TPT1 (tumor protein, translationally-controlled 1)

Gene

• Entrez ID: 7178
• Gene name: Tumor protein, translationally-controlled 1
• Gene symbol: TPT1
• Synonyms: HRF, TCTP, p02, p23
• Chromosome: 13
• Chromosome location: 13q14.13
• Summary: This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5`-TOP) in its 5` untranslated region that functions to repress its translation under quiescent cond

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT031462	hsa-miR-16-5p	Proteomics	18668040
MIRT052061	hsa-let-7b-5p	CLASH	23622248
MIRT048923	hsa-miR-92a-3p	CLASH	23622248
MIRT048923	hsa-miR-92a-3p	CLASH	23622248
MIRT048369	hsa-miR-29b-3p	CLASH	23622248
MIRT040607	hsa-miR-92b-3p	CLASH	23622248
MIRT039903	hsa-miR-615-3p	CLASH	23622248
MIRT036803	hsa-miR-374b-5p	CLASH	23622248
MIRT052823	hsa-miR-3200-3p	CLASH	23622248
MIRT445426	hsa-miR-100-3p	PAR-CLIP	22291592
MIRT445424	hsa-miR-3614-5p	PAR-CLIP	22291592
MIRT445423	hsa-miR-6500-3p	PAR-CLIP	22291592
MIRT445422	hsa-miR-5008-5p	PAR-CLIP	22291592
MIRT445421	hsa-miR-6089	PAR-CLIP	22291592
MIRT445419	hsa-miR-6765-5p	PAR-CLIP	22291592
MIRT445418	hsa-miR-1304-5p	PAR-CLIP	22291592
MIRT496305	hsa-miR-1245b-5p	PAR-CLIP	22291592
MIRT496304	hsa-miR-3142	PAR-CLIP	22291592
MIRT496303	hsa-miR-6840-3p	PAR-CLIP	22291592
MIRT496302	hsa-miR-1915-3p	PAR-CLIP	22291592
MIRT496301	hsa-miR-6764-5p	PAR-CLIP	22291592
MIRT496300	hsa-miR-4726-3p	PAR-CLIP	22291592
MIRT496299	hsa-miR-6887-3p	PAR-CLIP	22291592
MIRT496298	hsa-miR-6795-3p	PAR-CLIP	22291592
MIRT496297	hsa-miR-6069	PAR-CLIP	22291592
MIRT496296	hsa-miR-6826-3p	PAR-CLIP	22291592
MIRT445426	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT445424	hsa-miR-3614-5p	PAR-CLIP	22100165
MIRT445423	hsa-miR-6500-3p	PAR-CLIP	22100165
MIRT445422	hsa-miR-5008-5p	PAR-CLIP	22100165
MIRT445421	hsa-miR-6089	PAR-CLIP	22100165
MIRT445419	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT445418	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT445426	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT445424	hsa-miR-3614-5p	PAR-CLIP	22100165
MIRT445423	hsa-miR-6500-3p	PAR-CLIP	22100165
MIRT445422	hsa-miR-5008-5p	PAR-CLIP	22100165
MIRT445421	hsa-miR-6089	PAR-CLIP	22100165
MIRT445420	hsa-miR-3926	PAR-CLIP	22100165
MIRT445419	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT445418	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT439397	hsa-miR-544a	HITS-CLIP	24374217
MIRT726242	hsa-miR-27a-3p	HITS-CLIP	22473208
MIRT726241	hsa-miR-27b-3p	HITS-CLIP	22473208
MIRT439397	hsa-miR-544a	HITS-CLIP	24374217
MIRT445426	hsa-miR-100-3p	PAR-CLIP	22291592
MIRT445424	hsa-miR-3614-5p	PAR-CLIP	22291592
MIRT445423	hsa-miR-6500-3p	PAR-CLIP	22291592
MIRT445422	hsa-miR-5008-5p	PAR-CLIP	22291592
MIRT445421	hsa-miR-6089	PAR-CLIP	22291592
MIRT445419	hsa-miR-6765-5p	PAR-CLIP	22291592
MIRT445418	hsa-miR-1304-5p	PAR-CLIP	22291592
MIRT496305	hsa-miR-1245b-5p	PAR-CLIP	22291592
MIRT496304	hsa-miR-3142	PAR-CLIP	22291592
MIRT496303	hsa-miR-6840-3p	PAR-CLIP	22291592
MIRT496302	hsa-miR-1915-3p	PAR-CLIP	22291592
MIRT496301	hsa-miR-6764-5p	PAR-CLIP	22291592
MIRT496300	hsa-miR-4726-3p	PAR-CLIP	22291592
MIRT496299	hsa-miR-6887-3p	PAR-CLIP	22291592
MIRT496298	hsa-miR-6795-3p	PAR-CLIP	22291592
MIRT496297	hsa-miR-6069	PAR-CLIP	22291592
MIRT496296	hsa-miR-6826-3p	PAR-CLIP	22291592
MIRT445426	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT445424	hsa-miR-3614-5p	PAR-CLIP	22100165
MIRT445423	hsa-miR-6500-3p	PAR-CLIP	22100165
MIRT445422	hsa-miR-5008-5p	PAR-CLIP	22100165
MIRT445421	hsa-miR-6089	PAR-CLIP	22100165
MIRT445419	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT445418	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT445426	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT445424	hsa-miR-3614-5p	PAR-CLIP	22100165
MIRT445423	hsa-miR-6500-3p	PAR-CLIP	22100165
MIRT445422	hsa-miR-5008-5p	PAR-CLIP	22100165
MIRT445421	hsa-miR-6089	PAR-CLIP	22100165
MIRT445420	hsa-miR-3926	PAR-CLIP	22100165
MIRT445419	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT445418	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT756039	hsa-miR-145-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35371310
MIRT1450441	hsa-miR-1255a	CLIP-seq
MIRT1450442	hsa-miR-1255b	CLIP-seq
MIRT1450443	hsa-miR-125a-3p	CLIP-seq
MIRT1450444	hsa-miR-1272	CLIP-seq
MIRT1450445	hsa-miR-1322	CLIP-seq
MIRT1450446	hsa-miR-147	CLIP-seq
MIRT1450447	hsa-miR-1910	CLIP-seq
MIRT1450448	hsa-miR-298	CLIP-seq
MIRT1450449	hsa-miR-302f	CLIP-seq
MIRT1450450	hsa-miR-3064-3p	CLIP-seq
MIRT1450451	hsa-miR-3145-5p	CLIP-seq
MIRT1450452	hsa-miR-3670	CLIP-seq
MIRT1450453	hsa-miR-3691-5p	CLIP-seq
MIRT1450454	hsa-miR-3911	CLIP-seq
MIRT1450455	hsa-miR-3913-3p	CLIP-seq
MIRT1450456	hsa-miR-455-3p	CLIP-seq
MIRT1450457	hsa-miR-4676-5p	CLIP-seq
MIRT1450458	hsa-miR-4694-5p	CLIP-seq
MIRT1450459	hsa-miR-4709-3p	CLIP-seq
MIRT1450460	hsa-miR-4715-3p	CLIP-seq
MIRT1450461	hsa-miR-4752	CLIP-seq
MIRT1450462	hsa-miR-4786-3p	CLIP-seq
MIRT1450463	hsa-miR-489	CLIP-seq
MIRT1450464	hsa-miR-511	CLIP-seq
MIRT1450465	hsa-miR-548ac	CLIP-seq
MIRT1450466	hsa-miR-548ae	CLIP-seq
MIRT1450467	hsa-miR-548aj	CLIP-seq
MIRT1450468	hsa-miR-548am	CLIP-seq
MIRT1450469	hsa-miR-548d-3p	CLIP-seq
MIRT1450470	hsa-miR-548x	CLIP-seq
MIRT1450471	hsa-miR-548z	CLIP-seq
MIRT1450472	hsa-miR-552	CLIP-seq
MIRT1450473	hsa-miR-575	CLIP-seq
MIRT1450474	hsa-miR-644	CLIP-seq
MIRT1450441	hsa-miR-1255a	CLIP-seq
MIRT1450442	hsa-miR-1255b	CLIP-seq
MIRT1450444	hsa-miR-1272	CLIP-seq
MIRT1450445	hsa-miR-1322	CLIP-seq
MIRT1450446	hsa-miR-147	CLIP-seq
MIRT1450448	hsa-miR-298	CLIP-seq
MIRT1450453	hsa-miR-3691-5p	CLIP-seq
MIRT1450454	hsa-miR-3911	CLIP-seq
MIRT1555182	hsa-miR-4307	CLIP-seq
MIRT1450457	hsa-miR-4676-5p	CLIP-seq
MIRT1450458	hsa-miR-4694-5p	CLIP-seq
MIRT1555183	hsa-miR-4714-3p	CLIP-seq
MIRT1450461	hsa-miR-4752	CLIP-seq
MIRT1450462	hsa-miR-4786-3p	CLIP-seq
MIRT1450473	hsa-miR-575	CLIP-seq
MIRT1450474	hsa-miR-644	CLIP-seq
MIRT1450441	hsa-miR-1255a	CLIP-seq
MIRT1450442	hsa-miR-1255b	CLIP-seq
MIRT1450443	hsa-miR-125a-3p	CLIP-seq
MIRT1450444	hsa-miR-1272	CLIP-seq
MIRT2134655	hsa-miR-128	CLIP-seq
MIRT1450445	hsa-miR-1322	CLIP-seq
MIRT1450446	hsa-miR-147	CLIP-seq
MIRT1450447	hsa-miR-1910	CLIP-seq
MIRT2134656	hsa-miR-27a	CLIP-seq
MIRT2134657	hsa-miR-27b	CLIP-seq
MIRT1450448	hsa-miR-298	CLIP-seq
MIRT1450451	hsa-miR-3145-5p	CLIP-seq
MIRT1450453	hsa-miR-3691-5p	CLIP-seq
MIRT1450454	hsa-miR-3911	CLIP-seq
MIRT1450455	hsa-miR-3913-3p	CLIP-seq
MIRT1555182	hsa-miR-4307	CLIP-seq
MIRT1450456	hsa-miR-455-3p	CLIP-seq
MIRT1450457	hsa-miR-4676-5p	CLIP-seq
MIRT1450458	hsa-miR-4694-5p	CLIP-seq
MIRT2134658	hsa-miR-4698	CLIP-seq
MIRT1450461	hsa-miR-4752	CLIP-seq
MIRT1450462	hsa-miR-4786-3p	CLIP-seq
MIRT1450463	hsa-miR-489	CLIP-seq
MIRT1450464	hsa-miR-511	CLIP-seq
MIRT1450465	hsa-miR-548ac	CLIP-seq
MIRT1450466	hsa-miR-548ae	CLIP-seq
MIRT1450467	hsa-miR-548aj	CLIP-seq
MIRT1450468	hsa-miR-548am	CLIP-seq
MIRT1450469	hsa-miR-548d-3p	CLIP-seq
MIRT1450470	hsa-miR-548x	CLIP-seq
MIRT1450471	hsa-miR-548z	CLIP-seq
MIRT1450472	hsa-miR-552	CLIP-seq
MIRT1450473	hsa-miR-575	CLIP-seq
MIRT1450474	hsa-miR-644	CLIP-seq
MIRT1450441	hsa-miR-1255a	CLIP-seq
MIRT1450442	hsa-miR-1255b	CLIP-seq
MIRT1450444	hsa-miR-1272	CLIP-seq
MIRT2134655	hsa-miR-128	CLIP-seq
MIRT1450445	hsa-miR-1322	CLIP-seq
MIRT1450446	hsa-miR-147	CLIP-seq
MIRT1450447	hsa-miR-1910	CLIP-seq
MIRT2134656	hsa-miR-27a	CLIP-seq
MIRT2134657	hsa-miR-27b	CLIP-seq
MIRT1450448	hsa-miR-298	CLIP-seq
MIRT1450451	hsa-miR-3145-5p	CLIP-seq
MIRT2355962	hsa-miR-3646	CLIP-seq
MIRT1450452	hsa-miR-3670	CLIP-seq
MIRT1450453	hsa-miR-3691-5p	CLIP-seq
MIRT1450454	hsa-miR-3911	CLIP-seq
MIRT1450455	hsa-miR-3913-3p	CLIP-seq
MIRT1555182	hsa-miR-4307	CLIP-seq
MIRT1450456	hsa-miR-455-3p	CLIP-seq
MIRT1450457	hsa-miR-4676-5p	CLIP-seq
MIRT1450458	hsa-miR-4694-5p	CLIP-seq
MIRT2134658	hsa-miR-4698	CLIP-seq
MIRT1450459	hsa-miR-4709-3p	CLIP-seq
MIRT1450461	hsa-miR-4752	CLIP-seq
MIRT1450462	hsa-miR-4786-3p	CLIP-seq
MIRT1450463	hsa-miR-489	CLIP-seq
MIRT1450464	hsa-miR-511	CLIP-seq
MIRT1450465	hsa-miR-548ac	CLIP-seq
MIRT1450466	hsa-miR-548ae	CLIP-seq
MIRT1450467	hsa-miR-548aj	CLIP-seq
MIRT1450468	hsa-miR-548am	CLIP-seq
MIRT1450469	hsa-miR-548d-3p	CLIP-seq
MIRT1450470	hsa-miR-548x	CLIP-seq
MIRT1450471	hsa-miR-548z	CLIP-seq
MIRT1450473	hsa-miR-575	CLIP-seq
MIRT1450474	hsa-miR-644	CLIP-seq
MIRT1450443	hsa-miR-125a-3p	CLIP-seq
MIRT1450447	hsa-miR-1910	CLIP-seq
MIRT1450455	hsa-miR-3913-3p	CLIP-seq
MIRT1450456	hsa-miR-455-3p	CLIP-seq
MIRT1450463	hsa-miR-489	CLIP-seq
MIRT1450464	hsa-miR-511	CLIP-seq
MIRT1450472	hsa-miR-552	CLIP-seq
MIRT1450441	hsa-miR-1255a	CLIP-seq
MIRT1450442	hsa-miR-1255b	CLIP-seq
MIRT2134655	hsa-miR-128	CLIP-seq
MIRT1450446	hsa-miR-147	CLIP-seq
MIRT1450447	hsa-miR-1910	CLIP-seq
MIRT2134656	hsa-miR-27a	CLIP-seq
MIRT2134657	hsa-miR-27b	CLIP-seq
MIRT1450451	hsa-miR-3145-5p	CLIP-seq
MIRT1450453	hsa-miR-3691-5p	CLIP-seq
MIRT1450454	hsa-miR-3911	CLIP-seq
MIRT1450455	hsa-miR-3913-3p	CLIP-seq
MIRT1555182	hsa-miR-4307	CLIP-seq
MIRT1450456	hsa-miR-455-3p	CLIP-seq
MIRT1450458	hsa-miR-4694-5p	CLIP-seq
MIRT1450461	hsa-miR-4752	CLIP-seq
MIRT1450463	hsa-miR-489	CLIP-seq
MIRT1450464	hsa-miR-511	CLIP-seq
MIRT1450465	hsa-miR-548ac	CLIP-seq
MIRT1450466	hsa-miR-548ae	CLIP-seq
MIRT1450467	hsa-miR-548aj	CLIP-seq
MIRT1450468	hsa-miR-548am	CLIP-seq
MIRT1450469	hsa-miR-548d-3p	CLIP-seq
MIRT1450470	hsa-miR-548x	CLIP-seq
MIRT1450471	hsa-miR-548z	CLIP-seq
MIRT1450474	hsa-miR-644	CLIP-seq
MIRT1450441	hsa-miR-1255a	CLIP-seq
MIRT1450442	hsa-miR-1255b	CLIP-seq
MIRT2134655	hsa-miR-128	CLIP-seq
MIRT1450446	hsa-miR-147	CLIP-seq
MIRT1450447	hsa-miR-1910	CLIP-seq
MIRT2134656	hsa-miR-27a	CLIP-seq
MIRT2134657	hsa-miR-27b	CLIP-seq
MIRT1450451	hsa-miR-3145-5p	CLIP-seq
MIRT1450453	hsa-miR-3691-5p	CLIP-seq
MIRT1450454	hsa-miR-3911	CLIP-seq
MIRT1450455	hsa-miR-3913-3p	CLIP-seq
MIRT1555182	hsa-miR-4307	CLIP-seq
MIRT1450456	hsa-miR-455-3p	CLIP-seq
MIRT1450458	hsa-miR-4694-5p	CLIP-seq
MIRT1450461	hsa-miR-4752	CLIP-seq
MIRT1450463	hsa-miR-489	CLIP-seq
MIRT1450464	hsa-miR-511	CLIP-seq
MIRT1450465	hsa-miR-548ac	CLIP-seq
MIRT1450466	hsa-miR-548ae	CLIP-seq
MIRT1450467	hsa-miR-548aj	CLIP-seq
MIRT1450468	hsa-miR-548am	CLIP-seq
MIRT1450469	hsa-miR-548d-3p	CLIP-seq
MIRT1450470	hsa-miR-548x	CLIP-seq
MIRT1450471	hsa-miR-548z	CLIP-seq
MIRT1450474	hsa-miR-644	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
VDR	Activation	19815065

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IDA	15162379
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005509	Function	Calcium ion binding	IDA	15162379, 15958728
GO:0005515	Function	Protein binding	IPI	16730713, 17301792, 18325344, 21081126, 21278788, 22451927, 25277244, 25416956, 27607350
GO:0005615	Component	Extracellular space	IDA	15319436
GO:0005634	Component	Nucleus	IDA	11598139
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	15162379
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005771	Component	Multivesicular body	IDA	15319436
GO:0005829	Component	Cytosol	IDA
GO:0005881	Component	Cytoplasmic microtubule	IDA	15162379
GO:0006816	Process	Calcium ion transport	IC	15958728
GO:0006874	Process	Cellular calcium ion homeostasis	IC	15958728
GO:0009615	Process	Response to virus	IEP	16548883
GO:0042981	Process	Regulation of apoptotic process	NAS	15162379
GO:0043066	Process	Negative regulation of apoptotic process	TAS	16130169
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:1902230	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP	11598139

Other IDs

• MIM: 600763
• HGNC: 12022
• e!Ensembl: ENSG00000133112

Protein

• UniProt ID: P13693
• Protein name: Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23)
• Protein function: Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:183253
• PDB: 1YZ1, 2HR9, 3EBM, 4Z9V, 5O9L, 5O9M, 6IZB, 6IZE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00838	TCTP	1 → 168	Translationally controlled tumour protein	Domain

• Sequence:

  MIIYRDLISHDEMFSDIYKIREIADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGE
  GTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAE
  QIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKC

• Sequence length: 172

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17199135
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	12872291

Unknown
Disease name	Disease term	dbSNP ID	References
Kidney neoplasm	Kidney Neoplasm		28321044
Kidney cancer	Malignant neoplasm of kidney		28321044
Prostatic neoplasms	Prostatic Neoplasms		17199135