TPP2 (tripeptidyl peptidase 2)

Gene

• Entrez ID: 7174
• Gene name: Tripeptidyl peptidase 2
• Gene symbol: TPP2
• Synonyms: IMD78, TPP-2, TPP-II, TPPII
• Chromosome: 13
• Chromosome location: 13q33.1
• Summary: This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular ma

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1566356753	G>C	Likely-pathogenic	Splice donor variant
rs1595184407	->A	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs1595188566	C>-	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020939	hsa-miR-155-5p	Proteomics	18668040
MIRT032480	hsa-let-7b-5p	Proteomics	18668040
MIRT1450038	hsa-miR-1207-5p	CLIP-seq
MIRT1450039	hsa-miR-1299	CLIP-seq
MIRT1450040	hsa-miR-3646	CLIP-seq
MIRT1450041	hsa-miR-4514	CLIP-seq
MIRT1450042	hsa-miR-4652-3p	CLIP-seq
MIRT1450043	hsa-miR-4670-3p	CLIP-seq
MIRT1450044	hsa-miR-4692	CLIP-seq
MIRT1450045	hsa-miR-4736	CLIP-seq
MIRT1450046	hsa-miR-4763-3p	CLIP-seq
MIRT1450047	hsa-miR-4782-5p	CLIP-seq
MIRT1450048	hsa-miR-516b	CLIP-seq
MIRT1450049	hsa-miR-875-3p	CLIP-seq
MIRT1450050	hsa-miR-940	CLIP-seq
MIRT2134520	hsa-miR-1265	CLIP-seq
MIRT2134521	hsa-miR-1298	CLIP-seq
MIRT2134522	hsa-miR-3144-3p	CLIP-seq
MIRT2134523	hsa-miR-3163	CLIP-seq
MIRT2134524	hsa-miR-3194-3p	CLIP-seq
MIRT2134525	hsa-miR-335	CLIP-seq
MIRT2134526	hsa-miR-3605-5p	CLIP-seq
MIRT2134527	hsa-miR-376a	CLIP-seq
MIRT2134528	hsa-miR-376b	CLIP-seq
MIRT2134529	hsa-miR-3941	CLIP-seq
MIRT2134530	hsa-miR-4477a	CLIP-seq
MIRT2134531	hsa-miR-4502	CLIP-seq
MIRT2134532	hsa-miR-4539	CLIP-seq
MIRT2134533	hsa-miR-4643	CLIP-seq
MIRT2134534	hsa-miR-466	CLIP-seq
MIRT2134535	hsa-miR-4666-5p	CLIP-seq
MIRT2134536	hsa-miR-4672	CLIP-seq
MIRT2134537	hsa-miR-4762-3p	CLIP-seq
MIRT2134538	hsa-miR-4777-5p	CLIP-seq
MIRT2134539	hsa-miR-4789-3p	CLIP-seq
MIRT2134540	hsa-miR-630	CLIP-seq
MIRT2134541	hsa-miR-660	CLIP-seq
MIRT2134542	hsa-miR-664	CLIP-seq
MIRT2134521	hsa-miR-1298	CLIP-seq
MIRT2355830	hsa-miR-2681	CLIP-seq
MIRT2355831	hsa-miR-320e	CLIP-seq
MIRT2134527	hsa-miR-376a	CLIP-seq
MIRT2134528	hsa-miR-376b	CLIP-seq
MIRT2134529	hsa-miR-3941	CLIP-seq
MIRT2134531	hsa-miR-4502	CLIP-seq
MIRT2134533	hsa-miR-4643	CLIP-seq
MIRT2134534	hsa-miR-466	CLIP-seq
MIRT2134536	hsa-miR-4672	CLIP-seq
MIRT2355832	hsa-miR-4724-3p	CLIP-seq
MIRT2134537	hsa-miR-4762-3p	CLIP-seq
MIRT2134539	hsa-miR-4789-3p	CLIP-seq
MIRT2355833	hsa-miR-548n	CLIP-seq
MIRT2355834	hsa-miR-548t	CLIP-seq
MIRT2134540	hsa-miR-630	CLIP-seq
MIRT2134542	hsa-miR-664	CLIP-seq
MIRT2134520	hsa-miR-1265	CLIP-seq
MIRT2134521	hsa-miR-1298	CLIP-seq
MIRT2134524	hsa-miR-3194-3p	CLIP-seq
MIRT2134525	hsa-miR-335	CLIP-seq
MIRT2134526	hsa-miR-3605-5p	CLIP-seq
MIRT2396256	hsa-miR-3647-3p	CLIP-seq
MIRT2134527	hsa-miR-376a	CLIP-seq
MIRT2134528	hsa-miR-376b	CLIP-seq
MIRT2134531	hsa-miR-4502	CLIP-seq
MIRT2134532	hsa-miR-4539	CLIP-seq
MIRT2134537	hsa-miR-4762-3p	CLIP-seq
MIRT2396257	hsa-miR-4764-5p	CLIP-seq
MIRT2134540	hsa-miR-630	CLIP-seq
MIRT2134542	hsa-miR-664	CLIP-seq
MIRT2649356	hsa-miR-138	CLIP-seq
MIRT2649357	hsa-miR-2113	CLIP-seq
MIRT2649358	hsa-miR-218	CLIP-seq
MIRT2649359	hsa-miR-30a	CLIP-seq
MIRT2649360	hsa-miR-30b	CLIP-seq
MIRT2649361	hsa-miR-30c	CLIP-seq
MIRT2649362	hsa-miR-30d	CLIP-seq
MIRT2649363	hsa-miR-30e	CLIP-seq
MIRT2649364	hsa-miR-3127-3p	CLIP-seq
MIRT2649365	hsa-miR-3679-3p	CLIP-seq
MIRT2649366	hsa-miR-4252	CLIP-seq
MIRT2649367	hsa-miR-4446-5p	CLIP-seq
MIRT2649368	hsa-miR-4495	CLIP-seq
MIRT2649369	hsa-miR-4776-3p	CLIP-seq
MIRT2649370	hsa-miR-579	CLIP-seq
MIRT2134520	hsa-miR-1265	CLIP-seq
MIRT2134521	hsa-miR-1298	CLIP-seq
MIRT2649356	hsa-miR-138	CLIP-seq
MIRT2649357	hsa-miR-2113	CLIP-seq
MIRT2649358	hsa-miR-218	CLIP-seq
MIRT2649364	hsa-miR-3127-3p	CLIP-seq
MIRT2134524	hsa-miR-3194-3p	CLIP-seq
MIRT2134525	hsa-miR-335	CLIP-seq
MIRT2134526	hsa-miR-3605-5p	CLIP-seq
MIRT2396256	hsa-miR-3647-3p	CLIP-seq
MIRT2693982	hsa-miR-3662	CLIP-seq
MIRT2649365	hsa-miR-3679-3p	CLIP-seq
MIRT2134527	hsa-miR-376a	CLIP-seq
MIRT2134528	hsa-miR-376b	CLIP-seq
MIRT2134529	hsa-miR-3941	CLIP-seq
MIRT2649366	hsa-miR-4252	CLIP-seq
MIRT2649367	hsa-miR-4446-5p	CLIP-seq
MIRT2134531	hsa-miR-4502	CLIP-seq
MIRT2134532	hsa-miR-4539	CLIP-seq
MIRT2134533	hsa-miR-4643	CLIP-seq
MIRT2134534	hsa-miR-466	CLIP-seq
MIRT2134536	hsa-miR-4672	CLIP-seq
MIRT2134537	hsa-miR-4762-3p	CLIP-seq
MIRT2396257	hsa-miR-4764-5p	CLIP-seq
MIRT2134539	hsa-miR-4789-3p	CLIP-seq
MIRT2649370	hsa-miR-579	CLIP-seq
MIRT2134540	hsa-miR-630	CLIP-seq
MIRT2134542	hsa-miR-664	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0004175	Function	Endopeptidase activity	TAS	9974389
GO:0004177	Function	Aminopeptidase activity	IEA
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 31515488
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	TAS	9974389
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0008240	Function	Tripeptidyl-peptidase activity	IBA	21873635
GO:0016604	Component	Nuclear body	IDA
GO:0042802	Function	Identical protein binding	IPI	22483107

Other IDs

• MIM: 190470
• HGNC: 12016
• e!Ensembl: ENSG00000134900

Protein

• UniProt ID: P29144
• Protein name: Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II)
• Protein function: Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00082	Peptidase_S8	35 → 500	Subtilase family	Domain
  PF12580	TPPII	777 → 964	Tripeptidyl peptidase II	Family

• Sequence:

  MATAATEEPFPFHGLLPKKETGAASFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDG
  KPKIVDIIDTTGSGDVNTATEVEPKDGEIVGLSGRVLKIPASWTNPSGKYHIGIKNGYDF
  YPKALKERIQKERKEKIWDPVHRVALAEACRKQEEFDVANNGSSQANKLIKEELQSQVEL
  LNSFEKKYSDPGPVYDCLVWHDGEVWRACIDSNEDGDLSKSTVLRNYKEAQEYGSFGTAE
  MLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTR
  LSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNIIYVSSA
  GNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGAL
  GVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALILSGLKANNIDYTVHSVRR
  ALENTAVKADNIEVFAQGHGIIQVDKAYDYLVQNTSFANKLGFTVTVGNNRGIYLRDPVQ
  VAAPSDHGVGIEPVFPENTENSEKISLQLHLALTSNSSWVQCPSHLELMNQCRHINIRVD
  PRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIR
  RHFIEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLTE
  AFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLK
  YEDLAPCITLKNWVQTLRPVSAKTKPLGSRDVLPNNRQLYEMVLTYNFHQPKSGEVTPSC
  PLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDL
  ERLKDLPFIVSHRLSNTLSLDIHENHSFALLGKKKSSNLTLPPKYNQPFFVTSLPDDKIP
  KGAGPGCYLAGSLTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEE
  FTEALRDLKIQWMTKLDSSDIYNELKETYPNYLPLYVARLHQLDAEKERMKRLNEIVDAA
  NAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHTQA
  QDGAISTDAEGKEEEGESPLDSLAETFWETTKWTDLFDNKVLTFAYKHALVNKMYGRGLK
  FATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF

• Sequence length: 1249

Pathways

Reactome:

Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Autoimmune hemolytic anemia	Autoimmune hemolytic anemia
Autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome	Autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome
Evans syndrome	Evans syndrome		25525876
Immune thrombocytopenic purpura	Immune thrombocytopenic purpura
Lupus erythematosus	Lupus Erythematosus, Systemic
Lymphopenia	Lymphopenia
Otitis media	Recurrent otitis media	rs601338, rs1047781, rs1800028
Stroke	Cerebrovascular accident