GediPNet logo

VCAM1 (vascular cell adhesion molecule 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7412
Gene nameGene Name - the full gene name approved by the HGNC.
Vascular cell adhesion molecule 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
VCAM1
SynonymsGene synonyms aliases
CD106, INCAM-100
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p21.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004007 hsa-miR-200a-3p Microarray 17875710
MIRT004081 hsa-miR-126-3p Luciferase reporter assay, Western blot 18227515
MIRT004081 hsa-miR-126-3p Luciferase reporter assay, Western blot 18227515
MIRT020917 hsa-miR-155-5p qRT-PCR 21310411
MIRT004081 hsa-miR-126-3p Reporter assay;Other 18227515
Transcription factors
Transcription factor Regulation Reference
EP300 Activation 19281832
HDAC4 Activation 19281832
HOXA9 Unknown 22269951
IKBKB Repression 18600306
IRF1 Unknown 15265939;22182512
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0002102 Component Podosome IDA 15220135
GO:0002526 Process Acute inflammatory response IEA
GO:0002544 Process Chronic inflammatory response IEA
GO:0005178 Function Integrin binding IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P19320
Protein name Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1]
Protein function Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium thr
PDB 1IJ9 , 1VCA , 1VSC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07679 I-set
25 112
Immunoglobulin I-set domain
Domain
PF05790 C2-set
133 221
Immunoglobulin C2-set domain
Domain
PF00047 ig
229 306
Immunoglobulin domain
Domain
PF07679 I-set
314 400
Immunoglobulin I-set domain
Domain
PF05790 C2-set
421 509
Immunoglobulin C2-set domain
Domain
PF13927 Ig_3
515 583
Domain
PF07679 I-set
605 685
Immunoglobulin I-set domain
Domain
Sequence
Sequence length 739
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  NF-kappa B signaling pathway
Cell adhesion molecules
TNF signaling pathway
Leukocyte transendothelial migration
AGE-RAGE signaling pathway in diabetic complications
African trypanosomiasis
Malaria
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Anemia Anemia, Sickle Cell rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505 16916123
Cholestasis Cholestasis rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 21224055
Cholestasis of pregnancy Cholestasis of pregnancy, Familial intrahepatic cholestasis of pregnancy rs11568372, rs121918440, rs387906527, rs72552778, rs387906528, rs72552780, rs769910565, rs188824058, rs375315619, rs754287486, rs764513998, rs759202962, rs377160065, rs1562965036, rs764296800, rs1584665400, rs1584671714, rs1187517509, rs1584684209, rs533310204, rs571555115, rs1584754706, rs1584754766, rs1584763429, rs757693457, rs1574445178, rs1584742063, rs1584750660, rs752563752 28851649
Dermatitis Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 27206134
Unknown
Disease name Disease term dbSNP ID References
Atherosclerosis Atherosclerosis rs699947, rs59439148 12677255
Cardiovascular diseases Cardiovascular Diseases 25575156, 16332659
Liver carcinoma Liver carcinoma 22922871
Myocardial ischemia Myocardial Ischemia 16214533

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412