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C2 (complement C2)
Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
717
Gene nameGene Name - the full gene name approved by the HGNC.
Complement C2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
C2
SynonymsGene synonyms aliases
ARMD14, CO2
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.33
SummarySummary of gene provided in NCBI Entrez Gene.
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. D
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT017726 hsa-miR-335-5p Microarray 18185580
MIRT017726 hsa-miR-335-5p Microarray 18185580
MIRT021561 hsa-miR-142-3p Microarray 17612493
MIRT2188317 hsa-miR-1827 CLIP-seq
MIRT2188318 hsa-miR-1910 CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0005515 Function Protein binding IPI 25910212, 32296183
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space TAS 8621452
GO:0006508 Process Proteolysis IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P06681
Protein name Complement C2 (C3/C5 convertase) [Cleaved into: Complement C2a; Serine protease complement C2b (EC 3.4.21.43)]
Protein function Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune
PDB 2I6Q , 2I6S , 2ODP , 2ODQ , 3ERB , 8ACF , 8ACI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00084 Sushi
89 → 144
Sushi repeat (SCR repeat)
 Domain
PF00084 Sushi
151 → 204
Sushi repeat (SCR repeat)
 Domain
PF00092 VWA
254 → 451
von Willebrand factor type A domain
 Domain
PF00089 Trypsin
466 → 711
Trypsin
 Domain
Sequence
Sequence length 752
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Complement and coagulation cascades
Alcoholic liver disease
Pertussis
Staphylococcus aureus infection
Coronavirus disease - COVID-19
Systemic lupus erythematosus 		  Initial triggering of complement
Activation of C3 and C5
Regulation of Complement cascade
Associated diseases
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Age-related macular degeneration MACULAR DEGENERATION, AGE-RELATED, 14, Age related macular degeneration rs2133900556, rs199474657, rs2274700, rs1410996, rs61750120, rs1800728, rs62654397, rs61749423, rs61751412, rs61749439, rs61751398, rs61752417, rs62645946, rs1801269, rs62646860, rs61750142, rs61750145, rs61750152, rs61751377, rs61753029, rs61751407, rs61751389, rs61750645, rs61750648, rs879255520, rs752147871, rs886044750, rs886044749, rs746541266, rs756840095, rs886044725, rs749526785, rs1057518955, rs1057518767, rs371489809, rs1064793014, rs1571264574, rs1659524475 22705344, 20385819, 21665990, 16518403, 22694956, 23577725
Complement component deficiency COMPLEMENT COMPONENT 2 DEFICIENCY, Complement deficiency disease rs387906509, rs1467298230, rs1022194067, rs774370086, rs121964922, rs372345940, rs121913052, rs121913053, rs460897, rs121913054, rs121913056, rs121913058, rs796052138, rs41286844, rs121909592, rs34000044, rs121909594, rs121909587, rs121909588, rs387906554, rs587776846, rs2135727106, rs460184, rs775967055, rs398122811, rs140813121, rs146187042, rs372968576, rs398122867, rs398122868, rs9332736, rs398124644, rs142881576, rs531103546, rs764871530, rs778518669, rs139491301, rs61469168, rs1554718962, rs1565789104, rs1579848888, rs779723422, rs867425110, rs770367814 9670930, 8621452, 7901282, 1577763, 7901282
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537 29212778, 28714975, 30104761
Dermatitis Dermatitis, Irritant rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 27258892
Unknown
Disease name Disease term dbSNP ID References
Dermatomyositis Dermatomyositis, Adult type dermatomyositis, Dermatomyositis, Childhood Type 3501473
Development disorder Child Development Disorders, Pervasive 28540026
Endometriosis Endometriosis rs1800629, rs1143634 28881265
Exudative macular degeneration Exudative age-related macular degeneration, exudative macular degeneration 22705344

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