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HSP90B1 (heat shock protein 90 beta family member 1)

Gene

7184

Heat shock protein 90 beta family member 1

HSP90B1

ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1

12q23.3

This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this

Show/Hide all(331)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003874	hsa-miR-15a-5p	Microarray	18362358
MIRT004368	hsa-miR-16-5p	Microarray	18362358
MIRT004158	hsa-miR-192-5p	Microarray	16822819
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay	23208072
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay	23208072
MIRT017651	hsa-miR-335-5p	Microarray	18185580
MIRT020159	hsa-miR-130b-3p	Sequencing	20371350
MIRT023707	hsa-miR-1-3p	Proteomics	18668040
MIRT025974	hsa-miR-148a-3p	Sequencing	20371350
MIRT049100	hsa-miR-92a-3p	CLASH	23622248
MIRT045853	hsa-miR-128-3p	CLASH	23622248
MIRT041729	hsa-miR-484	CLASH	23622248
MIRT041729	hsa-miR-484	CLASH	23622248
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT475512	hsa-miR-302f	PAR-CLIP	20371350
MIRT475509	hsa-miR-3123	PAR-CLIP	20371350
MIRT475507	hsa-miR-1910-3p	PAR-CLIP	20371350
MIRT475506	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT475502	hsa-miR-3919	PAR-CLIP	20371350
MIRT475498	hsa-miR-6125	PAR-CLIP	20371350
MIRT475495	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT475491	hsa-miR-658	PAR-CLIP	20371350
MIRT475489	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT475488	hsa-miR-1273e	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	23446348
MIRT523132	hsa-miR-206	PAR-CLIP	23446348
MIRT523131	hsa-miR-613	PAR-CLIP	23446348
MIRT523130	hsa-miR-433-3p	PAR-CLIP	23446348
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	23446348
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	23446348
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	23446348
MIRT523126	hsa-miR-4262	PAR-CLIP	23446348
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	23446348
MIRT523124	hsa-miR-4272	PAR-CLIP	23446348
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	23446348
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	23446348
MIRT523121	hsa-miR-3915	PAR-CLIP	23446348
MIRT475512	hsa-miR-302f	PAR-CLIP	23592263
MIRT475511	hsa-miR-512-5p	PAR-CLIP	23592263
MIRT475510	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT475509	hsa-miR-3123	PAR-CLIP	23592263
MIRT475508	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT475507	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT475506	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT475505	hsa-miR-3929	PAR-CLIP	23592263
MIRT475504	hsa-miR-4419b	PAR-CLIP	23592263
MIRT475503	hsa-miR-4478	PAR-CLIP	23592263
MIRT475502	hsa-miR-3919	PAR-CLIP	23592263
MIRT475501	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT475499	hsa-miR-4459	PAR-CLIP	23592263
MIRT475500	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT475498	hsa-miR-6125	PAR-CLIP	23592263
MIRT475497	hsa-miR-3664-3p	PAR-CLIP	23592263
MIRT475496	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT475495	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT475494	hsa-miR-1827	PAR-CLIP	23592263
MIRT475493	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT475492	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT475491	hsa-miR-658	PAR-CLIP	23592263
MIRT475490	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT475489	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT475488	hsa-miR-1273e	PAR-CLIP	23592263
MIRT475487	hsa-miR-665	PAR-CLIP	23592263
MIRT440482	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440482	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay, Western blot	25880332
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay, Western blot	25880332
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay, Western blot	25880332
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay, Western blot	25880332
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT475488	hsa-miR-1273e	PAR-CLIP	27292025
MIRT475495	hsa-miR-219b-3p	PAR-CLIP	27292025
MIRT475489	hsa-miR-25-5p	PAR-CLIP	27292025
MIRT475512	hsa-miR-302f	PAR-CLIP	27292025
MIRT475498	hsa-miR-6125	PAR-CLIP	27292025
MIRT475491	hsa-miR-658	PAR-CLIP	27292025
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT475512	hsa-miR-302f	PAR-CLIP	20371350
MIRT475509	hsa-miR-3123	PAR-CLIP	20371350
MIRT475507	hsa-miR-1910-3p	PAR-CLIP	20371350
MIRT475506	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT475502	hsa-miR-3919	PAR-CLIP	20371350
MIRT475498	hsa-miR-6125	PAR-CLIP	20371350
MIRT475495	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT475491	hsa-miR-658	PAR-CLIP	20371350
MIRT475489	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT475488	hsa-miR-1273e	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	23446348
MIRT523132	hsa-miR-206	PAR-CLIP	23446348
MIRT523131	hsa-miR-613	PAR-CLIP	23446348
MIRT523130	hsa-miR-433-3p	PAR-CLIP	23446348
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	23446348
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	23446348
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	23446348
MIRT523126	hsa-miR-4262	PAR-CLIP	23446348
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	23446348
MIRT523124	hsa-miR-4272	PAR-CLIP	23446348
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	23446348
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	23446348
MIRT523121	hsa-miR-3915	PAR-CLIP	23446348
MIRT475512	hsa-miR-302f	PAR-CLIP	23592263
MIRT475511	hsa-miR-512-5p	PAR-CLIP	23592263
MIRT475510	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT475509	hsa-miR-3123	PAR-CLIP	23592263
MIRT475508	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT475507	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT475506	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT475505	hsa-miR-3929	PAR-CLIP	23592263
MIRT475504	hsa-miR-4419b	PAR-CLIP	23592263
MIRT475503	hsa-miR-4478	PAR-CLIP	23592263
MIRT475502	hsa-miR-3919	PAR-CLIP	23592263
MIRT475501	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT475499	hsa-miR-4459	PAR-CLIP	23592263
MIRT475500	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT475498	hsa-miR-6125	PAR-CLIP	23592263
MIRT475497	hsa-miR-3664-3p	PAR-CLIP	23592263
MIRT475496	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT475495	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT475494	hsa-miR-1827	PAR-CLIP	23592263
MIRT475493	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT475492	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT475491	hsa-miR-658	PAR-CLIP	23592263
MIRT475490	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT475489	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT475488	hsa-miR-1273e	PAR-CLIP	23592263
MIRT475487	hsa-miR-665	PAR-CLIP	23592263
MIRT1055890	hsa-miR-148a	CLIP-seq
MIRT1055891	hsa-miR-148b	CLIP-seq
MIRT1055892	hsa-miR-150	CLIP-seq
MIRT1055893	hsa-miR-152	CLIP-seq
MIRT1055894	hsa-miR-188-3p	CLIP-seq
MIRT1055895	hsa-miR-1909	CLIP-seq
MIRT1055896	hsa-miR-1914	CLIP-seq
MIRT1055897	hsa-miR-23a	CLIP-seq
MIRT1055898	hsa-miR-23b	CLIP-seq
MIRT1055899	hsa-miR-23c	CLIP-seq
MIRT1055900	hsa-miR-3122	CLIP-seq
MIRT1055901	hsa-miR-3171	CLIP-seq
MIRT1055902	hsa-miR-3913-5p	CLIP-seq
MIRT1055903	hsa-miR-3938	CLIP-seq
MIRT1055904	hsa-miR-4495	CLIP-seq
MIRT1055905	hsa-miR-450b-3p	CLIP-seq
MIRT1055906	hsa-miR-4643	CLIP-seq
MIRT1055907	hsa-miR-466	CLIP-seq
MIRT1055908	hsa-miR-4661-3p	CLIP-seq
MIRT1055909	hsa-miR-4693-3p	CLIP-seq
MIRT1055910	hsa-miR-4710	CLIP-seq
MIRT1055911	hsa-miR-4713-3p	CLIP-seq
MIRT1055912	hsa-miR-4713-5p	CLIP-seq
MIRT1055913	hsa-miR-4789-3p	CLIP-seq
MIRT1055914	hsa-miR-4789-5p	CLIP-seq
MIRT1055915	hsa-miR-4792	CLIP-seq
MIRT1055916	hsa-miR-513a-3p	CLIP-seq
MIRT1055917	hsa-miR-522	CLIP-seq
MIRT1055918	hsa-miR-532-3p	CLIP-seq
MIRT1055919	hsa-miR-638	CLIP-seq
MIRT1055920	hsa-miR-642a	CLIP-seq
MIRT1055921	hsa-miR-769-3p	CLIP-seq
MIRT1055890	hsa-miR-148a	CLIP-seq
MIRT1055891	hsa-miR-148b	CLIP-seq
MIRT1055893	hsa-miR-152	CLIP-seq
MIRT1055895	hsa-miR-1909	CLIP-seq
MIRT1055894	hsa-miR-188-3p	CLIP-seq
MIRT2245156	hsa-miR-181a	CLIP-seq
MIRT2245157	hsa-miR-181b	CLIP-seq
MIRT2245158	hsa-miR-181c	CLIP-seq
MIRT2245159	hsa-miR-181d	CLIP-seq
MIRT1055894	hsa-miR-188-3p	CLIP-seq
MIRT1055896	hsa-miR-1914	CLIP-seq
MIRT2245160	hsa-miR-223	CLIP-seq
MIRT1055897	hsa-miR-23a	CLIP-seq
MIRT1055898	hsa-miR-23b	CLIP-seq
MIRT1055899	hsa-miR-23c	CLIP-seq
MIRT2245161	hsa-miR-3074-5p	CLIP-seq
MIRT2245162	hsa-miR-3121-3p	CLIP-seq
MIRT1055903	hsa-miR-3938	CLIP-seq
MIRT2245163	hsa-miR-433	CLIP-seq
MIRT1055904	hsa-miR-4495	CLIP-seq
MIRT1055908	hsa-miR-4661-3p	CLIP-seq
MIRT2245164	hsa-miR-499-3p	CLIP-seq
MIRT2245165	hsa-miR-499a-3p	CLIP-seq
MIRT1055916	hsa-miR-513a-3p	CLIP-seq
MIRT1055920	hsa-miR-642a	CLIP-seq
MIRT2245166	hsa-miR-935	CLIP-seq
MIRT2245160	hsa-miR-223	CLIP-seq
MIRT2245164	hsa-miR-499-3p	CLIP-seq
MIRT2245165	hsa-miR-499a-3p	CLIP-seq
MIRT2245166	hsa-miR-935	CLIP-seq
MIRT2548076	hsa-miR-1	CLIP-seq
MIRT1055890	hsa-miR-148a	CLIP-seq
MIRT1055891	hsa-miR-148b	CLIP-seq
MIRT1055892	hsa-miR-150	CLIP-seq
MIRT1055893	hsa-miR-152	CLIP-seq
MIRT2245156	hsa-miR-181a	CLIP-seq
MIRT2245157	hsa-miR-181b	CLIP-seq
MIRT2245158	hsa-miR-181c	CLIP-seq
MIRT2245159	hsa-miR-181d	CLIP-seq
MIRT1055894	hsa-miR-188-3p	CLIP-seq
MIRT1055895	hsa-miR-1909	CLIP-seq
MIRT2245160	hsa-miR-223	CLIP-seq
MIRT1055897	hsa-miR-23a	CLIP-seq
MIRT1055898	hsa-miR-23b	CLIP-seq
MIRT1055899	hsa-miR-23c	CLIP-seq
MIRT2245162	hsa-miR-3121-3p	CLIP-seq
MIRT1055901	hsa-miR-3171	CLIP-seq
MIRT2548077	hsa-miR-3928	CLIP-seq
MIRT2245163	hsa-miR-433	CLIP-seq
MIRT1055904	hsa-miR-4495	CLIP-seq
MIRT1055912	hsa-miR-4713-5p	CLIP-seq
MIRT2245164	hsa-miR-499-3p	CLIP-seq
MIRT2245165	hsa-miR-499a-3p	CLIP-seq
MIRT1055916	hsa-miR-513a-3p	CLIP-seq
MIRT1055918	hsa-miR-532-3p	CLIP-seq
MIRT2548078	hsa-miR-548ac	CLIP-seq
MIRT2548079	hsa-miR-548d-3p	CLIP-seq
MIRT2548080	hsa-miR-548z	CLIP-seq
MIRT2245166	hsa-miR-935	CLIP-seq
MIRT2548076	hsa-miR-1	CLIP-seq
MIRT1055890	hsa-miR-148a	CLIP-seq
MIRT1055891	hsa-miR-148b	CLIP-seq
MIRT1055892	hsa-miR-150	CLIP-seq
MIRT1055893	hsa-miR-152	CLIP-seq
MIRT2245156	hsa-miR-181a	CLIP-seq
MIRT2245157	hsa-miR-181b	CLIP-seq
MIRT2245158	hsa-miR-181c	CLIP-seq
MIRT2245159	hsa-miR-181d	CLIP-seq
MIRT1055894	hsa-miR-188-3p	CLIP-seq
MIRT1055895	hsa-miR-1909	CLIP-seq
MIRT1055896	hsa-miR-1914	CLIP-seq
MIRT2245160	hsa-miR-223	CLIP-seq
MIRT1055897	hsa-miR-23a	CLIP-seq
MIRT1055898	hsa-miR-23b	CLIP-seq
MIRT1055899	hsa-miR-23c	CLIP-seq
MIRT2245161	hsa-miR-3074-5p	CLIP-seq
MIRT2245162	hsa-miR-3121-3p	CLIP-seq
MIRT1055901	hsa-miR-3171	CLIP-seq
MIRT2548077	hsa-miR-3928	CLIP-seq
MIRT2245163	hsa-miR-433	CLIP-seq
MIRT1055904	hsa-miR-4495	CLIP-seq
MIRT1055912	hsa-miR-4713-5p	CLIP-seq
MIRT2245164	hsa-miR-499-3p	CLIP-seq
MIRT2245165	hsa-miR-499a-3p	CLIP-seq
MIRT1055916	hsa-miR-513a-3p	CLIP-seq
MIRT1055918	hsa-miR-532-3p	CLIP-seq
MIRT2548078	hsa-miR-548ac	CLIP-seq
MIRT2548079	hsa-miR-548d-3p	CLIP-seq
MIRT2548080	hsa-miR-548z	CLIP-seq
MIRT2245166	hsa-miR-935	CLIP-seq

Show/Hide all(47)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IDA	15620698
GO:0002224	Process	Toll-like receptor signaling pathway	TAS
GO:0003723	Function	RNA binding	IDA	11958450
GO:0005509	Function	Calcium ion binding	TAS	10497210
GO:0005515	Function	Protein binding	IPI	9596688, 11907036, 11958450, 15845869, 18264092, 23349634, 23995768, 26496610, 30021884, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA	17344063, 30188326
GO:0005783	Component	Endoplasmic reticulum	TAS	16130169
GO:0005788	Component	Endoplasmic reticulum lumen	IDA	10497210
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	10497210
GO:0005829	Component	Cytosol	IDA	9596688
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006457	Process	Protein folding	IBA	21873635
GO:0006898	Process	Receptor-mediated endocytosis	TAS
GO:0015031	Process	Protein transport	NAS	15845869
GO:0016020	Component	Membrane	HDA	19946888
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019903	Function	Protein phosphatase binding	IDA	19000834
GO:0030433	Process	Ubiquitin-dependent ERAD pathway	IBA	21873635
GO:0030433	Process	Ubiquitin-dependent ERAD pathway	IMP	18264092
GO:0030496	Component	Midbody	IDA	15166316
GO:0030970	Process	Retrograde protein transport, ER to cytosol	IMP	25660456
GO:0031247	Process	Actin rod assembly	IDA	19000834
GO:0032991	Component	Protein-containing complex	IDA	23349634
GO:0033018	Component	Sarcoplasmic reticulum lumen	IEA
GO:0034975	Process	Protein folding in endoplasmic reticulum	TAS	22013210
GO:0034976	Process	Response to endoplasmic reticulum stress	TAS	22934019
GO:0036500	Process	ATF6-mediated unfolded protein response	TAS
GO:0042470	Component	Melanosome	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	10497210, 15192333
GO:0043066	Process	Negative regulation of apoptotic process	TAS	16130169
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IDA	19000834
GO:0043687	Process	Post-translational protein modification	TAS
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0048471	Component	Perinuclear region of cytoplasm	IBA	21873635
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	10497210
GO:0050750	Function	Low-density lipoprotein particle receptor binding	IDA
GO:0051082	Function	Unfolded protein binding	IBA	21873635
GO:0051208	Process	Sequestering of calcium ion	NAS	15192333
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	23658023
GO:0070062	Component	Extracellular exosome	HDA	19199708, 20458337
GO:0071318	Process	Cellular response to ATP	IDA	19000834
GO:0071682	Component	Endocytic vesicle lumen	TAS

MIM	HGNC	e!Ensembl
191175	12028	ENSG00000166598

Protein

UniProt ID

P14625

Protein name

Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)

Protein function

ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LR

PDB

4NH9 , 7ULL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02518	HATPase_c	96 → 255	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	Domain
PF00183	HSP90	257 → 781	Hsp90 protein	Family

Sequence

MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDG
LNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISL
TDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNT
LGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAK
EEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD
DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKY
NDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDE
SEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMER
IMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDE
EMDVGTDEEEETAKESTAEKDEL

Sequence length

803

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway IL-17 signaling pathway Estrogen signaling pathway Thyroid hormone synthesis Salmonella infection Pathways in cancer Chemical carcinogenesis - receptor activation Prostate cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis		Trafficking and processing of endosomal TLR Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17566973

Show/Hide Unknown Diseases (2)

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		17805476, 19125190, 18771604
Prostatic neoplasms	Prostatic Neoplasms		17566973

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