TNFRSF1B (TNF receptor superfamily member 1B)

Gene

• Entrez ID: 7133
• Gene name: TNF receptor superfamily member 1B
• Gene symbol: TNFRSF1B
• Synonyms: CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
• Chromosome: 1
• Chromosome location: 1p36.22
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT717194	hsa-miR-96-3p	HITS-CLIP	19536157
MIRT717193	hsa-miR-299-3p	HITS-CLIP	19536157
MIRT717192	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT717191	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT717190	hsa-miR-6072	HITS-CLIP	19536157
MIRT717189	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT717188	hsa-miR-3909	HITS-CLIP	19536157
MIRT717187	hsa-miR-6852-3p	HITS-CLIP	19536157
MIRT439411	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT439411	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT129887	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT129893	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT129958	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT129959	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT717194	hsa-miR-96-3p	HITS-CLIP	19536157
MIRT717193	hsa-miR-299-3p	HITS-CLIP	19536157
MIRT717192	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT717191	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT717190	hsa-miR-6072	HITS-CLIP	19536157
MIRT717189	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT717188	hsa-miR-3909	HITS-CLIP	19536157
MIRT717187	hsa-miR-6852-3p	HITS-CLIP	19536157
MIRT1443038	hsa-miR-122	CLIP-seq
MIRT1443039	hsa-miR-1224-3p	CLIP-seq
MIRT1443040	hsa-miR-1260	CLIP-seq
MIRT1443041	hsa-miR-1260b	CLIP-seq
MIRT1443042	hsa-miR-1280	CLIP-seq
MIRT1443043	hsa-miR-1307	CLIP-seq
MIRT1443044	hsa-miR-150	CLIP-seq
MIRT1443045	hsa-miR-3135b	CLIP-seq
MIRT1443046	hsa-miR-3155	CLIP-seq
MIRT1443047	hsa-miR-3155b	CLIP-seq
MIRT1443048	hsa-miR-3170	CLIP-seq
MIRT1443049	hsa-miR-3187-3p	CLIP-seq
MIRT1443050	hsa-miR-323b-3p	CLIP-seq
MIRT1443051	hsa-miR-3652	CLIP-seq
MIRT1443052	hsa-miR-3663-5p	CLIP-seq
MIRT1443053	hsa-miR-3929	CLIP-seq
MIRT1443054	hsa-miR-4419b	CLIP-seq
MIRT1443055	hsa-miR-4430	CLIP-seq
MIRT1443056	hsa-miR-4435	CLIP-seq
MIRT1443057	hsa-miR-4478	CLIP-seq
MIRT1443058	hsa-miR-450b-3p	CLIP-seq
MIRT1443059	hsa-miR-4532	CLIP-seq
MIRT1443060	hsa-miR-4638-5p	CLIP-seq
MIRT1443061	hsa-miR-4695-3p	CLIP-seq
MIRT1443062	hsa-miR-4701-5p	CLIP-seq
MIRT1443063	hsa-miR-4713-3p	CLIP-seq
MIRT1443064	hsa-miR-4713-5p	CLIP-seq
MIRT1443065	hsa-miR-4716-5p	CLIP-seq
MIRT1443066	hsa-miR-4731-3p	CLIP-seq
MIRT1443067	hsa-miR-4755-3p	CLIP-seq
MIRT1443068	hsa-miR-4772-3p	CLIP-seq
MIRT1443069	hsa-miR-4781-3p	CLIP-seq
MIRT1443070	hsa-miR-4786-3p	CLIP-seq
MIRT1443071	hsa-miR-4801	CLIP-seq
MIRT1443072	hsa-miR-484	CLIP-seq
MIRT1443073	hsa-miR-532-3p	CLIP-seq
MIRT1443074	hsa-miR-548s	CLIP-seq
MIRT1443075	hsa-miR-588	CLIP-seq
MIRT1443076	hsa-miR-635	CLIP-seq
MIRT1443077	hsa-miR-638	CLIP-seq
MIRT1443078	hsa-miR-720	CLIP-seq
MIRT1443079	hsa-miR-769-3p	CLIP-seq
MIRT2132600	hsa-miR-103b	CLIP-seq
MIRT2132601	hsa-miR-1178	CLIP-seq
MIRT2132602	hsa-miR-1184	CLIP-seq
MIRT2132603	hsa-miR-1207-3p	CLIP-seq
MIRT2132604	hsa-miR-1207-5p	CLIP-seq
MIRT1443038	hsa-miR-122	CLIP-seq
MIRT2132605	hsa-miR-125a-3p	CLIP-seq
MIRT1443043	hsa-miR-1307	CLIP-seq
MIRT2132606	hsa-miR-142-3p	CLIP-seq
MIRT1443045	hsa-miR-3135b	CLIP-seq
MIRT2132607	hsa-miR-3150a-5p	CLIP-seq
MIRT2132608	hsa-miR-3150b-5p	CLIP-seq
MIRT1443046	hsa-miR-3155	CLIP-seq
MIRT1443047	hsa-miR-3155b	CLIP-seq
MIRT1443049	hsa-miR-3187-3p	CLIP-seq
MIRT1443051	hsa-miR-3652	CLIP-seq
MIRT1443052	hsa-miR-3663-5p	CLIP-seq
MIRT2132609	hsa-miR-3665	CLIP-seq
MIRT2132610	hsa-miR-3677-5p	CLIP-seq
MIRT2132611	hsa-miR-371-5p	CLIP-seq
MIRT1443053	hsa-miR-3929	CLIP-seq
MIRT2132612	hsa-miR-3934	CLIP-seq
MIRT2132613	hsa-miR-3944-5p	CLIP-seq
MIRT2132614	hsa-miR-4280	CLIP-seq
MIRT1443054	hsa-miR-4419b	CLIP-seq
MIRT1443055	hsa-miR-4430	CLIP-seq
MIRT1443056	hsa-miR-4435	CLIP-seq
MIRT1443057	hsa-miR-4478	CLIP-seq
MIRT2132615	hsa-miR-4634	CLIP-seq
MIRT1443060	hsa-miR-4638-5p	CLIP-seq
MIRT1443061	hsa-miR-4695-3p	CLIP-seq
MIRT1443062	hsa-miR-4701-5p	CLIP-seq
MIRT2132616	hsa-miR-4736	CLIP-seq
MIRT1443067	hsa-miR-4755-3p	CLIP-seq
MIRT2132617	hsa-miR-4763-3p	CLIP-seq
MIRT1443068	hsa-miR-4772-3p	CLIP-seq
MIRT1443072	hsa-miR-484	CLIP-seq
MIRT1443074	hsa-miR-548s	CLIP-seq
MIRT1443075	hsa-miR-588	CLIP-seq
MIRT2132618	hsa-miR-601	CLIP-seq
MIRT2132619	hsa-miR-639	CLIP-seq
MIRT2132620	hsa-miR-640	CLIP-seq
MIRT2132621	hsa-miR-645	CLIP-seq
MIRT1443078	hsa-miR-720	CLIP-seq
MIRT2132622	hsa-miR-764	CLIP-seq
MIRT2132600	hsa-miR-103b	CLIP-seq
MIRT2353571	hsa-miR-106a	CLIP-seq
MIRT2353572	hsa-miR-106b	CLIP-seq
MIRT2132601	hsa-miR-1178	CLIP-seq
MIRT2132602	hsa-miR-1184	CLIP-seq
MIRT2132604	hsa-miR-1207-5p	CLIP-seq
MIRT1443038	hsa-miR-122	CLIP-seq
MIRT2353573	hsa-miR-1225-3p	CLIP-seq
MIRT2353574	hsa-miR-1343	CLIP-seq
MIRT2132606	hsa-miR-142-3p	CLIP-seq
MIRT1443044	hsa-miR-150	CLIP-seq
MIRT2353575	hsa-miR-17	CLIP-seq
MIRT2353576	hsa-miR-1825	CLIP-seq
MIRT2353577	hsa-miR-1972	CLIP-seq
MIRT2353578	hsa-miR-199a-5p	CLIP-seq
MIRT2353579	hsa-miR-199b-5p	CLIP-seq
MIRT2353580	hsa-miR-20a	CLIP-seq
MIRT2353581	hsa-miR-20b	CLIP-seq
MIRT2353582	hsa-miR-302a	CLIP-seq
MIRT2353583	hsa-miR-302b	CLIP-seq
MIRT2353584	hsa-miR-302c	CLIP-seq
MIRT2353585	hsa-miR-302d	CLIP-seq
MIRT2353586	hsa-miR-302e	CLIP-seq
MIRT1443045	hsa-miR-3135b	CLIP-seq
MIRT1443046	hsa-miR-3155	CLIP-seq
MIRT1443047	hsa-miR-3155b	CLIP-seq
MIRT2353587	hsa-miR-3166	CLIP-seq
MIRT2353588	hsa-miR-3180-5p	CLIP-seq
MIRT1443049	hsa-miR-3187-3p	CLIP-seq
MIRT2353589	hsa-miR-3614-5p	CLIP-seq
MIRT1443051	hsa-miR-3652	CLIP-seq
MIRT2132610	hsa-miR-3677-5p	CLIP-seq
MIRT2132611	hsa-miR-371-5p	CLIP-seq
MIRT2353590	hsa-miR-372	CLIP-seq
MIRT2353591	hsa-miR-373	CLIP-seq
MIRT2353592	hsa-miR-378g	CLIP-seq
MIRT2353593	hsa-miR-3925-3p	CLIP-seq
MIRT2132614	hsa-miR-4280	CLIP-seq
MIRT2353594	hsa-miR-4427	CLIP-seq
MIRT1443055	hsa-miR-4430	CLIP-seq
MIRT2353595	hsa-miR-4437	CLIP-seq
MIRT2353596	hsa-miR-4457	CLIP-seq
MIRT1443058	hsa-miR-450b-3p	CLIP-seq
MIRT2132615	hsa-miR-4634	CLIP-seq
MIRT2353597	hsa-miR-4674	CLIP-seq
MIRT1443061	hsa-miR-4695-3p	CLIP-seq
MIRT1443063	hsa-miR-4713-3p	CLIP-seq
MIRT2353598	hsa-miR-4714-3p	CLIP-seq
MIRT2353599	hsa-miR-4717-5p	CLIP-seq
MIRT1443066	hsa-miR-4731-3p	CLIP-seq
MIRT2353600	hsa-miR-4731-5p	CLIP-seq
MIRT2132616	hsa-miR-4736	CLIP-seq
MIRT2353601	hsa-miR-4749-3p	CLIP-seq
MIRT2132617	hsa-miR-4763-3p	CLIP-seq
MIRT1443071	hsa-miR-4801	CLIP-seq
MIRT1443072	hsa-miR-484	CLIP-seq
MIRT2353602	hsa-miR-512-3p	CLIP-seq
MIRT2353603	hsa-miR-519d	CLIP-seq
MIRT2353604	hsa-miR-520a-3p	CLIP-seq
MIRT2353605	hsa-miR-520b	CLIP-seq
MIRT2353606	hsa-miR-520c-3p	CLIP-seq
MIRT2353607	hsa-miR-520d-3p	CLIP-seq
MIRT2353608	hsa-miR-520e	CLIP-seq
MIRT2353609	hsa-miR-520g	CLIP-seq
MIRT2353610	hsa-miR-520h	CLIP-seq
MIRT1443077	hsa-miR-638	CLIP-seq
MIRT2132619	hsa-miR-639	CLIP-seq
MIRT2353611	hsa-miR-665	CLIP-seq
MIRT1443078	hsa-miR-720	CLIP-seq
MIRT1443079	hsa-miR-769-3p	CLIP-seq
MIRT2353612	hsa-miR-93	CLIP-seq
MIRT2132600	hsa-miR-103b	CLIP-seq
MIRT2132602	hsa-miR-1184	CLIP-seq
MIRT1443038	hsa-miR-122	CLIP-seq
MIRT1443043	hsa-miR-1307	CLIP-seq
MIRT2396115	hsa-miR-193b	CLIP-seq
MIRT1443045	hsa-miR-3135b	CLIP-seq
MIRT1443046	hsa-miR-3155	CLIP-seq
MIRT1443047	hsa-miR-3155b	CLIP-seq
MIRT1443049	hsa-miR-3187-3p	CLIP-seq
MIRT2353589	hsa-miR-3614-5p	CLIP-seq
MIRT1443051	hsa-miR-3652	CLIP-seq
MIRT2132611	hsa-miR-371-5p	CLIP-seq
MIRT2396116	hsa-miR-4258	CLIP-seq
MIRT1443055	hsa-miR-4430	CLIP-seq
MIRT1443058	hsa-miR-450b-3p	CLIP-seq
MIRT2396117	hsa-miR-4529-5p	CLIP-seq
MIRT1443060	hsa-miR-4638-5p	CLIP-seq
MIRT1443061	hsa-miR-4695-3p	CLIP-seq
MIRT2396118	hsa-miR-4707-3p	CLIP-seq
MIRT1443063	hsa-miR-4713-3p	CLIP-seq
MIRT2396119	hsa-miR-4735-5p	CLIP-seq
MIRT1443068	hsa-miR-4772-3p	CLIP-seq
MIRT2396120	hsa-miR-4796-3p	CLIP-seq
MIRT1443072	hsa-miR-484	CLIP-seq
MIRT2353609	hsa-miR-520g	CLIP-seq
MIRT2353610	hsa-miR-520h	CLIP-seq
MIRT1443077	hsa-miR-638	CLIP-seq
MIRT2132619	hsa-miR-639	CLIP-seq
MIRT1443078	hsa-miR-720	CLIP-seq
MIRT1443079	hsa-miR-769-3p	CLIP-seq
MIRT2132604	hsa-miR-1207-5p	CLIP-seq
MIRT2396115	hsa-miR-193b	CLIP-seq
MIRT1443049	hsa-miR-3187-3p	CLIP-seq
MIRT2353589	hsa-miR-3614-5p	CLIP-seq
MIRT2441447	hsa-miR-4260	CLIP-seq
MIRT2441448	hsa-miR-4436b-3p	CLIP-seq
MIRT1443058	hsa-miR-450b-3p	CLIP-seq
MIRT2396117	hsa-miR-4529-5p	CLIP-seq
MIRT1443063	hsa-miR-4713-3p	CLIP-seq
MIRT2132616	hsa-miR-4736	CLIP-seq
MIRT2132617	hsa-miR-4763-3p	CLIP-seq
MIRT2396120	hsa-miR-4796-3p	CLIP-seq
MIRT2353609	hsa-miR-520g	CLIP-seq
MIRT2353610	hsa-miR-520h	CLIP-seq
MIRT1443077	hsa-miR-638	CLIP-seq
MIRT1443079	hsa-miR-769-3p	CLIP-seq
MIRT2462063	hsa-miR-1273f	CLIP-seq
MIRT1443045	hsa-miR-3135b	CLIP-seq
MIRT1443046	hsa-miR-3155	CLIP-seq
MIRT1443047	hsa-miR-3155b	CLIP-seq
MIRT1443048	hsa-miR-3170	CLIP-seq
MIRT1443051	hsa-miR-3652	CLIP-seq
MIRT2462064	hsa-miR-3686	CLIP-seq
MIRT2462065	hsa-miR-411	CLIP-seq
MIRT1443055	hsa-miR-4430	CLIP-seq
MIRT2462066	hsa-miR-4446-3p	CLIP-seq
MIRT2462067	hsa-miR-4652-3p	CLIP-seq
MIRT2462068	hsa-miR-4715-3p	CLIP-seq
MIRT2396119	hsa-miR-4735-5p	CLIP-seq
MIRT2462069	hsa-miR-4742-3p	CLIP-seq
MIRT1443072	hsa-miR-484	CLIP-seq
MIRT2462063	hsa-miR-1273f	CLIP-seq
MIRT1443048	hsa-miR-3170	CLIP-seq
MIRT2462064	hsa-miR-3686	CLIP-seq
MIRT2462065	hsa-miR-411	CLIP-seq
MIRT2462067	hsa-miR-4652-3p	CLIP-seq
MIRT2396119	hsa-miR-4735-5p	CLIP-seq
MIRT2462069	hsa-miR-4742-3p	CLIP-seq
MIRT2647785	hsa-miR-1197	CLIP-seq
MIRT1443038	hsa-miR-122	CLIP-seq
MIRT2462063	hsa-miR-1273f	CLIP-seq
MIRT2647786	hsa-miR-3135	CLIP-seq
MIRT1443045	hsa-miR-3135b	CLIP-seq
MIRT1443048	hsa-miR-3170	CLIP-seq
MIRT2647787	hsa-miR-3650	CLIP-seq
MIRT1443051	hsa-miR-3652	CLIP-seq
MIRT2462064	hsa-miR-3686	CLIP-seq
MIRT2462065	hsa-miR-411	CLIP-seq
MIRT2647788	hsa-miR-4428	CLIP-seq
MIRT1443055	hsa-miR-4430	CLIP-seq
MIRT1443059	hsa-miR-4532	CLIP-seq
MIRT2462067	hsa-miR-4652-3p	CLIP-seq
MIRT2396119	hsa-miR-4735-5p	CLIP-seq
MIRT2462069	hsa-miR-4742-3p	CLIP-seq
MIRT2647789	hsa-miR-644	CLIP-seq
MIRT2647790	hsa-miR-663b	CLIP-seq
MIRT1443038	hsa-miR-122	CLIP-seq
MIRT2462063	hsa-miR-1273f	CLIP-seq
MIRT1443043	hsa-miR-1307	CLIP-seq
MIRT1443045	hsa-miR-3135b	CLIP-seq
MIRT1443051	hsa-miR-3652	CLIP-seq
MIRT2462064	hsa-miR-3686	CLIP-seq
MIRT2462065	hsa-miR-411	CLIP-seq
MIRT2693702	hsa-miR-4279	CLIP-seq
MIRT2693703	hsa-miR-4297	CLIP-seq
MIRT1443055	hsa-miR-4430	CLIP-seq
MIRT1443060	hsa-miR-4638-5p	CLIP-seq
MIRT2462067	hsa-miR-4652-3p	CLIP-seq
MIRT1443061	hsa-miR-4695-3p	CLIP-seq
MIRT2396119	hsa-miR-4735-5p	CLIP-seq
MIRT2462069	hsa-miR-4742-3p	CLIP-seq
MIRT2693704	hsa-miR-532-5p	CLIP-seq
MIRT1443078	hsa-miR-720	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
JUN	Activation	9743209

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002718	Process	Regulation of cytokine production involved in immune response	ISS
GO:0002724	Process	Regulation of T cell cytokine production	IBA	21873635
GO:0002724	Process	Regulation of T cell cytokine production	ISS
GO:0002947	Component	Tumor necrosis factor receptor superfamily complex	TAS	24966471
GO:0003176	Process	Aortic valve development	ISS
GO:0003177	Process	Pulmonary valve development	ISS
GO:0003332	Process	Negative regulation of extracellular matrix constituent secretion	ISS
GO:0005031	Function	Tumor necrosis factor-activated receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	8069916, 10848577, 11244088, 14743216, 24070898, 25609706
GO:0005576	Component	Extracellular region	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	IEA
GO:0007568	Process	Aging	IEA
GO:0008630	Process	Intrinsic apoptotic signaling pathway in response to DNA damage	IBA	21873635
GO:0010614	Process	Negative regulation of cardiac muscle hypertrophy	IEA
GO:0016020	Component	Membrane	TAS	24966471
GO:0016021	Component	Integral component of membrane	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	11279055
GO:0031641	Process	Regulation of myelination	ISS
GO:0031643	Process	Positive regulation of myelination	IBA	21873635
GO:0031643	Process	Positive regulation of myelination	ISS
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS	24966471
GO:0035579	Component	Specific granule membrane	TAS
GO:0042129	Process	Regulation of T cell proliferation	IBA	21873635
GO:0042129	Process	Regulation of T cell proliferation	ISS
GO:0043025	Component	Neuronal cell body	IEA
GO:0043120	Function	Tumor necrosis factor binding	IBA	21873635
GO:0043120	Function	Tumor necrosis factor binding	IPI	9435233
GO:0043196	Component	Varicosity	IEA
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045121	Component	Membrane raft	IDA	17010968
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	IBA	21873635
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	ISS
GO:0050779	Process	RNA destabilization	IEA
GO:0051044	Process	Positive regulation of membrane protein ectodomain proteolysis	IBA	21873635
GO:0051044	Process	Positive regulation of membrane protein ectodomain proteolysis	IMP	22480688
GO:0060548	Process	Negative regulation of cell death	ISS
GO:0071222	Process	Cellular response to lipopolysaccharide	IMP	22480688
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IBA	21873635
GO:0150077	Process	Regulation of neuroinflammatory response	ISS
GO:0150079	Process	Negative regulation of neuroinflammatory response	IBA	21873635
GO:0150079	Process	Negative regulation of neuroinflammatory response	ISS
GO:0150098	Process	Glial cell-neuron signaling	ISS
GO:1901215	Process	Negative regulation of neuron death	IBA	21873635
GO:1901215	Process	Negative regulation of neuron death	ISS
GO:1902339	Process	Positive regulation of apoptotic process involved in morphogenesis	ISS
GO:2001141	Process	Regulation of RNA biosynthetic process	ISS

Other IDs

• MIM: 191191
• HGNC: 11917
• e!Ensembl: ENSG00000028137

Protein

• UniProt ID: P20333
• Protein name: Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis fac
• Protein function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor media
• PDB: 1CA9, 3ALQ, 8HLB, 9CU8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00020	TNFR_c6	40 → 75	TNFR/NGFR cysteine-rich region	Domain
  PF00020	TNFR_c6	78 → 118	TNFR/NGFR cysteine-rich region	Domain
  PF00020	TNFR_c6	120 → 161	TNFR/NGFR cysteine-rich region	Domain

• Sequence:

  MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPG
  QHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTC
  RPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICR
  PHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTS
  FLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKV
  PHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGE
  ARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQ
  VPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS

• Sequence length: 461

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
TNF signaling pathway
Adipocytokine signaling pathway
Amyotrophic lateral sclerosis
Pathways of neurodegeneration - multiple diseases
Human immunodeficiency virus 1 infection

Reactome:

TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	16139734
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	11882518
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605	30595370
Lymphoma	Lymphoma, T-Cell, Cutaneous	rs11540652, rs1592119138, rs1592123162, rs1599367044
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	11782876
Palmoplantar keratoderma	Keratoderma, Palmoplantar	rs59616921, rs1568039793, rs746488412, rs200564757, rs1567027297, rs781596375, rs1567027610, rs398123054, rs398123055, rs398123056, rs398123057, rs398122949, rs398122950, rs397515639, rs398122951, rs397515640, rs397515641, rs142859678, rs797044479, rs577442939, rs672601344, rs568609861, rs1057518846, rs1182196436, rs1567037561
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	11126399, 20842464
Sezary syndrome	Sezary Syndrome	rs587776632	26258847

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia
Cerebral ischemia	Brain Ischemia		15829914
Ectropion	Ectropion
Eczema	Eczema
Exfoliative dermatitis	Exfoliative dermatitis
Gangrene	Gangrene
Hyperkeratosis	Hyperkeratosis
Hypoalbuminemia	Hypoalbuminemia		15044820
Immunologic deficiency syndromes	Immunologic Deficiency Syndromes
Liver cirrhosis	Liver Cirrhosis		20353583
Liver fibrosis	Fibrosis, Liver		20353583
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	17094069, 16458261, 24047966, 24094876, 17094069, 16458261, 24094876, 24047966
Nail dystrophy	Dystrophia unguium
Nervous system diseases	Peripheral Nervous System Diseases
Non-alcoholic fatty liver disease	Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis		20353583
Paranoid schizophrenia	Paranoid Schizophrenia		20842464
Poikiloderma	Poikiloderma
Skin neoplasms	Skin Neoplasms