-CLIP	23824327
MIRT648390	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT648389	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT648388	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT648387	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT648386	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT648385	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT648384	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT648383	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT648382	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT648381	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT648393	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT648394	hsa-miR-4469	HITS-CLIP	23824327
MIRT648392	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT648391	hsa-miR-4287	HITS-CLIP	23824327
MIRT648390	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT648389	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT648388	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT648387	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT648386	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT648385	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT648384	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT648383	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT648382	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT648381	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT1518510	hsa-miR-1245	CLIP-seq
MIRT1518511	hsa-miR-1267	CLIP-seq
MIRT1518512	hsa-miR-142-5p	CLIP-seq
MIRT1518513	hsa-miR-216a	CLIP-seq
MIRT1518514	hsa-miR-298	CLIP-seq
MIRT1518515	hsa-miR-3185	CLIP-seq
MIRT1518516	hsa-miR-340	CLIP-seq
MIRT1518517	hsa-miR-3647-3p	CLIP-seq
MIRT1518518	hsa-miR-3678-3p	CLIP-seq
MIRT1518519	hsa-miR-3681	CLIP-seq
MIRT1518520	hsa-miR-4422	CLIP-seq
MIRT1518521	hsa-miR-4684-3p	CLIP-seq
MIRT1518522	hsa-miR-4694-3p	CLIP-seq
MIRT1518523	hsa-miR-490-5p	CLIP-seq
MIRT1518524	hsa-miR-494	CLIP-seq
MIRT1518525	hsa-miR-520d-5p	CLIP-seq
MIRT1518526	hsa-miR-524-5p	CLIP-seq
MIRT1518527	hsa-miR-548n	CLIP-seq
MIRT1518528	hsa-miR-942	CLIP-seq
MIRT2156467	hsa-miR-1271	CLIP-seq
MIRT2156468	hsa-miR-204	CLIP-seq
MIRT2156469	hsa-miR-211	CLIP-seq
MIRT2156470	hsa-miR-3117-5p	CLIP-seq
MIRT2156471	hsa-miR-3120-3p	CLIP-seq
MIRT1518515	hsa-miR-3185	CLIP-seq
MIRT2156472	hsa-miR-323-3p	CLIP-seq
MIRT2156473	hsa-miR-3614-5p	CLIP-seq
MIRT2156474	hsa-miR-374c	CLIP-seq
MIRT2156475	hsa-miR-4277	CLIP-seq
MIRT2156476	hsa-miR-4431	CLIP-seq
MIRT2156477	hsa-miR-4503	CLIP-seq
MIRT2156478	hsa-miR-4719	CLIP-seq
MIRT1518523	hsa-miR-490-5p	CLIP-seq
MIRT2156479	hsa-miR-548c-3p	CLIP-seq
MIRT2156480	hsa-miR-616	CLIP-seq
MIRT2156481	hsa-miR-642b	CLIP-seq
MIRT2156482	hsa-miR-653	CLIP-seq
MIRT2156483	hsa-miR-655	CLIP-seq
MIRT2156484	hsa-miR-767-5p	CLIP-seq
MIRT2156485	hsa-miR-922	CLIP-seq
MIRT1518528	hsa-miR-942	CLIP-seq
MIRT2156486	hsa-miR-96	CLIP-seq
MIRT2156467	hsa-miR-1271	CLIP-seq
MIRT2376008	hsa-miR-128	CLIP-seq
MIRT2156468	hsa-miR-204	CLIP-seq
MIRT2156469	hsa-miR-211	CLIP-seq
MIRT2376009	hsa-miR-2113	CLIP-seq
MIRT2376010	hsa-miR-218	CLIP-seq
MIRT2376011	hsa-miR-27a	CLIP-seq
MIRT2376012	hsa-miR-27b	CLIP-seq
MIRT2156470	hsa-miR-3117-5p	CLIP-seq
MIRT1518515	hsa-miR-3185	CLIP-seq
MIRT2156472	hsa-miR-323-3p	CLIP-seq
MIRT2156473	hsa-miR-3614-5p	CLIP-seq
MIRT2376013	hsa-miR-3622b-5p	CLIP-seq
MIRT2376014	hsa-miR-3692	CLIP-seq
MIRT2376015	hsa-miR-4253	CLIP-seq
MIRT2156476	hsa-miR-4431	CLIP-seq
MIRT2156477	hsa-miR-4503	CLIP-seq
MIRT2376016	hsa-miR-4716-5p	CLIP-seq
MIRT2376017	hsa-miR-4761-3p	CLIP-seq
MIRT1518523	hsa-miR-490-5p	CLIP-seq
MIRT2156480	hsa-miR-616	CLIP-seq
MIRT2156481	hsa-miR-642b	CLIP-seq
MIRT2156482	hsa-miR-653	CLIP-seq
MIRT2156484	hsa-miR-767-5p	CLIP-seq
MIRT1518528	hsa-miR-942	CLIP-seq
MIRT2156486	hsa-miR-96	CLIP-seq
MIRT2156467	hsa-miR-1271	CLIP-seq
MIRT2156468	hsa-miR-204	CLIP-seq
MIRT2156469	hsa-miR-211	CLIP-seq
MIRT2156470	hsa-miR-3117-5p	CLIP-seq
MIRT1518515	hsa-miR-3185	CLIP-seq
MIRT2156472	hsa-miR-323-3p	CLIP-seq
MIRT2156473	hsa-miR-3614-5p	CLIP-seq
MIRT2156476	hsa-miR-4431	CLIP-seq
MIRT2156477	hsa-miR-4503	CLIP-seq
MIRT1518523	hsa-miR-490-5p	CLIP-seq
MIRT1518524	hsa-miR-494	CLIP-seq
MIRT2156481	hsa-miR-642b	CLIP-seq
MIRT2156482	hsa-miR-653	CLIP-seq
MIRT2156484	hsa-miR-767-5p	CLIP-seq
MIRT1518528	hsa-miR-942	CLIP-seq
MIRT2156486	hsa-miR-96	CLIP-seq
MIRT2156468	hsa-miR-204	CLIP-seq
MIRT2156469	hsa-miR-211	CLIP-seq
MIRT1518528	hsa-miR-942	CLIP-seq
MIRT2441814	hsa-miR-4464	CLIP-seq
MIRT2156477	hsa-miR-4503	CLIP-seq
MIRT2441815	hsa-miR-4748	CLIP-seq
MIRT2156468	hsa-miR-204	CLIP-seq
MIRT2156469	hsa-miR-211	CLIP-seq
MIRT1518528	hsa-miR-942	CLIP-seq
MIRT2464101	hsa-miR-1253	CLIP-seq
MIRT2464102	hsa-miR-4428	CLIP-seq
MIRT2464103	hsa-miR-4434	CLIP-seq
MIRT2464104	hsa-miR-4516	CLIP-seq
MIRT2464105	hsa-miR-549	CLIP-seq
MIRT2464101	hsa-miR-1253	CLIP-seq
MIRT2464102	hsa-miR-4428	CLIP-seq
MIRT2464103	hsa-miR-4434	CLIP-seq
MIRT2464104	hsa-miR-4516	CLIP-seq
MIRT2464105	hsa-miR-549	CLIP-seq
MIRT2668454	hsa-miR-1207-5p	CLIP-seq
MIRT2156467	hsa-miR-1271	CLIP-seq
MIRT2376008	hsa-miR-128	CLIP-seq
MIRT2668455	hsa-miR-1321	CLIP-seq
MIRT2668456	hsa-miR-1323	CLIP-seq
MIRT2668457	hsa-miR-194	CLIP-seq
MIRT2376011	hsa-miR-27a	CLIP-seq
MIRT2376012	hsa-miR-27b	CLIP-seq
MIRT2668458	hsa-miR-28-5p	CLIP-seq
MIRT2156470	hsa-miR-3117-5p	CLIP-seq
MIRT2668459	hsa-miR-3139	CLIP-seq
MIRT1518515	hsa-miR-3185	CLIP-seq
MIRT2156472	hsa-miR-323-3p	CLIP-seq
MIRT2156473	hsa-miR-3614-5p	CLIP-seq
MIRT2668460	hsa-miR-3650	CLIP-seq
MIRT2668461	hsa-miR-3689d	CLIP-seq
MIRT2668462	hsa-miR-3713	CLIP-seq
MIRT2668463	hsa-miR-3714	CLIP-seq
MIRT2668464	hsa-miR-371-5p	CLIP-seq
MIRT2668465	hsa-miR-371b-5p	CLIP-seq
MIRT2668466	hsa-miR-378	CLIP-seq
MIRT2668467	hsa-miR-378b	CLIP-seq
MIRT2668468	hsa-miR-378c	CLIP-seq
MIRT2668469	hsa-miR-378d	CLIP-seq
MIRT2668470	hsa-miR-378e	CLIP-seq
MIRT2668471	hsa-miR-378f	CLIP-seq
MIRT2668472	hsa-miR-378h	CLIP-seq
MIRT2668473	hsa-miR-378i	CLIP-seq
MIRT2668474	hsa-miR-380	CLIP-seq
MIRT2668475	hsa-miR-422a	CLIP-seq
MIRT2668476	hsa-miR-4270	CLIP-seq
MIRT2668477	hsa-miR-4424	CLIP-seq
MIRT2156476	hsa-miR-4431	CLIP-seq
MIRT2668478	hsa-miR-4441	CLIP-seq
MIRT2441814	hsa-miR-4464	CLIP-seq
MIRT2668479	hsa-miR-4493	CLIP-seq
MIRT2156477	hsa-miR-4503	CLIP-seq
MIRT2668480	hsa-miR-4633-3p	CLIP-seq
MIRT2668481	hsa-miR-4635	CLIP-seq
MIRT2156478	hsa-miR-4719	CLIP-seq
MIRT2668482	hsa-miR-4739	CLIP-seq
MIRT2441815	hsa-miR-4748	CLIP-seq
MIRT2668483	hsa-miR-4756-5p	CLIP-seq
MIRT2668484	hsa-miR-4760-3p	CLIP-seq
MIRT2668485	hsa-miR-4763-3p	CLIP-seq
MIRT1518523	hsa-miR-490-5p	CLIP-seq
MIRT1518524	hsa-miR-494	CLIP-seq
MIRT2668486	hsa-miR-513a-3p	CLIP-seq
MIRT2668487	hsa-miR-513b	CLIP-seq
MIRT2668488	hsa-miR-513c	CLIP-seq
MIRT2668489	hsa-miR-514b-5p	CLIP-seq
MIRT2668490	hsa-miR-548o	CLIP-seq
MIRT2668491	hsa-miR-578	CLIP-seq
MIRT2668492	hsa-miR-607	CLIP-seq
MIRT2156481	hsa-miR-642b	CLIP-seq
MIRT2156482	hsa-miR-653	CLIP-seq
MIRT2668493	hsa-miR-664	CLIP-seq
MIRT2668494	hsa-miR-708	CLIP-seq
MIRT2156484	hsa-miR-767-5p	CLIP-seq
MIRT2668495	hsa-miR-940	CLIP-seq
MIRT2156486	hsa-miR-96	CLIP-seq
MIRT2668454	hsa-miR-1207-5p	CLIP-seq
MIRT2156467	hsa-miR-1271	CLIP-seq
MIRT2376008	hsa-miR-128	CLIP-seq
MIRT2668455	hsa-miR-1321	CLIP-seq
MIRT2668456	hsa-miR-1323	CLIP-seq
MIRT2668457	hsa-miR-194	CLIP-seq
MIRT2376011	hsa-miR-27a	CLIP-seq
MIRT2376012	hsa-miR-27b	CLIP-seq
MIRT2156470	hsa-miR-3117-5p	CLIP-seq
MIRT1518515	hsa-miR-3185	CLIP-seq
MIRT2156472	hsa-miR-323-3p	CLIP-seq
MIRT2156473	hsa-miR-3614-5p	CLIP-seq
MIRT2668460	hsa-miR-3650	CLIP-seq
MIRT2668461	hsa-miR-3689d	CLIP-seq
MIRT2668462	hsa-miR-3713	CLIP-seq
MIRT2668463	hsa-miR-3714	CLIP-seq
MIRT2668465	hsa-miR-371b-5p	CLIP-seq
MIRT2668466	hsa-miR-378	CLIP-seq
MIRT2668467	hsa-miR-378b	CLIP-seq
MIRT2668468	hsa-miR-378c	CLIP-seq
MIRT2668469	hsa-miR-378d	CLIP-seq
MIRT2668470	hsa-miR-378e	CLIP-seq
MIRT2668471	hsa-miR-378f	CLIP-seq
MIRT2668472	hsa-miR-378h	CLIP-seq
MIRT2668473	hsa-miR-378i	CLIP-seq
MIRT2668474	hsa-miR-380	CLIP-seq
MIRT2668475	hsa-miR-422a	CLIP-seq
MIRT2668476	hsa-miR-4270	CLIP-seq
MIRT2668477	hsa-miR-4424	CLIP-seq
MIRT2156476	hsa-miR-4431	CLIP-seq
MIRT2668478	hsa-miR-4441	CLIP-seq
MIRT2441814	hsa-miR-4464	CLIP-seq
MIRT2668479	hsa-miR-4493	CLIP-seq
MIRT2156477	hsa-miR-4503	CLIP-seq
MIRT2668481	hsa-miR-4635	CLIP-seq
MIRT2156478	hsa-miR-4719	CLIP-seq
MIRT2668482	hsa-miR-4739	CLIP-seq
MIRT2441815	hsa-miR-4748	CLIP-seq
MIRT2668483	hsa-miR-4756-5p	CLIP-seq
MIRT2668484	hsa-miR-4760-3p	CLIP-seq
MIRT2668485	hsa-miR-4763-3p	CLIP-seq
MIRT1518523	hsa-miR-490-5p	CLIP-seq
MIRT1518524	hsa-miR-494	CLIP-seq
MIRT2668487	hsa-miR-513b	CLIP-seq
MIRT2668490	hsa-miR-548o	CLIP-seq
MIRT2668491	hsa-miR-578	CLIP-seq
MIRT2156481	hsa-miR-642b	CLIP-seq
MIRT2156482	hsa-miR-653	CLIP-seq
MIRT2156484	hsa-miR-767-5p	CLIP-seq
MIRT2668495	hsa-miR-940	CLIP-seq
MIRT2156486	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0003677	Function	DNA binding	ISS
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0006355	Process	Regulation of transcription, DNA-templated	NAS	14630903
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0008270	Function	Zinc ion binding	TAS	1946370
GO:0042476	Process	Odontogenesis	NAS	14630903

Other IDs

• MIM: 194529
• HGNC: 13012
• e!Ensembl: ENSG00000165512

Protein

• UniProt ID: P17026
• Protein name: Zinc finger protein 22 (Zinc finger protein KOX15) (Zinc finger protein Krox-26)
• Protein function: Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	55 → 77	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	83 → 105	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	111 → 133	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	139 → 161	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	167 → 189	Zinc finger, C2H2 type	Domain

• Sequence:

  MRLAKPKAGISRSSSQGKAYENKRKTGRQRQKWGMTIRFDSSFSRLRRSLDDKPYKCTEC
  EKSFSQSSTLFQHQKIHTGKKSHKCADCGKSFFQSSNLIQHRRIHTGEKPYKCDECGESF
  KQSSNLIQHQRIHTGEKPYQCDECGRCFSQSSHLIQHQRTHTGEKPYQCSECGKCFSQSS
  HLRQHMKVHKEEKPRKTRGKNIRVKTHLPSWKAGTGRKSVAGLR

• Sequence length: 224

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243