TNFSF4 (TNF superfamily member 4)

Gene

• Entrez ID: 7292
• Gene name: TNF superfamily member 4
• Gene symbol: TNFSF4
• Synonyms: CD134L, CD252, GP34, OX-40L, OX4OL, TNLG2B, TXGP1
• Chromosome: 1
• Chromosome location: 1q25.1
• Summary: This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene h

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT670334	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT670333	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT670332	hsa-miR-603	HITS-CLIP	23824327
MIRT670331	hsa-miR-3941	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT670334	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT670333	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT670332	hsa-miR-603	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT670331	hsa-miR-3941	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT670334	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT670334	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT670334	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT670334	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT670333	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT670333	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT670333	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT670333	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT670331	hsa-miR-3941	HITS-CLIP	27418678
MIRT670331	hsa-miR-3941	HITS-CLIP	27418678
MIRT670331	hsa-miR-3941	HITS-CLIP	27418678
MIRT670331	hsa-miR-3941	HITS-CLIP	27418678
MIRT670332	hsa-miR-603	HITS-CLIP	27418678
MIRT670332	hsa-miR-603	HITS-CLIP	27418678
MIRT670332	hsa-miR-603	HITS-CLIP	27418678
MIRT670332	hsa-miR-603	HITS-CLIP	27418678
MIRT615655	hsa-miR-8485	HITS-CLIP	27418678
MIRT615655	hsa-miR-8485	HITS-CLIP	27418678
MIRT615655	hsa-miR-8485	HITS-CLIP	27418678
MIRT615655	hsa-miR-8485	HITS-CLIP	27418678
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT670334	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT670333	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT670332	hsa-miR-603	HITS-CLIP	23824327
MIRT670331	hsa-miR-3941	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT670334	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT670333	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT670332	hsa-miR-603	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT670331	hsa-miR-3941	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT1443526	hsa-miR-10a	CLIP-seq
MIRT1443527	hsa-miR-10b	CLIP-seq
MIRT1443528	hsa-miR-1255a	CLIP-seq
MIRT1443529	hsa-miR-1255b	CLIP-seq
MIRT1443530	hsa-miR-125a-5p	CLIP-seq
MIRT1443531	hsa-miR-125b	CLIP-seq
MIRT1443532	hsa-miR-1273f	CLIP-seq
MIRT1443533	hsa-miR-141	CLIP-seq
MIRT1443534	hsa-miR-143	CLIP-seq
MIRT1443535	hsa-miR-145	CLIP-seq
MIRT1443536	hsa-miR-186	CLIP-seq
MIRT1443537	hsa-miR-1972	CLIP-seq
MIRT1443538	hsa-miR-198	CLIP-seq
MIRT1443539	hsa-miR-200a	CLIP-seq
MIRT1443540	hsa-miR-2278	CLIP-seq
MIRT1443541	hsa-miR-2682	CLIP-seq
MIRT1443542	hsa-miR-27a	CLIP-seq
MIRT1443543	hsa-miR-27b	CLIP-seq
MIRT1443544	hsa-miR-2964a-5p	CLIP-seq
MIRT1443545	hsa-miR-3120-5p	CLIP-seq
MIRT1443546	hsa-miR-3133	CLIP-seq
MIRT1443547	hsa-miR-3152-5p	CLIP-seq
MIRT1443548	hsa-miR-3177-5p	CLIP-seq
MIRT1443549	hsa-miR-329	CLIP-seq
MIRT1443550	hsa-miR-3605-5p	CLIP-seq
MIRT1443551	hsa-miR-3908	CLIP-seq
MIRT1443552	hsa-miR-4310	CLIP-seq
MIRT1443553	hsa-miR-4319	CLIP-seq
MIRT1443554	hsa-miR-4324	CLIP-seq
MIRT1443555	hsa-miR-4421	CLIP-seq
MIRT1443556	hsa-miR-4459	CLIP-seq
MIRT1443557	hsa-miR-449c	CLIP-seq
MIRT1443558	hsa-miR-4652-3p	CLIP-seq
MIRT1443559	hsa-miR-4690-5p	CLIP-seq
MIRT1443560	hsa-miR-4708-5p	CLIP-seq
MIRT1443561	hsa-miR-4722-5p	CLIP-seq
MIRT1443562	hsa-miR-4747-5p	CLIP-seq
MIRT1443563	hsa-miR-4770	CLIP-seq
MIRT1443564	hsa-miR-4774-3p	CLIP-seq
MIRT1443565	hsa-miR-513a-5p	CLIP-seq
MIRT1443566	hsa-miR-522	CLIP-seq
MIRT1443567	hsa-miR-634	CLIP-seq
MIRT1443568	hsa-miR-764	CLIP-seq
MIRT1443569	hsa-miR-940	CLIP-seq
MIRT2132730	hsa-miR-1252	CLIP-seq
MIRT2132731	hsa-miR-216b	CLIP-seq
MIRT2132732	hsa-miR-224	CLIP-seq
MIRT2132733	hsa-miR-339-5p	CLIP-seq
MIRT2132734	hsa-miR-3606	CLIP-seq
MIRT2132735	hsa-miR-3611	CLIP-seq
MIRT2132736	hsa-miR-4287	CLIP-seq
MIRT2132737	hsa-miR-4420	CLIP-seq
MIRT2132738	hsa-miR-4469	CLIP-seq
MIRT2132739	hsa-miR-4685-3p	CLIP-seq
MIRT2132740	hsa-miR-4713-5p	CLIP-seq
MIRT2132741	hsa-miR-4786-3p	CLIP-seq
MIRT2353818	hsa-miR-101	CLIP-seq
MIRT1443549	hsa-miR-329	CLIP-seq
MIRT2132734	hsa-miR-3606	CLIP-seq
MIRT2132741	hsa-miR-4786-3p	CLIP-seq
MIRT2353819	hsa-miR-586	CLIP-seq
MIRT2396138	hsa-miR-219-5p	CLIP-seq
MIRT2396139	hsa-miR-4782-3p	CLIP-seq
MIRT2396140	hsa-miR-483-3p	CLIP-seq
MIRT2396141	hsa-miR-578	CLIP-seq
MIRT2441449	hsa-miR-1270	CLIP-seq
MIRT2441450	hsa-miR-1299	CLIP-seq
MIRT2441451	hsa-miR-4290	CLIP-seq
MIRT2441452	hsa-miR-4683	CLIP-seq
MIRT2441453	hsa-miR-4687-5p	CLIP-seq
MIRT2441454	hsa-miR-4782-5p	CLIP-seq
MIRT2441455	hsa-miR-516b	CLIP-seq
MIRT2441456	hsa-miR-620	CLIP-seq
MIRT2462104	hsa-miR-103b	CLIP-seq
MIRT1443549	hsa-miR-329	CLIP-seq
MIRT2462105	hsa-miR-376c	CLIP-seq
MIRT2647893	hsa-miR-122	CLIP-seq
MIRT2132730	hsa-miR-1252	CLIP-seq
MIRT1443528	hsa-miR-1255a	CLIP-seq
MIRT1443529	hsa-miR-1255b	CLIP-seq
MIRT2441449	hsa-miR-1270	CLIP-seq
MIRT2647894	hsa-miR-1273g	CLIP-seq
MIRT2441450	hsa-miR-1299	CLIP-seq
MIRT2647895	hsa-miR-138	CLIP-seq
MIRT2647896	hsa-miR-147	CLIP-seq
MIRT2647897	hsa-miR-153	CLIP-seq
MIRT2647898	hsa-miR-188-5p	CLIP-seq
MIRT1443537	hsa-miR-1972	CLIP-seq
MIRT1443538	hsa-miR-198	CLIP-seq
MIRT1443540	hsa-miR-2278	CLIP-seq
MIRT2647899	hsa-miR-2467-3p	CLIP-seq
MIRT2647900	hsa-miR-2467-5p	CLIP-seq
MIRT1443541	hsa-miR-2682	CLIP-seq
MIRT1443545	hsa-miR-3120-5p	CLIP-seq
MIRT2647901	hsa-miR-3134	CLIP-seq
MIRT1443547	hsa-miR-3152-5p	CLIP-seq
MIRT2647902	hsa-miR-3160-3p	CLIP-seq
MIRT1443548	hsa-miR-3177-5p	CLIP-seq
MIRT2647903	hsa-miR-3188	CLIP-seq
MIRT2647904	hsa-miR-3202	CLIP-seq
MIRT1443549	hsa-miR-329	CLIP-seq
MIRT2132733	hsa-miR-339-5p	CLIP-seq
MIRT2647905	hsa-miR-3591-5p	CLIP-seq
MIRT1443550	hsa-miR-3605-5p	CLIP-seq
MIRT2132734	hsa-miR-3606	CLIP-seq
MIRT2647906	hsa-miR-3617	CLIP-seq
MIRT2647907	hsa-miR-3678-3p	CLIP-seq
MIRT1443551	hsa-miR-3908	CLIP-seq
MIRT2647908	hsa-miR-3911	CLIP-seq
MIRT2647909	hsa-miR-3915	CLIP-seq
MIRT2647910	hsa-miR-3928	CLIP-seq
MIRT2647911	hsa-miR-3975	CLIP-seq
MIRT2647912	hsa-miR-4280	CLIP-seq
MIRT2441451	hsa-miR-4290	CLIP-seq
MIRT1443552	hsa-miR-4310	CLIP-seq
MIRT2647913	hsa-miR-4316	CLIP-seq
MIRT1443555	hsa-miR-4421	CLIP-seq
MIRT2647914	hsa-miR-4426	CLIP-seq
MIRT1443556	hsa-miR-4459	CLIP-seq
MIRT2647915	hsa-miR-4476	CLIP-seq
MIRT1443557	hsa-miR-449c	CLIP-seq
MIRT2647916	hsa-miR-4533	CLIP-seq
MIRT2647917	hsa-miR-4534	CLIP-seq
MIRT2647918	hsa-miR-4633-3p	CLIP-seq
MIRT2647919	hsa-miR-4647	CLIP-seq
MIRT1443558	hsa-miR-4652-3p	CLIP-seq
MIRT2647920	hsa-miR-4662b	CLIP-seq
MIRT2441452	hsa-miR-4683	CLIP-seq
MIRT2441453	hsa-miR-4687-5p	CLIP-seq
MIRT1443559	hsa-miR-4690-5p	CLIP-seq
MIRT2647921	hsa-miR-4719	CLIP-seq
MIRT1443561	hsa-miR-4722-5p	CLIP-seq
MIRT1443562	hsa-miR-4747-5p	CLIP-seq
MIRT1443564	hsa-miR-4774-3p	CLIP-seq
MIRT2647922	hsa-miR-4777-5p	CLIP-seq
MIRT2441454	hsa-miR-4782-5p	CLIP-seq
MIRT2132741	hsa-miR-4786-3p	CLIP-seq
MIRT2647923	hsa-miR-4786-5p	CLIP-seq
MIRT2647924	hsa-miR-4789-3p	CLIP-seq
MIRT2647925	hsa-miR-4802-3p	CLIP-seq
MIRT2647926	hsa-miR-485-5p	CLIP-seq
MIRT2441455	hsa-miR-516b	CLIP-seq
MIRT2647927	hsa-miR-518d-5p	CLIP-seq
MIRT2647928	hsa-miR-519b-5p	CLIP-seq
MIRT2647929	hsa-miR-519c-5p	CLIP-seq
MIRT2647930	hsa-miR-520c-5p	CLIP-seq
MIRT2647931	hsa-miR-526a	CLIP-seq
MIRT2647932	hsa-miR-548q	CLIP-seq
MIRT2441456	hsa-miR-620	CLIP-seq
MIRT1443567	hsa-miR-634	CLIP-seq
MIRT2647933	hsa-miR-641	CLIP-seq
MIRT2647934	hsa-miR-644	CLIP-seq
MIRT1443568	hsa-miR-764	CLIP-seq
MIRT2647935	hsa-miR-769-5p	CLIP-seq
MIRT1443569	hsa-miR-940	CLIP-seq
MIRT1443538	hsa-miR-198	CLIP-seq
MIRT2647909	hsa-miR-3915	CLIP-seq
MIRT2647910	hsa-miR-3928	CLIP-seq
MIRT2647914	hsa-miR-4426	CLIP-seq
MIRT2647919	hsa-miR-4647	CLIP-seq
MIRT2647920	hsa-miR-4662b	CLIP-seq
MIRT2647921	hsa-miR-4719	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HDAC11	Activation	21239696

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001819	Process	Positive regulation of cytokine production	IBA	21873635
GO:0002215	Process	Defense response to nematode	ISS
GO:0002526	Process	Acute inflammatory response	ISS
GO:0002639	Process	Positive regulation of immunoglobulin production	ISS
GO:0002726	Process	Positive regulation of T cell cytokine production	ISS
GO:0002819	Process	Regulation of adaptive immune response	ISS
GO:0002830	Process	Positive regulation of type 2 immune response	ISS
GO:0002891	Process	Positive regulation of immunoglobulin mediated immune response	ISS
GO:0005102	Function	Signaling receptor binding	TAS	7913952
GO:0005125	Function	Cytokine activity	IEA
GO:0005164	Function	Tumor necrosis factor receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	16905106
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	17166734
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	NAS	18397322
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	TAS	7913952
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	7913952
GO:0009615	Process	Response to virus	ISS
GO:0009986	Component	Cell surface	IDA	18397322
GO:0032689	Process	Negative regulation of interferon-gamma production	ISS
GO:0032700	Process	Negative regulation of interleukin-17 production	IDA	18501882
GO:0032729	Process	Positive regulation of interferon-gamma production	IDA	18501882
GO:0032733	Process	Positive regulation of interleukin-10 production	ISS
GO:0032735	Process	Positive regulation of interleukin-12 production	ISS
GO:0032736	Process	Positive regulation of interleukin-13 production	ISS
GO:0032753	Process	Positive regulation of interleukin-4 production	IDA	18501882
GO:0032755	Process	Positive regulation of interleukin-6 production	IDA	20844189
GO:0032813	Function	Tumor necrosis factor receptor superfamily binding	IBA	21873635
GO:0032813	Function	Tumor necrosis factor receptor superfamily binding	ISS
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS
GO:0035709	Process	Memory T cell activation	ISS
GO:0035712	Process	T-helper 2 cell activation	ISS
GO:0035713	Process	Response to nitrogen dioxide	ISS
GO:0042102	Process	Positive regulation of T cell proliferation	IBA	21873635
GO:0043372	Process	Positive regulation of CD4-positive, alpha-beta T cell differentiation	ISS
GO:0043382	Process	Positive regulation of memory T cell differentiation	ISS
GO:0043433	Process	Negative regulation of DNA-binding transcription factor activity	ISS
GO:0045590	Process	Negative regulation of regulatory T cell differentiation	ISS
GO:0045626	Process	Negative regulation of T-helper 1 cell differentiation	ISS
GO:0045630	Process	Positive regulation of T-helper 2 cell differentiation	ISS
GO:0045892	Process	Negative regulation of transcription, DNA-templated	ISS
GO:0046641	Process	Positive regulation of alpha-beta T cell proliferation	ISS
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:0050729	Process	Positive regulation of inflammatory response	IDA	20844189
GO:0050871	Process	Positive regulation of B cell activation	ISS
GO:0071222	Process	Cellular response to lipopolysaccharide	IDA	20844189
GO:0071380	Process	Cellular response to prostaglandin E stimulus	IDA	19029446
GO:0071954	Process	Chemokine (C-C motif) ligand 11 production	ISS
GO:1900281	Process	Positive regulation of CD4-positive, alpha-beta T cell costimulation	ISS
GO:2000572	Process	Positive regulation of interleukin-4-dependent isotype switching to IgE isotypes	ISS

Other IDs

• MIM: 603594
• HGNC: 11934
• e!Ensembl: ENSG00000117586

Protein

• UniProt ID: P23510
• Protein name: Tumor necrosis factor ligand superfamily member 4 (Glycoprotein Gp34) (OX40 ligand) (OX40L) (TAX transcriptionally-activated glycoprotein 1) (CD antigen CD252)
• Protein function: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
• PDB: 2HEV
• Sequence:

  MERVQPLEENVGNAARPRFERNKLLLVASVIQGLGLLLCFTYICLHFSALQVSHRYPRIQ
  SIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQ
  KDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEF
  CVL

• Sequence length: 183

Pathways

KEGG:

Cytokine-cytokine receptor interaction

Reactome:

TNFs bind their physiological receptors

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	31036433
Myocardial infarction	Myocardial Infarction	rs12316150, rs41303970, rs909253, rs7291467, rs2234693
Narcolepsy	Narcolepsy, Narcolepsy type 1	rs104894574, rs387906655	23459209
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840
Systemic lupus erythematosus	Systemic lupus erythematosus	rs77571059, rs10954213, rs2070197, rs72556554, rs3219018, rs121912990, rs1575496354, rs7574865, rs1307379746, rs758750492, rs1575497576

Unknown
Disease name	Disease term	dbSNP ID	References
Amnesia	Amnesia, Transient Global
Cataplexy	Cataplexy
Eczema	Eczema		30595370
Hallucinations	Hallucinations
Lupus erythematosus	Lupus Erythematosus, Systemic		22654485, 18059267, 24091983, 19838193, 22820624, 23943494, 22850862, 21905002
Narcolepsy-cataplexy syndrome	Narcolepsy-Cataplexy Syndrome		23459209
Nonbacterial verrucal endocardiosis	Libman-Sacks Disease		19838193, 18059267