TLE4 (TLE family member 4, transcriptional corepressor)

Gene

• Entrez ID: 7091
• Gene name: TLE family member 4, transcriptional corepressor
• Gene symbol: TLE4
• Synonyms: BCE-1, BCE1, E(spI), E(spl), ESG, ESG4, GRG4, Grg-4
• Chromosome: 9
• Chromosome location: 9q21.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005105	hsa-miR-155-5p	Microarray	19193853
MIRT016236	hsa-miR-548b-3p	Sequencing	20371350
MIRT017745	hsa-miR-335-5p	Microarray	18185580
MIRT005105	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT021114	hsa-miR-186-5p	Sequencing	20371350
MIRT027063	hsa-miR-103a-3p	Sequencing	20371350
MIRT029323	hsa-miR-26b-5p	Microarray	19088304
MIRT031643	hsa-miR-16-5p	Sequencing	20371350
MIRT032123	hsa-let-7d-5p	Sequencing	20371350
MIRT046892	hsa-miR-221-3p	CLASH	23622248
MIRT041429	hsa-miR-193b-3p	CLASH	23622248
MIRT726317	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726318	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT031643	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726316	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT1426331	hsa-miR-124	CLIP-seq
MIRT1426332	hsa-miR-1264	CLIP-seq
MIRT1426333	hsa-miR-15a	CLIP-seq
MIRT1426334	hsa-miR-15b	CLIP-seq
MIRT1426335	hsa-miR-16	CLIP-seq
MIRT1426336	hsa-miR-195	CLIP-seq
MIRT1426337	hsa-miR-3127-5p	CLIP-seq
MIRT1426338	hsa-miR-3613-3p	CLIP-seq
MIRT1426339	hsa-miR-424	CLIP-seq
MIRT1426340	hsa-miR-4270	CLIP-seq
MIRT1426341	hsa-miR-4441	CLIP-seq
MIRT1426342	hsa-miR-4524	CLIP-seq
MIRT1426343	hsa-miR-497	CLIP-seq
MIRT1426344	hsa-miR-499-3p	CLIP-seq
MIRT1426345	hsa-miR-499a-3p	CLIP-seq
MIRT1426346	hsa-miR-503	CLIP-seq
MIRT1426347	hsa-miR-506	CLIP-seq
MIRT1426348	hsa-miR-513a-3p	CLIP-seq
MIRT1426349	hsa-miR-545	CLIP-seq
MIRT1426350	hsa-miR-548ac	CLIP-seq
MIRT1426351	hsa-miR-548an	CLIP-seq
MIRT1426352	hsa-miR-548d-3p	CLIP-seq
MIRT1426353	hsa-miR-548z	CLIP-seq
MIRT1426354	hsa-miR-640	CLIP-seq
MIRT1426355	hsa-miR-646	CLIP-seq
MIRT1557192	hsa-miR-3617	CLIP-seq
MIRT1557193	hsa-miR-641	CLIP-seq
MIRT2349492	hsa-miR-1208	CLIP-seq
MIRT2349493	hsa-miR-1279	CLIP-seq
MIRT2349494	hsa-miR-137	CLIP-seq
MIRT2349495	hsa-miR-2115	CLIP-seq
MIRT2349496	hsa-miR-3977	CLIP-seq
MIRT2349497	hsa-miR-4420	CLIP-seq
MIRT2349498	hsa-miR-4716-5p	CLIP-seq
MIRT1426344	hsa-miR-499-3p	CLIP-seq
MIRT1426345	hsa-miR-499a-3p	CLIP-seq
MIRT2349499	hsa-miR-5096	CLIP-seq
MIRT2349500	hsa-miR-516a-3p	CLIP-seq
MIRT2349501	hsa-miR-944	CLIP-seq
MIRT2434048	hsa-miR-106a	CLIP-seq
MIRT2434049	hsa-miR-106b	CLIP-seq
MIRT2434050	hsa-miR-17	CLIP-seq
MIRT2434051	hsa-miR-20a	CLIP-seq
MIRT2434052	hsa-miR-20b	CLIP-seq
MIRT2434053	hsa-miR-2116	CLIP-seq
MIRT2434054	hsa-miR-302a	CLIP-seq
MIRT2434055	hsa-miR-302b	CLIP-seq
MIRT2434056	hsa-miR-302c	CLIP-seq
MIRT2434057	hsa-miR-302d	CLIP-seq
MIRT2434058	hsa-miR-302e	CLIP-seq
MIRT2434059	hsa-miR-3150b-3p	CLIP-seq
MIRT2434060	hsa-miR-3691-3p	CLIP-seq
MIRT2434061	hsa-miR-372	CLIP-seq
MIRT2434062	hsa-miR-373	CLIP-seq
MIRT2434063	hsa-miR-374a	CLIP-seq
MIRT2434064	hsa-miR-374b	CLIP-seq
MIRT2434065	hsa-miR-374c	CLIP-seq
MIRT2434066	hsa-miR-411	CLIP-seq
MIRT2434067	hsa-miR-4434	CLIP-seq
MIRT2434068	hsa-miR-4459	CLIP-seq
MIRT2434069	hsa-miR-4516	CLIP-seq
MIRT2434070	hsa-miR-4677-5p	CLIP-seq
MIRT2434071	hsa-miR-4699-5p	CLIP-seq
MIRT2349498	hsa-miR-4716-5p	CLIP-seq
MIRT2434072	hsa-miR-4784	CLIP-seq
MIRT2434073	hsa-miR-513a-5p	CLIP-seq
MIRT2434074	hsa-miR-519d	CLIP-seq
MIRT2434075	hsa-miR-520a-3p	CLIP-seq
MIRT2434076	hsa-miR-520b	CLIP-seq
MIRT2434077	hsa-miR-520c-3p	CLIP-seq
MIRT2434078	hsa-miR-520d-3p	CLIP-seq
MIRT2434079	hsa-miR-520e	CLIP-seq
MIRT2434080	hsa-miR-520g	CLIP-seq
MIRT2434081	hsa-miR-520h	CLIP-seq
MIRT2434082	hsa-miR-622	CLIP-seq
MIRT2434083	hsa-miR-655	CLIP-seq
MIRT2434084	hsa-miR-665	CLIP-seq
MIRT2434085	hsa-miR-765	CLIP-seq
MIRT2434086	hsa-miR-93	CLIP-seq
MIRT2441299	hsa-miR-183	CLIP-seq
MIRT1426337	hsa-miR-3127-5p	CLIP-seq
MIRT1557192	hsa-miR-3617	CLIP-seq
MIRT2441300	hsa-miR-3657	CLIP-seq
MIRT1426340	hsa-miR-4270	CLIP-seq
MIRT1426341	hsa-miR-4441	CLIP-seq
MIRT2441301	hsa-miR-4669	CLIP-seq
MIRT1557193	hsa-miR-641	CLIP-seq
MIRT2441299	hsa-miR-183	CLIP-seq
MIRT2442747	hsa-miR-208a	CLIP-seq
MIRT2442748	hsa-miR-208b	CLIP-seq
MIRT1426337	hsa-miR-3127-5p	CLIP-seq
MIRT1557192	hsa-miR-3617	CLIP-seq
MIRT2441300	hsa-miR-3657	CLIP-seq
MIRT2442749	hsa-miR-3913-3p	CLIP-seq
MIRT1426340	hsa-miR-4270	CLIP-seq
MIRT1426341	hsa-miR-4441	CLIP-seq
MIRT2441301	hsa-miR-4669	CLIP-seq
MIRT2442750	hsa-miR-489	CLIP-seq
MIRT2442751	hsa-miR-499-5p	CLIP-seq
MIRT1557193	hsa-miR-641	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003714	Function	Transcription corepressor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	24676634
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	NAS	1303260
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IBA	21873635
GO:0008150	Process	Biological_process	ND
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IEA
GO:0070491	Function	Repressing transcription factor binding	IBA	21873635
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IBA	21873635
GO:1904837	Process	Beta-catenin-TCF complex assembly	TAS
GO:1990907	Component	Beta-catenin-TCF complex	IDA	28296634

Other IDs

• MIM: 605132
• HGNC: 11840
• e!Ensembl: ENSG00000106829

Protein

• UniProt ID: Q04727
• Protein name: Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)
• Protein function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be mo
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03920	TLE_N	8 → 138	Groucho/TLE N-terminal Q-rich domain	Family
  PF00400	WD40	571 → 605	WD domain, G-beta repeat	Repeat
  PF00400	WD40	609 → 647	WD domain, G-beta repeat	Repeat

• Sequence:

  MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEK
  TEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQV
  TMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
  HLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIA
  ARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASIASSS
  STPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASSL
  RTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSP
  VVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQ
  INTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCR
  LLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGN
  IAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFT
  SQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTG
  KDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY

• Sequence length: 773

Pathways

KEGG:

Wnt signaling pathway
Notch signaling pathway

Reactome:

Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	12376462
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Unknown
Disease name	Disease term	dbSNP ID	References
Anaplastic carcinoma	Anaplastic carcinoma		12376462
Bipolar disorder	Bipolar Disorder		21254220
Myocardial ischemia	Myocardial Ischemia		16214533