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TIMP2 (TIMP metallopeptidase inhibitor 2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7077
Gene nameGene Name - the full gene name approved by the HGNC.
TIMP metallopeptidase inhibitor 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TIMP2
SynonymsGene synonyms aliases
CSC-21K, DDC8
ChromosomeChromosome number
17
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q25.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role a
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006198 hsa-miR-519d-3p Luciferase reporter assay, Western blot 22262409
MIRT006198 hsa-miR-519d-3p Luciferase reporter assay, Western blot 22262409
MIRT006198 hsa-miR-519d-3p Luciferase reporter assay, Western blot 22262409
MIRT006639 hsa-miR-519c-3p Luciferase reporter assay, qRT-PCR, Western blot 22262409
MIRT006769 hsa-miR-200c-3p Luciferase reporter assay 22685266
Transcription factors
Transcription factor Regulation Reference
ETV4 Unknown 8810321
HIF1A Activation 17332917
JUN Unknown 8810321
NR4A1 Activation 22551568
PTTG1 Repression 19351864
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IBA 21873635
GO:0002020 Function Protease binding IPI 9573338
GO:0005178 Function Integrin binding IEA
GO:0005515 Function Protein binding IPI 12032297, 24112707, 28514442, 32296183
GO:0005576 Component Extracellular region TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P16035
Protein name Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)
Protein function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
PDB 1BR9 , 1GXD , 2TMP , 4ILW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00965 TIMP
25 203
Tissue inhibitor of metalloproteinase
Domain
Sequence
Sequence length 220
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Activation of Matrix Metalloproteinases
Neutrophil degranulation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Cholestasis Cholestasis, Extrahepatic rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 28789951
Myocardial infarction Myocardial Infarction rs12316150, rs41303970, rs909253, rs7291467, rs2234693 24358288
Tumoral calcinosis Tumoral calcinosis rs104894343, rs104894344, rs745655924, rs137853086, rs375879489, rs761396172, rs137853087, rs137853091, rs137853088, rs137853089, rs137853090, rs766750282, rs760830864, rs786205250, rs267606841, rs1555096583, rs1220533001, rs762936774, rs775341386 24142982
Unknown
Disease name Disease term dbSNP ID References
Urinary bladder cancer Malignant neoplasm of urinary bladder 30548095
Bladder neoplasm Bladder Neoplasm 30548095
Diverticular diseases Diverticular Diseases 30177863
Dupuytren contracture Dupuytren Contracture, Dupuytren`s Disease 21732829

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