TRPV1 (transient receptor potential cation channel subfamily V member 1)

Gene

• Entrez ID: 7442
• Gene name: Transient receptor potential cation channel subfamily V member 1
• Gene symbol: TRPV1
• Synonyms: VR1
• Chromosome: 17
• Chromosome location: 17p13.2
• Summary: Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a r

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024445	hsa-miR-215-5p	Microarray	19074876
MIRT026638	hsa-miR-192-5p	Microarray	19074876
MIRT051594	hsa-let-7e-5p	CLASH	23622248
MIRT1457805	hsa-miR-1178	CLIP-seq
MIRT1457806	hsa-miR-1227	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT1457808	hsa-miR-1253	CLIP-seq
MIRT1457809	hsa-miR-1262	CLIP-seq
MIRT1457810	hsa-miR-1273g	CLIP-seq
MIRT1457811	hsa-miR-1909	CLIP-seq
MIRT1457812	hsa-miR-217	CLIP-seq
MIRT1457813	hsa-miR-2467-5p	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT1457815	hsa-miR-335	CLIP-seq
MIRT1457816	hsa-miR-342-3p	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT1457821	hsa-miR-3911	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457823	hsa-miR-3926	CLIP-seq
MIRT1457824	hsa-miR-3934	CLIP-seq
MIRT1457825	hsa-miR-4252	CLIP-seq
MIRT1457826	hsa-miR-4270	CLIP-seq
MIRT1457827	hsa-miR-4284	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457829	hsa-miR-4441	CLIP-seq
MIRT1457830	hsa-miR-4443	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457832	hsa-miR-4473	CLIP-seq
MIRT1457833	hsa-miR-450b-3p	CLIP-seq
MIRT1457834	hsa-miR-4695-5p	CLIP-seq
MIRT1457835	hsa-miR-4701-3p	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT1457837	hsa-miR-4747-5p	CLIP-seq
MIRT1457838	hsa-miR-4764-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457841	hsa-miR-512-3p	CLIP-seq
MIRT1457842	hsa-miR-520f	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457845	hsa-miR-548c-3p	CLIP-seq
MIRT1457846	hsa-miR-548s	CLIP-seq
MIRT1457847	hsa-miR-550a	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT1457849	hsa-miR-658	CLIP-seq
MIRT1457850	hsa-miR-665	CLIP-seq
MIRT1457851	hsa-miR-671-5p	CLIP-seq
MIRT1457852	hsa-miR-769-3p	CLIP-seq
MIRT1457853	hsa-miR-890	CLIP-seq
MIRT1457854	hsa-miR-1343	CLIP-seq
MIRT1457855	hsa-miR-3074-5p	CLIP-seq
MIRT1457856	hsa-miR-378g	CLIP-seq
MIRT1457857	hsa-miR-4699-3p	CLIP-seq
MIRT1457858	hsa-miR-4729	CLIP-seq
MIRT1457859	hsa-miR-579	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457823	hsa-miR-3926	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457837	hsa-miR-4747-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457846	hsa-miR-548s	CLIP-seq
MIRT1457847	hsa-miR-550a	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT1457851	hsa-miR-671-5p	CLIP-seq
MIRT1457853	hsa-miR-890	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT2137348	hsa-miR-1285	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT1457815	hsa-miR-335	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457823	hsa-miR-3926	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT2137349	hsa-miR-4738-3p	CLIP-seq
MIRT1457837	hsa-miR-4747-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457846	hsa-miR-548s	CLIP-seq
MIRT1457847	hsa-miR-550a	CLIP-seq
MIRT2137350	hsa-miR-564	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT1457851	hsa-miR-671-5p	CLIP-seq
MIRT2137351	hsa-miR-766	CLIP-seq
MIRT1457853	hsa-miR-890	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT1457815	hsa-miR-335	CLIP-seq
MIRT1457816	hsa-miR-342-3p	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457823	hsa-miR-3926	CLIP-seq
MIRT1457827	hsa-miR-4284	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457846	hsa-miR-548s	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT1457853	hsa-miR-890	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT1457816	hsa-miR-342-3p	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT2462459	hsa-miR-186	CLIP-seq
MIRT2462460	hsa-miR-3120-5p	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT2462461	hsa-miR-3613-3p	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT2462462	hsa-miR-371-5p	CLIP-seq
MIRT2462463	hsa-miR-371b-5p	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT2462464	hsa-miR-4778-5p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457845	hsa-miR-548c-3p	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT2137349	hsa-miR-4738-3p	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT2462459	hsa-miR-186	CLIP-seq
MIRT2462460	hsa-miR-3120-5p	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT2651543	hsa-miR-3163	CLIP-seq
MIRT1457815	hsa-miR-335	CLIP-seq
MIRT2462461	hsa-miR-3613-3p	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT2462462	hsa-miR-371-5p	CLIP-seq
MIRT2462463	hsa-miR-371b-5p	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457823	hsa-miR-3926	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT1457837	hsa-miR-4747-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT2462464	hsa-miR-4778-5p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457845	hsa-miR-548c-3p	CLIP-seq
MIRT1457846	hsa-miR-548s	CLIP-seq
MIRT1457847	hsa-miR-550a	CLIP-seq
MIRT2137350	hsa-miR-564	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT1457851	hsa-miR-671-5p	CLIP-seq
MIRT1457853	hsa-miR-890	CLIP-seq
MIRT2137349	hsa-miR-4738-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	ISS
GO:0005216	Function	Ion channel activity	IBA	21873635
GO:0005230	Function	Extracellular ligand-gated ion channel activity	IDA	11226139
GO:0005231	Function	Excitatory extracellular ligand-gated ion channel activity	ISS
GO:0005262	Function	Calcium channel activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	29656858
GO:0005516	Function	Calmodulin binding	ISS
GO:0005524	Function	ATP binding	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	ISS
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	9349813
GO:0007635	Process	Chemosensory behavior	TAS	9349813
GO:0015278	Function	Calcium-release channel activity	ISS
GO:0016021	Component	Integral component of membrane	IDA	10201375
GO:0031226	Component	Intrinsic component of plasma membrane	ISS
GO:0032591	Component	Dendritic spine membrane	IEA
GO:0034605	Process	Cellular response to heat	IDA	11226139
GO:0035091	Function	Phosphatidylinositol binding	ISS
GO:0045211	Component	Postsynaptic membrane	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0050955	Process	Thermoception	IDA	10201375
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IEA
GO:0051219	Function	Phosphoprotein binding	IPI	19801576
GO:0051289	Process	Protein homotetramerization	ISS
GO:0060079	Process	Excitatory postsynaptic potential	IEA
GO:0070588	Process	Calcium ion transmembrane transport	ISS
GO:0070588	Process	Calcium ion transmembrane transport	TAS
GO:0071312	Process	Cellular response to alkaloid	ISS
GO:0071318	Process	Cellular response to ATP	ISS
GO:0071468	Process	Cellular response to acidic pH	IDA	11226139
GO:0098703	Process	Calcium ion import across plasma membrane	IBA	21873635
GO:0098703	Process	Calcium ion import across plasma membrane	IDA	11226139
GO:1901594	Process	Response to capsazepine	IMP	11226139
GO:1901594	Process	Response to capsazepine	ISS

Other IDs

• MIM: 602076
• HGNC: 12716
• e!Ensembl: ENSG00000196689

Protein

• UniProt ID: Q8NER1
• Protein name: Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)
• Protein function: Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:11050376, PubMed:11243859, PubMed:11226139, PubMed:12077606). Seems to mediate proton influx and may be involved in intracellular
• PDB: 6L93, 8GF8, 8GF9, 8GFA, 8JQR, 8X94, 8YCP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12796	Ank_2	118 → 232	Ankyrin repeats (3 copies)	Repeat
  PF00520	Ion_trans	432 → 695	Ion transport protein	Family

• Sequence:

  MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP
  VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE
  AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI
  ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT
  KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
  DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE
  PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
  RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL
  SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS
  MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
  DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF
  IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA
  FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS
  SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK

• Sequence length: 839

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels

Reactome:

TRP channels

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Epilepsy	Epilepsy, Temporal Lobe, Uncinate Epilepsy, Epilepsy, Benign Psychomotor, Childhood, Epilepsy, Lateral Temporal	rs113994140, rs119454947, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs1805032, rs387906420, rs121917752, rs121918622, rs121434579, rs1581220270, rs281865564, rs387907313, rs397514564, rs397514670, rs768241563, rs587776973, rs587776974, rs587776975, rs879255234, rs587776976, rs587776977, rs121917993, rs398123588, rs13306758, rs587777363, rs587777364, rs587777458, rs587777459, rs541024038, rs797044545, rs730882240, rs786205703, rs794726859, rs796053126, rs796053035, rs796053216, rs796052839, rs869025201, rs797044999, rs797044998, rs797045045, rs794726762, rs869312971, rs869312972, rs879255652, rs886037938, rs886037958, rs886037959, rs886037960, rs886037961, rs886037962, rs886037965, rs886037966, rs886039245, rs886039246, rs886039251, rs886039252, rs772872014, rs886039253, rs886039256, rs757511744, rs886039261, rs886039263, rs578185749, rs886039266, rs886039268, rs886039269, rs886039273, rs368820286, rs1057518801, rs1057518688, rs1057519107, rs1057519273, rs752753379, rs767795673, rs1057519424, rs755946598, rs760609867, rs1057521066, rs1057524233, rs1060501488, rs1060501487, rs755127868, rs751533302, rs771373457, rs1475605360, rs1555401942, rs1553567864, rs200661329, rs766667249, rs1556607762, rs1555882921, rs1555882867, rs1555900914, rs1553546836, rs77216276, rs755595256, rs1554169267, rs747661902, rs2105890565, rs1021001959, rs1555441032, rs1555439541, rs1556526609, rs1315483224, rs759952667, rs1555885023, rs1553456695, rs1555942720, rs1569083500, rs1559127505, rs1206309859, rs1567139896, rs1567134495, rs1431914212, rs1569166925, rs1569255443, rs1568955379, rs1567152003, rs374158137, rs1567129567, rs1569523728, rs1568991466, rs1569186093, rs1569254004, rs1372605067, rs1569067939, rs1568963062, rs1563959514, rs1569012755, rs1559118914, rs1602338615, rs1596522356, rs1364913665, rs1596522300, rs1596526976, rs1229740428, rs1596385588, rs1596500172, rs1596505517, rs1601925213, rs1601970168, rs1602010382, rs1602903591, rs1603014297, rs1603014708, rs1601875057, rs1601970824, rs1601755632, rs1587393982, rs1592977444, rs1575562076, rs1570998206, rs1588057922, rs1596528731, rs1602349641, rs1587401875, rs2065899210, rs1596526915, rs2093486364, rs2056165149, rs2056100951, rs781482552, rs1899868619, rs1900088045, rs1898675878, rs1898686157, rs1898837245, rs1898844513, rs2082841677, rs2085727988, rs2092933941, rs2091657024, rs1899864955, rs1898844907, rs2083056830, rs2084070588, rs1899713412, rs2082695884, rs1977106116, rs1977105425, rs1443687532	20144892
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	17347480

Unknown
Disease name	Disease term	dbSNP ID	References
Atherosclerosis	Atherosclerosis	rs699947, rs59439148	21908651
Benign neoplasm	Benign Neoplasm		21349818
Urinary bladder cancer	Malignant neoplasm of urinary bladder		19502594
Bladder neoplasm	Bladder Neoplasm		19502594
Esophageal diseases	Esophageal Diseases		19566590
Eosinophilia	Esophagitis		16091555
Malignant neoplasm	Malignant Neoplasms		21349818
Neoplasms	Neoplasms		21349818
Pancreatitis	Pancreatitis	rs61734659	17698068