TMPRSS2 (transmembrane serine protease 2)

Gene

• Entrez ID: 7113
• Gene name: Transmembrane serine protease 2
• Gene symbol: TMPRSS2
• Synonyms: PRSS10
• Chromosome: 21
• Chromosome location: 21q22.3
• Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT734703	hsa-miR-98-5p	qRT-PCR	33359190
MIRT734704	hsa-miR-32-3p	qRT-PCR	33359190
MIRT734705	hsa-miR-214-3p	qRT-PCR	33359190
MIRT1441037	hsa-miR-182	CLIP-seq
MIRT1441038	hsa-miR-3130-3p	CLIP-seq
MIRT1441039	hsa-miR-3173-5p	CLIP-seq
MIRT1441040	hsa-miR-330-3p	CLIP-seq
MIRT1441041	hsa-miR-361-3p	CLIP-seq
MIRT1441042	hsa-miR-362-5p	CLIP-seq
MIRT1441043	hsa-miR-3665	CLIP-seq
MIRT1441044	hsa-miR-3679-3p	CLIP-seq
MIRT1441045	hsa-miR-3682-3p	CLIP-seq
MIRT1441046	hsa-miR-3944-5p	CLIP-seq
MIRT1441047	hsa-miR-4253	CLIP-seq
MIRT1441048	hsa-miR-4279	CLIP-seq
MIRT1441049	hsa-miR-4433	CLIP-seq
MIRT1441050	hsa-miR-4470	CLIP-seq
MIRT1441051	hsa-miR-4688	CLIP-seq
MIRT1441052	hsa-miR-4691-5p	CLIP-seq
MIRT1441053	hsa-miR-4717-5p	CLIP-seq
MIRT1441054	hsa-miR-4722-3p	CLIP-seq
MIRT1441055	hsa-miR-4733-3p	CLIP-seq
MIRT1441056	hsa-miR-4755-3p	CLIP-seq
MIRT1441057	hsa-miR-4758-3p	CLIP-seq
MIRT1441058	hsa-miR-500b	CLIP-seq
MIRT1441059	hsa-miR-550b	CLIP-seq
MIRT1441060	hsa-miR-646	CLIP-seq
MIRT1441061	hsa-miR-657	CLIP-seq
MIRT1441062	hsa-miR-665	CLIP-seq
MIRT1441063	hsa-miR-767-5p	CLIP-seq
MIRT1441064	hsa-miR-769-5p	CLIP-seq
MIRT1441065	hsa-miR-890	CLIP-seq
MIRT1441066	hsa-let-7a	CLIP-seq
MIRT1441067	hsa-let-7b	CLIP-seq
MIRT1441068	hsa-let-7c	CLIP-seq
MIRT1441069	hsa-let-7d	CLIP-seq
MIRT1441070	hsa-let-7e	CLIP-seq
MIRT1441071	hsa-let-7f	CLIP-seq
MIRT1441072	hsa-let-7g	CLIP-seq
MIRT1441073	hsa-let-7i	CLIP-seq
MIRT1441074	hsa-miR-185	CLIP-seq
MIRT1441075	hsa-miR-202	CLIP-seq
MIRT1441076	hsa-miR-3144-5p	CLIP-seq
MIRT1441077	hsa-miR-3145-3p	CLIP-seq
MIRT1441078	hsa-miR-3180-5p	CLIP-seq
MIRT1441079	hsa-miR-3191	CLIP-seq
MIRT1441080	hsa-miR-3908	CLIP-seq
MIRT1441081	hsa-miR-3929	CLIP-seq
MIRT1441082	hsa-miR-3942-5p	CLIP-seq
MIRT1441083	hsa-miR-4306	CLIP-seq
MIRT1441084	hsa-miR-4419b	CLIP-seq
MIRT1441085	hsa-miR-4458	CLIP-seq
MIRT1441086	hsa-miR-4478	CLIP-seq
MIRT1441087	hsa-miR-4500	CLIP-seq
MIRT1441088	hsa-miR-4505	CLIP-seq
MIRT1441089	hsa-miR-4644	CLIP-seq
MIRT1441090	hsa-miR-4652-5p	CLIP-seq
MIRT1441091	hsa-miR-4667-5p	CLIP-seq
MIRT1441092	hsa-miR-4700-5p	CLIP-seq
MIRT1441093	hsa-miR-4703-5p	CLIP-seq
MIRT1441094	hsa-miR-4731-5p	CLIP-seq
MIRT1441095	hsa-miR-4752	CLIP-seq
MIRT1441096	hsa-miR-4766-3p	CLIP-seq
MIRT1441097	hsa-miR-4803	CLIP-seq
MIRT1441098	hsa-miR-494	CLIP-seq
MIRT1441099	hsa-miR-579	CLIP-seq
MIRT1441100	hsa-miR-664	CLIP-seq
MIRT1441062	hsa-miR-665	CLIP-seq
MIRT1441101	hsa-miR-98	CLIP-seq
MIRT1441066	hsa-let-7a	CLIP-seq
MIRT1441067	hsa-let-7b	CLIP-seq
MIRT1441068	hsa-let-7c	CLIP-seq
MIRT1441069	hsa-let-7d	CLIP-seq
MIRT1441070	hsa-let-7e	CLIP-seq
MIRT1441071	hsa-let-7f	CLIP-seq
MIRT1441072	hsa-let-7g	CLIP-seq
MIRT1441073	hsa-let-7i	CLIP-seq
MIRT2132064	hsa-miR-140-3p	CLIP-seq
MIRT2132065	hsa-miR-3202	CLIP-seq
MIRT2132066	hsa-miR-4310	CLIP-seq
MIRT1441085	hsa-miR-4458	CLIP-seq
MIRT2132067	hsa-miR-4475	CLIP-seq
MIRT1441087	hsa-miR-4500	CLIP-seq
MIRT2132068	hsa-miR-4533	CLIP-seq
MIRT1441060	hsa-miR-646	CLIP-seq
MIRT1441101	hsa-miR-98	CLIP-seq
MIRT2353176	hsa-miR-2277-3p	CLIP-seq
MIRT2353177	hsa-miR-542-3p	CLIP-seq
MIRT1441060	hsa-miR-646	CLIP-seq
MIRT1441066	hsa-let-7a	CLIP-seq
MIRT1441067	hsa-let-7b	CLIP-seq
MIRT1441068	hsa-let-7c	CLIP-seq
MIRT1441069	hsa-let-7d	CLIP-seq
MIRT1441070	hsa-let-7e	CLIP-seq
MIRT1441071	hsa-let-7f	CLIP-seq
MIRT1441072	hsa-let-7g	CLIP-seq
MIRT1441073	hsa-let-7i	CLIP-seq
MIRT1441085	hsa-miR-4458	CLIP-seq
MIRT1441087	hsa-miR-4500	CLIP-seq
MIRT1441060	hsa-miR-646	CLIP-seq
MIRT1441101	hsa-miR-98	CLIP-seq
MIRT1441066	hsa-let-7a	CLIP-seq
MIRT1441067	hsa-let-7b	CLIP-seq
MIRT1441068	hsa-let-7c	CLIP-seq
MIRT1441069	hsa-let-7d	CLIP-seq
MIRT1441070	hsa-let-7e	CLIP-seq
MIRT1441071	hsa-let-7f	CLIP-seq
MIRT1441072	hsa-let-7g	CLIP-seq
MIRT1441073	hsa-let-7i	CLIP-seq
MIRT1441085	hsa-miR-4458	CLIP-seq
MIRT1441087	hsa-miR-4500	CLIP-seq
MIRT2396078	hsa-miR-596	CLIP-seq
MIRT2396079	hsa-miR-939	CLIP-seq
MIRT1441101	hsa-miR-98	CLIP-seq
MIRT2646811	hsa-miR-3176	CLIP-seq
MIRT2646812	hsa-miR-3922-3p	CLIP-seq
MIRT2646813	hsa-miR-4446-3p	CLIP-seq
MIRT2646814	hsa-miR-4639-5p	CLIP-seq
MIRT2646815	hsa-miR-4685-5p	CLIP-seq
MIRT2646816	hsa-miR-4701-5p	CLIP-seq
MIRT2646817	hsa-miR-588	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
AR	Activation	20308527;21761340
AR	Unknown	23192983
ERG	Unknown	24418414
NKX3-1	Unknown	24418414

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005044	Function	Scavenger receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	21068237
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA	21068237
GO:0005887	Component	Integral component of plasma membrane	TAS	9325052
GO:0006508	Process	Proteolysis	IDA	21068237, 24227843
GO:0006897	Process	Endocytosis	IEA
GO:0008236	Function	Serine-type peptidase activity	TAS	9325052
GO:0016540	Process	Protein autoprocessing	IBA	21873635
GO:0016540	Process	Protein autoprocessing	IMP	21068237
GO:0046598	Process	Positive regulation of viral entry into host cell	IDA	21068237, 24227843, 32404436
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145

Other IDs

• MIM: 602060
• HGNC: 11876
• e!Ensembl: ENSG00000184012

Protein

• UniProt ID: O15393
• Protein name: Transmembrane protease serine 2 (EC 3.4.21.122) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain]
• Protein function: Plasma membrane-anchored serine protease that cleaves at arginine residues (PubMed:32703818, PubMed:35676539, PubMed:37990007, PubMed:38964328). Participates in proteolytic cascades of relevance for the normal physiologic function of the prostat
• PDB: 7MEQ, 7XYD, 7Y0E, 7Y0F, 8HD8, 8JHZ, 8JI0, 8S0L, 8S0M, 8S0N, 8V04, 8V1F, 8VGT, 8Y1D, 8Y1E, 8Y7X, 8Y7Y, 8Y87, 8Y88, 8Y89, 8Y8A, 8Y8B, 8YOY, 8YQQ, 9IZN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15494	SRCR_2	153 → 248	Scavenger receptor cysteine-rich domain	Domain
  PF00089	Trypsin	256 → 484	Trypsin	Domain

• Sequence:

  MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
  SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
  DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
  GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
  CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
  PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
  VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
  TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
  TDWIYRQMRADG

• Sequence length: 492

Pathways

KEGG:

Influenza A
Coronavirus disease - COVID-19
Transcriptional misregulation in cancer
Prostate cancer

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	18798265, 28783165, 25735316, 29610475

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		29610475, 28783165, 25735316, 18798265