VIPR2 (vasoactive intestinal peptide receptor 2)

Gene

• Entrez ID: 7434
• Gene name: Vasoactive intestinal peptide receptor 2
• Gene symbol: VIPR2
• Synonyms: C16DUPq36.3, DUP7q36.3, PACAP-R-3, PACAP-R3, VIP-R-2, VPAC2, VPAC2R, VPCAP2R
• Chromosome: 7
• Chromosome location: 7q36.3
• Summary: This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its act

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1485013	hsa-miR-10a	CLIP-seq
MIRT1485014	hsa-miR-10b	CLIP-seq
MIRT1485015	hsa-miR-1271	CLIP-seq
MIRT1485016	hsa-miR-1285	CLIP-seq
MIRT1485017	hsa-miR-1286	CLIP-seq
MIRT1485018	hsa-miR-1909	CLIP-seq
MIRT1485019	hsa-miR-1915	CLIP-seq
MIRT1485020	hsa-miR-3158-3p	CLIP-seq
MIRT1485021	hsa-miR-3187-5p	CLIP-seq
MIRT1485022	hsa-miR-320a	CLIP-seq
MIRT1485023	hsa-miR-320b	CLIP-seq
MIRT1485024	hsa-miR-320c	CLIP-seq
MIRT1485025	hsa-miR-320d	CLIP-seq
MIRT1485026	hsa-miR-320e	CLIP-seq
MIRT1485027	hsa-miR-326	CLIP-seq
MIRT1485028	hsa-miR-330-5p	CLIP-seq
MIRT1485029	hsa-miR-339-5p	CLIP-seq
MIRT1485030	hsa-miR-378	CLIP-seq
MIRT1485031	hsa-miR-378b	CLIP-seq
MIRT1485032	hsa-miR-378c	CLIP-seq
MIRT1485033	hsa-miR-378d	CLIP-seq
MIRT1485034	hsa-miR-378e	CLIP-seq
MIRT1485035	hsa-miR-378f	CLIP-seq
MIRT1485036	hsa-miR-378h	CLIP-seq
MIRT1485037	hsa-miR-378i	CLIP-seq
MIRT1485038	hsa-miR-3941	CLIP-seq
MIRT1485039	hsa-miR-3944-5p	CLIP-seq
MIRT1485040	hsa-miR-422a	CLIP-seq
MIRT1485041	hsa-miR-4258	CLIP-seq
MIRT1485042	hsa-miR-4261	CLIP-seq
MIRT1485043	hsa-miR-4270	CLIP-seq
MIRT1485044	hsa-miR-4327	CLIP-seq
MIRT1485045	hsa-miR-4421	CLIP-seq
MIRT1485046	hsa-miR-4429	CLIP-seq
MIRT1485047	hsa-miR-4436a	CLIP-seq
MIRT1485048	hsa-miR-4441	CLIP-seq
MIRT1485049	hsa-miR-4455	CLIP-seq
MIRT1485050	hsa-miR-4466	CLIP-seq
MIRT1485051	hsa-miR-4468	CLIP-seq
MIRT1485052	hsa-miR-4496	CLIP-seq
MIRT1485053	hsa-miR-4505	CLIP-seq
MIRT1485054	hsa-miR-4638-3p	CLIP-seq
MIRT1485055	hsa-miR-4643	CLIP-seq
MIRT1485056	hsa-miR-4651	CLIP-seq
MIRT1485057	hsa-miR-466	CLIP-seq
MIRT1485058	hsa-miR-4672	CLIP-seq
MIRT1485059	hsa-miR-4684-5p	CLIP-seq
MIRT1485060	hsa-miR-4685-5p	CLIP-seq
MIRT1485061	hsa-miR-4708-3p	CLIP-seq
MIRT1485062	hsa-miR-4717-3p	CLIP-seq
MIRT1485063	hsa-miR-4722-5p	CLIP-seq
MIRT1485064	hsa-miR-4731-5p	CLIP-seq
MIRT1485065	hsa-miR-4749-3p	CLIP-seq
MIRT1485066	hsa-miR-4754	CLIP-seq
MIRT1485067	hsa-miR-4756-3p	CLIP-seq
MIRT1485068	hsa-miR-4793-5p	CLIP-seq
MIRT1485069	hsa-miR-4794	CLIP-seq
MIRT1485070	hsa-miR-4802-3p	CLIP-seq
MIRT1485071	hsa-miR-488	CLIP-seq
MIRT1485072	hsa-miR-548c-3p	CLIP-seq
MIRT1485073	hsa-miR-593	CLIP-seq
MIRT1485074	hsa-miR-608	CLIP-seq
MIRT1485075	hsa-miR-612	CLIP-seq
MIRT1485076	hsa-miR-637	CLIP-seq
MIRT1485077	hsa-miR-675	CLIP-seq
MIRT1485078	hsa-miR-873	CLIP-seq
MIRT1485079	hsa-miR-96	CLIP-seq
MIRT2145923	hsa-miR-24	CLIP-seq
MIRT2145924	hsa-miR-3178	CLIP-seq
MIRT1485027	hsa-miR-326	CLIP-seq
MIRT1485028	hsa-miR-330-5p	CLIP-seq
MIRT1485029	hsa-miR-339-5p	CLIP-seq
MIRT2145925	hsa-miR-3689a-3p	CLIP-seq
MIRT2145926	hsa-miR-3689c	CLIP-seq
MIRT2145927	hsa-miR-4437	CLIP-seq
MIRT2145928	hsa-miR-4474-3p	CLIP-seq
MIRT2145929	hsa-miR-450b-5p	CLIP-seq
MIRT2145930	hsa-miR-4728-5p	CLIP-seq
MIRT2145931	hsa-miR-494	CLIP-seq
MIRT2145932	hsa-miR-507	CLIP-seq
MIRT2145933	hsa-miR-541	CLIP-seq
MIRT2145934	hsa-miR-557	CLIP-seq
MIRT2145935	hsa-miR-604	CLIP-seq
MIRT2145936	hsa-miR-647	CLIP-seq
MIRT2145937	hsa-miR-654-5p	CLIP-seq
MIRT2145938	hsa-miR-765	CLIP-seq
MIRT2366337	hsa-miR-1267	CLIP-seq
MIRT2366338	hsa-miR-1273	CLIP-seq
MIRT2366339	hsa-miR-1976	CLIP-seq
MIRT2145923	hsa-miR-24	CLIP-seq
MIRT2366340	hsa-miR-3122	CLIP-seq
MIRT2366341	hsa-miR-3175	CLIP-seq
MIRT2145925	hsa-miR-3689a-3p	CLIP-seq
MIRT2145926	hsa-miR-3689c	CLIP-seq
MIRT2366342	hsa-miR-3913-5p	CLIP-seq
MIRT2366343	hsa-miR-4252	CLIP-seq
MIRT2366344	hsa-miR-4279	CLIP-seq
MIRT2366345	hsa-miR-4284	CLIP-seq
MIRT2366346	hsa-miR-4418	CLIP-seq
MIRT2366347	hsa-miR-4486	CLIP-seq
MIRT2366348	hsa-miR-455-3p	CLIP-seq
MIRT2366349	hsa-miR-4649-5p	CLIP-seq
MIRT2366350	hsa-miR-4717-5p	CLIP-seq
MIRT1485063	hsa-miR-4722-5p	CLIP-seq
MIRT2145930	hsa-miR-4728-5p	CLIP-seq
MIRT2366351	hsa-miR-4798-3p	CLIP-seq
MIRT2366352	hsa-miR-509-3-5p	CLIP-seq
MIRT2366353	hsa-miR-509-5p	CLIP-seq
MIRT2366354	hsa-miR-661	CLIP-seq
MIRT1485013	hsa-miR-10a	CLIP-seq
MIRT1485014	hsa-miR-10b	CLIP-seq
MIRT2463182	hsa-miR-3150a-5p	CLIP-seq
MIRT2463183	hsa-miR-3150b-5p	CLIP-seq
MIRT1485029	hsa-miR-339-5p	CLIP-seq
MIRT2463184	hsa-miR-3613-3p	CLIP-seq
MIRT2463185	hsa-miR-3681	CLIP-seq
MIRT2463186	hsa-miR-371-5p	CLIP-seq
MIRT2463187	hsa-miR-371b-5p	CLIP-seq
MIRT1485045	hsa-miR-4421	CLIP-seq
MIRT2463188	hsa-miR-4662a-5p	CLIP-seq
MIRT2463189	hsa-miR-4676-5p	CLIP-seq
MIRT1485059	hsa-miR-4684-5p	CLIP-seq
MIRT2463190	hsa-miR-4755-3p	CLIP-seq
MIRT2463191	hsa-miR-4786-5p	CLIP-seq
MIRT1485068	hsa-miR-4793-5p	CLIP-seq
MIRT1485069	hsa-miR-4794	CLIP-seq
MIRT2463192	hsa-miR-4796-3p	CLIP-seq
MIRT1485072	hsa-miR-548c-3p	CLIP-seq
MIRT2463193	hsa-miR-548t	CLIP-seq
MIRT2463194	hsa-miR-575	CLIP-seq
MIRT1485073	hsa-miR-593	CLIP-seq
MIRT1485013	hsa-miR-10a	CLIP-seq
MIRT1485014	hsa-miR-10b	CLIP-seq
MIRT1485029	hsa-miR-339-5p	CLIP-seq
MIRT2463184	hsa-miR-3613-3p	CLIP-seq
MIRT1485045	hsa-miR-4421	CLIP-seq
MIRT2463188	hsa-miR-4662a-5p	CLIP-seq
MIRT2463189	hsa-miR-4676-5p	CLIP-seq
MIRT1485059	hsa-miR-4684-5p	CLIP-seq
MIRT2463190	hsa-miR-4755-3p	CLIP-seq
MIRT1485072	hsa-miR-548c-3p	CLIP-seq
MIRT2463194	hsa-miR-575	CLIP-seq
MIRT1485073	hsa-miR-593	CLIP-seq
MIRT1485013	hsa-miR-10a	CLIP-seq
MIRT1485014	hsa-miR-10b	CLIP-seq
MIRT2366338	hsa-miR-1273	CLIP-seq
MIRT2659892	hsa-miR-1908	CLIP-seq
MIRT2366340	hsa-miR-3122	CLIP-seq
MIRT1485029	hsa-miR-339-5p	CLIP-seq
MIRT2463184	hsa-miR-3613-3p	CLIP-seq
MIRT2145925	hsa-miR-3689a-3p	CLIP-seq
MIRT2145926	hsa-miR-3689c	CLIP-seq
MIRT2366342	hsa-miR-3913-5p	CLIP-seq
MIRT1485045	hsa-miR-4421	CLIP-seq
MIRT2366347	hsa-miR-4486	CLIP-seq
MIRT2366348	hsa-miR-455-3p	CLIP-seq
MIRT2366349	hsa-miR-4649-5p	CLIP-seq
MIRT2463188	hsa-miR-4662a-5p	CLIP-seq
MIRT2463189	hsa-miR-4676-5p	CLIP-seq
MIRT1485059	hsa-miR-4684-5p	CLIP-seq
MIRT2145930	hsa-miR-4728-5p	CLIP-seq
MIRT2659893	hsa-miR-4730	CLIP-seq
MIRT2463190	hsa-miR-4755-3p	CLIP-seq
MIRT2659894	hsa-miR-4767	CLIP-seq
MIRT2463191	hsa-miR-4786-5p	CLIP-seq
MIRT1485068	hsa-miR-4793-5p	CLIP-seq
MIRT1485069	hsa-miR-4794	CLIP-seq
MIRT1485072	hsa-miR-548c-3p	CLIP-seq
MIRT2463194	hsa-miR-575	CLIP-seq
MIRT1485073	hsa-miR-593	CLIP-seq
MIRT2366354	hsa-miR-661	CLIP-seq
MIRT2659895	hsa-miR-663	CLIP-seq
MIRT1485013	hsa-miR-10a	CLIP-seq
MIRT1485014	hsa-miR-10b	CLIP-seq
MIRT2659892	hsa-miR-1908	CLIP-seq
MIRT2366340	hsa-miR-3122	CLIP-seq
MIRT1485029	hsa-miR-339-5p	CLIP-seq
MIRT2463184	hsa-miR-3613-3p	CLIP-seq
MIRT2145925	hsa-miR-3689a-3p	CLIP-seq
MIRT2145926	hsa-miR-3689c	CLIP-seq
MIRT2366342	hsa-miR-3913-5p	CLIP-seq
MIRT1485045	hsa-miR-4421	CLIP-seq
MIRT2463188	hsa-miR-4662a-5p	CLIP-seq
MIRT2463189	hsa-miR-4676-5p	CLIP-seq
MIRT1485059	hsa-miR-4684-5p	CLIP-seq
MIRT2145930	hsa-miR-4728-5p	CLIP-seq
MIRT2659893	hsa-miR-4730	CLIP-seq
MIRT2463190	hsa-miR-4755-3p	CLIP-seq
MIRT2659894	hsa-miR-4767	CLIP-seq
MIRT2463191	hsa-miR-4786-5p	CLIP-seq
MIRT1485068	hsa-miR-4793-5p	CLIP-seq
MIRT1485069	hsa-miR-4794	CLIP-seq
MIRT1485072	hsa-miR-548c-3p	CLIP-seq
MIRT2463194	hsa-miR-575	CLIP-seq
MIRT1485073	hsa-miR-593	CLIP-seq
MIRT2659895	hsa-miR-663	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	TAS	7811244
GO:0004999	Function	Vasoactive intestinal polypeptide receptor activity	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	7811244
GO:0007165	Process	Signal transduction	TAS	7811244
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007267	Process	Cell-cell signaling	TAS	8757618
GO:0008528	Function	G protein-coupled peptide receptor activity	IBA	21873635
GO:0017046	Function	Peptide hormone binding	IBA	21873635

Other IDs

• MIM: 601970
• HGNC: 12695
• e!Ensembl: ENSG00000106018

Protein

• UniProt ID: P41587
• Protein name: Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2 receptor) (VPAC2R)
• Protein function: G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7811244, PubMed:35477937, PubMed:8933357). Binds VIP and both PACAP27 an
• PDB: 2X57, 7VQX, 7WBJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02793	HRM	49 → 112	Hormone receptor domain	Family
  PF00002	7tm_2	123 → 371	7 transmembrane receptor (Secretin family)	Family

• Sequence:

  MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNIT
  CWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKI
  TFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKD
  DVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRC
  FLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFI
  SIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFE
  LCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQ
  FHRGSRAQSFLQTETSVI

• Sequence length: 438

Pathways

KEGG:

cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling

Reactome:

G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Myopia	Myopia, Degenerative	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805, rs782555528, rs1554862601, rs1586620121, rs1387950081, rs2051026773, rs1422332023	23406873
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21285140

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		20072116