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TOP2B (DNA topoisomerase II beta)

Gene

DNA topoisomerase II beta

TOP2B

BILU, TOPIIB, top2beta

3

3p24.2

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional str

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs886039770	G>A	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant

Show/Hide all(145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029687	hsa-miR-26b-5p	Microarray	19088304
MIRT708527	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT708526	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT708525	hsa-miR-1248	HITS-CLIP	19536157
MIRT708524	hsa-miR-1290	HITS-CLIP	19536157
MIRT708523	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT708522	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT708521	hsa-miR-450b-3p	HITS-CLIP	19536157
MIRT708520	hsa-miR-769-3p	HITS-CLIP	19536157
MIRT708519	hsa-miR-6728-5p	HITS-CLIP	19536157
MIRT708518	hsa-miR-5089-5p	HITS-CLIP	19536157
MIRT708517	hsa-miR-3180-5p	HITS-CLIP	19536157
MIRT708516	hsa-miR-6513-5p	HITS-CLIP	19536157
MIRT708527	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT708526	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT708525	hsa-miR-1248	HITS-CLIP	19536157
MIRT708524	hsa-miR-1290	HITS-CLIP	19536157
MIRT708523	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT708522	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT708521	hsa-miR-450b-3p	HITS-CLIP	19536157
MIRT708520	hsa-miR-769-3p	HITS-CLIP	19536157
MIRT708519	hsa-miR-6728-5p	HITS-CLIP	19536157
MIRT708518	hsa-miR-5089-5p	HITS-CLIP	19536157
MIRT708517	hsa-miR-3180-5p	HITS-CLIP	19536157
MIRT708516	hsa-miR-6513-5p	HITS-CLIP	19536157
MIRT756214	hsa-miR-9-3p	Luciferase reporter assay, Western blotting, qRT-PCR	36410793
MIRT756215	hsa-miR-9-5p	Luciferase reporter assay, Western blotting, qRT-PCR	36410793
MIRT1447272	hsa-miR-101	CLIP-seq
MIRT1447273	hsa-miR-1253	CLIP-seq
MIRT1447274	hsa-miR-1276	CLIP-seq
MIRT1447275	hsa-miR-1283	CLIP-seq
MIRT1447276	hsa-miR-1324	CLIP-seq
MIRT1447277	hsa-miR-140-3p	CLIP-seq
MIRT1447278	hsa-miR-1537	CLIP-seq
MIRT1447279	hsa-miR-23a	CLIP-seq
MIRT1447280	hsa-miR-23b	CLIP-seq
MIRT1447281	hsa-miR-23c	CLIP-seq
MIRT1447282	hsa-miR-297	CLIP-seq
MIRT1447283	hsa-miR-3145-3p	CLIP-seq
MIRT1447284	hsa-miR-3177-3p	CLIP-seq
MIRT1447285	hsa-miR-3919	CLIP-seq
MIRT1447286	hsa-miR-4251	CLIP-seq
MIRT1447287	hsa-miR-4275	CLIP-seq
MIRT1447288	hsa-miR-4329	CLIP-seq
MIRT1447289	hsa-miR-4511	CLIP-seq
MIRT1447290	hsa-miR-4645-3p	CLIP-seq
MIRT1447291	hsa-miR-4668-3p	CLIP-seq
MIRT1447292	hsa-miR-4698	CLIP-seq
MIRT1447293	hsa-miR-4731-3p	CLIP-seq
MIRT1447294	hsa-miR-4796-5p	CLIP-seq
MIRT1447295	hsa-miR-4801	CLIP-seq
MIRT1447296	hsa-miR-499-3p	CLIP-seq
MIRT1447297	hsa-miR-499a-3p	CLIP-seq
MIRT1447298	hsa-miR-548a-3p	CLIP-seq
MIRT1447299	hsa-miR-548ac	CLIP-seq
MIRT1447300	hsa-miR-548b-3p	CLIP-seq
MIRT1447301	hsa-miR-548d-3p	CLIP-seq
MIRT1447302	hsa-miR-548e	CLIP-seq
MIRT1447303	hsa-miR-548f	CLIP-seq
MIRT1447304	hsa-miR-548g	CLIP-seq
MIRT1447305	hsa-miR-548z	CLIP-seq
MIRT1447306	hsa-miR-567	CLIP-seq
MIRT1447283	hsa-miR-3145-3p	CLIP-seq
MIRT1447296	hsa-miR-499-3p	CLIP-seq
MIRT1447297	hsa-miR-499a-3p	CLIP-seq
MIRT1447272	hsa-miR-101	CLIP-seq
MIRT1447275	hsa-miR-1283	CLIP-seq
MIRT1447276	hsa-miR-1324	CLIP-seq
MIRT1447277	hsa-miR-140-3p	CLIP-seq
MIRT1447278	hsa-miR-1537	CLIP-seq
MIRT1447279	hsa-miR-23a	CLIP-seq
MIRT1447280	hsa-miR-23b	CLIP-seq
MIRT1447281	hsa-miR-23c	CLIP-seq
MIRT1447284	hsa-miR-3177-3p	CLIP-seq
MIRT1447287	hsa-miR-4275	CLIP-seq
MIRT1447290	hsa-miR-4645-3p	CLIP-seq
MIRT1447291	hsa-miR-4668-3p	CLIP-seq
MIRT1447294	hsa-miR-4796-5p	CLIP-seq
MIRT1447296	hsa-miR-499-3p	CLIP-seq
MIRT1447297	hsa-miR-499a-3p	CLIP-seq
MIRT1447299	hsa-miR-548ac	CLIP-seq
MIRT1447301	hsa-miR-548d-3p	CLIP-seq
MIRT1447305	hsa-miR-548z	CLIP-seq
MIRT1447272	hsa-miR-101	CLIP-seq
MIRT1447275	hsa-miR-1283	CLIP-seq
MIRT1447276	hsa-miR-1324	CLIP-seq
MIRT1447279	hsa-miR-23a	CLIP-seq
MIRT1447280	hsa-miR-23b	CLIP-seq
MIRT1447281	hsa-miR-23c	CLIP-seq
MIRT2354872	hsa-miR-3137	CLIP-seq
MIRT1447284	hsa-miR-3177-3p	CLIP-seq
MIRT2354873	hsa-miR-3613-3p	CLIP-seq
MIRT1447287	hsa-miR-4275	CLIP-seq
MIRT1447290	hsa-miR-4645-3p	CLIP-seq
MIRT1447291	hsa-miR-4668-3p	CLIP-seq
MIRT2354874	hsa-miR-4703-3p	CLIP-seq
MIRT1447294	hsa-miR-4796-5p	CLIP-seq
MIRT1447296	hsa-miR-499-3p	CLIP-seq
MIRT1447297	hsa-miR-499a-3p	CLIP-seq
MIRT2354875	hsa-miR-513a-3p	CLIP-seq
MIRT2354876	hsa-miR-579	CLIP-seq
MIRT2354877	hsa-miR-607	CLIP-seq
MIRT1447273	hsa-miR-1253	CLIP-seq
MIRT1447285	hsa-miR-3919	CLIP-seq
MIRT1447293	hsa-miR-4731-3p	CLIP-seq
MIRT1447295	hsa-miR-4801	CLIP-seq
MIRT1447279	hsa-miR-23a	CLIP-seq
MIRT1447280	hsa-miR-23b	CLIP-seq
MIRT1447281	hsa-miR-23c	CLIP-seq
MIRT1447273	hsa-miR-1253	CLIP-seq
MIRT1447274	hsa-miR-1276	CLIP-seq
MIRT2648628	hsa-miR-2113	CLIP-seq
MIRT2648629	hsa-miR-218	CLIP-seq
MIRT1447282	hsa-miR-297	CLIP-seq
MIRT1447283	hsa-miR-3145-3p	CLIP-seq
MIRT1447285	hsa-miR-3919	CLIP-seq
MIRT1447289	hsa-miR-4511	CLIP-seq
MIRT1447293	hsa-miR-4731-3p	CLIP-seq
MIRT1447295	hsa-miR-4801	CLIP-seq
MIRT1447298	hsa-miR-548a-3p	CLIP-seq
MIRT1447300	hsa-miR-548b-3p	CLIP-seq
MIRT1447302	hsa-miR-548e	CLIP-seq
MIRT1447303	hsa-miR-548f	CLIP-seq
MIRT1447304	hsa-miR-548g	CLIP-seq
MIRT1447306	hsa-miR-567	CLIP-seq
MIRT2648630	hsa-miR-653	CLIP-seq
MIRT2648631	hsa-miR-9	CLIP-seq
MIRT1447273	hsa-miR-1253	CLIP-seq
MIRT1447274	hsa-miR-1276	CLIP-seq
MIRT1447282	hsa-miR-297	CLIP-seq
MIRT1447283	hsa-miR-3145-3p	CLIP-seq
MIRT1447284	hsa-miR-3177-3p	CLIP-seq
MIRT1447285	hsa-miR-3919	CLIP-seq
MIRT1447289	hsa-miR-4511	CLIP-seq
MIRT1447291	hsa-miR-4668-3p	CLIP-seq
MIRT1447293	hsa-miR-4731-3p	CLIP-seq
MIRT1447294	hsa-miR-4796-5p	CLIP-seq
MIRT1447295	hsa-miR-4801	CLIP-seq
MIRT1447298	hsa-miR-548a-3p	CLIP-seq
MIRT1447300	hsa-miR-548b-3p	CLIP-seq
MIRT1447302	hsa-miR-548e	CLIP-seq
MIRT1447303	hsa-miR-548f	CLIP-seq
MIRT1447304	hsa-miR-548g	CLIP-seq
MIRT1447306	hsa-miR-567	CLIP-seq
MIRT2648630	hsa-miR-653	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000712	Process	Resolution of meiotic recombination intermediates	IBA	21873635
GO:0000792	Component	Heterochromatin	IDA	9049244
GO:0000819	Process	Sister chromatid segregation	IBA	21873635
GO:0001764	Process	Neuron migration	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IDA	9049244
GO:0003918	Function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IDA	10684600
GO:0005080	Function	Protein kinase C binding	IPI	16611985
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	9049244, 9155056, 17567603
GO:0005654	Component	Nucleoplasm	IDA	9049244
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	8299728, 9155056
GO:0005730	Component	Nucleolus	IDA	9049244
GO:0005829	Component	Cytosol	IDA	9049244
GO:0006265	Process	DNA topological change	IDA	10684600
GO:0007409	Process	Axonogenesis	IEA
GO:0008022	Function	Protein C-terminus binding	IPI	10666337
GO:0019899	Function	Enzyme binding	IPI	17567603
GO:0030900	Process	Forebrain development	IEA
GO:0042826	Function	Histone deacetylase binding	IPI	11062478, 11136718
GO:0045870	Process	Positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP	16712776
GO:0046872	Function	Metal ion binding	IEA
GO:0046982	Function	Protein heterodimerization activity	IPI	10473615
GO:1990904	Component	Ribonucleoprotein complex	ISS

MIM	HGNC	e!Ensembl
126431	11990	ENSG00000077097

Protein

UniProt ID

Protein name

DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)

Protein function

Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Pl

PDB

3QX3 , 4G0U , 4G0V , 4G0W , 4J3N , 5GWI , 5GWJ , 5ZAD , 5ZEN , 5ZQF , 5ZRF , 7QFN , 7QFO , 7YQ8 , 7ZBG , 8KE7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02518	HATPase_c	97 → 246	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	Domain
PF00204	DNA_gyraseB	287 → 451	DNA gyrase B	Domain
PF01751	Toprim	477 → 592	Toprim domain	Family
PF16898	TOPRIM_C	594 → 732	C-terminal associated domain of TOPRIM	Family
PF00521	DNA_topoisoIV	734 → 1190	DNA gyrase/topoisomerase IV, subunit A	Family
PF08070	DTHCT	1508 → 1610	DTHCT (NUC029) region	Family

Sequence

MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQ
LEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRD
KNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT
GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITF
QPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKL
DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE
VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFF
KAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLIL
TEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVK
ASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFR
YAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI
NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHH
GEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP
AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM
LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV
LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNS
MVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI
QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSG
PDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVE
SQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK
KKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTS
SGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDD
DADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKK
SQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPS
SDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNP
GRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDV
DFAMFN

Sequence length

1626

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance		SUMOylation of DNA replication proteins

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Autism spectrum disorder	Autism Spectrum Disorders	rs724159978, rs75184679, rs119103221, rs9332964, rs121912562, rs1594344233, rs727504317, rs111033204, rs1801086, rs587784464, rs724159948, rs764659822, rs794727977, rs796052733, rs796052728, rs762292772, rs864321694, rs869312878, rs758432471, rs750896617, rs886039692, rs886039770, rs201037487, rs200483989, rs1057518198, rs1057517708, rs780267761, rs1555910143, rs1057519632, rs775225727, rs751037529, rs1064794848, rs1064795655, rs1131691548, rs1135401811, rs1553248081, rs1454466097, rs1554480537, rs1553578503, rs1553518509, rs774152851, rs1554481395, rs1554464807, rs1554401434, rs1452048149, rs370498156, rs756691187, rs1557863430, rs1557863440, rs1557863546, rs769581210, rs202098093, rs1276388879, rs778792467, rs760059077, rs373783340, rs1557867853, rs772572695, rs753214391, rs749270162, rs548226228, rs1557870645, rs1557874046, rs749548928, rs754532606, rs1557901347, rs1557902023, rs1557909572, rs574335012, rs1557909821, rs1372713010, rs561369202, rs1476293577, rs1557910728, rs1557911386, rs375045125, rs998675361, rs1557916296, rs1557935477, rs866632178, rs1561824498, rs1396313317, rs1564801388, rs1564801473, rs1564950387, rs1565527302, rs1569513495, rs1569305431, rs143944436, rs1563183492, rs1561846159, rs1565819425, rs1562957809, rs1585645641, rs1585016242, rs1595127294, rs1585667374, rs1585653028, rs1585653240, rs1592919048, rs1585645384, rs1789927813
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	30804561

Show/Hide Unknown Diseases (4)

Unknown
Disease name	Disease term	dbSNP ID	References
B-cell immunodeficiency-limb anomaly-urogenital malformation syndrome	B-cell immunodeficiency-limb anomaly-urogenital malformation syndrome
Monocytic leukemia	Leukemia, Monocytic, Chronic		16932348
Myeloid leukemia	Myeloid Leukemia		16932348
Prostatic neoplasms	Prostatic Intraepithelial Neoplasias		20601956

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