TTK (TTK protein kinase)

Gene

• Entrez ID: 7272
• Gene name: TTK protein kinase
• Gene symbol: TTK
• Synonyms: CT96, ESK, MPH1, MPS1, MPS1L1, PYT
• Chromosome: 6
• Chromosome location: 6q14.1
• Summary: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required f

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1057520011	G>T	Likely-pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001746	hsa-miR-376a-5p	Luciferase reporter assay	17322061
MIRT001746	hsa-miR-376a-5p	Luciferase reporter assay	17322061
MIRT019665	hsa-miR-376a-3p	Reporter assay	17322061
MIRT024895	hsa-miR-215-5p	Microarray	19074876
MIRT026393	hsa-miR-192-5p	Microarray	19074876
MIRT438190	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT438190	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT438190	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT438190	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT169515	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT169516	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT1462125	hsa-miR-105	CLIP-seq
MIRT1462126	hsa-miR-1273g	CLIP-seq
MIRT1462127	hsa-miR-1283	CLIP-seq
MIRT1462128	hsa-miR-129-5p	CLIP-seq
MIRT1462129	hsa-miR-1297	CLIP-seq
MIRT1462130	hsa-miR-132	CLIP-seq
MIRT1462131	hsa-miR-1323	CLIP-seq
MIRT1462132	hsa-miR-140-5p	CLIP-seq
MIRT1462133	hsa-miR-212	CLIP-seq
MIRT1462134	hsa-miR-26a	CLIP-seq
MIRT1462135	hsa-miR-26b	CLIP-seq
MIRT1462136	hsa-miR-2964a-5p	CLIP-seq
MIRT1462137	hsa-miR-323b-3p	CLIP-seq
MIRT1462138	hsa-miR-335	CLIP-seq
MIRT1462139	hsa-miR-338-5p	CLIP-seq
MIRT1462140	hsa-miR-3618	CLIP-seq
MIRT1462141	hsa-miR-3662	CLIP-seq
MIRT1462142	hsa-miR-3668	CLIP-seq
MIRT1462143	hsa-miR-3671	CLIP-seq
MIRT1462144	hsa-miR-3692	CLIP-seq
MIRT1462145	hsa-miR-3919	CLIP-seq
MIRT1462146	hsa-miR-3935	CLIP-seq
MIRT1462147	hsa-miR-3941	CLIP-seq
MIRT1462148	hsa-miR-4301	CLIP-seq
MIRT1462149	hsa-miR-4328	CLIP-seq
MIRT1462150	hsa-miR-4465	CLIP-seq
MIRT1462151	hsa-miR-455-3p	CLIP-seq
MIRT1462152	hsa-miR-466	CLIP-seq
MIRT1462153	hsa-miR-4662a-5p	CLIP-seq
MIRT1462154	hsa-miR-4672	CLIP-seq
MIRT1462155	hsa-miR-4680-3p	CLIP-seq
MIRT1462156	hsa-miR-4724-5p	CLIP-seq
MIRT1462157	hsa-miR-4731-3p	CLIP-seq
MIRT1462158	hsa-miR-4801	CLIP-seq
MIRT1462159	hsa-miR-511	CLIP-seq
MIRT1462160	hsa-miR-548o	CLIP-seq
MIRT1462161	hsa-miR-570	CLIP-seq
MIRT1462162	hsa-miR-582-5p	CLIP-seq
MIRT1462163	hsa-miR-607	CLIP-seq
MIRT1462164	hsa-miR-616	CLIP-seq
MIRT1462165	hsa-miR-628-5p	CLIP-seq
MIRT2138881	hsa-miR-4699-3p	CLIP-seq
MIRT2138882	hsa-miR-520d-5p	CLIP-seq
MIRT2138883	hsa-miR-561	CLIP-seq
MIRT1462162	hsa-miR-582-5p	CLIP-seq
MIRT1462125	hsa-miR-105	CLIP-seq
MIRT1462128	hsa-miR-129-5p	CLIP-seq
MIRT1462129	hsa-miR-1297	CLIP-seq
MIRT1462130	hsa-miR-132	CLIP-seq
MIRT1462131	hsa-miR-1323	CLIP-seq
MIRT1462133	hsa-miR-212	CLIP-seq
MIRT1462134	hsa-miR-26a	CLIP-seq
MIRT1462135	hsa-miR-26b	CLIP-seq
MIRT1462136	hsa-miR-2964a-5p	CLIP-seq
MIRT1462138	hsa-miR-335	CLIP-seq
MIRT1462141	hsa-miR-3662	CLIP-seq
MIRT1462142	hsa-miR-3668	CLIP-seq
MIRT1462143	hsa-miR-3671	CLIP-seq
MIRT1462144	hsa-miR-3692	CLIP-seq
MIRT1462146	hsa-miR-3935	CLIP-seq
MIRT1462150	hsa-miR-4465	CLIP-seq
MIRT1462151	hsa-miR-455-3p	CLIP-seq
MIRT1462153	hsa-miR-4662a-5p	CLIP-seq
MIRT2138881	hsa-miR-4699-3p	CLIP-seq
MIRT1462159	hsa-miR-511	CLIP-seq
MIRT1462160	hsa-miR-548o	CLIP-seq
MIRT1462163	hsa-miR-607	CLIP-seq
MIRT1462164	hsa-miR-616	CLIP-seq
MIRT1462165	hsa-miR-628-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F4	Repression	17981789

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000776	Component	Kinetochore	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IBA	21873635
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	19273613
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	25468996
GO:0005819	Component	Spindle	IBA	21873635
GO:0007051	Process	Spindle organization	TAS	10366450
GO:0007052	Process	Mitotic spindle organization	TAS	7737118
GO:0007059	Process	Chromosome segregation	IBA	21873635
GO:0007094	Process	Mitotic spindle assembly checkpoint	IBA	21873635
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	1639825
GO:0010862	Process	Positive regulation of pathway-restricted SMAD protein phosphorylation	TAS	19018011
GO:0016020	Component	Membrane	HDA	19946888
GO:0016321	Process	Female meiosis chromosome segregation	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0018107	Process	Peptidyl-threonine phosphorylation	IEA
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IEA
GO:0033316	Process	Meiotic spindle assembly checkpoint	IBA	21873635
GO:0034501	Process	Protein localization to kinetochore	IBA	21873635
GO:0043515	Function	Kinetochore binding	IEA
GO:0046777	Process	Protein autophosphorylation	IEA
GO:0051304	Process	Chromosome separation	IEA
GO:1903096	Process	Protein localization to meiotic spindle midzone	IEA

Other IDs

• MIM: 604092
• HGNC: 12401
• e!Ensembl: ENSG00000112742

Protein

• UniProt ID: P33981
• Protein name: Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
• Protein function: Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMe
• PDB: 2X9E, 2ZMC, 2ZMD, 3CEK, 3DBQ, 3GFW, 3H9F, 3HMN, 3HMO, 3HMP, 3VQU, 3W1F, 3WYX, 3WYY, 3WZJ, 3WZK, 4B94, 4BHZ, 4BI0, 4BI1, 4BI2, 4C4E, 4C4F, 4C4G, 4C4H, 4C4I, 4C4J, 4CV8, 4CV9, 4CVA, 4D2S, 4H7X, 4H7Y, 4JS8, 4JT3, 4O6L, 4ZEG, 5AP0, 5AP1, 5AP2, 5AP3, 5AP4, 5AP5, 5AP6, 5AP7, 5EH0, 5EHL, 5EHO, 5EHY, 5EI2, 5EI6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	525 → 791	Protein kinase domain	Domain

• Sequence:

  MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
  NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
  AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
  EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
  LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
  TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
  ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
  KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
  LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
  QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
  VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
  KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
  GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
  SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
  SHNSSSSKTFEKKRGKK

• Sequence length: 857

Pathways

KEGG:

Cell cycle

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560
Sclerocystic ovaries	Sclerocystic Ovaries		21411543
Pancreatic neoplasm	Pancreatic Neoplasm		20581473
Polycystic ovary syndrome	Polycystic Ovary Syndrome		21411543