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WNT7A (Wnt family member 7A)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7476
Gene nameGene Name - the full gene name approved by the HGNC.
Wnt family member 7A
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
WNT7A
SynonymsGene synonyms aliases
SANTOS, Wnt-7a
ChromosomeChromosome number
3
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p25.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fat
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs75651130 G>A,C Conflicting-interpretations-of-pathogenicity Synonymous variant, coding sequence variant, missense variant
rs104893832 C>T Pathogenic Missense variant, coding sequence variant
rs104893835 G>A Pathogenic Missense variant, coding sequence variant
rs149363953 G>A Conflicting-interpretations-of-pathogenicity Coding sequence variant, synonymous variant
rs149962459 C>T Conflicting-interpretations-of-pathogenicity Coding sequence variant, synonymous variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT054418 hsa-miR-195-5p Luciferase reporter assay, Western blot 24520312
MIRT054420 hsa-miR-497-5p Luciferase reporter assay, Western blot 24520312
MIRT607119 hsa-miR-8485 HITS-CLIP 23313552
MIRT607118 hsa-miR-329-3p HITS-CLIP 23313552
MIRT607117 hsa-miR-362-3p HITS-CLIP 23313552
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000578 Process Embryonic axis specification IMP 16826533
GO:0001502 Process Cartilage condensation IDA 17202865
GO:0001525 Process Angiogenesis IEA
GO:0002062 Process Chondrocyte differentiation IDA 17202865
GO:0005102 Function Signaling receptor binding IPI 12857724
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O00755
Protein name Protein Wnt-7a
Protein function Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patt
PDB 4UZQ , 8TZO , 8TZP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00110 wnt
40 349
wnt family
Family
Sequence
Sequence length 349
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  mTOR signaling pathway
Wnt signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Melanogenesis
Cushing syndrome
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  WNT ligand biogenesis and trafficking
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, Familial rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs1885090126, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs749428135, rs371575563, rs1402429085, rs1218712729, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087 11796754
Anonychia ANONYCHIA rs74315420, rs74315421, rs74315422, rs74315423, rs387907026, rs387907027, rs387907028, rs780261665, rs775644973, rs370554150
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Ectrodactyly Ectrodactyly rs1850314485
Unknown
Disease name Disease term dbSNP ID References
Al awadi syndrome Al Awadi syndrome 17431918, 16826533, 20949531, 21271649, 23266637, 23922166, 27638328
Elbow ankylosis Ankylosis of the elbow joint
Clinodactyly Clinodactyly of fingers, Clinodactyly
Congenital clubfoot Congenital clubfoot

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