UCP3 (uncoupling protein 3)

Gene

• Entrez ID: 7352
• Gene name: Uncoupling protein 3
• Gene symbol: UCP3
• Synonyms: SLC25A9
• Chromosome: 11
• Chromosome location: 11q13.4
• Summary: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proto

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs2229707	C>T	Benign, pathogenic	Missense variant, coding sequence variant
rs17848368	G>A	Pathogenic	Coding sequence variant, missense variant
rs45476292	C>A,T	Benign, pathogenic	Coding sequence variant, splice donor variant, synonymous variant
rs104894319	G>A	Pathogenic, likely-benign	Coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT038202	hsa-miR-342-5p	CLASH	23622248
MIRT1472788	hsa-miR-1301	CLIP-seq
MIRT1472789	hsa-miR-1470	CLIP-seq
MIRT1472790	hsa-miR-193a-5p	CLIP-seq
MIRT1472791	hsa-miR-210	CLIP-seq
MIRT1472792	hsa-miR-214	CLIP-seq
MIRT1472793	hsa-miR-296-5p	CLIP-seq
MIRT1472794	hsa-miR-3158-3p	CLIP-seq
MIRT1472795	hsa-miR-3166	CLIP-seq
MIRT1472796	hsa-miR-34a	CLIP-seq
MIRT1472797	hsa-miR-34c-5p	CLIP-seq
MIRT1472798	hsa-miR-3619-5p	CLIP-seq
MIRT1472799	hsa-miR-3657	CLIP-seq
MIRT1472800	hsa-miR-3663-5p	CLIP-seq
MIRT1472801	hsa-miR-3688-5p	CLIP-seq
MIRT1472802	hsa-miR-3929	CLIP-seq
MIRT1472803	hsa-miR-3944-5p	CLIP-seq
MIRT1472804	hsa-miR-4419b	CLIP-seq
MIRT1472805	hsa-miR-4478	CLIP-seq
MIRT1472806	hsa-miR-449a	CLIP-seq
MIRT1472807	hsa-miR-449b	CLIP-seq
MIRT1472808	hsa-miR-4530	CLIP-seq
MIRT1472809	hsa-miR-4635	CLIP-seq
MIRT1472810	hsa-miR-4660	CLIP-seq
MIRT1472811	hsa-miR-4667-3p	CLIP-seq
MIRT1472812	hsa-miR-4669	CLIP-seq
MIRT1472813	hsa-miR-4716-5p	CLIP-seq
MIRT1472814	hsa-miR-4717-3p	CLIP-seq
MIRT1472815	hsa-miR-5047	CLIP-seq
MIRT1472816	hsa-miR-520d-5p	CLIP-seq
MIRT1472817	hsa-miR-524-5p	CLIP-seq
MIRT1472818	hsa-miR-526b	CLIP-seq
MIRT1472819	hsa-miR-542-5p	CLIP-seq
MIRT1472820	hsa-miR-545	CLIP-seq
MIRT1472821	hsa-miR-578	CLIP-seq
MIRT1472822	hsa-miR-598	CLIP-seq
MIRT1472823	hsa-miR-761	CLIP-seq
MIRT1557259	hsa-miR-1272	CLIP-seq
MIRT1557260	hsa-miR-1827	CLIP-seq
MIRT1557261	hsa-miR-3935	CLIP-seq
MIRT2362882	hsa-miR-130a	CLIP-seq
MIRT2362883	hsa-miR-130b	CLIP-seq
MIRT2362884	hsa-miR-148a	CLIP-seq
MIRT2362885	hsa-miR-148b	CLIP-seq
MIRT2362886	hsa-miR-152	CLIP-seq
MIRT2362887	hsa-miR-19a	CLIP-seq
MIRT2362888	hsa-miR-19b	CLIP-seq
MIRT2362889	hsa-miR-223	CLIP-seq
MIRT2362890	hsa-miR-301a	CLIP-seq
MIRT2362891	hsa-miR-301b	CLIP-seq
MIRT2362892	hsa-miR-30a	CLIP-seq
MIRT2362893	hsa-miR-30b	CLIP-seq
MIRT2362894	hsa-miR-30c	CLIP-seq
MIRT2362895	hsa-miR-30d	CLIP-seq
MIRT2362896	hsa-miR-30e	CLIP-seq
MIRT2362897	hsa-miR-3655	CLIP-seq
MIRT2362898	hsa-miR-3666	CLIP-seq
MIRT2362899	hsa-miR-4295	CLIP-seq
MIRT2362900	hsa-miR-454	CLIP-seq
MIRT2362901	hsa-miR-4697-3p	CLIP-seq
MIRT2362902	hsa-miR-4774-3p	CLIP-seq
MIRT1472820	hsa-miR-545	CLIP-seq
MIRT2434448	hsa-miR-370	CLIP-seq
MIRT2434449	hsa-miR-4740-3p	CLIP-seq
MIRT2434448	hsa-miR-370	CLIP-seq
MIRT2434449	hsa-miR-4740-3p	CLIP-seq
MIRT2434448	hsa-miR-370	CLIP-seq
MIRT2434449	hsa-miR-4740-3p	CLIP-seq
MIRT2362882	hsa-miR-130a	CLIP-seq
MIRT2362883	hsa-miR-130b	CLIP-seq
MIRT2362884	hsa-miR-148a	CLIP-seq
MIRT2362885	hsa-miR-148b	CLIP-seq
MIRT2362886	hsa-miR-152	CLIP-seq
MIRT2362887	hsa-miR-19a	CLIP-seq
MIRT2362888	hsa-miR-19b	CLIP-seq
MIRT2362889	hsa-miR-223	CLIP-seq
MIRT2362890	hsa-miR-301a	CLIP-seq
MIRT2362891	hsa-miR-301b	CLIP-seq
MIRT2362897	hsa-miR-3655	CLIP-seq
MIRT2362898	hsa-miR-3666	CLIP-seq
MIRT2362899	hsa-miR-4295	CLIP-seq
MIRT2362900	hsa-miR-454	CLIP-seq
MIRT2362901	hsa-miR-4697-3p	CLIP-seq
MIRT2656950	hsa-miR-1207-5p	CLIP-seq
MIRT2656951	hsa-miR-4459	CLIP-seq
MIRT2656952	hsa-miR-4722-5p	CLIP-seq
MIRT2656953	hsa-miR-4736	CLIP-seq
MIRT2656954	hsa-miR-4763-3p	CLIP-seq
MIRT2656955	hsa-miR-665	CLIP-seq
MIRT2656950	hsa-miR-1207-5p	CLIP-seq
MIRT2656951	hsa-miR-4459	CLIP-seq
MIRT2656952	hsa-miR-4722-5p	CLIP-seq
MIRT2656953	hsa-miR-4736	CLIP-seq
MIRT2656954	hsa-miR-4763-3p	CLIP-seq
MIRT2656955	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000303	Process	Response to superoxide	IEA
GO:0001666	Process	Response to hypoxia	IEA
GO:0005215	Function	Transporter activity	TAS	9196039
GO:0005515	Function	Protein binding	IPI	24008843
GO:0005739	Component	Mitochondrion	TAS	9180264
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006629	Process	Lipid metabolic process	TAS	10935638
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0007568	Process	Aging	IEA
GO:0007584	Process	Response to nutrient	IEA
GO:0007585	Process	Respiratory gaseous exchange by respiratory system	TAS	9180264
GO:0009409	Process	Response to cold	IBA	21873635
GO:0014823	Process	Response to activity	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0017077	Function	Oxidative phosphorylation uncoupler activity	IBA	21873635
GO:0032868	Process	Response to insulin	IEA
GO:0032870	Process	Cellular response to hormone stimulus	IEA
GO:0051384	Process	Response to glucocorticoid	IEA
GO:1902600	Process	Proton transmembrane transport	TAS
GO:1990542	Process	Mitochondrial transmembrane transport	IBA	21873635
GO:1990845	Process	Adaptive thermogenesis	IBA	21873635

Other IDs

• MIM: 602044
• HGNC: 12519
• e!Ensembl: ENSG00000175564

Protein

• UniProt ID: P55916
• Protein name: Putative mitochondrial transporter UCP3 (Solute carrier family 25 member 9) (Uncoupling protein-3) (UCP 3)
• Protein function: Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed:21775425, PubMed:36114012). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00153	Mito_carr	10 → 110	Mitochondrial carrier protein	Family
  PF00153	Mito_carr	112 → 211	Mitochondrial carrier protein	Family
  PF00153	Mito_carr	214 → 305	Mitochondrial carrier protein	Family

• Sequence:

  MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRG
  VLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRI
  LAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWK
  GTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDV
  VKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA
  LMKVQMLRESPF

• Sequence length: 312

Pathways

Reactome:

The fatty acid cycling model
The proton buffering model

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	9769326
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	22919386

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		22919386