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VRK2 (VRK serine/threonine kinase 2)
Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7444
Gene nameGene Name - the full gene name approved by the HGNC.
VRK serine/threonine kinase 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
VRK2
SynonymsGene synonyms aliases
-
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p16.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associ
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT1487504 hsa-miR-2053 CLIP-seq
MIRT1487505 hsa-miR-2117 CLIP-seq
MIRT1487506 hsa-miR-4273 CLIP-seq
MIRT1487507 hsa-miR-4753-3p CLIP-seq
MIRT2367274 hsa-miR-3117-5p CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 14645249, 16495336, 16704422
GO:0005515 Function Protein binding IPI 16963744, 20679487, 22752157, 32296183
GO:0005524 Function ATP binding IEA
GO:0005634 Component Nucleus IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q86Y07
Protein name Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)
Protein function Serine/threonine kinase that regulates several signal transduction pathways (PubMed:14645249, PubMed:16495336, PubMed:16704422, PubMed:17709393, PubMed:18286207, PubMed:18617507, PubMed:20679487). Isoform 1 modulates the stress response to hypox
PDB 2V62 , 5UU1 , 6NCG , 8Q1Z , 9FET
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
29 → 311
Protein kinase domain
 Domain
Sequence 
MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV
KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD
QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM
LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI
EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI
SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS
EETNADVYYYRIIIPVLLMLVFLALFFL
Sequence length 508
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
Reactome
    Nuclear Envelope Breakdown
Initiation of Nuclear Envelope (NE) Reformation
Associated diseases
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Fanconi anemia FANCONI ANEMIA, COMPLEMENTATION GROUP L rs121918164, rs118203997, rs118203998, rs118203999, rs397507552, rs778507965, rs747851434, rs587776570, rs121907930, rs794726660, rs137852986, rs730880277, rs730880278, rs104894221, rs587778340, rs104894222, rs121434425, rs200479612, rs121434426, rs397507561, rs149616199, rs397507560, rs587776640, rs267606998, rs267606999, rs121434505, rs121434506, rs878854342, rs80359550, rs80359604, rs80359070, rs80358695, rs80358979, rs80359180, rs81002897, rs81002899, rs1569085810, rs121917786, rs121917787, rs121917788, rs104886458, rs121917783, rs104886456, rs121917784, rs104886457, rs794726667, rs104886459, rs121917785, rs794726668, rs149364097, rs1596534281, rs1218169126, rs773642409, rs1567178071, rs387907159, rs1569083185, rs1569083464, rs80359271, rs80359507, rs28897743, rs397507404, rs397507553, rs397507559, rs80358533, rs276174859, rs80359024, rs55770810, rs397509400, rs149364215, rs397509401, rs397509402, rs80359161, rs80359773, rs515726073, rs180177143, rs180177112, rs180177113, rs180177126, rs180177133, rs180177135, rs180177085, rs180177092, rs587779904, rs587779909, rs587780224, rs587780228, rs587778134, rs587780240, rs587781410, rs587780259, rs148100796, rs587778319, rs587778337, rs587778345, rs587777945, rs587776416, rs587780840, rs587781287, rs200293302, rs587781416, rs587781490, rs587781655, rs368796923, rs587776410, rs587781985, rs587781995, rs587782036, rs587782170, rs574552037, rs587782410, rs180177110, rs587782528, rs587782533, rs587782699, rs587782702, rs587782818, rs587783028, rs730881710, rs730881709, rs730881708, rs730881731, rs730881619, rs730881876, rs730881879, rs730881942, rs730881939, rs730881940, rs730881931, rs730881941, rs730881933, rs730881649, rs786203488, rs786203945, rs786202563, rs786201909, rs587782286, rs770637624, rs786203384, rs775537066, rs747604569, rs763009188, rs786204205, rs786204246, rs756367276, rs786204204, rs786204238, rs774209201, rs781542763, rs377294947, rs752160950, rs774357609, rs796052212, rs879255255, rs747622521, rs772359099, rs797045116, rs375656231, rs762902309, rs869320684, rs869320685, rs797045175, rs797045570, rs863224506, rs863224441, rs863224827, rs780825099, rs779582317, rs775171520, rs371897078, rs766105286, rs770318990, rs864622739, rs747892390, rs149277003, rs864622188, rs864622187, rs864622611, rs864622277, rs869312763, rs762128147, rs876658813, rs747148023, rs757128712, rs767796996, rs876659497, rs876658644, rs760235677, rs876658652, rs876659874, rs759292615, rs771654971, rs775735278, rs769039987, rs878855046, rs766567785, rs145394391, rs878853671, rs878854181, rs878855162, rs574034197, rs878853663, rs878853660, rs759877008, rs878855177, rs760551339, rs878855143, rs755471995, rs879254329, rs587780653, rs886038169, rs886038189, rs370510954, rs761988162, rs529201454, rs886063898, rs760412752, rs867319477, rs1057516455, rs1057517170, rs1057516488, rs1057516963, rs1057516298, rs944083227, rs1057516313, rs1057516919, rs1057516248, rs1057516792, rs1057517125, rs1057517203, rs1057516917, rs1057516247, rs1057516291, rs1057516384, rs1057517219, rs1057517147, rs1057517131, rs868273545, rs372163487, rs1057516430, rs773159223, rs1057517641, rs1057517643, rs1057517648, rs1057519413, rs1057517812, rs112832879, rs1057521855, rs1060499823, rs774170058, rs1060501862, rs1554842611, rs745495865, rs147021911, rs758597713, rs769248873, rs1060501900, rs1060501878, rs755546887, rs1060501879, rs1060502748, rs1060501880, rs1060501876, rs555449842, rs1060502605, rs1060502601, rs774586107, rs768793789, rs1060499606, rs754850404, rs759900071, rs1064795597, rs776054094, rs1057519366, rs753211631, rs754367349, rs182657062, rs1553608812, rs1188581065, rs1555547474, rs1555548428, rs149551759, rs772751654, rs780020495, rs773906241, rs368728266, rs769547477, rs756140957, rs1555603011, rs1553435610, rs1554829415, rs1554829441, rs1554833186, rs1166587869, rs1447482674, rs781479923, rs777825824, rs752720263, rs1432988639, rs1555536446, rs1555538740, rs1343140664, rs759899153, rs764122657, rs1555593715, rs1338138752, rs1555594864, rs1555605074, rs1555602141, rs1555593616, rs774684620, rs754929230, rs776529713, rs746993675, rs1555594912, rs1327086366, rs145310733, rs1555599288, rs1555593450, rs1413872299, rs1555605103, rs748589398, rs786202760, rs1555607022, rs1555593670, rs1555594590, rs1555602159, rs1555591308, rs539460201, rs774949203, rs1555286294, rs1028347439, rs1555603056, rs1484503633, rs1555429629, rs753105795, rs1553607671, rs1289665675, rs767518932, rs144567652, rs1315905872, rs1555536390, rs1166286386, rs760126773, rs755922289, rs1555591851, rs1555597094, rs915983602, rs765551897, rs768006618, rs1555594617, rs1410356625, rs1554830249, rs1268491295, rs1368374192, rs1364238660, rs1554827166, rs1554829561, rs1554830220, rs1554830789, rs1554827136, rs200719554, rs1554829555, rs1554829575, rs777918411, rs1554827159, rs1554858249, rs745882980, rs776969626, rs1555533693, rs940187828, rs753700179, rs771775516, rs986710868, rs1555534521, rs1555535472, rs34885858, rs751266148, rs1555536361, rs1555545421, rs1302083447, rs1381684916, rs1439817346, rs1555545517, rs1555540076, rs1555542860, rs775388912, rs1555547955, rs1555549451, rs1555552006, rs927630499, rs757504102, rs1555552506, rs1285346388, rs947311062, rs1247378731, rs1205909298, rs937874201, rs1555548512, rs1555564451, rs754104046, rs762526878, rs1555571116, rs1555548632, rs1485075318, rs147945881, rs753980264, rs758528624, rs1555561294, rs1365019056, rs183350210, rs751076878, rs774026652, rs761341952, rs1555581729, rs1348367722, rs1184639006, rs1477653630, rs1555574913, rs891323617, rs769479800, rs1555532944, rs1555535527, rs1555537347, rs1555538571, rs1278836130, rs745568821, rs1283284704, rs1458001028, rs1555545592, rs763378933, rs779375100, rs1555554788, rs976556567, rs753728435, rs1388128874, rs746518509, rs1232171121, rs772858764, rs1483028018, rs1484087361, rs1555532943, rs1555532946, rs1555534060, rs753063086, rs1555540048, rs372254398, rs1555545553, rs1173704265, rs1555547935, rs1448463647, rs1555549535, rs755104393, rs1555556175, rs1438828232, rs148473140, rs769580546, rs1555564436, rs1291524243, rs1555573118, rs1555575253, rs765277254, rs1555580427, rs1566260827, rs1569083679, rs1558737575, rs761039364, rs144729980, rs943009372, rs775076977, rs1205006300, rs1558727300, rs761291501, rs1563986439, rs1209807088, rs1566790465, rs1555364837, rs1567170994, rs752457319, rs1567601557, rs1567616135, rs779834525, rs1564641485, rs1564720605, rs1567782936, rs1567789009, rs1567166544, rs1374769712, rs1567786509, rs1567782755, rs1567179036, rs1567785872, rs1035139114, rs1564719070, rs1567799943, rs1567817415, rs1567593047, rs1564719151, rs773363446, rs1270367757, rs1156577591, rs903442271, rs200628199, rs1564678441, rs1567165630, rs1390620949, rs757418016, rs1567618264, rs1559399574, rs1567618907, rs769862233, rs757662453, rs1566232471, rs1567621042, rs1313006784, rs1060502588, rs1567799818, rs748000458, rs140404896, rs1291935778, rs200715208, rs1405317971, rs1567628967, rs1564720637, rs1566766719, rs140180549, rs374328858, rs753485145, rs758423821, rs1588029220, rs1588218493, rs1593903422, rs765686151, rs778744393, rs1594810556, rs1596318782, rs1596336945, rs1266198754, rs1598048941, rs1598067532, rs1186669727, rs761725308, rs1598127082, rs1598129626, rs752864343, rs1353992080, rs1598184500, rs1598191053, rs1452688134, rs1598448896, rs1598460178, rs1598460983, rs1588134748, rs754297345, rs1598120768, rs1598190568, rs1230207719, rs766989857, rs766875860, rs201811817, rs759590778, rs1601976527, rs1601976655, rs1601977379, rs1601977844, rs1601977912, rs143585647, rs1161918267, rs1602005062, rs1602005335, rs1602005463, rs1602006627, rs1602006737, rs1598116164, rs1581696699, rs1596324325, rs1596515638, rs1596519854, rs1596519879, rs1596520443, rs149851163, rs1183559927, rs1336033143, rs1598504016, rs1468320596, rs1479457172, rs753272712, rs1553433429, rs1573518300, rs1575723664, rs1575824608, rs1588101086, rs374176091, rs1588220728, rs1588220764, rs1588350264, rs1594810654, rs1588134571, rs1064793405, rs1588353886, rs1598449660, rs1598455598, rs1555593553, rs1598460710, rs45459799, rs1014112491, rs876660203, rs180177134, rs756487177, rs760150539, rs867467817, rs1825775052, rs1564667865, rs1825714345, rs1825725461, rs1831171802, rs1831172189, rs1858636931, rs1885850135, rs552052505, rs1887822022, rs773014744, rs374626826, rs1383262366, rs1888605629, rs1888681090, rs1888718087, rs757391108, rs1566782962, rs1379375089, rs2053066105, rs2053682638, rs1174332682, rs2040556390, rs2040788600, rs1281446470, rs748453841, rs2062172394, rs1035003476, rs766643461, rs779480428, rs2039078843, rs2039156731, rs1432415523, rs2040073991, rs2040090741, rs755018069, rs2040599267, rs2040853528, rs1411237340, rs2041026878, rs941660593, rs2041101553, rs2047807048, rs1567785888, rs2047958236, rs2048272509, rs2048274544, rs1829091761, rs1407605188, rs1491369358, rs1567642367, rs1175257797, rs1220672299, rs2038478071, rs2040523640, rs1885847871, rs2039603867, rs1685514075
Hirschsprung disease Hirschsprung Disease rs104893891, rs76262710, rs75075748, rs75996173, rs79014735, rs77316810, rs75076352, rs76087194, rs76534745, rs76764689, rs76449634, rs78098482, rs79661516, rs104894389, rs769735757, rs267606780, rs1568823467, rs377767412, rs193922699, rs75030001, rs606231342, rs1553540620, rs759944122, rs1057519322, rs1057519323, rs1057519052, rs1588873476, rs1588866040, rs1838178869 27702942
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 28540026, 19571808, 28991256, 23102693, 29483656, 21791550, 26198764, 30285260, 27922604
Unknown
Disease name Disease term dbSNP ID References
Congenital intestinal aganglionosis Congenital Intestinal Aganglionosis 27702942
Development disorder Child Development Disorders, Pervasive 28540026
Mental depression Major Depressive Disorder rs587778876, rs587778877 29942085, 27479909
Mood disorder Mood Disorders 29942085

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