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TRAF3 (TNF receptor associated factor 3)

Gene

7187

TNF receptor associated factor 3

TRAF3

CAP-1, CAP1, CD40bp, CRAF1, IIAE5, IMD132A, IMD132B, LAP1, RNF118

14q32.32

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in

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SNP ID	Visualize variation	Clinical significance	Consequence
rs143813189	C>T	Risk-factor, likely-benign	Coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006827	hsa-miR-32-5p	Luciferase reporter assay	22709905
MIRT006827	hsa-miR-32-5p	Luciferase reporter assay	22709905
MIRT028936	hsa-miR-26b-5p	Microarray	19088304
MIRT568696	hsa-miR-662	HITS-CLIP	23824327
MIRT568695	hsa-miR-4286	HITS-CLIP	23824327
MIRT568693	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT568692	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT568691	hsa-miR-4455	HITS-CLIP	23824327
MIRT568690	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT568696	hsa-miR-662	PAR-CLIP	20371350
MIRT568695	hsa-miR-4286	PAR-CLIP	20371350
MIRT568694	hsa-miR-4694-5p	PAR-CLIP	20371350
MIRT568693	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT568692	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT568691	hsa-miR-4455	PAR-CLIP	20371350
MIRT568690	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT486131	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT486129	hsa-miR-4707-3p	PAR-CLIP	23592263
MIRT486128	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT486127	hsa-miR-8085	PAR-CLIP	23592263
MIRT486126	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT568695	hsa-miR-4286	HITS-CLIP	28735896
MIRT568695	hsa-miR-4286	HITS-CLIP	28735896
MIRT734857	hsa-miR-153-3p	RNA-seq	33491670
MIRT735174	hsa-miR-214-3p	Western blotting, qRT-PCR, ELISA	32670749
MIRT737231	hsa-miR-1307-5p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), Immunofluorescence, qRT-PCR, In situ hybridization	33061854
MIRT568696	hsa-miR-662	HITS-CLIP	23824327
MIRT568695	hsa-miR-4286	HITS-CLIP	23824327
MIRT568693	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT568692	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT568691	hsa-miR-4455	HITS-CLIP	23824327
MIRT568690	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT568696	hsa-miR-662	PAR-CLIP	20371350
MIRT568695	hsa-miR-4286	PAR-CLIP	20371350
MIRT568694	hsa-miR-4694-5p	PAR-CLIP	20371350
MIRT568693	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT568692	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT568691	hsa-miR-4455	PAR-CLIP	20371350
MIRT568690	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT486131	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT486129	hsa-miR-4707-3p	PAR-CLIP	23592263
MIRT486128	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT486127	hsa-miR-8085	PAR-CLIP	23592263
MIRT486126	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT756227	hsa-miR-95-3p	Luciferase reporter assay, Western blotting, qRT-PCR	36727735
MIRT1450740	hsa-miR-1291	CLIP-seq
MIRT1450741	hsa-miR-1303	CLIP-seq
MIRT1450742	hsa-miR-146b-3p	CLIP-seq
MIRT1450743	hsa-miR-1915	CLIP-seq
MIRT1450744	hsa-miR-198	CLIP-seq
MIRT1450745	hsa-miR-3143	CLIP-seq
MIRT1450746	hsa-miR-3153	CLIP-seq
MIRT1450747	hsa-miR-329	CLIP-seq
MIRT1450748	hsa-miR-3613-3p	CLIP-seq
MIRT1450749	hsa-miR-362-3p	CLIP-seq
MIRT1450750	hsa-miR-3692	CLIP-seq
MIRT1450751	hsa-miR-3714	CLIP-seq
MIRT1450752	hsa-miR-3918	CLIP-seq
MIRT1450753	hsa-miR-3973	CLIP-seq
MIRT1450754	hsa-miR-4434	CLIP-seq
MIRT1450755	hsa-miR-4516	CLIP-seq
MIRT1450756	hsa-miR-4531	CLIP-seq
MIRT1450757	hsa-miR-4534	CLIP-seq
MIRT1450758	hsa-miR-4679	CLIP-seq
MIRT1450759	hsa-miR-4680-3p	CLIP-seq
MIRT1450760	hsa-miR-4685-5p	CLIP-seq
MIRT1450761	hsa-miR-4706	CLIP-seq
MIRT1450762	hsa-miR-4726-3p	CLIP-seq
MIRT1450763	hsa-miR-4728-3p	CLIP-seq
MIRT1450764	hsa-miR-4728-5p	CLIP-seq
MIRT1450765	hsa-miR-4749-5p	CLIP-seq
MIRT1450766	hsa-miR-4755-3p	CLIP-seq
MIRT1450767	hsa-miR-4768-3p	CLIP-seq
MIRT1450768	hsa-miR-4781-5p	CLIP-seq
MIRT1450769	hsa-miR-548a-5p	CLIP-seq
MIRT1450770	hsa-miR-548ab	CLIP-seq
MIRT1450771	hsa-miR-548ak	CLIP-seq
MIRT1450772	hsa-miR-548an	CLIP-seq
MIRT1450773	hsa-miR-548b-5p	CLIP-seq
MIRT1450774	hsa-miR-548c-5p	CLIP-seq
MIRT1450775	hsa-miR-548d-5p	CLIP-seq
MIRT1450776	hsa-miR-548h	CLIP-seq
MIRT1450777	hsa-miR-548i	CLIP-seq
MIRT1450778	hsa-miR-548j	CLIP-seq
MIRT1450779	hsa-miR-548w	CLIP-seq
MIRT1450780	hsa-miR-548y	CLIP-seq
MIRT1450781	hsa-miR-559	CLIP-seq
MIRT1450782	hsa-miR-607	CLIP-seq
MIRT1450783	hsa-miR-628-5p	CLIP-seq
MIRT1450784	hsa-miR-648	CLIP-seq
MIRT1450785	hsa-miR-665	CLIP-seq
MIRT1450786	hsa-miR-744	CLIP-seq
MIRT1450787	hsa-miR-933	CLIP-seq
MIRT1450788	hsa-miR-103a	CLIP-seq
MIRT1450789	hsa-miR-107	CLIP-seq
MIRT1450790	hsa-miR-1233	CLIP-seq
MIRT1450791	hsa-miR-1254	CLIP-seq
MIRT1450792	hsa-miR-1265	CLIP-seq
MIRT1450793	hsa-miR-128	CLIP-seq
MIRT1450794	hsa-miR-1285	CLIP-seq
MIRT1450795	hsa-miR-1290	CLIP-seq
MIRT1450740	hsa-miR-1291	CLIP-seq
MIRT1450796	hsa-miR-129-3p	CLIP-seq
MIRT1450797	hsa-miR-137	CLIP-seq
MIRT1450798	hsa-miR-139-5p	CLIP-seq
MIRT1450742	hsa-miR-146b-3p	CLIP-seq
MIRT1450799	hsa-miR-148a	CLIP-seq
MIRT1450800	hsa-miR-148b	CLIP-seq
MIRT1450801	hsa-miR-149	CLIP-seq
MIRT1450802	hsa-miR-152	CLIP-seq
MIRT1450803	hsa-miR-191	CLIP-seq
MIRT1450743	hsa-miR-1915	CLIP-seq
MIRT1450804	hsa-miR-1972	CLIP-seq
MIRT1450805	hsa-miR-214	CLIP-seq
MIRT1450806	hsa-miR-2355-3p	CLIP-seq
MIRT1450807	hsa-miR-2392	CLIP-seq
MIRT1450808	hsa-miR-27a	CLIP-seq
MIRT1450809	hsa-miR-27b	CLIP-seq
MIRT1450810	hsa-miR-299-3p	CLIP-seq
MIRT1450811	hsa-miR-3064-5p	CLIP-seq
MIRT1450812	hsa-miR-3116	CLIP-seq
MIRT1450813	hsa-miR-3120-3p	CLIP-seq
MIRT1450814	hsa-miR-3121-5p	CLIP-seq
MIRT1450815	hsa-miR-3127-3p	CLIP-seq
MIRT1450816	hsa-miR-3140-5p	CLIP-seq
MIRT1450817	hsa-miR-3145-5p	CLIP-seq
MIRT1450746	hsa-miR-3153	CLIP-seq
MIRT1450818	hsa-miR-3187-5p	CLIP-seq
MIRT1450819	hsa-miR-3194-3p	CLIP-seq
MIRT1450820	hsa-miR-3194-5p	CLIP-seq
MIRT1450821	hsa-miR-3607-3p	CLIP-seq
MIRT1450822	hsa-miR-3619-5p	CLIP-seq
MIRT1450823	hsa-miR-3667-3p	CLIP-seq
MIRT1450824	hsa-miR-3686	CLIP-seq
MIRT1450751	hsa-miR-3714	CLIP-seq
MIRT1450752	hsa-miR-3918	CLIP-seq
MIRT1450825	hsa-miR-3944-5p	CLIP-seq
MIRT1450826	hsa-miR-3960	CLIP-seq
MIRT1450753	hsa-miR-3973	CLIP-seq
MIRT1450827	hsa-miR-412	CLIP-seq
MIRT1450828	hsa-miR-4270	CLIP-seq
MIRT1450829	hsa-miR-4271	CLIP-seq
MIRT1450830	hsa-miR-4293	CLIP-seq
MIRT1450831	hsa-miR-4305	CLIP-seq
MIRT1450832	hsa-miR-4441	CLIP-seq
MIRT1450833	hsa-miR-4469	CLIP-seq
MIRT1450834	hsa-miR-4477b	CLIP-seq
MIRT1450835	hsa-miR-4479	CLIP-seq
MIRT1450836	hsa-miR-4511	CLIP-seq
MIRT1450837	hsa-miR-4646-3p	CLIP-seq
MIRT1450838	hsa-miR-4652-3p	CLIP-seq
MIRT1450758	hsa-miR-4679	CLIP-seq
MIRT1450760	hsa-miR-4685-5p	CLIP-seq
MIRT1450839	hsa-miR-4687-3p	CLIP-seq
MIRT1450840	hsa-miR-4696	CLIP-seq
MIRT1450761	hsa-miR-4706	CLIP-seq
MIRT1450841	hsa-miR-4711-3p	CLIP-seq
MIRT1450842	hsa-miR-4711-5p	CLIP-seq
MIRT1450843	hsa-miR-4722-5p	CLIP-seq
MIRT1450844	hsa-miR-4725-3p	CLIP-seq
MIRT1450762	hsa-miR-4726-3p	CLIP-seq
MIRT1450845	hsa-miR-4727-5p	CLIP-seq
MIRT1450846	hsa-miR-4731-5p	CLIP-seq
MIRT1450765	hsa-miR-4749-5p	CLIP-seq
MIRT1450766	hsa-miR-4755-3p	CLIP-seq
MIRT1450847	hsa-miR-4760-3p	CLIP-seq
MIRT1450848	hsa-miR-4763-5p	CLIP-seq
MIRT1450849	hsa-miR-4764-5p	CLIP-seq
MIRT1450767	hsa-miR-4768-3p	CLIP-seq
MIRT1450850	hsa-miR-4769-3p	CLIP-seq
MIRT1450768	hsa-miR-4781-5p	CLIP-seq
MIRT1450851	hsa-miR-4794	CLIP-seq
MIRT1450852	hsa-miR-4798-3p	CLIP-seq
MIRT1450853	hsa-miR-499-3p	CLIP-seq
MIRT1450854	hsa-miR-499a-3p	CLIP-seq
MIRT1450855	hsa-miR-513a-5p	CLIP-seq
MIRT1450856	hsa-miR-520d-5p	CLIP-seq
MIRT1450857	hsa-miR-524-5p	CLIP-seq
MIRT1450858	hsa-miR-539	CLIP-seq
MIRT1450769	hsa-miR-548a-5p	CLIP-seq
MIRT1450770	hsa-miR-548ab	CLIP-seq
MIRT1450771	hsa-miR-548ak	CLIP-seq
MIRT1450772	hsa-miR-548an	CLIP-seq
MIRT1450859	hsa-miR-548b-3p	CLIP-seq
MIRT1450773	hsa-miR-548b-5p	CLIP-seq
MIRT1450774	hsa-miR-548c-5p	CLIP-seq
MIRT1450775	hsa-miR-548d-5p	CLIP-seq
MIRT1450776	hsa-miR-548h	CLIP-seq
MIRT1450777	hsa-miR-548i	CLIP-seq
MIRT1450778	hsa-miR-548j	CLIP-seq
MIRT1450779	hsa-miR-548w	CLIP-seq
MIRT1450780	hsa-miR-548y	CLIP-seq
MIRT1450860	hsa-miR-550a	CLIP-seq
MIRT1450781	hsa-miR-559	CLIP-seq
MIRT1450861	hsa-miR-576-3p	CLIP-seq
MIRT1450862	hsa-miR-596	CLIP-seq
MIRT1450863	hsa-miR-600	CLIP-seq
MIRT1450864	hsa-miR-612	CLIP-seq
MIRT1450865	hsa-miR-615-3p	CLIP-seq
MIRT1450866	hsa-miR-661	CLIP-seq
MIRT1450785	hsa-miR-665	CLIP-seq
MIRT1450867	hsa-miR-711	CLIP-seq
MIRT1450868	hsa-miR-761	CLIP-seq
MIRT1450869	hsa-miR-802	CLIP-seq
MIRT1450870	hsa-miR-885-3p	CLIP-seq
MIRT1450871	hsa-miR-1202	CLIP-seq
MIRT1450872	hsa-miR-2467-5p	CLIP-seq
MIRT1450873	hsa-miR-3163	CLIP-seq
MIRT1450820	hsa-miR-3194-5p	CLIP-seq
MIRT1450874	hsa-miR-340	CLIP-seq
MIRT1450875	hsa-miR-3616-5p	CLIP-seq
MIRT1450876	hsa-miR-3647-5p	CLIP-seq
MIRT1450877	hsa-miR-3972	CLIP-seq
MIRT1450833	hsa-miR-4469	CLIP-seq
MIRT1450878	hsa-miR-4474-3p	CLIP-seq
MIRT1450879	hsa-miR-4722-3p	CLIP-seq
MIRT1450880	hsa-miR-4740-3p	CLIP-seq
MIRT1450881	hsa-miR-4795-5p	CLIP-seq
MIRT1450882	hsa-miR-503	CLIP-seq
MIRT1450855	hsa-miR-513a-5p	CLIP-seq
MIRT1450883	hsa-miR-548ad	CLIP-seq
MIRT1450884	hsa-miR-573	CLIP-seq
MIRT1450885	hsa-miR-595	CLIP-seq
MIRT1450886	hsa-miR-644	CLIP-seq
MIRT1450887	hsa-miR-658	CLIP-seq
MIRT1450788	hsa-miR-103a	CLIP-seq
MIRT1450789	hsa-miR-107	CLIP-seq
MIRT2134739	hsa-miR-1184	CLIP-seq
MIRT2134740	hsa-miR-1205	CLIP-seq
MIRT2134741	hsa-miR-1226	CLIP-seq
MIRT2134742	hsa-miR-1244	CLIP-seq
MIRT1450793	hsa-miR-128	CLIP-seq
MIRT1450794	hsa-miR-1285	CLIP-seq
MIRT2134743	hsa-miR-1286	CLIP-seq
MIRT2134744	hsa-miR-1322	CLIP-seq
MIRT1450797	hsa-miR-137	CLIP-seq
MIRT1450799	hsa-miR-148a	CLIP-seq
MIRT1450800	hsa-miR-148b	CLIP-seq
MIRT1450802	hsa-miR-152	CLIP-seq
MIRT2134745	hsa-miR-153	CLIP-seq
MIRT2134746	hsa-miR-15a	CLIP-seq
MIRT2134747	hsa-miR-15b	CLIP-seq
MIRT2134748	hsa-miR-16	CLIP-seq
MIRT2134749	hsa-miR-1825	CLIP-seq
MIRT1450803	hsa-miR-191	CLIP-seq
MIRT1450743	hsa-miR-1915	CLIP-seq
MIRT2134750	hsa-miR-195	CLIP-seq
MIRT2134751	hsa-miR-199a-3p	CLIP-seq
MIRT2134752	hsa-miR-199b-3p	CLIP-seq
MIRT1450805	hsa-miR-214	CLIP-seq
MIRT1450808	hsa-miR-27a	CLIP-seq
MIRT1450809	hsa-miR-27b	CLIP-seq
MIRT2134753	hsa-miR-3129-5p	CLIP-seq
MIRT2134754	hsa-miR-3158-5p	CLIP-seq
MIRT1450818	hsa-miR-3187-5p	CLIP-seq
MIRT2134755	hsa-miR-338-3p	CLIP-seq
MIRT1450874	hsa-miR-340	CLIP-seq
MIRT1450822	hsa-miR-3619-5p	CLIP-seq
MIRT2134756	hsa-miR-3646	CLIP-seq
MIRT2134757	hsa-miR-3647-3p	CLIP-seq
MIRT2134758	hsa-miR-3662	CLIP-seq
MIRT1450823	hsa-miR-3667-3p	CLIP-seq
MIRT1450751	hsa-miR-3714	CLIP-seq
MIRT1450825	hsa-miR-3944-5p	CLIP-seq
MIRT2134759	hsa-miR-424	CLIP-seq
MIRT2134760	hsa-miR-4267	CLIP-seq
MIRT1450831	hsa-miR-4305	CLIP-seq
MIRT1450754	hsa-miR-4434	CLIP-seq
MIRT2134761	hsa-miR-4436b-3p	CLIP-seq
MIRT2134762	hsa-miR-4443	CLIP-seq
MIRT2134763	hsa-miR-4457	CLIP-seq
MIRT2134764	hsa-miR-4468	CLIP-seq
MIRT1450833	hsa-miR-4469	CLIP-seq
MIRT2134765	hsa-miR-450b-5p	CLIP-seq
MIRT1450755	hsa-miR-4516	CLIP-seq
MIRT2134766	hsa-miR-4530	CLIP-seq
MIRT1450756	hsa-miR-4531	CLIP-seq
MIRT2134767	hsa-miR-4643	CLIP-seq
MIRT2134768	hsa-miR-4646-5p	CLIP-seq
MIRT2134769	hsa-miR-4676-5p	CLIP-seq
MIRT2134770	hsa-miR-4693-3p	CLIP-seq
MIRT2134771	hsa-miR-4700-3p	CLIP-seq
MIRT1450842	hsa-miR-4711-5p	CLIP-seq
MIRT2134772	hsa-miR-4715-3p	CLIP-seq
MIRT1450843	hsa-miR-4722-5p	CLIP-seq
MIRT1450762	hsa-miR-4726-3p	CLIP-seq
MIRT1450846	hsa-miR-4731-5p	CLIP-seq
MIRT2134773	hsa-miR-4733-3p	CLIP-seq
MIRT2134774	hsa-miR-4766-5p	CLIP-seq
MIRT1450767	hsa-miR-4768-3p	CLIP-seq
MIRT2134775	hsa-miR-486-3p	CLIP-seq
MIRT2134776	hsa-miR-497	CLIP-seq
MIRT2134777	hsa-miR-5095	CLIP-seq
MIRT2134778	hsa-miR-5096	CLIP-seq
MIRT1450855	hsa-miR-513a-5p	CLIP-seq
MIRT2134779	hsa-miR-513b	CLIP-seq
MIRT2134780	hsa-miR-521	CLIP-seq
MIRT1450858	hsa-miR-539	CLIP-seq
MIRT2134781	hsa-miR-542-3p	CLIP-seq
MIRT2134782	hsa-miR-544	CLIP-seq
MIRT2134783	hsa-miR-550b	CLIP-seq
MIRT2134784	hsa-miR-556-5p	CLIP-seq
MIRT2134785	hsa-miR-570	CLIP-seq
MIRT2134786	hsa-miR-575	CLIP-seq
MIRT1450863	hsa-miR-600	CLIP-seq
MIRT1450864	hsa-miR-612	CLIP-seq
MIRT2134787	hsa-miR-642b	CLIP-seq
MIRT2134788	hsa-miR-718	CLIP-seq
MIRT1450868	hsa-miR-761	CLIP-seq
MIRT1450869	hsa-miR-802	CLIP-seq
MIRT1450798	hsa-miR-139-5p	CLIP-seq
MIRT2356025	hsa-miR-147	CLIP-seq
MIRT2356026	hsa-miR-1911	CLIP-seq
MIRT2356027	hsa-miR-224	CLIP-seq
MIRT1450817	hsa-miR-3145-5p	CLIP-seq
MIRT2356028	hsa-miR-3185	CLIP-seq
MIRT2356029	hsa-miR-33a	CLIP-seq
MIRT2356030	hsa-miR-33b	CLIP-seq
MIRT2356031	hsa-miR-4738-3p	CLIP-seq
MIRT1450767	hsa-miR-4768-3p	CLIP-seq
MIRT2356032	hsa-miR-510	CLIP-seq
MIRT1450856	hsa-miR-520d-5p	CLIP-seq
MIRT2356033	hsa-miR-520g	CLIP-seq
MIRT2356034	hsa-miR-520h	CLIP-seq
MIRT1450857	hsa-miR-524-5p	CLIP-seq
MIRT2356035	hsa-miR-581	CLIP-seq
MIRT1450863	hsa-miR-600	CLIP-seq
MIRT2356036	hsa-miR-616	CLIP-seq
MIRT2356037	hsa-miR-892a	CLIP-seq
MIRT1450788	hsa-miR-103a	CLIP-seq
MIRT1450789	hsa-miR-107	CLIP-seq
MIRT1450798	hsa-miR-139-5p	CLIP-seq
MIRT2462272	hsa-miR-4304	CLIP-seq
MIRT2462273	hsa-miR-451b	CLIP-seq
MIRT1450856	hsa-miR-520d-5p	CLIP-seq
MIRT1450857	hsa-miR-524-5p	CLIP-seq
MIRT1450863	hsa-miR-600	CLIP-seq
MIRT2649500	hsa-miR-1207-3p	CLIP-seq
MIRT2649501	hsa-miR-1470	CLIP-seq
MIRT2649502	hsa-miR-4283	CLIP-seq
MIRT1450833	hsa-miR-4469	CLIP-seq
MIRT2649503	hsa-miR-4489	CLIP-seq
MIRT2649504	hsa-miR-4492	CLIP-seq
MIRT2649505	hsa-miR-4498	CLIP-seq
MIRT2649506	hsa-miR-4667-3p	CLIP-seq
MIRT2649507	hsa-miR-4690-3p	CLIP-seq
MIRT1450846	hsa-miR-4731-5p	CLIP-seq
MIRT2649508	hsa-miR-762	CLIP-seq
MIRT2649509	hsa-miR-766	CLIP-seq
MIRT2694024	hsa-miR-1182	CLIP-seq
MIRT2694025	hsa-miR-193a-5p	CLIP-seq
MIRT2694026	hsa-miR-2114	CLIP-seq
MIRT2694027	hsa-miR-3127-5p	CLIP-seq
MIRT2694028	hsa-miR-3182	CLIP-seq
MIRT2694029	hsa-miR-3660	CLIP-seq
MIRT2694030	hsa-miR-4256	CLIP-seq
MIRT2694031	hsa-miR-4526	CLIP-seq
MIRT1450766	hsa-miR-4755-3p	CLIP-seq
MIRT2694032	hsa-miR-554	CLIP-seq

Show/Hide all(39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001817	Process	Regulation of cytokine production	ISS
GO:0002224	Process	Toll-like receptor signaling pathway	ISS
GO:0004842	Function	Ubiquitin-protein transferase activity	IBA	21873635
GO:0004842	Function	Ubiquitin-protein transferase activity	TAS
GO:0005164	Function	Tumor necrosis factor receptor binding	IBA	21873635
GO:0005164	Function	Tumor necrosis factor receptor binding	IPI	11728344
GO:0005515	Function	Protein binding	IPI	7527023, 10791955, 12005438, 12270937, 14743216, 15280356, 19419966, 19893624, 20080758, 20138174, 20174559, 20732415, 21903422, 23153539, 23333941, 23871208, 25241761, 27980081, 28514442, 30561431, 30833792, 31980649, 32296183, 32514408
GO:0005739	Component	Mitochondrion	IEA
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	TAS	7530216
GO:0008063	Process	Toll signaling pathway	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IBA	21873635
GO:0009898	Component	Cytoplasmic side of plasma membrane	ISS
GO:0016579	Process	Protein deubiquitination	TAS
GO:0019901	Function	Protein kinase binding	IEA
GO:0019903	Function	Protein phosphatase binding	IPI	23871208
GO:0030162	Process	Regulation of proteolysis	IMP	20185819
GO:0031625	Function	Ubiquitin protein ligase binding	IBA	21873635
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	11279055
GO:0031996	Function	Thioesterase binding	IPI	11279055
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IBA	21873635
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IMP	20185819
GO:0032648	Process	Regulation of interferon-beta production	ISS
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IBA	21873635
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IMP	20185819
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS
GO:0035631	Component	CD40 receptor complex	ISS
GO:0035666	Process	TRIF-dependent toll-like receptor signaling pathway	TAS
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043122	Process	Regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0045087	Process	Innate immune response	IEA
GO:0046330	Process	Positive regulation of JNK cascade	IBA	21873635
GO:0050688	Process	Regulation of defense response to virus	ISS
GO:0070534	Process	Protein K63-linked ubiquitination	IBA	21873635
GO:0098802	Component	Plasma membrane signaling receptor complex	IBA	21873635

MIM	HGNC	e!Ensembl
601896	12033	ENSG00000131323

Protein

UniProt ID

Q13114

Protein name

TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)

Protein function

Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both i

PDB

1FLK , 1FLL , 1KZZ , 1L0A , 1RF3 , 1ZMS , 2ECY , 2GKW , 8T5P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02176	zf-TRAF	136 → 192	TRAF-type zinc finger	Family
PF02176	zf-TRAF	192 → 251	TRAF-type zinc finger	Family

Sequence

MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVL
CSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNE
SRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHC
KSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV
FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI
EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR
VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW
KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRG
EYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQ
TVLENGTYIKDDTIFIKVIVDTSDLPDP

Sequence length

568

Interactions

View interactions

	KEGG		Reactome
	NF-kappa B signaling pathway Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Alcoholic liver disease Hepatitis C Hepatitis B Measles Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Small cell lung cancer Lipid and atherosclerosis		TRAF3 deficiency - HSE TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ovarian tumor domain proteases TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	30929738
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	24076602

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