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TPO (thyroid peroxidase)
Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7173
Gene nameGene Name - the full gene name approved by the HGNC.
Thyroid peroxidase
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TPO
SynonymsGene synonyms aliases
MSA, TDH2A, TPX
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p25.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pa
SNPsSNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
SNP ID Visualize variation Clinical significance Consequence
rs104893669 A>G,T Pathogenic Coding sequence variant, missense variant
rs121908082 C>A,G,T Pathogenic Coding sequence variant, missense variant, intron variant, stop gained, synonymous variant
rs121908083 T>G Pathogenic Coding sequence variant, missense variant
rs121908084 G>A,C Pathogenic Intron variant, coding sequence variant, missense variant
rs121908085 G>A Pathogenic Intron variant, coding sequence variant, missense variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT018757 hsa-miR-335-5p Microarray 18185580
MIRT030038 hsa-miR-26b-5p Microarray 19088304
MIRT736607 hsa-let-7a-3p RNA-seq, qRT-PCR 32824820
MIRT1449916 hsa-miR-1292 CLIP-seq
MIRT1449917 hsa-miR-3122 CLIP-seq
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
CLOCK Unknown 22284746
FOXA2 Activation 8602863
FOXE1 Unknown 10329730;20094846
TTF2 Activation 8602863
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0004447 Function Iodide peroxidase activity IEA
GO:0004601 Function Peroxidase activity IBA 21873635
GO:0004601 Function Peroxidase activity TAS
GO:0005509 Function Calcium ion binding IEA
GO:0005615 Component Extracellular space HDA 22664934
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P07202
Protein name Thyroid peroxidase (TPO) (EC 1.11.1.8)
Protein function Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03098 An_peroxidase
151 → 709
Animal haem peroxidase
 Domain
PF00084 Sushi
742 → 794
Sushi repeat (SCR repeat)
 Domain
PF07645 EGF_CA
796 → 838
Calcium-binding EGF domain
 Domain
Sequence 
MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
Sequence length 933
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Tyrosine metabolism
Metabolic pathways
Thyroid hormone synthesis
Autoimmune thyroid disease 		  Thyroxine biosynthesis
Associated diseases
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Autoimmune diseases Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 rs41285370, rs869025224 27869686, 30595370, 30595370
Congenital hypothyroidism Congenital Hypothyroidism rs121909180, rs121912646, rs121912648, rs1587178555, rs530719719, rs189261858, rs567500345, rs560702757, rs374620255, rs774517670 12564727, 17381485, 14751036, 16187919, 27166716
Deficiency of iodide peroxidase Deficiency of iodide peroxidase (disorder) rs121908082, rs104893669, rs121908083, rs121908084, rs121908085, rs760307139, rs121908086, rs1573459560, rs770781635, rs1573380429, rs121908088, rs1491142370, rs1057518950, rs140124953, rs763941231, rs766399662, rs1558307375, rs763662774, rs1667768234 12938097, 11874711, 12213873, 10084596, 27166716, 27305979, 11916616, 11061528, 12864797, 7550241, 16684826, 27617131, 12843174, 23512414, 1401057, 16284446, 11415848, 17468186, 9024270, 10468986, 27373559, 12490071, 23236987, 9924196, 18029453, 15745925, 24482635, 25241611, 14751036
Developmental delay Global developmental delay, Gross motor development delay rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074
Unknown
Disease name Disease term dbSNP ID References
Bipolar disorder Bipolar Disorder 17141745
Congenital exomphalos Congenital exomphalos
Congenital myxedema Myxedema, Congenital 16187919, 14751036, 17381485, 12564727
Dwarfism Dwarfism

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