C3 (complement C3)

Gene

• Entrez ID: 718
• Gene name: Complement C3
• Gene symbol: C3
• Synonyms: AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs2230199	G>C,T	Risk-factor, benign	Coding sequence variant, missense variant
rs11569534	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs11569541	A>G,T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs111595742	T>A,C	Pathogenic	Splice acceptor variant
rs121909583	C>T	Risk-factor	Coding sequence variant, missense variant
rs121909584	G>A	Risk-factor	Coding sequence variant, missense variant
rs121909585	C>T	Risk-factor	Coding sequence variant, missense variant
rs121909586	G>A,C	Risk-factor	Stop gained, coding sequence variant, synonymous variant
rs147859257	T>G	Uncertain-significance, benign, risk-factor	Missense variant, coding sequence variant
rs539992721	T>C,G	Likely-pathogenic	Coding sequence variant, missense variant
rs775015499	C>A,T	Likely-pathogenic	Missense variant, coding sequence variant
rs794729228	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1568229677	CA>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599507415	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1599510478	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1599518940	->G	Likely-pathogenic	Frameshift variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027814	hsa-miR-98-5p	Microarray	19088304
MIRT030181	hsa-miR-26b-5p	Microarray	19088304
MIRT696544	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT542444	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT542445	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT542443	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT696543	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT542441	hsa-miR-4486	HITS-CLIP	23313552
MIRT461959	hsa-miR-5186	HITS-CLIP	23313552
MIRT461958	hsa-miR-4537	HITS-CLIP	23313552
MIRT461952	hsa-miR-4252	HITS-CLIP	23313552
MIRT542439	hsa-miR-1273a	HITS-CLIP	23313552
MIRT542438	hsa-miR-4649-5p	HITS-CLIP	23313552
MIRT542437	hsa-miR-6729-5p	HITS-CLIP	23313552
MIRT461948	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT542436	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT542435	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT696542	hsa-miR-7703	HITS-CLIP	23313552
MIRT461945	hsa-miR-550b-2-5p	HITS-CLIP	23313552
MIRT696541	hsa-miR-216a-5p	HITS-CLIP	23313552
MIRT696540	hsa-miR-216b-5p	HITS-CLIP	23313552
MIRT696539	hsa-miR-302f	HITS-CLIP	23313552
MIRT696538	hsa-miR-890	HITS-CLIP	23313552
MIRT696537	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT696536	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT696535	hsa-miR-940	HITS-CLIP	23313552
MIRT696534	hsa-miR-3929	HITS-CLIP	23313552
MIRT696533	hsa-miR-4419b	HITS-CLIP	23313552
MIRT696532	hsa-miR-4478	HITS-CLIP	23313552
MIRT696531	hsa-miR-5690	HITS-CLIP	23313552
MIRT696529	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT696530	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT696528	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT696527	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT696526	hsa-miR-1827	HITS-CLIP	23313552
MIRT696525	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT696524	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT696523	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT696522	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT696521	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT696520	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT696519	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT696518	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT696517	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT461950	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT696516	hsa-miR-1273e	HITS-CLIP	23313552
MIRT696515	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT696514	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT696513	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT696512	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT696511	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT696510	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT696509	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT696508	hsa-miR-3689c	HITS-CLIP	23313552
MIRT696507	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT696506	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT696505	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT696504	hsa-miR-665	HITS-CLIP	23313552
MIRT665050	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT680473	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT461960	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT680472	hsa-miR-4532	HITS-CLIP	23824327
MIRT665049	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT680471	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT665048	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT665047	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT680470	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT680469	hsa-miR-3135b	HITS-CLIP	23824327
MIRT680468	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT680467	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT665046	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT680466	hsa-miR-4284	HITS-CLIP	23824327
MIRT665045	hsa-miR-5698	HITS-CLIP	23824327
MIRT665050	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT665049	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT665048	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT665047	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT665046	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT665045	hsa-miR-5698	HITS-CLIP	23824327
MIRT542446	hsa-miR-4432	PAR-CLIP	21572407
MIRT542447	hsa-miR-589-3p	PAR-CLIP	21572407
MIRT542444	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542445	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT542443	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542441	hsa-miR-4486	PAR-CLIP	21572407
MIRT542442	hsa-miR-4522	PAR-CLIP	21572407
MIRT542440	hsa-miR-661	PAR-CLIP	21572407
MIRT542439	hsa-miR-1273a	PAR-CLIP	21572407
MIRT542438	hsa-miR-4649-5p	PAR-CLIP	21572407
MIRT542437	hsa-miR-6729-5p	PAR-CLIP	21572407
MIRT542436	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542435	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT542434	hsa-miR-5001-3p	PAR-CLIP	21572407
MIRT519243	hsa-miR-4438	PAR-CLIP	23446348
MIRT519242	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT519241	hsa-miR-6889-3p	PAR-CLIP	23446348
MIRT461952	hsa-miR-4252	PAR-CLIP	23446348
MIRT519240	hsa-miR-5095	PAR-CLIP	23446348
MIRT519239	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT461960	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT461959	hsa-miR-5186	PAR-CLIP	23592263
MIRT461958	hsa-miR-4537	PAR-CLIP	23592263
MIRT461957	hsa-miR-6134	PAR-CLIP	23592263
MIRT461956	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461955	hsa-miR-6086	PAR-CLIP	23592263
MIRT461954	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT461952	hsa-miR-4252	PAR-CLIP	23592263
MIRT461953	hsa-miR-3689d	PAR-CLIP	23592263
MIRT461951	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT461950	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT461949	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT461948	hsa-miR-1227-3p	PAR-CLIP	23592263
MIRT461947	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT461946	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT461945	hsa-miR-550b-2-5p	PAR-CLIP	23592263
MIRT461944	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT542439	hsa-miR-1273a	PAR-CLIP	27292025
MIRT696512	hsa-miR-1273h-5p	PAR-CLIP	27292025
MIRT030181	hsa-miR-26b-5p	PAR-CLIP	27292025
MIRT696511	hsa-miR-30b-3p	PAR-CLIP	27292025
MIRT696510	hsa-miR-3689a-3p	PAR-CLIP	27292025
MIRT696509	hsa-miR-3689b-3p	PAR-CLIP	27292025
MIRT696508	hsa-miR-3689c	PAR-CLIP	27292025
MIRT542446	hsa-miR-4432	PAR-CLIP	27292025
MIRT542441	hsa-miR-4486	PAR-CLIP	27292025
MIRT542442	hsa-miR-4522	PAR-CLIP	27292025
MIRT542438	hsa-miR-4649-5p	PAR-CLIP	27292025
MIRT542434	hsa-miR-5001-3p	PAR-CLIP	27292025
MIRT542447	hsa-miR-589-3p	PAR-CLIP	27292025
MIRT542436	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT542435	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT542437	hsa-miR-6729-5p	PAR-CLIP	27292025
MIRT696507	hsa-miR-6779-5p	PAR-CLIP	27292025
MIRT696506	hsa-miR-6780a-5p	PAR-CLIP	27292025
MIRT542444	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT542445	hsa-miR-939-3p	PAR-CLIP	27292025
MIRT696544	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT542444	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT542445	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT542443	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT696543	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT542441	hsa-miR-4486	HITS-CLIP	23313552
MIRT461959	hsa-miR-5186	HITS-CLIP	23313552
MIRT461958	hsa-miR-4537	HITS-CLIP	23313552
MIRT461952	hsa-miR-4252	HITS-CLIP	23313552
MIRT542439	hsa-miR-1273a	HITS-CLIP	23313552
MIRT542438	hsa-miR-4649-5p	HITS-CLIP	23313552
MIRT542437	hsa-miR-6729-5p	HITS-CLIP	23313552
MIRT461948	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT542436	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT542435	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT696542	hsa-miR-7703	HITS-CLIP	23313552
MIRT461945	hsa-miR-550b-2-5p	HITS-CLIP	23313552
MIRT696541	hsa-miR-216a-5p	HITS-CLIP	23313552
MIRT696540	hsa-miR-216b-5p	HITS-CLIP	23313552
MIRT696539	hsa-miR-302f	HITS-CLIP	23313552
MIRT696538	hsa-miR-890	HITS-CLIP	23313552
MIRT696537	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT696536	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT696535	hsa-miR-940	HITS-CLIP	23313552
MIRT696534	hsa-miR-3929	HITS-CLIP	23313552
MIRT696533	hsa-miR-4419b	HITS-CLIP	23313552
MIRT696532	hsa-miR-4478	HITS-CLIP	23313552
MIRT696531	hsa-miR-5690	HITS-CLIP	23313552
MIRT696529	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT696530	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT696528	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT696527	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT696526	hsa-miR-1827	HITS-CLIP	23313552
MIRT696525	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT696524	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT696523	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT696522	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT696521	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT696520	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT696519	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT696518	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT696517	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT461950	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT696516	hsa-miR-1273e	HITS-CLIP	23313552
MIRT696515	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT696514	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT696513	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT696512	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT696511	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT696510	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT696509	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT696508	hsa-miR-3689c	HITS-CLIP	23313552
MIRT696507	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT696506	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT696505	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT696504	hsa-miR-665	HITS-CLIP	23313552
MIRT665050	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT680473	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT461960	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT680472	hsa-miR-4532	HITS-CLIP	23824327
MIRT665049	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT680471	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT665048	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT665047	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT680470	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT680469	hsa-miR-3135b	HITS-CLIP	23824327
MIRT680468	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT680467	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT665046	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT680466	hsa-miR-4284	HITS-CLIP	23824327
MIRT665045	hsa-miR-5698	HITS-CLIP	23824327
MIRT665050	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT665049	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT665048	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT665047	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT665046	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT665045	hsa-miR-5698	HITS-CLIP	23824327
MIRT542446	hsa-miR-4432	PAR-CLIP	21572407
MIRT542447	hsa-miR-589-3p	PAR-CLIP	21572407
MIRT542444	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542445	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT542443	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542441	hsa-miR-4486	PAR-CLIP	21572407
MIRT542442	hsa-miR-4522	PAR-CLIP	21572407
MIRT542440	hsa-miR-661	PAR-CLIP	21572407
MIRT542439	hsa-miR-1273a	PAR-CLIP	21572407
MIRT542438	hsa-miR-4649-5p	PAR-CLIP	21572407
MIRT542437	hsa-miR-6729-5p	PAR-CLIP	21572407
MIRT542436	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542435	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT542434	hsa-miR-5001-3p	PAR-CLIP	21572407
MIRT519243	hsa-miR-4438	PAR-CLIP	23446348
MIRT519242	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT519241	hsa-miR-6889-3p	PAR-CLIP	23446348
MIRT461952	hsa-miR-4252	PAR-CLIP	23446348
MIRT519240	hsa-miR-5095	PAR-CLIP	23446348
MIRT519239	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT461960	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT461959	hsa-miR-5186	PAR-CLIP	23592263
MIRT461958	hsa-miR-4537	PAR-CLIP	23592263
MIRT461957	hsa-miR-6134	PAR-CLIP	23592263
MIRT461956	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461955	hsa-miR-6086	PAR-CLIP	23592263
MIRT461954	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT461952	hsa-miR-4252	PAR-CLIP	23592263
MIRT461953	hsa-miR-3689d	PAR-CLIP	23592263
MIRT461951	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT461950	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT461949	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT461948	hsa-miR-1227-3p	PAR-CLIP	23592263
MIRT461947	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT461946	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT461945	hsa-miR-550b-2-5p	PAR-CLIP	23592263
MIRT461944	hsa-miR-6516-5p	PAR-CLIP	23592263

Transcription factors

Transcription factor	Regulation	Reference
CEBPD	Unknown	8385337

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001798	Process	Positive regulation of type IIa hypersensitivity	IEA
GO:0001934	Process	Positive regulation of protein phosphorylation	IDA	15833747
GO:0001970	Process	Positive regulation of activation of membrane attack complex	IEA
GO:0004866	Function	Endopeptidase inhibitor activity	IEA
GO:0005102	Function	Signaling receptor binding	TAS	9164946
GO:0005515	Function	Protein binding	IPI	7483825, 11705926, 12438350, 12540846, 16530040, 17051150, 18796626, 19255449, 20042240, 21317894, 21979047, 22518841, 23086448, 26627825, 27814381, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470, 23580065
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	25645918
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006955	Process	Immune response	TAS	4097977
GO:0006956	Process	Complement activation	IBA	21873635
GO:0006956	Process	Complement activation	IMP	19302245
GO:0006956	Process	Complement activation	TAS
GO:0006957	Process	Complement activation, alternative pathway	TAS
GO:0006958	Process	Complement activation, classical pathway	IEA
GO:0007165	Process	Signal transduction	TAS	10085065
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0009617	Process	Response to bacterium	IEA
GO:0009986	Component	Cell surface	IEA
GO:0010575	Process	Positive regulation of vascular endothelial growth factor production	IDA	16452172
GO:0010828	Process	Positive regulation of glucose transmembrane transport	IDA	9059512, 15833747
GO:0010866	Process	Regulation of triglyceride biosynthetic process	IDA	10432298
GO:0010884	Process	Positive regulation of lipid storage	IDA	9555951
GO:0010951	Process	Negative regulation of endopeptidase activity	IEA
GO:0016322	Process	Neuron remodeling	ISS
GO:0030449	Process	Regulation of complement activation	TAS
GO:0031715	Function	C5L2 anaphylatoxin chemotactic receptor binding	IDA	15833747
GO:0032991	Component	Protein-containing complex	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0035846	Process	Oviduct epithelium development	IEA
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043687	Process	Post-translational protein modification	TAS
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0045745	Process	Positive regulation of G protein-coupled receptor signaling pathway	IDA	15833747
GO:0045766	Process	Positive regulation of angiogenesis	IEA
GO:0048260	Process	Positive regulation of receptor-mediated endocytosis	ISS
GO:0050776	Process	Regulation of immune response	TAS
GO:0060100	Process	Positive regulation of phagocytosis, engulfment	ISS
GO:0070062	Component	Extracellular exosome	HDA	21362503, 23533145
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0097242	Process	Amyloid-beta clearance	ISS
GO:0097278	Process	Complement-dependent cytotoxicity	IEA
GO:0150062	Process	Complement-mediated synapse pruning	ISS
GO:0150064	Process	Vertebrate eye-specific patterning	ISS
GO:1905114	Process	Cell surface receptor signaling pathway involved in cell-cell signaling	IEA
GO:2000427	Process	Positive regulation of apoptotic cell clearance	IMP	19302245

Other IDs

• MIM: 120700
• HGNC: 1318
• e!Ensembl: ENSG00000125730

Protein

• UniProt ID: P01024
• Protein name: Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b (Com
• Protein function: Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive im
• PDB: 1C3D, 1GHQ, 1W2S, 2A73, 2A74, 2GOX, 2I07, 2ICE, 2ICF, 2NOJ, 2QKI, 2WII, 2WIN, 2WY7, 2WY8, 2XQW, 2XWB, 2XWJ, 3D5R, 3D5S, 3G6J, 3L3O, 3L5N, 3NMS, 3OED, 3OHX, 3OXU, 3RJ3, 3T4A, 4HW5, 4HWJ, 4I6O, 4M76, 4ONT, 4ZH1, 5FO7, 5FO8, 5FO9, 5FOA, 5FOB, 5NBQ, 5O32, 5O35, 6EHG, 6RMT, 6RMU, 6RUR, 6RUV, 6S0B, 6YO6, 7AKK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17790	MG1	23 → 124	Macroglobulin domain MG1	Domain
  PF01835	MG2	129 → 224	MG2 domain	Domain
  PF17791	MG3	226 → 308	Macroglobulin domain MG3	Domain
  PF17789	MG4	355 → 446	Macroglobulin domain MG4	Domain
  PF07703	A2M_BRD	456 → 605	Alpha-2-macroglobulin bait region domain	Domain
  PF01821	ANATO	693 → 728	Anaphylotoxin-like domain	Domain
  PF00207	A2M	770 → 866	Alpha-2-macroglobulin family	Family
  PF07678	TED_complement	983 → 1282	A-macroglobulin TED domain	Domain
  PF07677	A2M_recep	1398 → 1493	A-macroglobulin receptor binding domain	Domain
  PF01759	NTR	1534 → 1644	UNC-6/NTR/C345C module	Domain

• Sequence:

  MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVH
  DFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKV
  VLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSL
  SSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTE
  KFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEV
  VLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKT
  PKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPL
  SITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMD
  RAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGA
  SGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDK
  GVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAEL
  QCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEAC
  KKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKE
  PPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVV
  RNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVI
  VPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKE
  DIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTP
  TVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTA
  YVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKD
  MALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMG
  RLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQR
  YYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLR
  SEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDA
  KNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSD
  RNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDG
  KLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDE
  YIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSY
  IIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN

• Sequence length: 1663

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Phagosome
Complement and coagulation cascades
Neutrophil extracellular trap formation
Alcoholic liver disease
Shigellosis
Pertussis
Legionellosis
Leishmaniasis
Chagas disease
Staphylococcus aureus infection
Tuberculosis
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Coronavirus disease - COVID-19
Viral carcinogenesis
Systemic lupus erythematosus

Reactome:

Alternative complement activation
Activation of C3 and C5
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (i) signalling events
Neutrophil degranulation
Post-translational protein phosphorylation
Purinergic signaling in leishmaniasis infection
Regulation of Complement cascade

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
C3 deficiency	Complement component 3 deficiency	rs112996548, rs111595742, rs1568229677, rs1599518940	4117597
Complement component deficiency	COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE, Complement deficiency disease	rs387906509, rs1467298230, rs1022194067, rs774370086, rs121964922, rs372345940, rs121913052, rs121913053, rs460897, rs121913054, rs121913056, rs121913058, rs796052138, rs41286844, rs121909592, rs34000044, rs121909594, rs121909587, rs121909588, rs387906554, rs587776846, rs2135727106, rs460184, rs775967055, rs398122811, rs140813121, rs146187042, rs372968576, rs398122867, rs398122868, rs9332736, rs398124644, rs142881576, rs531103546, rs764871530, rs778518669, rs139491301, rs61469168, rs1554718962, rs1565789104, rs1579848888, rs779723422, rs867425110, rs770367814	4117597, 18796626, 15781264, 26471127, 7961791, 4117597
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	20504758
Hemolytic uremic syndrome	Atypical Hemolytic Uremic Syndrome, Atypical hemolytic uremic syndrome with complement gene abnormality, Hemolytic-Uremic Syndrome	rs398124292, rs121964913, rs121964914, rs121964915, rs121918667, rs33972593, rs117905900, rs121909748, rs460897, rs796052136, rs121913055, rs796052137, rs121913060, rs121913063, rs1558056827, rs1255421232, rs1441937053, rs121909590, rs121909583, rs121909584, rs121909586, rs460184, rs104886189, rs312262694, rs312262697, rs312262698, rs312262696, rs138924661, rs869312973, rs886039869, rs886039868, rs886043418, rs1057516191, rs1131690796, rs1553273733, rs1553251787, rs777787526, rs769742294, rs775015499, rs1555599211, rs1558162157, rs1600410451, rs368615806, rs1573026975, rs1573087200, rs1571588257, rs147972030, rs1906529223, rs749415630, rs1573076111, rs1300996807, rs1571616755, rs1571617647, rs1579173999, rs1599510478	26471127
Hypertension	Hypertensive disease	rs13306026, rs13333226
Age-related macular degeneration	Age related macular degeneration, Macular Degeneration, Age-Related, 9, NON RARE IN EUROPE: Age-related macular degeneration	rs2133900556, rs199474657, rs2274700, rs1410996, rs61750120, rs1800728, rs62654397, rs61749423, rs61751412, rs61749439, rs61751398, rs61752417, rs62645946, rs1801269, rs62646860, rs61750142, rs61750145, rs61750152, rs61751377, rs61753029, rs61751407, rs61751389, rs61750645, rs61750648, rs879255520, rs752147871, rs886044750, rs886044749, rs746541266, rs756840095, rs886044725, rs749526785, rs1057518955, rs1057518767, rs371489809, rs1064793014, rs1571264574, rs1659524475	17767156, 20385826, 23455636, 20861866, 29346644, 24036952, 20385819, 24036949, 24036950, 22705344, 26691988, 21665990, 24036952, 17634448
Nephrotic syndrome	Nephrotic Syndrome	rs876657369, rs121912601, rs121912602, rs876657370, rs121912603, rs121912604, rs121912605, rs121907900, rs121907901, rs28941778, rs587776576, rs28942089, rs587776577, rs28941777, rs121907910, rs1568296260, rs119473033, rs74315342, rs74315343, rs74315345, rs74315346, rs74315347, rs74315348, rs121434394, rs267606919, rs121912488, rs267606953, rs267606954, rs267606955, rs104886210, rs1591732280, rs1591750243, rs140511594, rs140781106, rs147972030, rs587776969, rs386833863, rs386833880, rs386833882, rs386833892, rs386833895, rs386833909, rs386833911, rs386833920, rs386833935, rs386833947, rs1555763603, rs398122978, rs398122979, rs398122980, rs369573693, rs398122981, rs398122982, rs398122983, rs200482683, rs730882194, rs180177201, rs587777552, rs587777553, rs775170915, rs749740335, rs12568913, rs530318579, rs786204583, rs786204708, rs786204632, rs138656762, rs797044992, rs797044994, rs797044995, rs864321632, rs864321687, rs864321688, rs864321633, rs869025495, rs869025541, rs869312747, rs145473779, rs757674160, rs869320695, rs138909849, rs869312984, rs1057516900, rs763818901, rs199506378, rs1057517164, rs1057516523, rs1057516414, rs778055996, rs1057516395, rs1057516747, rs1057516880, rs1057516680, rs778217926, rs1057519347, rs764587648, rs1060499703, rs121907903, rs769259446, rs1131692252, rs1131692253, rs1131692254, rs1131692255, rs1131692256, rs746887949, rs1131692235, rs1135402911, rs1135402912, rs1135402913, rs1554946480, rs1555331969, rs773173317, rs1555816634, rs775006954, rs1320543506, rs534522842, rs1272948499, rs1191455921, rs1291398331, rs1554939785, rs776016942, rs1031744496, rs748812981, rs755972674, rs1553312833, rs967339926, rs1462028977, rs1212702104, rs1167223941, rs762631237, rs1553316575, rs1553315173, rs1553316648, rs1553316611, rs780761368, rs368572297, rs1568070817, rs1321552081, rs1558108130, rs1558091788, rs1565707103, rs1558355124, rs1564622701, rs1351580598, rs1589475328, rs1589413498, rs1572255744, rs1572262824, rs761410195, rs1602413491, rs1590326226, rs375998390, rs570583897, rs369363545, rs201488687, rs1334894971, rs763782471, rs138047529, rs895782232, rs1572255047, rs1589433172, rs1589509476, rs1572277600, rs1572282458, rs1584675898, rs759043857, rs1853443391
Renal insufficiency	Renal Insufficiency	rs1596536873

Unknown
Disease name	Disease term	dbSNP ID	References
Antibody deficiency syndrome	Antibody Deficiency Syndrome		1350678
Cerebral infraction	Infarction, Middle Cerebral Artery		23199288
C3 glomerulopathy	C3 glomerulopathy	rs318240755, rs368209619, rs140215003, rs9427662, rs34533956, rs57960694, rs565457964, rs375481393, rs201084185, rs16840956, rs61745675, rs147791058, rs147488267, rs7532068, rs114023763, rs140691305, rs139017763, rs35662416, rs751010317, rs185709089, rs772780646, rs771972507, rs12097550, rs143140599, rs41306229, rs141358257, rs556270179, rs550747814	26471127
Cerebral ischemia	Brain Stem Ischemia, Transient, Transient Cerebral Ischemia		23199288
Cerebral thrombosis	Middle Cerebral Artery Thrombosis		23199288
Exudative macular degeneration	Exudative age-related macular degeneration, exudative macular degeneration		22705344, 26691988, 26691988, 22705344
Geographic atrophy	Geographic Atrophy		26691988, 22705344
Henoch-schonlein nephritis	Henoch-Schoenlein Purpura		1353212
Heymann nephritis	Heymann Nephritis		25954969
Immunologic deficiency syndromes	Immunologic Deficiency Syndromes		1350678
Kidney failure	Kidney Failure, Acute		28885000
Lupus erythematosus	Lupus Erythematosus, Systemic
Membranous glomerulonephritis	Membranous glomerulonephritis, Idiopathic Membranous Glomerulonephritis		25954969
Microangiopathic hemolytic anemia	Microangiopathic hemolytic anemia
Paratuberculosis	Paratuberculosis		22633222
Pemphigus	Pemphigus		74171
Pemphigus foliaceus	Pemphigus Foliaceus		74171
Pemphigus vulgaris	Pemphigus Vulgaris		74171
Acute kidney insufficiency	Acute Kidney Insufficiency		28885000
Transient ischemic attack	Transient Ischemic Attack, Posterior Circulation Transient Ischemic Attack, Carotid Circulation Transient Ischemic Attack, Transient Ischemic Attack, Vertebrobasilar Circulation, Crescendo Transient Ischemic Attacks, Transient Ischemic Attack, Anterior Circulation		23199288