TLR5 (toll like receptor 5)

Gene

• Entrez ID: 7100
• Gene name: Toll like receptor 5
• Gene symbol: TLR5
• Synonyms: MELIOS, SLE1, SLEB1, TIL3
• Chromosome: 1
• Chromosome location: 1q41
• Summary: This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are express

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs2072493	T>A,C	Risk-factor	Coding sequence variant, missense variant
rs5744168	G>A	Risk-factor, protective	Coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT451800	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT451799	hsa-miR-3185	PAR-CLIP	23592263
MIRT451798	hsa-miR-4645-3p	PAR-CLIP	23592263
MIRT451797	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT451796	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT451795	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT451794	hsa-miR-5194	PAR-CLIP	23592263
MIRT451793	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT451792	hsa-miR-4271	PAR-CLIP	23592263
MIRT451791	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT451789	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT451790	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT451788	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT451800	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT451799	hsa-miR-3185	PAR-CLIP	23592263
MIRT451798	hsa-miR-4645-3p	PAR-CLIP	23592263
MIRT451797	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT451796	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT451795	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT451794	hsa-miR-5194	PAR-CLIP	23592263
MIRT451793	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT451792	hsa-miR-4271	PAR-CLIP	23592263
MIRT451791	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT451789	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT451790	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT451788	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT755873	hsa-miR-27a-3p	Luciferase reporter assay, Western blotting, qRT-PCR, RNA pull down assay	34539823
MIRT1426957	hsa-miR-103a	CLIP-seq
MIRT1426958	hsa-miR-107	CLIP-seq
MIRT1426959	hsa-miR-19a	CLIP-seq
MIRT1426960	hsa-miR-19b	CLIP-seq
MIRT1426961	hsa-miR-2116	CLIP-seq
MIRT1426962	hsa-miR-3607-5p	CLIP-seq
MIRT1426963	hsa-miR-3658	CLIP-seq
MIRT1426964	hsa-miR-3714	CLIP-seq
MIRT1426965	hsa-miR-376c	CLIP-seq
MIRT1426966	hsa-miR-4484	CLIP-seq
MIRT1426967	hsa-miR-4662a-3p	CLIP-seq
MIRT1426968	hsa-miR-4677-5p	CLIP-seq
MIRT1426969	hsa-miR-4716-5p	CLIP-seq
MIRT1426970	hsa-miR-4729	CLIP-seq
MIRT1426971	hsa-miR-4766-5p	CLIP-seq
MIRT1426972	hsa-miR-518a-5p	CLIP-seq
MIRT1426973	hsa-miR-527	CLIP-seq
MIRT1426974	hsa-miR-548an	CLIP-seq
MIRT1426975	hsa-miR-577	CLIP-seq
MIRT1426976	hsa-miR-579	CLIP-seq
MIRT2127900	hsa-miR-3174	CLIP-seq
MIRT2127901	hsa-miR-3606	CLIP-seq
MIRT2127902	hsa-miR-3689d	CLIP-seq
MIRT2127903	hsa-miR-376a	CLIP-seq
MIRT2127904	hsa-miR-376b	CLIP-seq
MIRT2127905	hsa-miR-4443	CLIP-seq
MIRT2127906	hsa-miR-548p	CLIP-seq
MIRT2127907	hsa-miR-587	CLIP-seq
MIRT2127908	hsa-miR-921	CLIP-seq
MIRT2349555	hsa-miR-425	CLIP-seq
MIRT2395857	hsa-miR-1253	CLIP-seq
MIRT2395858	hsa-miR-3156-5p	CLIP-seq
MIRT2395859	hsa-miR-3200-5p	CLIP-seq
MIRT2395860	hsa-miR-4251	CLIP-seq
MIRT2395861	hsa-miR-4329	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002224	Process	Toll-like receptor signaling pathway	IBA	21873635
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005149	Function	Interleukin-1 receptor binding	IPI	12925853
GO:0005515	Function	Protein binding	IPI	30158114
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0032757	Process	Positive regulation of interleukin-8 production	IDA	17128265
GO:0034123	Process	Positive regulation of toll-like receptor signaling pathway	IDA	17128265
GO:0034146	Process	Toll-like receptor 5 signaling pathway	TAS
GO:0038023	Function	Signaling receptor activity	IBA	21873635
GO:0042742	Process	Defense response to bacterium	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445

Other IDs

• MIM: 603031
• HGNC: 11851
• e!Ensembl: ENSG00000187554

Protein

• UniProt ID: O60602
• Protein name: Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
• Protein function: Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molec
• PDB: 3J0A, 8AR2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	79 → 131	Leucine rich repeat	Repeat
  PF13855	LRR_8	288 → 348	Leucine rich repeat	Repeat
  PF13855	LRR_8	491 → 538	Leucine rich repeat	Repeat
  PF01582	TIR	692 → 858	TIR domain	Family

• Sequence:

  MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
  VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
  LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
  QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
  DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
  FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
  KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
  INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
  GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
  LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
  IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
  TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
  DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
  SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKE
  KEKKKDNNIPLQTVATIS

• Sequence length: 858

Pathways

KEGG:

Toll-like receptor signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Legionellosis
Inflammatory bowel disease

Reactome:

Toll Like Receptor 5 (TLR5) Cascade
MyD88 deficiency (TLR5)
IRAK4 deficiency (TLR5)
MyD88 cascade initiated on plasma membrane

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	16284379

Unknown
Disease name	Disease term	dbSNP ID	References
Legionnaires` disease	Legionnaires` Disease
Lupus erythematosus	Lupus Erythematosus, Systemic
Nonbacterial verrucal endocardiosis	Libman-Sacks Disease
Prostatic neoplasms	Prostatic Neoplasms		16284379