U2AF1 (U2 small nuclear RNA auxiliary factor 1)

Gene

• Entrez ID: 7307
• Gene name: U2 small nuclear RNA auxiliary factor 1
• Gene symbol: U2AF1
• Synonyms: FP793, RN, RNU2AF1, U2AF35, U2AFBP
• Chromosome: 21
• Chromosome location: 21q22.3
• Summary: This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which pl

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	21572407
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	21572407
MIRT452698	hsa-miR-3166	PAR-CLIP	21572407
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	21572407
MIRT452698	hsa-miR-3166	PAR-CLIP	23446348
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23446348
MIRT452698	hsa-miR-3166	PAR-CLIP	23446348
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23446348
MIRT452698	hsa-miR-3166	PAR-CLIP	24398324
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	24398324
MIRT452698	hsa-miR-3166	PAR-CLIP	23592263
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23592263
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	26701625
MIRT452698	hsa-miR-3166	PAR-CLIP	26701625
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	21572407
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	21572407
MIRT452698	hsa-miR-3166	PAR-CLIP	21572407
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	21572407
MIRT452698	hsa-miR-3166	PAR-CLIP	23446348
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23446348
MIRT452698	hsa-miR-3166	PAR-CLIP	23446348
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23446348
MIRT452698	hsa-miR-3166	PAR-CLIP	24398324
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	24398324
MIRT452698	hsa-miR-3166	PAR-CLIP	23592263
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23592263
MIRT1465944	hsa-miR-133a	CLIP-seq
MIRT1465945	hsa-miR-133b	CLIP-seq
MIRT1465946	hsa-miR-3545-3p	CLIP-seq
MIRT1465947	hsa-miR-4705	CLIP-seq
MIRT1465948	hsa-miR-548ag	CLIP-seq
MIRT1465949	hsa-miR-548ai	CLIP-seq
MIRT1465950	hsa-miR-548c-3p	CLIP-seq
MIRT1465951	hsa-miR-582-3p	CLIP-seq
MIRT1465952	hsa-miR-1273d	CLIP-seq
MIRT1465953	hsa-miR-1283	CLIP-seq
MIRT1465944	hsa-miR-133a	CLIP-seq
MIRT1465945	hsa-miR-133b	CLIP-seq
MIRT1465954	hsa-miR-297	CLIP-seq
MIRT1465955	hsa-miR-3149	CLIP-seq
MIRT1465956	hsa-miR-34c-3p	CLIP-seq
MIRT1465946	hsa-miR-3545-3p	CLIP-seq
MIRT1465957	hsa-miR-3622b-5p	CLIP-seq
MIRT1465958	hsa-miR-4307	CLIP-seq
MIRT1465959	hsa-miR-452	CLIP-seq
MIRT1465960	hsa-miR-4676-3p	CLIP-seq
MIRT1465947	hsa-miR-4705	CLIP-seq
MIRT1465948	hsa-miR-548ag	CLIP-seq
MIRT1465949	hsa-miR-548ai	CLIP-seq
MIRT1465950	hsa-miR-548c-3p	CLIP-seq
MIRT1465961	hsa-miR-567	CLIP-seq
MIRT1465951	hsa-miR-582-3p	CLIP-seq
MIRT1465962	hsa-miR-590-3p	CLIP-seq
MIRT1465952	hsa-miR-1273d	CLIP-seq
MIRT1465953	hsa-miR-1283	CLIP-seq
MIRT1465944	hsa-miR-133a	CLIP-seq
MIRT1465945	hsa-miR-133b	CLIP-seq
MIRT1465956	hsa-miR-34c-3p	CLIP-seq
MIRT1465946	hsa-miR-3545-3p	CLIP-seq
MIRT1465957	hsa-miR-3622b-5p	CLIP-seq
MIRT1465959	hsa-miR-452	CLIP-seq
MIRT1465960	hsa-miR-4676-3p	CLIP-seq
MIRT1465947	hsa-miR-4705	CLIP-seq
MIRT1465948	hsa-miR-548ag	CLIP-seq
MIRT1465949	hsa-miR-548ai	CLIP-seq
MIRT1465950	hsa-miR-548c-3p	CLIP-seq
MIRT1465951	hsa-miR-582-3p	CLIP-seq
MIRT1465962	hsa-miR-590-3p	CLIP-seq
MIRT1465952	hsa-miR-1273d	CLIP-seq
MIRT1465953	hsa-miR-1283	CLIP-seq
MIRT1465944	hsa-miR-133a	CLIP-seq
MIRT1465945	hsa-miR-133b	CLIP-seq
MIRT2360799	hsa-miR-3127-3p	CLIP-seq
MIRT1465956	hsa-miR-34c-3p	CLIP-seq
MIRT1465946	hsa-miR-3545-3p	CLIP-seq
MIRT1465957	hsa-miR-3622b-5p	CLIP-seq
MIRT1465947	hsa-miR-4705	CLIP-seq
MIRT1465948	hsa-miR-548ag	CLIP-seq
MIRT1465949	hsa-miR-548ai	CLIP-seq
MIRT1465950	hsa-miR-548c-3p	CLIP-seq
MIRT1465951	hsa-miR-582-3p	CLIP-seq
MIRT1465962	hsa-miR-590-3p	CLIP-seq
MIRT1465952	hsa-miR-1273d	CLIP-seq
MIRT1465962	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA	21873635
GO:0000398	Process	MRNA splicing, via spliceosome	IC	9731529, 11991638
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	11551507, 15652350, 16189514, 17577209, 18559666, 20696395, 21460037, 21516116, 21988832, 22365833, 23455924, 23602568, 25416956, 25959826, 28514442, 32814053
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IBA	21873635
GO:0005681	Component	Spliceosomal complex	IDA	9731529
GO:0006397	Process	MRNA processing	TAS	1388271
GO:0006405	Process	RNA export from nucleus	TAS
GO:0006406	Process	MRNA export from nucleus	TAS
GO:0008380	Process	RNA splicing	TAS	1388271
GO:0015030	Component	Cajal body	TAS	1388271
GO:0016607	Component	Nuclear speck	ISS
GO:0030628	Function	Pre-mRNA 3'-splice site binding	IBA	21873635
GO:0031124	Process	MRNA 3'-end processing	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:0089701	Component	U2AF complex	IBA	21873635
GO:0089701	Component	U2AF complex	IDA	1824937, 2531895

Other IDs

• MIM: 191317
• HGNC: 12453
• e!Ensembl: ENSG00000160201

Protein

• UniProt ID: Q01081
• Protein name: Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit)
• Protein function: Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly med
• PDB: 1JMT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00642	zf-CCCH	13 → 39	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family
  PF00076	RRM_1	82 → 141	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00642	zf-CCCH	149 → 175	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family

• Sequence:

  MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
  SADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
  EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
  LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
  

• Sequence length: 240

Pathways

KEGG:

Spliceosome
Shigellosis

Reactome:

Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma of the head and neck	Squamous cell carcinoma of the head and neck	rs121909237, rs121909250, rs121909251, rs121909252, rs28934571, rs28934574, rs28934576, rs28934578, rs121912664, rs397516436, rs121912666, rs397514495, rs587782705, rs193920774, rs730882001, rs786201838, rs587782144, rs866775781, rs730882008, rs1567549584, rs1597371666, rs1597365075	26619011
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	24498085, 26619011, 23029227, 22158538
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	26619011
Myelodysplastic syndrome	MYELODYSPLASTIC SYNDROME	rs193303018, rs387906631, rs1576745225, rs373145711, rs752746786, rs377023736, rs373221034, rs1576749014, rs1600586587	23861105, 26619011, 22158538, 25311244
Osteoporosis	Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287	18924182
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Unknown
Disease name	Disease term	dbSNP ID	References
Uterine cervix neoplasm	Uterine Cervical Neoplasm		26619011
Endometrial cancer	Uterine Carcinosarcoma		26619011
Lymphocytic leukemia	Chronic Lymphocytic Leukemia
Malignant uterine corpus neoplasm	Malignant Uterine Corpus Neoplasm		26619011
Pancreatic adenocarcinoma	Adenocarcinoma of pancreas	rs121908291, rs139375029, rs587780197, rs587780198, rs587780200, rs374741161, rs368806050, rs113676921, rs587780753, rs550499593, rs143544548, rs587780754, rs587780755, rs587780756, rs114593924, rs587780757, rs587780758, rs532961259, rs587780759, rs535155432, rs543821321, rs587780760, rs587780761, rs368350042, rs368890611, rs200060953, rs559000839, rs587780762, rs142116575, rs150764613, rs62333013, rs59633770, rs370602081, rs759105985, rs535118290, rs528879194, rs863224705, rs758706279, rs780516159, rs863224383, rs863224384, rs777359545, rs863224385, rs570874237, rs863224386, rs753092219, rs769161509, rs143417961, rs140360991, rs201707558, rs863224702, rs754158038, rs863224382, rs761530979, rs780692056, rs863224703, rs114250766, rs113515140, rs863224704, rs561750970, rs864622627, rs864622590, rs864622422, rs864622140, rs730882137, rs864622087, rs864622226, rs864622591, rs864622321, rs864622158, rs864622531, rs767729090, rs749041581, rs768485147, rs864622234, rs864622355, rs864622316, rs864622388, rs764242515, rs778134231, rs771679229, rs746599370, rs551131343, rs878854264, rs878854265, rs878854266, rs878854267, rs878854268, rs376654786, rs373500403, rs114171764, rs376394488, rs61051061, rs1806729, rs548068667, rs781516286, rs1059444, rs750112132, rs7673220, rs1060502975, rs778471055, rs925242863, rs143717202, rs372414187, rs927644209, rs764265611, rs1060502976, rs554297134, rs997146277, rs1060502974, rs1060504775, rs200020758, rs1060502973, rs777453756, rs952110792, rs1553965295, rs1553973196, rs1177108180, rs1477864263, rs368472947, rs182571219, rs1553984987, rs1263751006, rs201979617, rs1358006173, rs151071844, rs115937217, rs568490721, rs189021816, rs1319983866, rs1553965480, rs1553969553, rs1385898569, rs1553965526, rs1553968628, rs763802548, rs752296365, rs1553965214, rs1474793366, rs1553965326, rs778313832, rs1318598425, rs1470434769, rs755223646, rs557697540, rs747702421, rs1560940853, rs1560839872, rs1216822754, rs751364707, rs372708613, rs1560929667, rs1306250811, rs774034818, rs551420048, rs1581871066, rs1221751077, rs1220928329, rs759161069, rs757164572, rs115274645, rs769973229, rs115988233, rs767384375, rs778210310, rs1305250587, rs1239099971, rs1025237623, rs1211489449, rs900642927, rs1400689367, rs140584890, rs757885388, rs1231114395, rs996343137, rs1275232115, rs1046350904, rs762267147, rs373066707, rs867266337, rs1460784357, rs748432333, rs769517051, rs1560937938, rs750033888, rs781065277, rs1751999027, rs1246689760, rs1752077261, rs1754079127, rs1754736103, rs1757056910, rs114673468, rs756934356, rs1176026649, rs1762161869, rs200399043, rs1447433925, rs1389221540, rs893660432, rs1762582426	26619011
Prostatic neoplasms	Prostatic Neoplasms		29610475
Bladder carcinoma	Transitional cell carcinoma of bladder		26619011