TST (thiosulfate sulfurtransferase)

Gene

• Entrez ID: 7263
• Gene name: Thiosulfate sulfurtransferase
• Gene symbol: TST
• Synonyms: RDS
• Chromosome: 22
• Chromosome location: 22q12.3
• Summary: This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016237	hsa-miR-548b-3p	Sequencing	20371350
MIRT032127	hsa-let-7d-5p	Sequencing	20371350
MIRT032251	hsa-let-7b-5p	Proteomics	18668040
MIRT1460633	hsa-miR-101	CLIP-seq
MIRT1460634	hsa-miR-144	CLIP-seq
MIRT1460635	hsa-miR-145	CLIP-seq
MIRT1460636	hsa-miR-1537	CLIP-seq
MIRT1460637	hsa-miR-1825	CLIP-seq
MIRT1460638	hsa-miR-199a-5p	CLIP-seq
MIRT1460639	hsa-miR-199b-5p	CLIP-seq
MIRT1460640	hsa-miR-205	CLIP-seq
MIRT1460641	hsa-miR-224	CLIP-seq
MIRT1460642	hsa-miR-298	CLIP-seq
MIRT1460643	hsa-miR-3120-3p	CLIP-seq
MIRT1460644	hsa-miR-412	CLIP-seq
MIRT1460645	hsa-miR-4511	CLIP-seq
MIRT1460646	hsa-miR-4792	CLIP-seq
MIRT1460647	hsa-miR-4799-5p	CLIP-seq
MIRT1460648	hsa-miR-548ac	CLIP-seq
MIRT1460649	hsa-miR-548ae	CLIP-seq
MIRT1460650	hsa-miR-548aj	CLIP-seq
MIRT1460651	hsa-miR-548am	CLIP-seq
MIRT1460652	hsa-miR-548an	CLIP-seq
MIRT1460653	hsa-miR-548d-3p	CLIP-seq
MIRT1460654	hsa-miR-548x	CLIP-seq
MIRT1460655	hsa-miR-548z	CLIP-seq
MIRT1460656	hsa-miR-561	CLIP-seq
MIRT1460657	hsa-miR-582-5p	CLIP-seq
MIRT1460658	hsa-miR-615-5p	CLIP-seq
MIRT1460659	hsa-miR-935	CLIP-seq
MIRT1460633	hsa-miR-101	CLIP-seq
MIRT1460634	hsa-miR-144	CLIP-seq
MIRT1460636	hsa-miR-1537	CLIP-seq
MIRT1460641	hsa-miR-224	CLIP-seq
MIRT1460657	hsa-miR-582-5p	CLIP-seq
MIRT1460658	hsa-miR-615-5p	CLIP-seq
MIRT1460659	hsa-miR-935	CLIP-seq
MIRT1460633	hsa-miR-101	CLIP-seq
MIRT1460634	hsa-miR-144	CLIP-seq
MIRT1460636	hsa-miR-1537	CLIP-seq
MIRT1460640	hsa-miR-205	CLIP-seq
MIRT1460641	hsa-miR-224	CLIP-seq
MIRT1460642	hsa-miR-298	CLIP-seq
MIRT1460644	hsa-miR-412	CLIP-seq
MIRT1460645	hsa-miR-4511	CLIP-seq
MIRT1460657	hsa-miR-582-5p	CLIP-seq
MIRT1460658	hsa-miR-615-5p	CLIP-seq
MIRT1460659	hsa-miR-935	CLIP-seq
MIRT1460643	hsa-miR-3120-3p	CLIP-seq
MIRT1460646	hsa-miR-4792	CLIP-seq
MIRT1460647	hsa-miR-4799-5p	CLIP-seq
MIRT1460648	hsa-miR-548ac	CLIP-seq
MIRT1460649	hsa-miR-548ae	CLIP-seq
MIRT1460650	hsa-miR-548aj	CLIP-seq
MIRT1460651	hsa-miR-548am	CLIP-seq
MIRT1460653	hsa-miR-548d-3p	CLIP-seq
MIRT1460654	hsa-miR-548x	CLIP-seq
MIRT1460655	hsa-miR-548z	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000098	Process	Sulfur amino acid catabolic process	TAS
GO:0004792	Function	Thiosulfate sulfurtransferase activity	IBA	21873635
GO:0004792	Function	Thiosulfate sulfurtransferase activity	TAS
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0008097	Function	5S rRNA binding	IDA	20663881, 21685364
GO:0009440	Process	Cyanate catabolic process	TAS	9070219
GO:0019346	Process	Transsulfuration	IBA	21873635
GO:0030855	Process	Epithelial cell differentiation	IDA	21492153
GO:0035928	Process	RRNA import into mitochondrion	IMP	20663881
GO:0051029	Process	RRNA transport	IDA	21685364

Other IDs

• MIM: 180370
• HGNC: 12388
• e!Ensembl: ENSG00000128311

Protein

• UniProt ID: Q16762
• Protein name: Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese)
• Protein function: Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By
• PDB: 8AGF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00581	Rhodanese	12 → 137	Rhodanese-like domain	Domain
  PF00581	Rhodanese	164 → 282	Rhodanese-like domain	Domain

• Sequence:

  MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGTREARKEYLERHVPGASFFD
  IEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVFG
  HRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQLV
  DSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVDL
  SQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA

• Sequence length: 297

Pathways

KEGG:

Cysteine and methionine metabolism
Sulfur metabolism
Metabolic pathways
Sulfur relay system

Reactome:

Degradation of cysteine and homocysteine

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Colitis	Colitis		19647029
Liver carcinoma	Liver carcinoma		21472284
Prostatic neoplasms	Prostatic Neoplasms		17013881