XBP1 (X-box binding protein 1)

Gene

• Entrez ID: 7494
• Gene name: X-box binding protein 1
• Gene symbol: XBP1
• Synonyms: TREB-5, TREB5, XBP-1, XBP2
• Chromosome: 22
• Chromosome location: 22q12.1|22q12
• Summary: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhance

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004462	hsa-miR-127-3p	Luciferase reporter assay	19530237
MIRT006375	hsa-miR-214-3p	ELISA, Flow, Luciferase reporter assay, qRT-PCR, Western blot	22359598
MIRT006375	hsa-miR-214-3p	ELISA, Flow, Luciferase reporter assay, qRT-PCR, Western blot	22359598
MIRT006375	hsa-miR-214-3p	ELISA, Flow, Luciferase reporter assay, qRT-PCR, Western blot	22359598
MIRT006375	hsa-miR-214-3p	ELISA, Flow, Luciferase reporter assay, qRT-PCR, Western blot	22359598
MIRT006375	hsa-miR-214-3p	ELISA, Flow, Luciferase reporter assay, qRT-PCR, Western blot	22359598
MIRT006375	hsa-miR-214-3p	ELISA, Flow, Luciferase reporter assay, qRT-PCR, Western blot	22359598
MIRT022880	hsa-miR-124-3p	Microarray	18668037
MIRT048823	hsa-miR-93-5p	CLASH	23622248
MIRT044687	hsa-miR-320a	CLASH	23622248
MIRT037784	hsa-miR-625-3p	CLASH	23622248
MIRT439138	hsa-let-7c-5p	3'LIFE	25074381
MIRT439138	hsa-let-7c-5p	3'LIFE	25074381
MIRT731734	hsa-miR-30a-3p	Luciferase reporter assay, qRT-PCR	26572862
MIRT731734	hsa-miR-30a-3p	Luciferase reporter assay, qRT-PCR	26572862
MIRT044687	hsa-miR-320a	Luciferase reporter assay, Western blotting, Immunofluorescence, qRT-PCR, Flow cytometry, Immunocytochemistry (ICC)	34112145
MIRT735003	hsa-miR-34a-5p	Luciferase reporter assay, Western blotting, Northern blotting, qRT-PCR	32531952
MIRT735436	hsa-miR-330-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	32386518
MIRT1495169	hsa-miR-1225-3p	CLIP-seq
MIRT1495170	hsa-miR-1251	CLIP-seq
MIRT1495171	hsa-miR-1269	CLIP-seq
MIRT1495172	hsa-miR-1269b	CLIP-seq
MIRT1495173	hsa-miR-1276	CLIP-seq
MIRT1495174	hsa-miR-1287	CLIP-seq
MIRT1495175	hsa-miR-1288	CLIP-seq
MIRT1495176	hsa-miR-1324	CLIP-seq
MIRT1495177	hsa-miR-144	CLIP-seq
MIRT1495178	hsa-miR-145	CLIP-seq
MIRT1495179	hsa-miR-186	CLIP-seq
MIRT1495180	hsa-miR-2054	CLIP-seq
MIRT1495181	hsa-miR-214	CLIP-seq
MIRT1495182	hsa-miR-2682	CLIP-seq
MIRT1495183	hsa-miR-302f	CLIP-seq
MIRT1495184	hsa-miR-3117-3p	CLIP-seq
MIRT1495185	hsa-miR-3119	CLIP-seq
MIRT1495186	hsa-miR-3121-3p	CLIP-seq
MIRT1495187	hsa-miR-3125	CLIP-seq
MIRT1495188	hsa-miR-3126-5p	CLIP-seq
MIRT1495189	hsa-miR-3132	CLIP-seq
MIRT1495190	hsa-miR-3133	CLIP-seq
MIRT1495191	hsa-miR-3135b	CLIP-seq
MIRT1495192	hsa-miR-3148	CLIP-seq
MIRT1495193	hsa-miR-3153	CLIP-seq
MIRT1495194	hsa-miR-3168	CLIP-seq
MIRT1495195	hsa-miR-3169	CLIP-seq
MIRT1495196	hsa-miR-3200-3p	CLIP-seq
MIRT1495197	hsa-miR-320b	CLIP-seq
MIRT1495198	hsa-miR-320d	CLIP-seq
MIRT1495199	hsa-miR-33a	CLIP-seq
MIRT1495200	hsa-miR-33b	CLIP-seq
MIRT1495201	hsa-miR-34a	CLIP-seq
MIRT1495202	hsa-miR-34c-5p	CLIP-seq
MIRT1495203	hsa-miR-3612	CLIP-seq
MIRT1495204	hsa-miR-3616-5p	CLIP-seq
MIRT1495205	hsa-miR-3617	CLIP-seq
MIRT1495206	hsa-miR-3618	CLIP-seq
MIRT1495207	hsa-miR-3619-5p	CLIP-seq
MIRT1495208	hsa-miR-3647-5p	CLIP-seq
MIRT1495209	hsa-miR-3665	CLIP-seq
MIRT1495210	hsa-miR-3682-5p	CLIP-seq
MIRT1495211	hsa-miR-376c	CLIP-seq
MIRT1495212	hsa-miR-3916	CLIP-seq
MIRT1495213	hsa-miR-3934	CLIP-seq
MIRT1495214	hsa-miR-3942-3p	CLIP-seq
MIRT1495215	hsa-miR-3943	CLIP-seq
MIRT1495216	hsa-miR-4271	CLIP-seq
MIRT1495217	hsa-miR-4275	CLIP-seq
MIRT1495218	hsa-miR-4291	CLIP-seq
MIRT1495219	hsa-miR-4313	CLIP-seq
MIRT1495220	hsa-miR-4419a	CLIP-seq
MIRT1495221	hsa-miR-4429	CLIP-seq
MIRT1495222	hsa-miR-4434	CLIP-seq
MIRT1495223	hsa-miR-4438	CLIP-seq
MIRT1495224	hsa-miR-4443	CLIP-seq
MIRT1495225	hsa-miR-449a	CLIP-seq
MIRT1495226	hsa-miR-449b	CLIP-seq
MIRT1495227	hsa-miR-449c	CLIP-seq
MIRT1495228	hsa-miR-4509	CLIP-seq
MIRT1495229	hsa-miR-4510	CLIP-seq
MIRT1495230	hsa-miR-4514	CLIP-seq
MIRT1495231	hsa-miR-4515	CLIP-seq
MIRT1495232	hsa-miR-4516	CLIP-seq
MIRT1495233	hsa-miR-4517	CLIP-seq
MIRT1495234	hsa-miR-4529-3p	CLIP-seq
MIRT1495235	hsa-miR-4531	CLIP-seq
MIRT1495236	hsa-miR-4539	CLIP-seq
MIRT1495237	hsa-miR-4635	CLIP-seq
MIRT1495238	hsa-miR-4645-5p	CLIP-seq
MIRT1495239	hsa-miR-4673	CLIP-seq
MIRT1495240	hsa-miR-4684-5p	CLIP-seq
MIRT1495241	hsa-miR-4690-5p	CLIP-seq
MIRT1495242	hsa-miR-4691-5p	CLIP-seq
MIRT1495243	hsa-miR-4692	CLIP-seq
MIRT1495244	hsa-miR-4694-3p	CLIP-seq
MIRT1495245	hsa-miR-4703-3p	CLIP-seq
MIRT1495246	hsa-miR-4704-5p	CLIP-seq
MIRT1495247	hsa-miR-4709-5p	CLIP-seq
MIRT1495248	hsa-miR-4712-3p	CLIP-seq
MIRT1495249	hsa-miR-4712-5p	CLIP-seq
MIRT1495250	hsa-miR-4716-3p	CLIP-seq
MIRT1495251	hsa-miR-4716-5p	CLIP-seq
MIRT1495252	hsa-miR-4719	CLIP-seq
MIRT1495253	hsa-miR-4725-3p	CLIP-seq
MIRT1495254	hsa-miR-4740-5p	CLIP-seq
MIRT1495255	hsa-miR-4759	CLIP-seq
MIRT1495256	hsa-miR-4764-5p	CLIP-seq
MIRT1495257	hsa-miR-513a-3p	CLIP-seq
MIRT1495258	hsa-miR-513b	CLIP-seq
MIRT1495259	hsa-miR-513c	CLIP-seq
MIRT1495260	hsa-miR-514b-5p	CLIP-seq
MIRT1495261	hsa-miR-522	CLIP-seq
MIRT1495262	hsa-miR-526b	CLIP-seq
MIRT1495263	hsa-miR-539	CLIP-seq
MIRT1495264	hsa-miR-548a-3p	CLIP-seq
MIRT1495265	hsa-miR-548b-3p	CLIP-seq
MIRT1495266	hsa-miR-548e	CLIP-seq
MIRT1495267	hsa-miR-548f	CLIP-seq
MIRT1495268	hsa-miR-548k	CLIP-seq
MIRT1495269	hsa-miR-548n	CLIP-seq
MIRT1495270	hsa-miR-548t	CLIP-seq
MIRT1495271	hsa-miR-550b	CLIP-seq
MIRT1495272	hsa-miR-573	CLIP-seq
MIRT1495273	hsa-miR-600	CLIP-seq
MIRT1495274	hsa-miR-619	CLIP-seq
MIRT1495275	hsa-miR-625	CLIP-seq
MIRT1495276	hsa-miR-633	CLIP-seq
MIRT1495277	hsa-miR-637	CLIP-seq
MIRT1495278	hsa-miR-641	CLIP-seq
MIRT1495279	hsa-miR-650	CLIP-seq
MIRT1495280	hsa-miR-654-3p	CLIP-seq
MIRT1495281	hsa-miR-761	CLIP-seq
MIRT1495282	hsa-miR-770-5p	CLIP-seq
MIRT1495283	hsa-miR-877	CLIP-seq
MIRT1495284	hsa-miR-922	CLIP-seq
MIRT1495285	hsa-miR-934	CLIP-seq
MIRT1495286	hsa-miR-942	CLIP-seq
MIRT1495169	hsa-miR-1225-3p	CLIP-seq
MIRT1495170	hsa-miR-1251	CLIP-seq
MIRT1495171	hsa-miR-1269	CLIP-seq
MIRT1495172	hsa-miR-1269b	CLIP-seq
MIRT1495173	hsa-miR-1276	CLIP-seq
MIRT1495174	hsa-miR-1287	CLIP-seq
MIRT1495175	hsa-miR-1288	CLIP-seq
MIRT1495176	hsa-miR-1324	CLIP-seq
MIRT1495177	hsa-miR-144	CLIP-seq
MIRT1495178	hsa-miR-145	CLIP-seq
MIRT1495180	hsa-miR-2054	CLIP-seq
MIRT1495181	hsa-miR-214	CLIP-seq
MIRT1495182	hsa-miR-2682	CLIP-seq
MIRT2149195	hsa-miR-2909	CLIP-seq
MIRT1495183	hsa-miR-302f	CLIP-seq
MIRT1495184	hsa-miR-3117-3p	CLIP-seq
MIRT1495186	hsa-miR-3121-3p	CLIP-seq
MIRT1495187	hsa-miR-3125	CLIP-seq
MIRT1495188	hsa-miR-3126-5p	CLIP-seq
MIRT1495189	hsa-miR-3132	CLIP-seq
MIRT1495191	hsa-miR-3135b	CLIP-seq
MIRT1495192	hsa-miR-3148	CLIP-seq
MIRT1495193	hsa-miR-3153	CLIP-seq
MIRT2149196	hsa-miR-3162-5p	CLIP-seq
MIRT1495194	hsa-miR-3168	CLIP-seq
MIRT1495195	hsa-miR-3169	CLIP-seq
MIRT1495196	hsa-miR-3200-3p	CLIP-seq
MIRT1495197	hsa-miR-320b	CLIP-seq
MIRT1495198	hsa-miR-320d	CLIP-seq
MIRT1495201	hsa-miR-34a	CLIP-seq
MIRT1495202	hsa-miR-34c-5p	CLIP-seq
MIRT1495204	hsa-miR-3616-5p	CLIP-seq
MIRT1495205	hsa-miR-3617	CLIP-seq
MIRT1495206	hsa-miR-3618	CLIP-seq
MIRT1495207	hsa-miR-3619-5p	CLIP-seq
MIRT1495208	hsa-miR-3647-5p	CLIP-seq
MIRT2149197	hsa-miR-3658	CLIP-seq
MIRT1495209	hsa-miR-3665	CLIP-seq
MIRT1495210	hsa-miR-3682-5p	CLIP-seq
MIRT1495211	hsa-miR-376c	CLIP-seq
MIRT1495212	hsa-miR-3916	CLIP-seq
MIRT1495213	hsa-miR-3934	CLIP-seq
MIRT1495214	hsa-miR-3942-3p	CLIP-seq
MIRT1495215	hsa-miR-3943	CLIP-seq
MIRT1495217	hsa-miR-4275	CLIP-seq
MIRT1495218	hsa-miR-4291	CLIP-seq
MIRT1495219	hsa-miR-4313	CLIP-seq
MIRT1495220	hsa-miR-4419a	CLIP-seq
MIRT1495221	hsa-miR-4429	CLIP-seq
MIRT1495222	hsa-miR-4434	CLIP-seq
MIRT1495223	hsa-miR-4438	CLIP-seq
MIRT1495225	hsa-miR-449a	CLIP-seq
MIRT1495226	hsa-miR-449b	CLIP-seq
MIRT1495227	hsa-miR-449c	CLIP-seq
MIRT1495228	hsa-miR-4509	CLIP-seq
MIRT1495229	hsa-miR-4510	CLIP-seq
MIRT1495230	hsa-miR-4514	CLIP-seq
MIRT1495231	hsa-miR-4515	CLIP-seq
MIRT1495232	hsa-miR-4516	CLIP-seq
MIRT1495233	hsa-miR-4517	CLIP-seq
MIRT1495234	hsa-miR-4529-3p	CLIP-seq
MIRT1495235	hsa-miR-4531	CLIP-seq
MIRT1495236	hsa-miR-4539	CLIP-seq
MIRT1495237	hsa-miR-4635	CLIP-seq
MIRT1495238	hsa-miR-4645-5p	CLIP-seq
MIRT2149198	hsa-miR-4662a-3p	CLIP-seq
MIRT2149199	hsa-miR-4668-5p	CLIP-seq
MIRT1495239	hsa-miR-4673	CLIP-seq
MIRT1495240	hsa-miR-4684-5p	CLIP-seq
MIRT1495241	hsa-miR-4690-5p	CLIP-seq
MIRT1495242	hsa-miR-4691-5p	CLIP-seq
MIRT1495243	hsa-miR-4692	CLIP-seq
MIRT1495244	hsa-miR-4694-3p	CLIP-seq
MIRT1495245	hsa-miR-4703-3p	CLIP-seq
MIRT1495246	hsa-miR-4704-5p	CLIP-seq
MIRT1495247	hsa-miR-4709-5p	CLIP-seq
MIRT1495248	hsa-miR-4712-3p	CLIP-seq
MIRT1495249	hsa-miR-4712-5p	CLIP-seq
MIRT1495251	hsa-miR-4716-5p	CLIP-seq
MIRT1495252	hsa-miR-4719	CLIP-seq
MIRT2149200	hsa-miR-4725-5p	CLIP-seq
MIRT1495254	hsa-miR-4740-5p	CLIP-seq
MIRT1495255	hsa-miR-4759	CLIP-seq
MIRT1495256	hsa-miR-4764-5p	CLIP-seq
MIRT2149201	hsa-miR-504	CLIP-seq
MIRT1495257	hsa-miR-513a-3p	CLIP-seq
MIRT1495258	hsa-miR-513b	CLIP-seq
MIRT1495259	hsa-miR-513c	CLIP-seq
MIRT1495260	hsa-miR-514b-5p	CLIP-seq
MIRT1495261	hsa-miR-522	CLIP-seq
MIRT1495262	hsa-miR-526b	CLIP-seq
MIRT1495264	hsa-miR-548a-3p	CLIP-seq
MIRT1495266	hsa-miR-548e	CLIP-seq
MIRT1495267	hsa-miR-548f	CLIP-seq
MIRT1495268	hsa-miR-548k	CLIP-seq
MIRT1495269	hsa-miR-548n	CLIP-seq
MIRT1495270	hsa-miR-548t	CLIP-seq
MIRT1495271	hsa-miR-550b	CLIP-seq
MIRT1495272	hsa-miR-573	CLIP-seq
MIRT2149202	hsa-miR-577	CLIP-seq
MIRT1495273	hsa-miR-600	CLIP-seq
MIRT1495274	hsa-miR-619	CLIP-seq
MIRT1495276	hsa-miR-633	CLIP-seq
MIRT1495277	hsa-miR-637	CLIP-seq
MIRT1495278	hsa-miR-641	CLIP-seq
MIRT1495280	hsa-miR-654-3p	CLIP-seq
MIRT1495281	hsa-miR-761	CLIP-seq
MIRT1495282	hsa-miR-770-5p	CLIP-seq
MIRT1495283	hsa-miR-877	CLIP-seq
MIRT1495284	hsa-miR-922	CLIP-seq
MIRT1495285	hsa-miR-934	CLIP-seq
MIRT1495286	hsa-miR-942	CLIP-seq
MIRT1495169	hsa-miR-1225-3p	CLIP-seq
MIRT1495170	hsa-miR-1251	CLIP-seq
MIRT1495171	hsa-miR-1269	CLIP-seq
MIRT1495172	hsa-miR-1269b	CLIP-seq
MIRT1495173	hsa-miR-1276	CLIP-seq
MIRT1495174	hsa-miR-1287	CLIP-seq
MIRT1495175	hsa-miR-1288	CLIP-seq
MIRT1495176	hsa-miR-1324	CLIP-seq
MIRT1495177	hsa-miR-144	CLIP-seq
MIRT1495178	hsa-miR-145	CLIP-seq
MIRT1495180	hsa-miR-2054	CLIP-seq
MIRT1495181	hsa-miR-214	CLIP-seq
MIRT1495182	hsa-miR-2682	CLIP-seq
MIRT1495184	hsa-miR-3117-3p	CLIP-seq
MIRT1495186	hsa-miR-3121-3p	CLIP-seq
MIRT1495188	hsa-miR-3126-5p	CLIP-seq
MIRT1495191	hsa-miR-3135b	CLIP-seq
MIRT1495192	hsa-miR-3148	CLIP-seq
MIRT1495194	hsa-miR-3168	CLIP-seq
MIRT1495195	hsa-miR-3169	CLIP-seq
MIRT1495196	hsa-miR-3200-3p	CLIP-seq
MIRT1495197	hsa-miR-320b	CLIP-seq
MIRT1495198	hsa-miR-320d	CLIP-seq
MIRT1495201	hsa-miR-34a	CLIP-seq
MIRT1495202	hsa-miR-34c-5p	CLIP-seq
MIRT1495203	hsa-miR-3612	CLIP-seq
MIRT1495204	hsa-miR-3616-5p	CLIP-seq
MIRT1495207	hsa-miR-3619-5p	CLIP-seq
MIRT1495208	hsa-miR-3647-5p	CLIP-seq
MIRT1495209	hsa-miR-3665	CLIP-seq
MIRT1495210	hsa-miR-3682-5p	CLIP-seq
MIRT1495211	hsa-miR-376c	CLIP-seq
MIRT1495213	hsa-miR-3934	CLIP-seq
MIRT1495214	hsa-miR-3942-3p	CLIP-seq
MIRT1495215	hsa-miR-3943	CLIP-seq
MIRT1495216	hsa-miR-4271	CLIP-seq
MIRT1495217	hsa-miR-4275	CLIP-seq
MIRT1495218	hsa-miR-4291	CLIP-seq
MIRT1495219	hsa-miR-4313	CLIP-seq
MIRT1495220	hsa-miR-4419a	CLIP-seq
MIRT1495221	hsa-miR-4429	CLIP-seq
MIRT1495222	hsa-miR-4434	CLIP-seq
MIRT1495223	hsa-miR-4438	CLIP-seq
MIRT1495224	hsa-miR-4443	CLIP-seq
MIRT1495225	hsa-miR-449a	CLIP-seq
MIRT1495226	hsa-miR-449b	CLIP-seq
MIRT1495227	hsa-miR-449c	CLIP-seq
MIRT1495228	hsa-miR-4509	CLIP-seq
MIRT1495229	hsa-miR-4510	CLIP-seq
MIRT1495230	hsa-miR-4514	CLIP-seq
MIRT1495231	hsa-miR-4515	CLIP-seq
MIRT1495232	hsa-miR-4516	CLIP-seq
MIRT1495233	hsa-miR-4517	CLIP-seq
MIRT1495234	hsa-miR-4529-3p	CLIP-seq
MIRT1495235	hsa-miR-4531	CLIP-seq
MIRT1495236	hsa-miR-4539	CLIP-seq
MIRT1495237	hsa-miR-4635	CLIP-seq
MIRT1495238	hsa-miR-4645-5p	CLIP-seq
MIRT1495239	hsa-miR-4673	CLIP-seq
MIRT1495240	hsa-miR-4684-5p	CLIP-seq
MIRT1495241	hsa-miR-4690-5p	CLIP-seq
MIRT1495242	hsa-miR-4691-5p	CLIP-seq
MIRT1495243	hsa-miR-4692	CLIP-seq
MIRT1495244	hsa-miR-4694-3p	CLIP-seq
MIRT1495245	hsa-miR-4703-3p	CLIP-seq
MIRT1495246	hsa-miR-4704-5p	CLIP-seq
MIRT1495247	hsa-miR-4709-5p	CLIP-seq
MIRT1495248	hsa-miR-4712-3p	CLIP-seq
MIRT1495249	hsa-miR-4712-5p	CLIP-seq
MIRT1495250	hsa-miR-4716-3p	CLIP-seq
MIRT1495253	hsa-miR-4725-3p	CLIP-seq
MIRT2149200	hsa-miR-4725-5p	CLIP-seq
MIRT1495254	hsa-miR-4740-5p	CLIP-seq
MIRT1495255	hsa-miR-4759	CLIP-seq
MIRT1495256	hsa-miR-4764-5p	CLIP-seq
MIRT2149201	hsa-miR-504	CLIP-seq
MIRT1495257	hsa-miR-513a-3p	CLIP-seq
MIRT1495259	hsa-miR-513c	CLIP-seq
MIRT1495260	hsa-miR-514b-5p	CLIP-seq
MIRT1495261	hsa-miR-522	CLIP-seq
MIRT1495264	hsa-miR-548a-3p	CLIP-seq
MIRT1495266	hsa-miR-548e	CLIP-seq
MIRT1495267	hsa-miR-548f	CLIP-seq
MIRT1495268	hsa-miR-548k	CLIP-seq
MIRT1495271	hsa-miR-550b	CLIP-seq
MIRT1495272	hsa-miR-573	CLIP-seq
MIRT1495273	hsa-miR-600	CLIP-seq
MIRT1495274	hsa-miR-619	CLIP-seq
MIRT1495275	hsa-miR-625	CLIP-seq
MIRT1495276	hsa-miR-633	CLIP-seq
MIRT1495277	hsa-miR-637	CLIP-seq
MIRT1495279	hsa-miR-650	CLIP-seq
MIRT1495280	hsa-miR-654-3p	CLIP-seq
MIRT1495281	hsa-miR-761	CLIP-seq
MIRT1495282	hsa-miR-770-5p	CLIP-seq
MIRT1495284	hsa-miR-922	CLIP-seq
MIRT1495286	hsa-miR-942	CLIP-seq
MIRT1495176	hsa-miR-1324	CLIP-seq
MIRT1495223	hsa-miR-4438	CLIP-seq
MIRT1495286	hsa-miR-942	CLIP-seq
MIRT1495178	hsa-miR-145	CLIP-seq
MIRT1495180	hsa-miR-2054	CLIP-seq
MIRT1495182	hsa-miR-2682	CLIP-seq
MIRT1495194	hsa-miR-3168	CLIP-seq
MIRT1495197	hsa-miR-320b	CLIP-seq
MIRT1495198	hsa-miR-320d	CLIP-seq
MIRT1495201	hsa-miR-34a	CLIP-seq
MIRT1495202	hsa-miR-34c-5p	CLIP-seq
MIRT2149197	hsa-miR-3658	CLIP-seq
MIRT1495210	hsa-miR-3682-5p	CLIP-seq
MIRT1495217	hsa-miR-4275	CLIP-seq
MIRT1495221	hsa-miR-4429	CLIP-seq
MIRT1495223	hsa-miR-4438	CLIP-seq
MIRT1495225	hsa-miR-449a	CLIP-seq
MIRT1495226	hsa-miR-449b	CLIP-seq
MIRT1495227	hsa-miR-449c	CLIP-seq
MIRT1495230	hsa-miR-4514	CLIP-seq
MIRT1495233	hsa-miR-4517	CLIP-seq
MIRT1495238	hsa-miR-4645-5p	CLIP-seq
MIRT2149198	hsa-miR-4662a-3p	CLIP-seq
MIRT1495239	hsa-miR-4673	CLIP-seq
MIRT1495242	hsa-miR-4691-5p	CLIP-seq
MIRT1495243	hsa-miR-4692	CLIP-seq
MIRT1495245	hsa-miR-4703-3p	CLIP-seq
MIRT1495249	hsa-miR-4712-5p	CLIP-seq
MIRT1495259	hsa-miR-513c	CLIP-seq
MIRT1495260	hsa-miR-514b-5p	CLIP-seq
MIRT1495268	hsa-miR-548k	CLIP-seq
MIRT1495269	hsa-miR-548n	CLIP-seq
MIRT1495270	hsa-miR-548t	CLIP-seq
MIRT1495271	hsa-miR-550b	CLIP-seq
MIRT2149202	hsa-miR-577	CLIP-seq
MIRT1495276	hsa-miR-633	CLIP-seq
MIRT1495282	hsa-miR-770-5p	CLIP-seq
MIRT1495286	hsa-miR-942	CLIP-seq
MIRT1495182	hsa-miR-2682	CLIP-seq
MIRT1495194	hsa-miR-3168	CLIP-seq
MIRT1495197	hsa-miR-320b	CLIP-seq
MIRT1495198	hsa-miR-320d	CLIP-seq
MIRT1495201	hsa-miR-34a	CLIP-seq
MIRT1495202	hsa-miR-34c-5p	CLIP-seq
MIRT2149197	hsa-miR-3658	CLIP-seq
MIRT1495217	hsa-miR-4275	CLIP-seq
MIRT1495221	hsa-miR-4429	CLIP-seq
MIRT1495223	hsa-miR-4438	CLIP-seq
MIRT1495225	hsa-miR-449a	CLIP-seq
MIRT1495226	hsa-miR-449b	CLIP-seq
MIRT1495227	hsa-miR-449c	CLIP-seq
MIRT1495230	hsa-miR-4514	CLIP-seq
MIRT1495236	hsa-miR-4539	CLIP-seq
MIRT1495238	hsa-miR-4645-5p	CLIP-seq
MIRT2149198	hsa-miR-4662a-3p	CLIP-seq
MIRT1495239	hsa-miR-4673	CLIP-seq
MIRT1495242	hsa-miR-4691-5p	CLIP-seq
MIRT1495243	hsa-miR-4692	CLIP-seq
MIRT1495245	hsa-miR-4703-3p	CLIP-seq
MIRT1495248	hsa-miR-4712-3p	CLIP-seq
MIRT1495259	hsa-miR-513c	CLIP-seq
MIRT1495260	hsa-miR-514b-5p	CLIP-seq
MIRT1495268	hsa-miR-548k	CLIP-seq
MIRT1495269	hsa-miR-548n	CLIP-seq
MIRT1495270	hsa-miR-548t	CLIP-seq
MIRT2149202	hsa-miR-577	CLIP-seq
MIRT1495286	hsa-miR-942	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATF6	Unknown	20003459;24269637
BACH2	Repression	24821775
BCL6	Repression	24821775
CEBPB	Activation	19717648
PAX5	Repression	8627152

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000987	Function	Cis-regulatory region sequence-specific DNA binding	IDA	2196176
GO:0001525	Process	Angiogenesis	ISS
GO:0001889	Process	Liver development	ISS
GO:0002639	Process	Positive regulation of immunoglobulin production	IDA	11460154
GO:0002639	Process	Positive regulation of immunoglobulin production	ISS
GO:0003677	Function	DNA binding	TAS	1718857
GO:0003700	Function	DNA-binding transcription factor activity	IDA	1903538, 8657566
GO:0005515	Function	Protein binding	IPI	20102225, 24670641, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	ISS
GO:0005783	Component	Endoplasmic reticulum	IDA	23529610
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006366	Process	Transcription by RNA polymerase II	ISS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	ISS
GO:0006633	Process	Fatty acid biosynthetic process	TAS	22013210
GO:0006914	Process	Autophagy	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006955	Process	Immune response	TAS	22013210
GO:0006990	Process	Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	IBA	21873635
GO:0006990	Process	Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	ISS
GO:0007517	Process	Muscle organ development	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	25656649
GO:0008284	Process	Positive regulation of cell population proliferation	IGI	25656649
GO:0010832	Process	Negative regulation of myotube differentiation	ISS
GO:0015031	Process	Protein transport	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0030335	Process	Positive regulation of cell migration	IDA	25656649
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	ISS
GO:0031670	Process	Cellular response to nutrient	ISS
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS
GO:0032869	Process	Cellular response to insulin stimulus	ISS
GO:0035356	Process	Cellular triglyceride homeostasis	ISS
GO:0035470	Process	Positive regulation of vascular wound healing	IDA	25656649
GO:0036498	Process	IRE1-mediated unfolded protein response	TAS	22013210, 22934019
GO:0036500	Process	ATF6-mediated unfolded protein response	TAS
GO:0042149	Process	Cellular response to glucose starvation	ISS
GO:0042632	Process	Cholesterol homeostasis	ISS
GO:0043066	Process	Negative regulation of apoptotic process	ISS
GO:0045348	Process	Positive regulation of MHC class II biosynthetic process	IMP	1903538
GO:0045579	Process	Positive regulation of B cell differentiation	IDA	11460154
GO:0045582	Process	Positive regulation of T cell differentiation	IDA	11460154
GO:0045600	Process	Positive regulation of fat cell differentiation	ISS
GO:0045766	Process	Positive regulation of angiogenesis	IMP	25656649
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	8657566
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	1903538
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046982	Function	Protein heterodimerization activity	IDA	1903538
GO:0048666	Process	Neuron development	ISS
GO:0055089	Process	Fatty acid homeostasis	ISS
GO:0055092	Process	Sterol homeostasis	ISS
GO:0060612	Process	Adipose tissue development	ISS
GO:0071222	Process	Cellular response to lipopolysaccharide	IDA	11460154
GO:0071230	Process	Cellular response to amino acid stimulus	ISS
GO:0071332	Process	Cellular response to fructose stimulus	ISS
GO:0071333	Process	Cellular response to glucose stimulus	ISS
GO:0071353	Process	Cellular response to interleukin-4	ISS
GO:0071375	Process	Cellular response to peptide hormone stimulus	ISS
GO:1900100	Process	Positive regulation of plasma cell differentiation	IDA	11460154
GO:1900103	Process	Positive regulation of endoplasmic reticulum unfolded protein response	IMP	16645094
GO:1902236	Process	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA	19135031
GO:1903489	Process	Positive regulation of lactation	ISS
GO:1990418	Process	Response to insulin-like growth factor stimulus	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000347	Process	Positive regulation of hepatocyte proliferation	ISS

Other IDs

• MIM: 194355
• HGNC: 12801
• e!Ensembl: ENSG00000100219

Protein

• UniProt ID: P17861
• Protein name: X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]
• Protein function: Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tiss
• PDB: 6R5Q, 6R6G, 6R6P, 6R7Q
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07716	bZIP_2	68 → 122	Basic region leucine zipper	Coiled-coil

• Sequence:

  MVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARK
  RQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLR
  EKTHGLVVENQELRQRLGMDALVAEEEAEAKGNEVRPVAGSAESAALRLRAPLQQVQAQL
  SPLQNISPWILAVLTLQIQSLISCWAFWTTWTQSCSSNALPQSLPAWRSSQRSTQKDPVP
  YQPPFLCQWGRHQPSWKPLMN

• Sequence length: 261

Pathways

KEGG:

Protein processing in endoplasmic reticulum
Non-alcoholic fatty liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Spinocerebellar ataxia
Pathways of neurodegeneration - multiple diseases
Lipid and atherosclerosis

Reactome:

XBP1(S) activates chaperone genes
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Carcinoma	Squamous cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	22960999
Esophagus neoplasm	Esophageal Neoplasms, Squamous cell carcinoma of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	22960999, 25129146
Glioma	Glioma, mixed gliomas, Malignant Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499, rs1060500122, rs781647403, rs1060500126, rs1554897889, rs1114167629, rs1114167656, rs587782603, rs1554893824, rs1554900615, rs1564568660, rs786204900, rs762518389, rs1339631701	21138464
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	16958950, 15184063, 16342282

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder, Bipolar I disorder		18771604, 25231123, 17217928
Fatty liver	Fatty Liver, Steatohepatitis		24097666
Major affective disorder	MAJOR AFFECTIVE DISORDER 7	rs1601436804
Non-alcoholic fatty liver disease	Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis		24097666