UPP1 (uridine phosphorylase 1)

Gene

• Entrez ID: 7378
• Gene name: Uridine phosphorylase 1
• Gene symbol: UPP1
• Synonyms: UDRPASE, UP, UPASE, UPP
• Chromosome: 7
• Chromosome location: 7p12.3
• Summary: This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2`- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024540	hsa-miR-215-5p	Microarray	19074876
MIRT026152	hsa-miR-192-5p	Microarray	19074876
MIRT1921023	hsa-miR-214	CLIP-seq
MIRT1921024	hsa-miR-31	CLIP-seq
MIRT1921025	hsa-miR-3619-5p	CLIP-seq
MIRT1921026	hsa-miR-4527	CLIP-seq
MIRT1921027	hsa-miR-761	CLIP-seq
MIRT1921023	hsa-miR-214	CLIP-seq
MIRT1921024	hsa-miR-31	CLIP-seq
MIRT1921025	hsa-miR-3619-5p	CLIP-seq
MIRT1921026	hsa-miR-4527	CLIP-seq
MIRT1921027	hsa-miR-761	CLIP-seq
MIRT1921023	hsa-miR-214	CLIP-seq
MIRT1921024	hsa-miR-31	CLIP-seq
MIRT1921025	hsa-miR-3619-5p	CLIP-seq
MIRT1921026	hsa-miR-4527	CLIP-seq
MIRT1921027	hsa-miR-761	CLIP-seq
MIRT1921023	hsa-miR-214	CLIP-seq
MIRT1921024	hsa-miR-31	CLIP-seq
MIRT1921025	hsa-miR-3619-5p	CLIP-seq
MIRT1921026	hsa-miR-4527	CLIP-seq
MIRT1921027	hsa-miR-761	CLIP-seq
MIRT2363723	hsa-miR-578	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
NFKB1	Activation	20544543
RELA	Activation	20544543
STAT1	Activation	20544543

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004850	Function	Uridine phosphorylase activity	IDA	7488099
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	7488099
GO:0006218	Process	Uridine catabolic process	IDA	7488099
GO:0009032	Function	Thymidine phosphorylase activity	IEA
GO:0042149	Process	Cellular response to glucose starvation	IEA
GO:0042802	Function	Identical protein binding	IPI	19291308, 20856879
GO:0043097	Process	Pyrimidine nucleoside salvage	TAS
GO:0044206	Process	UMP salvage	IEA
GO:0046050	Process	UMP catabolic process	IEA
GO:0046074	Process	DTMP catabolic process	IEA
GO:0046135	Process	Pyrimidine nucleoside catabolic process	TAS

Other IDs

• MIM: 191730
• HGNC: 12576
• e!Ensembl: ENSG00000183696

Protein

• UniProt ID: Q16831
• Protein name: Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3)
• Protein function: Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:7488099). Shows broad subs
• PDB: 3EUE, 3EUF, 3NBQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01048	PNP_UDP_1	54 → 304	Phosphorylase superfamily	Domain

• Sequence:

  MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGG
  SPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLH
  ELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKT
  DLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAY
  AAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVS
  YFIKKKLSKA

• Sequence length: 310

Pathways

KEGG:

Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism

Reactome:

Pyrimidine salvage
Pyrimidine catabolism

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	16033404