UGT2B17 (UDP glucuronosyltransferase family 2 member B17)

Gene

• Entrez ID: 7367
• Gene name: UDP glucuronosyltransferase family 2 member B17
• Gene symbol: UGT2B17
• Synonyms: BMND12, UDPGT2B17
• Chromosome: 4
• Chromosome location: 4q13.2
• Summary: This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and l

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017924	hsa-miR-335-5p	Microarray	18185580
MIRT021574	hsa-miR-142-3p	Microarray	17612493
MIRT732037	hsa-miR-409-3p	PC3M	26385605
MIRT732037	hsa-miR-409-3p	PC3M	26385605
MIRT1473636	hsa-miR-133a	CLIP-seq
MIRT1473637	hsa-miR-133b	CLIP-seq
MIRT1473638	hsa-miR-147	CLIP-seq
MIRT1473639	hsa-miR-2113	CLIP-seq
MIRT1473640	hsa-miR-3119	CLIP-seq
MIRT1473641	hsa-miR-3155	CLIP-seq
MIRT1473642	hsa-miR-3155b	CLIP-seq
MIRT1473643	hsa-miR-3911	CLIP-seq
MIRT1473644	hsa-miR-4436b-5p	CLIP-seq
MIRT1473645	hsa-miR-4797-3p	CLIP-seq
MIRT1473646	hsa-miR-484	CLIP-seq
MIRT1473647	hsa-miR-599	CLIP-seq
MIRT1473648	hsa-miR-644	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CDX2	Unknown	20070244
FOXA1	Activation	20628005
HNF1A	Activation	11191885
PBX2	Unknown	12065766

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001972	Function	Retinoic acid binding	IDA	20308471
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0008194	Function	UDP-glycosyltransferase activity	IBA	21873635
GO:0008202	Process	Steroid metabolic process	TAS	8798464
GO:0008210	Process	Estrogen metabolic process	IDA	18719240
GO:0015020	Function	Glucuronosyltransferase activity	IDA	18719240, 22579593
GO:0016020	Component	Membrane	TAS	8798464
GO:0016021	Component	Integral component of membrane	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0052695	Process	Cellular glucuronidation	IDA	18719240, 22579593

Other IDs

• MIM: 601903
• HGNC: 12547
• e!Ensembl: ENSG00000197888

Protein

• UniProt ID: O75795
• Protein name: UDP-glucuronosyltransferase 2B17 (UDPGT 2B17) (UGT2B17) (EC 2.4.1.17) (C19-steroid-specific UDP-glucuronosyltransferase) (C19-steroid-specific UDPGT)
• Protein function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either th
• PDB: 7YAN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00201	UDPGT	24 → 527	UDP-glucoronosyl and UDP-glucosyl transferase	Family

• Sequence:

  MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSA
  SILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEY
  SDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYT
  VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEV
  LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
  GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
  NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
  MSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA
  AHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD

• Sequence length: 530

Pathways

KEGG:

Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Steroid hormone biosynthesis
Retinol metabolism
Porphyrin metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Biosynthesis of cofactors
Bile secretion
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation

Reactome:

Glucuronidation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Adenocarcinoma	Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular	rs121913530, rs886039394, rs121913474	17416778
Carcinoma	Carcinoma, Cribriform, Carcinoma, Granular Cell	rs121912654, rs555607708, rs786202962, rs1564055259	17416778
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	17416778
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17826523

Unknown
Disease name	Disease term	dbSNP ID	References
Graft-vs-host disease	Graft-vs-Host Disease		19935662
Lung neoplasms	Lung Neoplasms		17416778
Prostatic neoplasms	Prostatic Neoplasms		17826523