UGT2B15 (UDP glucuronosyltransferase family 2 member B15)

Gene

• Entrez ID: 7366
• Gene name: UDP glucuronosyltransferase family 2 member B15
• Gene symbol: UGT2B15
• Synonyms: HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8
• Chromosome: 4
• Chromosome location: 4q13.2
• Summary: This gene encodes a glycosyltransferase that is invovled in the metabolism and elimination of toxic compounts, both endogenous and of xenobiotic origin. This gene plays a role in the regulation of estrogens and androgens. This locus is present in a cluste

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1902023	A>C	Drug-response	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1473629	hsa-miR-133a	CLIP-seq
MIRT1473630	hsa-miR-133b	CLIP-seq
MIRT1473631	hsa-miR-3119	CLIP-seq
MIRT1473632	hsa-miR-3155	CLIP-seq
MIRT1473633	hsa-miR-3155b	CLIP-seq
MIRT1473634	hsa-miR-4436b-5p	CLIP-seq
MIRT1473635	hsa-miR-484	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
AR	Unknown	18302198
CDX2	Unknown	20070244
ESR1	Activation	19487245
FOSL2	Activation	19487245
FOXA1	Unknown	20736324
JUN	Activation	19487245
SP1	Unknown	20070244

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001972	Function	Retinoic acid binding	IDA	20308471
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006805	Process	Xenobiotic metabolic process	TAS	7835232
GO:0008194	Function	UDP-glycosyltransferase activity	IBA	21873635
GO:0008202	Process	Steroid metabolic process	TAS	7835232
GO:0008210	Process	Estrogen metabolic process	IDA	18719240
GO:0015020	Function	Glucuronosyltransferase activity	IDA	18719240, 20056724, 22579593
GO:0016021	Component	Integral component of membrane	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0052695	Process	Cellular glucuronidation	IDA	18719240, 20056724, 22579593

Other IDs

• MIM: 600069
• HGNC: 12546
• e!Ensembl: ENSG00000196620

Protein

• UniProt ID: P54855
• Protein name: UDP-glucuronosyltransferase 2B15 (UDPGT 2B15) (UGT2B15) (EC 2.4.1.17) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3)
• Protein function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either th
• PDB: 6IPB, 7CJX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00201	UDPGT	24 → 527	UDP-glucoronosyl and UDP-glucosyl transferase	Family

• Sequence:

  MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSA
  STLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEY
  YDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYT
  FEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEV
  LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
  GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
  NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
  MSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVA
  AHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD

• Sequence length: 530

Pathways

KEGG:

Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Steroid hormone biosynthesis
Retinol metabolism
Porphyrin metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Biosynthesis of cofactors
Bile secretion
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation

Reactome:

Glucuronidation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	16859836

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		16859836