UBE2E2 (ubiquitin conjugating enzyme E2 E2)

Gene

• Entrez ID: 7325
• Gene name: Ubiquitin conjugating enzyme E2 E2
• Gene symbol: UBE2E2
• Synonyms: UBCH8
• Chromosome: 3
• Chromosome location: 3p24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045536	hsa-miR-149-5p	CLASH	23622248
MIRT045236	hsa-miR-186-5p	CLASH	23622248
MIRT1467423	hsa-miR-1207-5p	CLIP-seq
MIRT1467424	hsa-miR-128	CLIP-seq
MIRT1467425	hsa-miR-185	CLIP-seq
MIRT1467426	hsa-miR-3125	CLIP-seq
MIRT1467427	hsa-miR-3202	CLIP-seq
MIRT1467428	hsa-miR-3916	CLIP-seq
MIRT1467429	hsa-miR-4264	CLIP-seq
MIRT1467430	hsa-miR-4306	CLIP-seq
MIRT1467431	hsa-miR-4311	CLIP-seq
MIRT1467432	hsa-miR-4476	CLIP-seq
MIRT1467433	hsa-miR-4644	CLIP-seq
MIRT1467434	hsa-miR-4736	CLIP-seq
MIRT1467435	hsa-miR-4763-3p	CLIP-seq
MIRT1467436	hsa-miR-4796-3p	CLIP-seq
MIRT1467437	hsa-miR-4797-3p	CLIP-seq
MIRT1467438	hsa-miR-4797-5p	CLIP-seq
MIRT1467439	hsa-miR-548t	CLIP-seq
MIRT2140471	hsa-miR-132	CLIP-seq
MIRT2140472	hsa-miR-212	CLIP-seq
MIRT2140473	hsa-miR-3126-5p	CLIP-seq
MIRT2140474	hsa-miR-3182	CLIP-seq
MIRT2140475	hsa-miR-4709-5p	CLIP-seq
MIRT2140476	hsa-miR-4728-5p	CLIP-seq
MIRT2140477	hsa-miR-4734	CLIP-seq
MIRT1467423	hsa-miR-1207-5p	CLIP-seq
MIRT2361215	hsa-miR-1272	CLIP-seq
MIRT1467424	hsa-miR-128	CLIP-seq
MIRT2361216	hsa-miR-1322	CLIP-seq
MIRT2361217	hsa-miR-300	CLIP-seq
MIRT2361218	hsa-miR-3177-5p	CLIP-seq
MIRT2361219	hsa-miR-3613-3p	CLIP-seq
MIRT2361220	hsa-miR-369-3p	CLIP-seq
MIRT2361221	hsa-miR-374c	CLIP-seq
MIRT2361222	hsa-miR-381	CLIP-seq
MIRT2361223	hsa-miR-4461	CLIP-seq
MIRT2361224	hsa-miR-4658	CLIP-seq
MIRT2361225	hsa-miR-4691-3p	CLIP-seq
MIRT2361226	hsa-miR-4698	CLIP-seq
MIRT2361227	hsa-miR-4719	CLIP-seq
MIRT1467434	hsa-miR-4736	CLIP-seq
MIRT2361228	hsa-miR-4758-5p	CLIP-seq
MIRT1467435	hsa-miR-4763-3p	CLIP-seq
MIRT1467436	hsa-miR-4796-3p	CLIP-seq
MIRT2361229	hsa-miR-499-3p	CLIP-seq
MIRT2361230	hsa-miR-499a-3p	CLIP-seq
MIRT2361231	hsa-miR-520f	CLIP-seq
MIRT2361232	hsa-miR-522	CLIP-seq
MIRT1467439	hsa-miR-548t	CLIP-seq
MIRT2361233	hsa-miR-548u	CLIP-seq
MIRT2361234	hsa-miR-570	CLIP-seq
MIRT2361235	hsa-miR-640	CLIP-seq
MIRT2361236	hsa-miR-655	CLIP-seq
MIRT1467424	hsa-miR-128	CLIP-seq
MIRT2396579	hsa-miR-3157-5p	CLIP-seq
MIRT2396580	hsa-miR-361-5p	CLIP-seq
MIRT2361221	hsa-miR-374c	CLIP-seq
MIRT2361223	hsa-miR-4461	CLIP-seq
MIRT2361224	hsa-miR-4658	CLIP-seq
MIRT2361225	hsa-miR-4691-3p	CLIP-seq
MIRT2361228	hsa-miR-4758-5p	CLIP-seq
MIRT2361231	hsa-miR-520f	CLIP-seq
MIRT2361236	hsa-miR-655	CLIP-seq
MIRT2462780	hsa-miR-1197	CLIP-seq
MIRT2462781	hsa-miR-1226	CLIP-seq
MIRT2462782	hsa-miR-3158-3p	CLIP-seq
MIRT2462783	hsa-miR-4436a	CLIP-seq
MIRT2462784	hsa-miR-4446-3p	CLIP-seq
MIRT2462785	hsa-miR-4733-3p	CLIP-seq
MIRT2462786	hsa-miR-548v	CLIP-seq
MIRT2361215	hsa-miR-1272	CLIP-seq
MIRT2655044	hsa-miR-1297	CLIP-seq
MIRT2361216	hsa-miR-1322	CLIP-seq
MIRT2655045	hsa-miR-26a	CLIP-seq
MIRT2655046	hsa-miR-26b	CLIP-seq
MIRT2655047	hsa-miR-3065-5p	CLIP-seq
MIRT2655048	hsa-miR-3148	CLIP-seq
MIRT2655049	hsa-miR-3153	CLIP-seq
MIRT2655050	hsa-miR-3163	CLIP-seq
MIRT2655051	hsa-miR-3662	CLIP-seq
MIRT1467431	hsa-miR-4311	CLIP-seq
MIRT2655052	hsa-miR-4465	CLIP-seq
MIRT2655053	hsa-miR-4668-3p	CLIP-seq
MIRT2655054	hsa-miR-4668-5p	CLIP-seq
MIRT2655055	hsa-miR-4712-3p	CLIP-seq
MIRT2655056	hsa-miR-4733-5p	CLIP-seq
MIRT2655057	hsa-miR-4762-5p	CLIP-seq
MIRT2655058	hsa-miR-498	CLIP-seq
MIRT2655059	hsa-miR-548c-3p	CLIP-seq
MIRT2361234	hsa-miR-570	CLIP-seq
MIRT2655060	hsa-miR-577	CLIP-seq
MIRT2655061	hsa-miR-605	CLIP-seq
MIRT2462781	hsa-miR-1226	CLIP-seq
MIRT2361215	hsa-miR-1272	CLIP-seq
MIRT2655044	hsa-miR-1297	CLIP-seq
MIRT2361216	hsa-miR-1322	CLIP-seq
MIRT2655045	hsa-miR-26a	CLIP-seq
MIRT2655046	hsa-miR-26b	CLIP-seq
MIRT2655048	hsa-miR-3148	CLIP-seq
MIRT2655049	hsa-miR-3153	CLIP-seq
MIRT2462782	hsa-miR-3158-3p	CLIP-seq
MIRT2462784	hsa-miR-4446-3p	CLIP-seq
MIRT2655052	hsa-miR-4465	CLIP-seq
MIRT2655053	hsa-miR-4668-3p	CLIP-seq
MIRT2655054	hsa-miR-4668-5p	CLIP-seq
MIRT2462785	hsa-miR-4733-3p	CLIP-seq
MIRT2655056	hsa-miR-4733-5p	CLIP-seq
MIRT2655057	hsa-miR-4762-5p	CLIP-seq
MIRT2655058	hsa-miR-498	CLIP-seq
MIRT2655059	hsa-miR-548c-3p	CLIP-seq
MIRT2462786	hsa-miR-548v	CLIP-seq
MIRT2361234	hsa-miR-570	CLIP-seq
MIRT2655061	hsa-miR-605	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IBA	21873635
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	20061386
GO:0005515	Function	Protein binding	IPI	17460044, 19549727, 21516116, 24446487, 25416956, 26752685, 28514442, 29892012, 31515488, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006974	Process	Cellular response to DNA damage stimulus	IMP	21628527
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0032020	Process	ISG15-protein conjugation	IBA	21873635
GO:0032020	Process	ISG15-protein conjugation	IDA	16428300
GO:0042296	Function	ISG15 transferase activity	IBA	21873635
GO:0042296	Function	ISG15 transferase activity	IDA	16428300
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IBA	21873635
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IDA	9371400, 21628527
GO:0070534	Process	Protein K63-linked ubiquitination	IBA	21873635
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	20061386
GO:0070936	Process	Protein K48-linked ubiquitination	IBA	21873635
GO:0070936	Process	Protein K48-linked ubiquitination	IDA	20061386
GO:0070979	Process	Protein K11-linked ubiquitination	IBA	21873635
GO:0070979	Process	Protein K11-linked ubiquitination	IDA	20061386
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IGI	21628527

Other IDs

• MIM: 602163
• HGNC: 12478
• e!Ensembl: ENSG00000182247

Protein

• UniProt ID: Q96LR5
• Protein name: Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)
• Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.
• PDB: 1Y6L, 6W9A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00179	UQ_con	59 → 196	Ubiquitin-conjugating enzyme	Domain

• Sequence:

  MSTEAQRVDDSPSTSGGSSDGDQRESVQQEPEREQVQPKKKEGKISSKTAAKLSTSAKRI
  QKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPK
  VTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQ
  YMTNRAEHDRMARQWTKRYAT

• Sequence length: 201

Pathways

KEGG:

Ubiquitin mediated proteolysis

Reactome:

Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	23300278, 20818381, 24509480, 22885922, 30595370, 22158537, 28869590, 30718926, 30054458, 26818947

Unknown
Disease name	Disease term	dbSNP ID	References
Eczema	Eczema		30595370
Hepatocellular adenoma	Hepatocellular Adenoma		27914986
Liver carcinoma	Liver carcinoma		27914986
Vitiligo	Vitiligo		27723757