TIMP4 (TIMP metallopeptidase inhibitor 4)

Gene

• Entrez ID: 7079
• Gene name: TIMP metallopeptidase inhibitor 4
• Gene symbol: TIMP4
• Synonyms: TIMP-4
• Chromosome: 3
• Chromosome location: 3p25.2
• Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1425431	hsa-miR-1183	CLIP-seq
MIRT1425432	hsa-miR-1237	CLIP-seq
MIRT1425433	hsa-miR-3162-3p	CLIP-seq
MIRT1425434	hsa-miR-4713-5p	CLIP-seq
MIRT1425435	hsa-miR-4762-3p	CLIP-seq
MIRT2349242	hsa-miR-3127-3p	CLIP-seq
MIRT2349243	hsa-miR-3677-5p	CLIP-seq
MIRT2349244	hsa-miR-4312	CLIP-seq
MIRT2349245	hsa-miR-4435	CLIP-seq
MIRT2349246	hsa-miR-4494	CLIP-seq
MIRT2349247	hsa-miR-4645-3p	CLIP-seq
MIRT2349248	hsa-miR-670	CLIP-seq
MIRT2642615	hsa-miR-1184	CLIP-seq
MIRT2642616	hsa-miR-1205	CLIP-seq
MIRT2642617	hsa-miR-125a-3p	CLIP-seq
MIRT2642618	hsa-miR-146a	CLIP-seq
MIRT2642619	hsa-miR-146b-5p	CLIP-seq
MIRT2642620	hsa-miR-1909	CLIP-seq
MIRT2642621	hsa-miR-3158-5p	CLIP-seq
MIRT2642622	hsa-miR-3194-3p	CLIP-seq
MIRT2642623	hsa-miR-3926	CLIP-seq
MIRT2642624	hsa-miR-3934	CLIP-seq
MIRT2642625	hsa-miR-4428	CLIP-seq
MIRT2642626	hsa-miR-4436a	CLIP-seq
MIRT2642627	hsa-miR-451b	CLIP-seq
MIRT2642628	hsa-miR-4533	CLIP-seq
MIRT2642629	hsa-miR-4747-5p	CLIP-seq
MIRT2642630	hsa-miR-548s	CLIP-seq
MIRT2642631	hsa-miR-764	CLIP-seq
MIRT2642632	hsa-miR-885-3p	CLIP-seq
MIRT2642633	hsa-miR-892b	CLIP-seq
MIRT2642615	hsa-miR-1184	CLIP-seq
MIRT2642616	hsa-miR-1205	CLIP-seq
MIRT2642617	hsa-miR-125a-3p	CLIP-seq
MIRT2642618	hsa-miR-146a	CLIP-seq
MIRT2642619	hsa-miR-146b-5p	CLIP-seq
MIRT2642620	hsa-miR-1909	CLIP-seq
MIRT2642621	hsa-miR-3158-5p	CLIP-seq
MIRT2642622	hsa-miR-3194-3p	CLIP-seq
MIRT2642623	hsa-miR-3926	CLIP-seq
MIRT2642624	hsa-miR-3934	CLIP-seq
MIRT2642625	hsa-miR-4428	CLIP-seq
MIRT2642626	hsa-miR-4436a	CLIP-seq
MIRT2642627	hsa-miR-451b	CLIP-seq
MIRT2642628	hsa-miR-4533	CLIP-seq
MIRT2642629	hsa-miR-4747-5p	CLIP-seq
MIRT2642630	hsa-miR-548s	CLIP-seq
MIRT2642631	hsa-miR-764	CLIP-seq
MIRT2642632	hsa-miR-885-3p	CLIP-seq
MIRT2642633	hsa-miR-892b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002020	Function	Protease binding	IBA	21873635
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007417	Process	Central nervous system development	IEA
GO:0008150	Process	Biological_process	ND
GO:0008191	Function	Metalloendopeptidase inhibitor activity	IBA	21873635
GO:0008191	Function	Metalloendopeptidase inhibitor activity	NAS	8939999
GO:0009725	Process	Response to hormone	IBA	21873635
GO:0010033	Process	Response to organic substance	IBA	21873635
GO:0010951	Process	Negative regulation of endopeptidase activity	IBA	21873635
GO:0030017	Component	Sarcomere	IEA
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0034097	Process	Response to cytokine	IBA	21873635
GO:0042493	Process	Response to drug	IEA
GO:0042698	Process	Ovulation cycle	IEA
GO:0043434	Process	Response to peptide hormone	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051045	Process	Negative regulation of membrane protein ectodomain proteolysis	IBA	21873635

Other IDs

• MIM: 601915
• HGNC: 11823
• e!Ensembl: ENSG00000157150

Protein

• UniProt ID: Q99727
• Protein name: Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (TIMP-4)
• Protein function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00965	TIMP	28 → 207	Tissue inhibitor of metalloproteinase	Domain

• Sequence:

  MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA
  SADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQV
  LSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTD
  WLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP

• Sequence length: 224

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881