SF1 (splicing factor 1)

Gene

• Entrez ID: 7536
• Gene name: Splicing factor 1
• Gene symbol: SF1
• Synonyms: BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3` splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages o

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021119	hsa-miR-186-5p	Sequencing	20371350
MIRT046884	hsa-miR-221-3p	CLASH	23622248
MIRT044484	hsa-miR-320a	CLASH	23622248
MIRT036661	hsa-miR-935	CLASH	23622248
MIRT267768	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT267764	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT267766	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT571654	hsa-miR-21-3p	PAR-CLIP	20371350
MIRT571653	hsa-miR-3591-3p	PAR-CLIP	20371350
MIRT571652	hsa-miR-3919	PAR-CLIP	20371350
MIRT333872	hsa-miR-3158-5p	PAR-CLIP	20371350
MIRT571651	hsa-miR-1184	PAR-CLIP	20371350
MIRT571650	hsa-miR-1205	PAR-CLIP	20371350
MIRT571649	hsa-miR-17-3p	PAR-CLIP	20371350
MIRT571648	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT246745	hsa-miR-544a	PAR-CLIP	20371350
MIRT246751	hsa-miR-6738-3p	PAR-CLIP	20371350
MIRT560276	hsa-miR-3133	PAR-CLIP	20371350
MIRT021119	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT560275	hsa-miR-495-3p	PAR-CLIP	20371350
MIRT560274	hsa-miR-5688	PAR-CLIP	20371350
MIRT560273	hsa-miR-7-1-3p	PAR-CLIP	20371350
MIRT560272	hsa-miR-7-2-3p	PAR-CLIP	20371350
MIRT560271	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT560270	hsa-miR-577	PAR-CLIP	20371350
MIRT560269	hsa-miR-802	PAR-CLIP	20371350
MIRT560268	hsa-miR-3185	PAR-CLIP	20371350
MIRT560267	hsa-miR-548ao-5p	PAR-CLIP	20371350
MIRT560266	hsa-miR-548ax	PAR-CLIP	20371350
MIRT560265	hsa-miR-6124	PAR-CLIP	20371350
MIRT560264	hsa-miR-4294	PAR-CLIP	20371350
MIRT497366	hsa-miR-548ac	PAR-CLIP	22291592
MIRT497365	hsa-miR-548bb-3p	PAR-CLIP	22291592
MIRT497364	hsa-miR-548d-3p	PAR-CLIP	22291592
MIRT497363	hsa-miR-548h-3p	PAR-CLIP	22291592
MIRT497362	hsa-miR-548z	PAR-CLIP	22291592
MIRT497361	hsa-miR-548as-3p	PAR-CLIP	22291592
MIRT497360	hsa-miR-489-3p	PAR-CLIP	22291592
MIRT442736	hsa-miR-4258	PAR-CLIP	22100165
MIRT442735	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT442736	hsa-miR-4258	PAR-CLIP	22100165
MIRT442735	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT267768	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT267764	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT267766	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT571654	hsa-miR-21-3p	PAR-CLIP	20371350
MIRT571653	hsa-miR-3591-3p	PAR-CLIP	20371350
MIRT571652	hsa-miR-3919	PAR-CLIP	20371350
MIRT333872	hsa-miR-3158-5p	PAR-CLIP	20371350
MIRT571651	hsa-miR-1184	PAR-CLIP	20371350
MIRT571650	hsa-miR-1205	PAR-CLIP	20371350
MIRT571649	hsa-miR-17-3p	PAR-CLIP	20371350
MIRT571648	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT246745	hsa-miR-544a	PAR-CLIP	20371350
MIRT246751	hsa-miR-6738-3p	PAR-CLIP	20371350
MIRT560276	hsa-miR-3133	PAR-CLIP	20371350
MIRT021119	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT560275	hsa-miR-495-3p	PAR-CLIP	20371350
MIRT560274	hsa-miR-5688	PAR-CLIP	20371350
MIRT560273	hsa-miR-7-1-3p	PAR-CLIP	20371350
MIRT560272	hsa-miR-7-2-3p	PAR-CLIP	20371350
MIRT560271	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT560270	hsa-miR-577	PAR-CLIP	20371350
MIRT560269	hsa-miR-802	PAR-CLIP	20371350
MIRT560268	hsa-miR-3185	PAR-CLIP	20371350
MIRT560267	hsa-miR-548ao-5p	PAR-CLIP	20371350
MIRT560266	hsa-miR-548ax	PAR-CLIP	20371350
MIRT560265	hsa-miR-6124	PAR-CLIP	20371350
MIRT560264	hsa-miR-4294	PAR-CLIP	20371350
MIRT497366	hsa-miR-548ac	PAR-CLIP	22291592
MIRT497365	hsa-miR-548bb-3p	PAR-CLIP	22291592
MIRT497364	hsa-miR-548d-3p	PAR-CLIP	22291592
MIRT497363	hsa-miR-548h-3p	PAR-CLIP	22291592
MIRT497362	hsa-miR-548z	PAR-CLIP	22291592
MIRT497361	hsa-miR-548as-3p	PAR-CLIP	22291592
MIRT497360	hsa-miR-489-3p	PAR-CLIP	22291592
MIRT442736	hsa-miR-4258	PAR-CLIP	22100165
MIRT442735	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT442736	hsa-miR-4258	PAR-CLIP	22100165
MIRT442735	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT1341008	hsa-miR-1207-5p	CLIP-seq
MIRT1341009	hsa-miR-3148	CLIP-seq
MIRT1341010	hsa-miR-323-3p	CLIP-seq
MIRT1341011	hsa-miR-371-5p	CLIP-seq
MIRT1341012	hsa-miR-3939	CLIP-seq
MIRT1341013	hsa-miR-421	CLIP-seq
MIRT1341014	hsa-miR-4476	CLIP-seq
MIRT1341015	hsa-miR-4533	CLIP-seq
MIRT1341016	hsa-miR-4645-5p	CLIP-seq
MIRT1341017	hsa-miR-4673	CLIP-seq
MIRT1341018	hsa-miR-4709-5p	CLIP-seq
MIRT1341019	hsa-miR-4736	CLIP-seq
MIRT1341020	hsa-miR-4763-3p	CLIP-seq
MIRT1341021	hsa-miR-505	CLIP-seq
MIRT1341022	hsa-miR-508-5p	CLIP-seq
MIRT1341023	hsa-miR-523	CLIP-seq
MIRT1341024	hsa-miR-1294	CLIP-seq
MIRT1341025	hsa-miR-1324	CLIP-seq
MIRT1341026	hsa-miR-1469	CLIP-seq
MIRT1341027	hsa-miR-181a	CLIP-seq
MIRT1341028	hsa-miR-181b	CLIP-seq
MIRT1341029	hsa-miR-181c	CLIP-seq
MIRT1341030	hsa-miR-181d	CLIP-seq
MIRT1341031	hsa-miR-1825	CLIP-seq
MIRT1341032	hsa-miR-184	CLIP-seq
MIRT1341033	hsa-miR-185	CLIP-seq
MIRT1341034	hsa-miR-3122	CLIP-seq
MIRT1341009	hsa-miR-3148	CLIP-seq
MIRT1341035	hsa-miR-3189-3p	CLIP-seq
MIRT1341036	hsa-miR-329	CLIP-seq
MIRT1341037	hsa-miR-3676	CLIP-seq
MIRT1341038	hsa-miR-3913-5p	CLIP-seq
MIRT1341039	hsa-miR-4262	CLIP-seq
MIRT1341014	hsa-miR-4476	CLIP-seq
MIRT1341040	hsa-miR-450b-3p	CLIP-seq
MIRT1341015	hsa-miR-4533	CLIP-seq
MIRT1341041	hsa-miR-4643	CLIP-seq
MIRT1341042	hsa-miR-4690-3p	CLIP-seq
MIRT1341043	hsa-miR-4768-5p	CLIP-seq
MIRT1341044	hsa-miR-4786-5p	CLIP-seq
MIRT1341045	hsa-miR-4792	CLIP-seq
MIRT1341046	hsa-miR-4803	CLIP-seq
MIRT1341047	hsa-miR-4804-5p	CLIP-seq
MIRT1341048	hsa-miR-543	CLIP-seq
MIRT1341049	hsa-miR-769-3p	CLIP-seq
MIRT1341032	hsa-miR-184	CLIP-seq
MIRT1341050	hsa-miR-3175	CLIP-seq
MIRT1341035	hsa-miR-3189-3p	CLIP-seq
MIRT1341047	hsa-miR-4804-5p	CLIP-seq
MIRT1341051	hsa-miR-103a	CLIP-seq
MIRT1341052	hsa-miR-107	CLIP-seq
MIRT1341053	hsa-miR-1301	CLIP-seq
MIRT1341032	hsa-miR-184	CLIP-seq
MIRT1341033	hsa-miR-185	CLIP-seq
MIRT1341054	hsa-miR-298	CLIP-seq
MIRT1341009	hsa-miR-3148	CLIP-seq
MIRT1341050	hsa-miR-3175	CLIP-seq
MIRT1341035	hsa-miR-3189-3p	CLIP-seq
MIRT1341055	hsa-miR-34b	CLIP-seq
MIRT1341056	hsa-miR-4655-5p	CLIP-seq
MIRT1341057	hsa-miR-4799-5p	CLIP-seq
MIRT1341047	hsa-miR-4804-5p	CLIP-seq
MIRT1341058	hsa-miR-490-5p	CLIP-seq
MIRT1341059	hsa-miR-5047	CLIP-seq
MIRT1341060	hsa-miR-922	CLIP-seq
MIRT2100901	hsa-miR-183	CLIP-seq
MIRT1341032	hsa-miR-184	CLIP-seq
MIRT1341014	hsa-miR-4476	CLIP-seq
MIRT1341015	hsa-miR-4533	CLIP-seq
MIRT1341016	hsa-miR-4645-5p	CLIP-seq
MIRT1341017	hsa-miR-4673	CLIP-seq
MIRT2100902	hsa-miR-548aa	CLIP-seq
MIRT1341051	hsa-miR-103a	CLIP-seq
MIRT1341052	hsa-miR-107	CLIP-seq
MIRT2325427	hsa-miR-125a-3p	CLIP-seq
MIRT2325428	hsa-miR-129-3p	CLIP-seq
MIRT1341024	hsa-miR-1294	CLIP-seq
MIRT1341053	hsa-miR-1301	CLIP-seq
MIRT1341025	hsa-miR-1324	CLIP-seq
MIRT1341026	hsa-miR-1469	CLIP-seq
MIRT1341027	hsa-miR-181a	CLIP-seq
MIRT1341028	hsa-miR-181b	CLIP-seq
MIRT1341029	hsa-miR-181c	CLIP-seq
MIRT1341030	hsa-miR-181d	CLIP-seq
MIRT2325429	hsa-miR-1827	CLIP-seq
MIRT1341032	hsa-miR-184	CLIP-seq
MIRT1341033	hsa-miR-185	CLIP-seq
MIRT1341054	hsa-miR-298	CLIP-seq
MIRT1341034	hsa-miR-3122	CLIP-seq
MIRT1341009	hsa-miR-3148	CLIP-seq
MIRT2325430	hsa-miR-3153	CLIP-seq
MIRT2325431	hsa-miR-3154	CLIP-seq
MIRT1341050	hsa-miR-3175	CLIP-seq
MIRT1341035	hsa-miR-3189-3p	CLIP-seq
MIRT2325432	hsa-miR-3200-5p	CLIP-seq
MIRT1341036	hsa-miR-329	CLIP-seq
MIRT1341055	hsa-miR-34b	CLIP-seq
MIRT1341037	hsa-miR-3676	CLIP-seq
MIRT1341011	hsa-miR-371-5p	CLIP-seq
MIRT1341038	hsa-miR-3913-5p	CLIP-seq
MIRT2325433	hsa-miR-3925-5p	CLIP-seq
MIRT2325434	hsa-miR-3926	CLIP-seq
MIRT2325435	hsa-miR-3934	CLIP-seq
MIRT1341012	hsa-miR-3939	CLIP-seq
MIRT1341039	hsa-miR-4262	CLIP-seq
MIRT1341014	hsa-miR-4476	CLIP-seq
MIRT1341040	hsa-miR-450b-3p	CLIP-seq
MIRT1341015	hsa-miR-4533	CLIP-seq
MIRT1341041	hsa-miR-4643	CLIP-seq
MIRT2325436	hsa-miR-4649-3p	CLIP-seq
MIRT1341056	hsa-miR-4655-5p	CLIP-seq
MIRT2325437	hsa-miR-4660	CLIP-seq
MIRT2325438	hsa-miR-4694-3p	CLIP-seq
MIRT2325439	hsa-miR-4709-3p	CLIP-seq
MIRT1341044	hsa-miR-4786-5p	CLIP-seq
MIRT2325440	hsa-miR-4790-3p	CLIP-seq
MIRT1341045	hsa-miR-4792	CLIP-seq
MIRT1341057	hsa-miR-4799-5p	CLIP-seq
MIRT1341046	hsa-miR-4803	CLIP-seq
MIRT1341047	hsa-miR-4804-5p	CLIP-seq
MIRT2325441	hsa-miR-489	CLIP-seq
MIRT1341058	hsa-miR-490-5p	CLIP-seq
MIRT1341059	hsa-miR-5047	CLIP-seq
MIRT1341023	hsa-miR-523	CLIP-seq
MIRT1341048	hsa-miR-543	CLIP-seq
MIRT2325442	hsa-miR-548s	CLIP-seq
MIRT2325443	hsa-miR-764	CLIP-seq
MIRT1341049	hsa-miR-769-3p	CLIP-seq
MIRT1341060	hsa-miR-922	CLIP-seq
MIRT1341033	hsa-miR-185	CLIP-seq
MIRT1341051	hsa-miR-103a	CLIP-seq
MIRT1341052	hsa-miR-107	CLIP-seq
MIRT2325428	hsa-miR-129-3p	CLIP-seq
MIRT1341053	hsa-miR-1301	CLIP-seq
MIRT2621109	hsa-miR-146a	CLIP-seq
MIRT2621110	hsa-miR-146b-5p	CLIP-seq
MIRT1341033	hsa-miR-185	CLIP-seq
MIRT1341009	hsa-miR-3148	CLIP-seq
MIRT2325430	hsa-miR-3153	CLIP-seq
MIRT2325431	hsa-miR-3154	CLIP-seq
MIRT1341035	hsa-miR-3189-3p	CLIP-seq
MIRT1341010	hsa-miR-323-3p	CLIP-seq
MIRT1341055	hsa-miR-34b	CLIP-seq
MIRT2325433	hsa-miR-3925-5p	CLIP-seq
MIRT2325434	hsa-miR-3926	CLIP-seq
MIRT1341012	hsa-miR-3939	CLIP-seq
MIRT1341013	hsa-miR-421	CLIP-seq
MIRT2621111	hsa-miR-4475	CLIP-seq
MIRT1341014	hsa-miR-4476	CLIP-seq
MIRT1341015	hsa-miR-4533	CLIP-seq
MIRT2325439	hsa-miR-4709-3p	CLIP-seq
MIRT1341018	hsa-miR-4709-5p	CLIP-seq
MIRT2621112	hsa-miR-4747-5p	CLIP-seq
MIRT2325440	hsa-miR-4790-3p	CLIP-seq
MIRT1341057	hsa-miR-4799-5p	CLIP-seq
MIRT1341058	hsa-miR-490-5p	CLIP-seq
MIRT1341059	hsa-miR-5047	CLIP-seq
MIRT1341021	hsa-miR-505	CLIP-seq
MIRT1341023	hsa-miR-523	CLIP-seq
MIRT2621113	hsa-miR-539	CLIP-seq
MIRT2621114	hsa-miR-544	CLIP-seq
MIRT2100902	hsa-miR-548aa	CLIP-seq
MIRT2325442	hsa-miR-548s	CLIP-seq
MIRT1341060	hsa-miR-922	CLIP-seq
MIRT1341051	hsa-miR-103a	CLIP-seq
MIRT1341052	hsa-miR-107	CLIP-seq
MIRT2325428	hsa-miR-129-3p	CLIP-seq
MIRT1341053	hsa-miR-1301	CLIP-seq
MIRT2621109	hsa-miR-146a	CLIP-seq
MIRT2621110	hsa-miR-146b-5p	CLIP-seq
MIRT1341033	hsa-miR-185	CLIP-seq
MIRT1341054	hsa-miR-298	CLIP-seq
MIRT1341009	hsa-miR-3148	CLIP-seq
MIRT2325430	hsa-miR-3153	CLIP-seq
MIRT2325431	hsa-miR-3154	CLIP-seq
MIRT1341035	hsa-miR-3189-3p	CLIP-seq
MIRT1341010	hsa-miR-323-3p	CLIP-seq
MIRT1341055	hsa-miR-34b	CLIP-seq
MIRT2325433	hsa-miR-3925-5p	CLIP-seq
MIRT2325434	hsa-miR-3926	CLIP-seq
MIRT1341012	hsa-miR-3939	CLIP-seq
MIRT1341013	hsa-miR-421	CLIP-seq
MIRT2621111	hsa-miR-4475	CLIP-seq
MIRT1341015	hsa-miR-4533	CLIP-seq
MIRT2325439	hsa-miR-4709-3p	CLIP-seq
MIRT1341018	hsa-miR-4709-5p	CLIP-seq
MIRT2621112	hsa-miR-4747-5p	CLIP-seq
MIRT1341057	hsa-miR-4799-5p	CLIP-seq
MIRT1341058	hsa-miR-490-5p	CLIP-seq
MIRT1341059	hsa-miR-5047	CLIP-seq
MIRT1341021	hsa-miR-505	CLIP-seq
MIRT1341023	hsa-miR-523	CLIP-seq
MIRT2621113	hsa-miR-539	CLIP-seq
MIRT2621114	hsa-miR-544	CLIP-seq
MIRT2100902	hsa-miR-548aa	CLIP-seq
MIRT2325442	hsa-miR-548s	CLIP-seq
MIRT1341060	hsa-miR-922	CLIP-seq
MIRT1341035	hsa-miR-3189-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SOX9	Unknown	12837698
USF1	Unknown	18165439
USF2	Unknown	18165439

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000245	Process	Spliceosomal complex assembly	NAS	8752089
GO:0000389	Process	MRNA 3'-splice site recognition	TAS	15647371
GO:0000398	Process	MRNA splicing, via spliceosome	IC	9731529
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003714	Function	Transcription corepressor activity	TAS	9660765
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	TAS	8752089
GO:0003729	Function	MRNA binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10449420, 12718882, 16189514, 17332742, 17589525, 22365833, 23273425, 25416956, 26420826, 31515488
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	NAS	7912130
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IDA	9731529
GO:0005840	Component	Ribosome	NAS	8752089
GO:0008270	Function	Zinc ion binding	IEA
GO:0042802	Function	Identical protein binding	IPI	22365833, 26420826
GO:0045131	Function	Pre-mRNA branch point binding	IEA
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IEA
GO:0048024	Process	Regulation of mRNA splicing, via spliceosome	IBA	21873635

Other IDs

• MIM: 601516
• HGNC: 12950
• e!Ensembl: ENSG00000168066

Protein

• UniProt ID: Q15637
• Protein name: Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162)
• Protein function: Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:
• PDB: 1K1G, 1O0P, 1OPI, 2M09, 2M0G, 4FXW, 4FXX, 7VH9, 7VPX, 8PXX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16275	SF1-HH	18 → 130	Splicing factor 1 helix-hairpin domain	Domain
  PF00013	KH_1	137 → 224	KH domain	Domain
  PF00098	zf-CCHC	278 → 293	Zinc knuckle	Domain

• Sequence:

  MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIED
  LTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALN
  PDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGK
  GSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLR
  KMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDP
  QSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMS
  TTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGP
  PPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPP
  PPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGS
  IPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPP
  PPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPPQN

• Sequence length: 639

Pathways

Reactome:

mRNA Splicing - Major Pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22535842