Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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7328 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Ubiquitin conjugating enzyme E2 H |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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UBE2H |
SynonymsGene synonyms aliases
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E2-20K, GID3, UBC8, UBCH, UBCH2 |
ChromosomeChromosome number
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7 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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7q32.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P62256 |
Protein name |
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H) |
Protein function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:17588522, PubMed:20061386, PubMed:8132613). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 u |
PDB |
2Z5D
,
8PJN
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00179 |
UQ_con |
9 → 145 |
Ubiquitin-conjugating enzyme |
Domain |
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Sequence |
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Sequence length |
183 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Autism |
Autistic Disorder |
rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634 |
14639049 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Sclerocystic ovaries |
Sclerocystic Ovaries |
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21411543 |
Polycystic ovary syndrome |
Polycystic Ovary Syndrome |
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21411543 |
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