TPBG (trophoblast glycoprotein)

Gene

• Entrez ID: 7162
• Gene name: Trophoblast glycoprotein
• Gene symbol: TPBG
• Synonyms: 5T4, 5T4AG, M6P1, WAIF1
• Chromosome: 6
• Chromosome location: 6q14.1
• Summary: This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is ass

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020868	hsa-miR-155-5p	Proteomics	18668040
MIRT028555	hsa-miR-30a-5p	Proteomics	18668040
MIRT031878	hsa-miR-16-5p	Proteomics	18668040
MIRT032386	hsa-let-7b-5p	Proteomics	18668040
MIRT041063	hsa-miR-505-3p	CLASH	23622248
MIRT528648	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT528647	hsa-miR-141-5p	PAR-CLIP	22012620
MIRT528645	hsa-miR-6830-5p	PAR-CLIP	22012620
MIRT361344	hsa-miR-208a-5p	PAR-CLIP	24398324
MIRT361346	hsa-miR-208b-5p	PAR-CLIP	24398324
MIRT361349	hsa-miR-1827	PAR-CLIP	24398324
MIRT361350	hsa-miR-3140-3p	PAR-CLIP	24398324
MIRT499259	hsa-miR-516a-5p	PAR-CLIP	24398324
MIRT499258	hsa-miR-6765-5p	PAR-CLIP	24398324
MIRT392440	hsa-miR-653-5p	PAR-CLIP	24398324
MIRT361347	hsa-miR-1304-5p	PAR-CLIP	24398324
MIRT528648	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT528647	hsa-miR-141-5p	PAR-CLIP	22012620
MIRT528645	hsa-miR-6830-5p	PAR-CLIP	22012620
MIRT361344	hsa-miR-208a-5p	PAR-CLIP	24398324
MIRT361346	hsa-miR-208b-5p	PAR-CLIP	24398324
MIRT361349	hsa-miR-1827	PAR-CLIP	24398324
MIRT361350	hsa-miR-3140-3p	PAR-CLIP	24398324
MIRT499259	hsa-miR-516a-5p	PAR-CLIP	24398324
MIRT499258	hsa-miR-6765-5p	PAR-CLIP	24398324
MIRT392440	hsa-miR-653-5p	PAR-CLIP	24398324
MIRT361347	hsa-miR-1304-5p	PAR-CLIP	24398324
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448921	hsa-miR-1324	CLIP-seq
MIRT1448922	hsa-miR-298	CLIP-seq
MIRT1448923	hsa-miR-3120-3p	CLIP-seq
MIRT1448924	hsa-miR-323-3p	CLIP-seq
MIRT1448925	hsa-miR-329	CLIP-seq
MIRT1448926	hsa-miR-3605-5p	CLIP-seq
MIRT1448927	hsa-miR-3613-3p	CLIP-seq
MIRT1448928	hsa-miR-362-3p	CLIP-seq
MIRT1448929	hsa-miR-3944-5p	CLIP-seq
MIRT1448930	hsa-miR-451b	CLIP-seq
MIRT1448931	hsa-miR-452	CLIP-seq
MIRT1448932	hsa-miR-4523	CLIP-seq
MIRT1448933	hsa-miR-4676-3p	CLIP-seq
MIRT1448934	hsa-miR-4796-3p	CLIP-seq
MIRT1448935	hsa-miR-548a-5p	CLIP-seq
MIRT1448936	hsa-miR-548ab	CLIP-seq
MIRT1448937	hsa-miR-548ak	CLIP-seq
MIRT1448938	hsa-miR-548b-5p	CLIP-seq
MIRT1448939	hsa-miR-548c-5p	CLIP-seq
MIRT1448940	hsa-miR-548d-5p	CLIP-seq
MIRT1448941	hsa-miR-548g	CLIP-seq
MIRT1448942	hsa-miR-548h	CLIP-seq
MIRT1448943	hsa-miR-548i	CLIP-seq
MIRT1448944	hsa-miR-548j	CLIP-seq
MIRT1448945	hsa-miR-548n	CLIP-seq
MIRT1448946	hsa-miR-548w	CLIP-seq
MIRT1448947	hsa-miR-548y	CLIP-seq
MIRT1448948	hsa-miR-559	CLIP-seq
MIRT1448949	hsa-miR-600	CLIP-seq
MIRT1448950	hsa-miR-1224-5p	CLIP-seq
MIRT1448951	hsa-miR-1284	CLIP-seq
MIRT1448952	hsa-miR-1304	CLIP-seq
MIRT1448921	hsa-miR-1324	CLIP-seq
MIRT1448923	hsa-miR-3120-3p	CLIP-seq
MIRT1448953	hsa-miR-3150b-3p	CLIP-seq
MIRT1448954	hsa-miR-3915	CLIP-seq
MIRT1448930	hsa-miR-451b	CLIP-seq
MIRT1448955	hsa-miR-4641	CLIP-seq
MIRT1448956	hsa-miR-4689	CLIP-seq
MIRT1448957	hsa-miR-4731-3p	CLIP-seq
MIRT1448958	hsa-miR-4784	CLIP-seq
MIRT1448959	hsa-miR-4789-5p	CLIP-seq
MIRT1448960	hsa-miR-4801	CLIP-seq
MIRT1448961	hsa-miR-653	CLIP-seq
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448922	hsa-miR-298	CLIP-seq
MIRT2134329	hsa-miR-607	CLIP-seq
MIRT1448924	hsa-miR-323-3p	CLIP-seq
MIRT2134330	hsa-miR-3614-3p	CLIP-seq
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448951	hsa-miR-1284	CLIP-seq
MIRT2355529	hsa-miR-221	CLIP-seq
MIRT2355530	hsa-miR-222	CLIP-seq
MIRT1448924	hsa-miR-323-3p	CLIP-seq
MIRT1448926	hsa-miR-3605-5p	CLIP-seq
MIRT2355531	hsa-miR-3681	CLIP-seq
MIRT2355532	hsa-miR-3973	CLIP-seq
MIRT2355533	hsa-miR-4420	CLIP-seq
MIRT1448957	hsa-miR-4731-3p	CLIP-seq
MIRT1448959	hsa-miR-4789-5p	CLIP-seq
MIRT1448960	hsa-miR-4801	CLIP-seq
MIRT2355534	hsa-miR-520g	CLIP-seq
MIRT2355535	hsa-miR-520h	CLIP-seq
MIRT2355536	hsa-miR-548v	CLIP-seq
MIRT1448949	hsa-miR-600	CLIP-seq
MIRT2355537	hsa-miR-765	CLIP-seq
MIRT2434300	hsa-miR-3127-3p	CLIP-seq
MIRT2355533	hsa-miR-4420	CLIP-seq
MIRT2434301	hsa-miR-605	CLIP-seq
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448923	hsa-miR-3120-3p	CLIP-seq
MIRT1448930	hsa-miR-451b	CLIP-seq
MIRT1448955	hsa-miR-4641	CLIP-seq
MIRT2441494	hsa-miR-4716-5p	CLIP-seq
MIRT2441495	hsa-miR-4728-3p	CLIP-seq
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448950	hsa-miR-1224-5p	CLIP-seq
MIRT1448951	hsa-miR-1284	CLIP-seq
MIRT2649136	hsa-miR-142-5p	CLIP-seq
MIRT2649137	hsa-miR-1470	CLIP-seq
MIRT1448923	hsa-miR-3120-3p	CLIP-seq
MIRT2649138	hsa-miR-3145-3p	CLIP-seq
MIRT1448953	hsa-miR-3150b-3p	CLIP-seq
MIRT1448924	hsa-miR-323-3p	CLIP-seq
MIRT1448925	hsa-miR-329	CLIP-seq
MIRT1448928	hsa-miR-362-3p	CLIP-seq
MIRT1448954	hsa-miR-3915	CLIP-seq
MIRT1448930	hsa-miR-451b	CLIP-seq
MIRT1448932	hsa-miR-4523	CLIP-seq
MIRT1448955	hsa-miR-4641	CLIP-seq
MIRT2649139	hsa-miR-4667-3p	CLIP-seq
MIRT2649140	hsa-miR-4668-3p	CLIP-seq
MIRT1448956	hsa-miR-4689	CLIP-seq
MIRT2441494	hsa-miR-4716-5p	CLIP-seq
MIRT2441495	hsa-miR-4728-3p	CLIP-seq
MIRT1448957	hsa-miR-4731-3p	CLIP-seq
MIRT1448958	hsa-miR-4784	CLIP-seq
MIRT1448959	hsa-miR-4789-5p	CLIP-seq
MIRT1448960	hsa-miR-4801	CLIP-seq
MIRT1448935	hsa-miR-548a-5p	CLIP-seq
MIRT1448936	hsa-miR-548ab	CLIP-seq
MIRT1448937	hsa-miR-548ak	CLIP-seq
MIRT1448938	hsa-miR-548b-5p	CLIP-seq
MIRT2649141	hsa-miR-548c-3p	CLIP-seq
MIRT1448939	hsa-miR-548c-5p	CLIP-seq
MIRT1448940	hsa-miR-548d-5p	CLIP-seq
MIRT1448942	hsa-miR-548h	CLIP-seq
MIRT1448943	hsa-miR-548i	CLIP-seq
MIRT1448944	hsa-miR-548j	CLIP-seq
MIRT2649142	hsa-miR-548k	CLIP-seq
MIRT2649143	hsa-miR-548l	CLIP-seq
MIRT1448946	hsa-miR-548w	CLIP-seq
MIRT1448947	hsa-miR-548y	CLIP-seq
MIRT1448948	hsa-miR-559	CLIP-seq
MIRT1448949	hsa-miR-600	CLIP-seq
MIRT2434301	hsa-miR-605	CLIP-seq
MIRT1448920	hsa-miR-1206	CLIP-seq
MIRT1448950	hsa-miR-1224-5p	CLIP-seq
MIRT1448951	hsa-miR-1284	CLIP-seq
MIRT2649137	hsa-miR-1470	CLIP-seq
MIRT1448923	hsa-miR-3120-3p	CLIP-seq
MIRT1448953	hsa-miR-3150b-3p	CLIP-seq
MIRT1448924	hsa-miR-323-3p	CLIP-seq
MIRT1448925	hsa-miR-329	CLIP-seq
MIRT1448928	hsa-miR-362-3p	CLIP-seq
MIRT1448954	hsa-miR-3915	CLIP-seq
MIRT1448930	hsa-miR-451b	CLIP-seq
MIRT1448932	hsa-miR-4523	CLIP-seq
MIRT1448955	hsa-miR-4641	CLIP-seq
MIRT2649139	hsa-miR-4667-3p	CLIP-seq
MIRT2649140	hsa-miR-4668-3p	CLIP-seq
MIRT1448956	hsa-miR-4689	CLIP-seq
MIRT2441494	hsa-miR-4716-5p	CLIP-seq
MIRT2441495	hsa-miR-4728-3p	CLIP-seq
MIRT1448957	hsa-miR-4731-3p	CLIP-seq
MIRT1448958	hsa-miR-4784	CLIP-seq
MIRT1448959	hsa-miR-4789-5p	CLIP-seq
MIRT1448960	hsa-miR-4801	CLIP-seq
MIRT2649141	hsa-miR-548c-3p	CLIP-seq
MIRT1448949	hsa-miR-600	CLIP-seq
MIRT2434301	hsa-miR-605	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005887	Component	Integral component of plasma membrane	TAS	10366710
GO:0007155	Process	Cell adhesion	NAS	10366710
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0008355	Process	Olfactory learning	IEA
GO:0009986	Component	Cell surface	HDA	19581412
GO:0030425	Component	Dendrite	IEA
GO:0043679	Component	Axon terminus	IEA
GO:0050921	Process	Positive regulation of chemotaxis	IEA
GO:0051897	Process	Positive regulation of protein kinase B signaling	IEA
GO:0051932	Process	Synaptic transmission, GABAergic	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0060326	Process	Cell chemotaxis	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0072659	Process	Protein localization to plasma membrane	IEA
GO:0090497	Process	Mesenchymal cell migration	IEA
GO:0140059	Process	Dendrite arborization	IEA

Other IDs

• MIM: 190920
• HGNC: 12004
• e!Ensembl: ENSG00000146242

Protein

• UniProt ID: Q13641
• Protein name: Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1)
• Protein function: May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
• PDB: 4CNC, 4CNM, 6HBY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01462	LRRNT	61 → 90	Leucine rich repeat N-terminal domain	Family
  PF13855	LRR_8	91 → 154	Leucine rich repeat	Repeat
  PF13855	LRR_8	118 → 168	Leucine rich repeat	Repeat
  PF13855	LRR_8	210 → 270	Leucine rich repeat	Repeat
  PF13855	LRR_8	239 → 294	Leucine rich repeat	Repeat
  PF01463	LRRCT	320 → 345	Leucine rich repeat C-terminal domain	Family

• Sequence:

  MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPD
  QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL
  AALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL
  NHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLD
  LSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDC
  HMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLG
  IVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV
  

• Sequence length: 420

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881