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THRB (thyroid hormone receptor beta)

Gene

7068

Thyroid hormone receptor beta

THRB

C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, THRbeta, THRbeta1, TRb, TRbeta, TRbeta1, Thrbeta2

3p24.2

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that

Show/Hide all(49)

SNP ID	Visualize variation	Clinical significance	Consequence
rs28933408	G>A,C,T	Pathogenic	Missense variant, coding sequence variant
rs28999969	C>T	Pathogenic, conflicting-interpretations-of-pathogenicity	Intron variant, missense variant, coding sequence variant
rs28999970	C>A,T	Pathogenic	Intron variant, missense variant, coding sequence variant
rs28999971	C>T	Pathogenic	Intron variant, missense variant, coding sequence variant
rs121918686	C>A,G,T	Pathogenic, likely-pathogenic	Missense variant, intron variant, coding sequence variant
rs121918687	G>T	Pathogenic	Missense variant, coding sequence variant
rs121918688	C>G,T	Pathogenic	Missense variant, synonymous variant, intron variant, coding sequence variant
rs121918690	C>T	Pathogenic	Missense variant, coding sequence variant
rs121918691	T>C	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs121918692	T>C	Pathogenic	Missense variant, coding sequence variant
rs121918693	C>A,T	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs121918694	C>G,T	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs121918695	C>T	Pathogenic	Missense variant, coding sequence variant
rs121918696	G>A,T	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs121918697	G>A	Pathogenic	Missense variant, intron variant, coding sequence variant
rs121918698	C>T	Pathogenic	Missense variant, coding sequence variant
rs121918699	A>G	Pathogenic	Missense variant, coding sequence variant
rs121918700	C>G	Pathogenic	Missense variant, coding sequence variant
rs121918701	A>T	Pathogenic	Missense variant, coding sequence variant
rs121918702	A>C	Pathogenic	Missense variant, coding sequence variant
rs121918703	A>G	Pathogenic	Missense variant, coding sequence variant
rs121918704	A>G	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs121918705	G>T	Pathogenic	Stop gained, coding sequence variant
rs121918706	C>T	Pathogenic	Missense variant, coding sequence variant
rs121918707	G>A,C	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs121918708	C>T	Pathogenic	Missense variant, coding sequence variant
rs121918709	T>C	Pathogenic	Missense variant, intron variant, coding sequence variant
rs146617205	C>G,T	Conflicting-interpretations-of-pathogenicity	Intron variant
rs367757240	G>A	Pathogenic	Coding sequence variant, missense variant
rs387906515	GTG>-	Pathogenic	Inframe deletion, coding sequence variant, intron variant
rs750905761	G>A,C	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs1057519028	A>C,G	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs1060499695	T>C	Likely-pathogenic	Intron variant, missense variant, coding sequence variant
rs1354053223	A>C	Pathogenic, uncertain-significance	Intron variant, missense variant, coding sequence variant
rs1553609090	C>T	Pathogenic	Missense variant, coding sequence variant
rs1553609119	->G	Pathogenic	Frameshift variant, coding sequence variant
rs1553609152	G>A	Pathogenic	Missense variant, coding sequence variant
rs1553609157	C>A	Likely-pathogenic	Stop gained, coding sequence variant
rs1553609167	TC>AT	Pathogenic	Stop gained, coding sequence variant
rs1553609179	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1553609185	A>C	Pathogenic	Missense variant, coding sequence variant
rs1553609210	C>T	Pathogenic	Missense variant, coding sequence variant
rs1553610974	C>T	Pathogenic	Missense variant, intron variant, coding sequence variant
rs1553610984	G>C	Likely-pathogenic	Missense variant, intron variant, coding sequence variant
rs1553611038	G>T	Pathogenic	Missense variant, intron variant, coding sequence variant
rs1553611075	G>A	Pathogenic	Missense variant, coding sequence variant
rs1553611083	A>G	Pathogenic	Missense variant, coding sequence variant
rs1553611094	T>A,C	Pathogenic	Missense variant, coding sequence variant
rs1553613123	C>G	Likely-pathogenic	Missense variant, coding sequence variant

Show/Hide all(439)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005425	hsa-miR-27a-3p	Luciferase reporter assay, Northern blot, Western blot	21149577
MIRT005425	hsa-miR-27a-3p	Luciferase reporter assay, Northern blot, Western blot	21149577
MIRT005524	hsa-miR-204-5p	Luciferase reporter assay, qRT-PCR, Western blot	20691260
MIRT005524	hsa-miR-204-5p	Luciferase reporter assay, qRT-PCR, Western blot	20691260
MIRT054752	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	24849932
MIRT054753	hsa-miR-425-5p	Luciferase reporter assay, Real time PCR	24849932
MIRT054841	hsa-miR-452-5p	Luciferase reporter assay, qRT-PCR, Western blot	24440748
MIRT721499	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT721498	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT721497	hsa-miR-6509-3p	HITS-CLIP	19536157
MIRT721496	hsa-miR-4436b-5p	HITS-CLIP	19536157
MIRT721495	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT721494	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT713133	hsa-miR-4797-3p	HITS-CLIP	19536157
MIRT713132	hsa-miR-4264	HITS-CLIP	19536157
MIRT713131	hsa-miR-15b-3p	HITS-CLIP	19536157
MIRT713130	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713129	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713128	hsa-miR-6794-3p	HITS-CLIP	19536157
MIRT713133	hsa-miR-4797-3p	HITS-CLIP	19536157
MIRT713132	hsa-miR-4264	HITS-CLIP	19536157
MIRT713131	hsa-miR-15b-3p	HITS-CLIP	19536157
MIRT713130	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713129	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713128	hsa-miR-6794-3p	HITS-CLIP	19536157
MIRT443055	hsa-miR-4753-5p	PAR-CLIP	22100165
MIRT443054	hsa-miR-4778-5p	PAR-CLIP	22100165
MIRT306961	hsa-miR-4677-3p	PAR-CLIP	22100165
MIRT306962	hsa-miR-4679	PAR-CLIP	22100165
MIRT443053	hsa-miR-3926	PAR-CLIP	22100165
MIRT443052	hsa-miR-3689a-5p	PAR-CLIP	22100165
MIRT443051	hsa-miR-3689b-5p	PAR-CLIP	22100165
MIRT443050	hsa-miR-3689e	PAR-CLIP	22100165
MIRT443049	hsa-miR-3689f	PAR-CLIP	22100165
MIRT443048	hsa-miR-3161	PAR-CLIP	22100165
MIRT005425	hsa-miR-27a-3p	qRT-PCR	25156012
MIRT739207	hsa-miR-3611	HITS-CLIP	33718276
MIRT739214	hsa-miR-1270	HITS-CLIP	33718276
MIRT721499	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT721498	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT721497	hsa-miR-6509-3p	HITS-CLIP	19536157
MIRT721496	hsa-miR-4436b-5p	HITS-CLIP	19536157
MIRT721495	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT721494	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT713133	hsa-miR-4797-3p	HITS-CLIP	19536157
MIRT713132	hsa-miR-4264	HITS-CLIP	19536157
MIRT713131	hsa-miR-15b-3p	HITS-CLIP	19536157
MIRT713130	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713129	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713128	hsa-miR-6794-3p	HITS-CLIP	19536157
MIRT713133	hsa-miR-4797-3p	HITS-CLIP	19536157
MIRT713132	hsa-miR-4264	HITS-CLIP	19536157
MIRT713131	hsa-miR-15b-3p	HITS-CLIP	19536157
MIRT713130	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT713129	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT713128	hsa-miR-6794-3p	HITS-CLIP	19536157
MIRT443055	hsa-miR-4753-5p	PAR-CLIP	22100165
MIRT443054	hsa-miR-4778-5p	PAR-CLIP	22100165
MIRT306961	hsa-miR-4677-3p	PAR-CLIP	22100165
MIRT306962	hsa-miR-4679	PAR-CLIP	22100165
MIRT443053	hsa-miR-3926	PAR-CLIP	22100165
MIRT443052	hsa-miR-3689a-5p	PAR-CLIP	22100165
MIRT443051	hsa-miR-3689b-5p	PAR-CLIP	22100165
MIRT443050	hsa-miR-3689e	PAR-CLIP	22100165
MIRT443049	hsa-miR-3689f	PAR-CLIP	22100165
MIRT443048	hsa-miR-3161	PAR-CLIP	22100165
MIRT739934	hsa-miR-1252	CLIP-seq
MIRT1423654	hsa-miR-1281	CLIP-seq
MIRT739210	hsa-miR-143	CLIP-seq
MIRT1423655	hsa-miR-146b-3p	CLIP-seq
MIRT1423656	hsa-miR-18a	CLIP-seq
MIRT1423657	hsa-miR-18b	CLIP-seq
MIRT1423658	hsa-miR-216a	CLIP-seq
MIRT1423659	hsa-miR-216b	CLIP-seq
MIRT1423660	hsa-miR-3173-5p	CLIP-seq
MIRT1423661	hsa-miR-3190	CLIP-seq
MIRT1423662	hsa-miR-335	CLIP-seq
MIRT1423663	hsa-miR-4261	CLIP-seq
MIRT1423664	hsa-miR-4310	CLIP-seq
MIRT1423665	hsa-miR-4326	CLIP-seq
MIRT1423666	hsa-miR-4477b	CLIP-seq
MIRT1423667	hsa-miR-4480	CLIP-seq
MIRT1423668	hsa-miR-4491	CLIP-seq
MIRT1423669	hsa-miR-4657	CLIP-seq
MIRT739213	hsa-miR-4683	CLIP-seq
MIRT1423670	hsa-miR-4688	CLIP-seq
MIRT1423671	hsa-miR-4729	CLIP-seq
MIRT1423672	hsa-miR-4735-3p	CLIP-seq
MIRT739211	hsa-miR-4770	CLIP-seq
MIRT739208	hsa-miR-516a-3p	CLIP-seq
MIRT739209	hsa-miR-556-5p	CLIP-seq
MIRT1423673	hsa-miR-603	CLIP-seq
MIRT739212	hsa-miR-620	CLIP-seq
MIRT1423674	hsa-miR-659	CLIP-seq
MIRT1423675	hsa-miR-873	CLIP-seq
MIRT1423676	hsa-miR-874	CLIP-seq
MIRT739210	hsa-miR-143	CLIP-seq
MIRT739213	hsa-miR-4683	CLIP-seq
MIRT739211	hsa-miR-4770	CLIP-seq
MIRT739208	hsa-miR-516a-3p	CLIP-seq
MIRT739209	hsa-miR-556-5p	CLIP-seq
MIRT739212	hsa-miR-620	CLIP-seq
MIRT1423677	hsa-miR-1	CLIP-seq
MIRT1423678	hsa-miR-1179	CLIP-seq
MIRT1423679	hsa-miR-1910	CLIP-seq
MIRT1423680	hsa-miR-203	CLIP-seq
MIRT1423681	hsa-miR-206	CLIP-seq
MIRT1423682	hsa-miR-23a	CLIP-seq
MIRT1423683	hsa-miR-23b	CLIP-seq
MIRT1423684	hsa-miR-23c	CLIP-seq
MIRT1423685	hsa-miR-3127-3p	CLIP-seq
MIRT1423686	hsa-miR-3130-5p	CLIP-seq
MIRT1423687	hsa-miR-3153	CLIP-seq
MIRT1423662	hsa-miR-335	CLIP-seq
MIRT1423688	hsa-miR-3614-3p	CLIP-seq
MIRT1423689	hsa-miR-3667-3p	CLIP-seq
MIRT1423690	hsa-miR-3673	CLIP-seq
MIRT1423691	hsa-miR-3679-3p	CLIP-seq
MIRT1423692	hsa-miR-3685	CLIP-seq
MIRT1423693	hsa-miR-425	CLIP-seq
MIRT1423694	hsa-miR-4297	CLIP-seq
MIRT1423695	hsa-miR-4318	CLIP-seq
MIRT1423665	hsa-miR-4326	CLIP-seq
MIRT1423696	hsa-miR-4446-5p	CLIP-seq
MIRT1423697	hsa-miR-4482	CLIP-seq
MIRT1423698	hsa-miR-455-3p	CLIP-seq
MIRT1423699	hsa-miR-4668-5p	CLIP-seq
MIRT1423700	hsa-miR-4693-5p	CLIP-seq
MIRT1423701	hsa-miR-4700-3p	CLIP-seq
MIRT1423702	hsa-miR-4780	CLIP-seq
MIRT1423703	hsa-miR-499-3p	CLIP-seq
MIRT1423704	hsa-miR-499a-3p	CLIP-seq
MIRT1423705	hsa-miR-513a-5p	CLIP-seq
MIRT1423706	hsa-miR-613	CLIP-seq
MIRT1423674	hsa-miR-659	CLIP-seq
MIRT1423707	hsa-miR-892a	CLIP-seq
MIRT739210	hsa-miR-143	CLIP-seq
MIRT739213	hsa-miR-4683	CLIP-seq
MIRT739211	hsa-miR-4770	CLIP-seq
MIRT739208	hsa-miR-516a-3p	CLIP-seq
MIRT739209	hsa-miR-556-5p	CLIP-seq
MIRT739212	hsa-miR-620	CLIP-seq
MIRT1423680	hsa-miR-203	CLIP-seq
MIRT2126919	hsa-miR-338-5p	CLIP-seq
MIRT2126920	hsa-miR-3929	CLIP-seq
MIRT2126921	hsa-miR-4419b	CLIP-seq
MIRT2126922	hsa-miR-4478	CLIP-seq
MIRT2126923	hsa-miR-548aa	CLIP-seq
MIRT2348741	hsa-miR-10a	CLIP-seq
MIRT2348742	hsa-miR-10b	CLIP-seq
MIRT1423678	hsa-miR-1179	CLIP-seq
MIRT2348743	hsa-miR-1224-5p	CLIP-seq
MIRT2348744	hsa-miR-1245b-3p	CLIP-seq
MIRT2348745	hsa-miR-1246	CLIP-seq
MIRT2348746	hsa-miR-125a-3p	CLIP-seq
MIRT2348747	hsa-miR-1261	CLIP-seq
MIRT2348748	hsa-miR-1266	CLIP-seq
MIRT2348749	hsa-miR-1276	CLIP-seq
MIRT2348750	hsa-miR-1297	CLIP-seq
MIRT2348751	hsa-miR-1304	CLIP-seq
MIRT2348752	hsa-miR-136	CLIP-seq
MIRT2348753	hsa-miR-138	CLIP-seq
MIRT739210	hsa-miR-143	CLIP-seq
MIRT2348754	hsa-miR-154	CLIP-seq
MIRT2348755	hsa-miR-1587	CLIP-seq
MIRT2348756	hsa-miR-1827	CLIP-seq
MIRT2348757	hsa-miR-199a-3p	CLIP-seq
MIRT2348758	hsa-miR-199b-3p	CLIP-seq
MIRT2348759	hsa-miR-200b	CLIP-seq
MIRT2348760	hsa-miR-200c	CLIP-seq
MIRT2348761	hsa-miR-21	CLIP-seq
MIRT2348762	hsa-miR-2110	CLIP-seq
MIRT2348763	hsa-miR-217	CLIP-seq
MIRT1423682	hsa-miR-23a	CLIP-seq
MIRT1423683	hsa-miR-23b	CLIP-seq
MIRT1423684	hsa-miR-23c	CLIP-seq
MIRT2348764	hsa-miR-26a	CLIP-seq
MIRT2348765	hsa-miR-26b	CLIP-seq
MIRT2348766	hsa-miR-28-5p	CLIP-seq
MIRT2348767	hsa-miR-3129-5p	CLIP-seq
MIRT1423686	hsa-miR-3130-5p	CLIP-seq
MIRT2348768	hsa-miR-3139	CLIP-seq
MIRT2348769	hsa-miR-3146	CLIP-seq
MIRT2348770	hsa-miR-3147	CLIP-seq
MIRT2348771	hsa-miR-3150a-3p	CLIP-seq
MIRT2348772	hsa-miR-3150b-3p	CLIP-seq
MIRT2348773	hsa-miR-3175	CLIP-seq
MIRT2348774	hsa-miR-3184	CLIP-seq
MIRT2348775	hsa-miR-34c-3p	CLIP-seq
MIRT2348776	hsa-miR-3612	CLIP-seq
MIRT1423688	hsa-miR-3614-3p	CLIP-seq
MIRT2348777	hsa-miR-3619-3p	CLIP-seq
MIRT2348778	hsa-miR-3664-3p	CLIP-seq
MIRT2348779	hsa-miR-3665	CLIP-seq
MIRT2348780	hsa-miR-3689a-3p	CLIP-seq
MIRT2348781	hsa-miR-3689c	CLIP-seq
MIRT2348782	hsa-miR-378g	CLIP-seq
MIRT2348783	hsa-miR-383	CLIP-seq
MIRT2348784	hsa-miR-3907	CLIP-seq
MIRT2348785	hsa-miR-3908	CLIP-seq
MIRT2348786	hsa-miR-3915	CLIP-seq
MIRT2348787	hsa-miR-3922-5p	CLIP-seq
MIRT2348788	hsa-miR-3928	CLIP-seq
MIRT2348789	hsa-miR-3942-5p	CLIP-seq
MIRT2348790	hsa-miR-3973	CLIP-seq
MIRT2348791	hsa-miR-409-5p	CLIP-seq
MIRT2348792	hsa-miR-423-5p	CLIP-seq
MIRT2348793	hsa-miR-4254	CLIP-seq
MIRT2348794	hsa-miR-4257	CLIP-seq
MIRT2348795	hsa-miR-4282	CLIP-seq
MIRT2348796	hsa-miR-4289	CLIP-seq
MIRT2348797	hsa-miR-429	CLIP-seq
MIRT2348798	hsa-miR-4299	CLIP-seq
MIRT2348799	hsa-miR-4300	CLIP-seq
MIRT2348800	hsa-miR-4308	CLIP-seq
MIRT1423695	hsa-miR-4318	CLIP-seq
MIRT2348801	hsa-miR-4418	CLIP-seq
MIRT2348802	hsa-miR-4420	CLIP-seq
MIRT2348803	hsa-miR-4424	CLIP-seq
MIRT1423696	hsa-miR-4446-5p	CLIP-seq
MIRT2348804	hsa-miR-4453	CLIP-seq
MIRT2348805	hsa-miR-4462	CLIP-seq
MIRT2348806	hsa-miR-4465	CLIP-seq
MIRT2348807	hsa-miR-4473	CLIP-seq
MIRT2348808	hsa-miR-4474-3p	CLIP-seq
MIRT1423697	hsa-miR-4482	CLIP-seq
MIRT2348809	hsa-miR-4487	CLIP-seq
MIRT2348810	hsa-miR-4492	CLIP-seq
MIRT2348811	hsa-miR-4498	CLIP-seq
MIRT2348812	hsa-miR-4518	CLIP-seq
MIRT2348813	hsa-miR-4527	CLIP-seq
MIRT2348814	hsa-miR-4532	CLIP-seq
MIRT2348815	hsa-miR-4535	CLIP-seq
MIRT2348816	hsa-miR-4538	CLIP-seq
MIRT2348817	hsa-miR-4639-3p	CLIP-seq
MIRT2348818	hsa-miR-4640-5p	CLIP-seq
MIRT2348819	hsa-miR-4649-3p	CLIP-seq
MIRT2348820	hsa-miR-4656	CLIP-seq
MIRT2348821	hsa-miR-4659a-3p	CLIP-seq
MIRT2348822	hsa-miR-4659b-3p	CLIP-seq
MIRT1423699	hsa-miR-4668-5p	CLIP-seq
MIRT2348823	hsa-miR-4675	CLIP-seq
MIRT1423670	hsa-miR-4688	CLIP-seq
MIRT2348824	hsa-miR-4689	CLIP-seq
MIRT2348825	hsa-miR-4694-3p	CLIP-seq
MIRT1423701	hsa-miR-4700-3p	CLIP-seq
MIRT2348826	hsa-miR-4703-5p	CLIP-seq
MIRT2348827	hsa-miR-4710	CLIP-seq
MIRT2348828	hsa-miR-4712-3p	CLIP-seq
MIRT2348829	hsa-miR-4716-5p	CLIP-seq
MIRT2348830	hsa-miR-4718	CLIP-seq
MIRT2348831	hsa-miR-4719	CLIP-seq
MIRT2348832	hsa-miR-4726-5p	CLIP-seq
MIRT2348833	hsa-miR-4736	CLIP-seq
MIRT2348834	hsa-miR-4741	CLIP-seq
MIRT2348835	hsa-miR-4757-5p	CLIP-seq
MIRT2348836	hsa-miR-4762-5p	CLIP-seq
MIRT2348837	hsa-miR-4766-3p	CLIP-seq
MIRT739211	hsa-miR-4770	CLIP-seq
MIRT2348838	hsa-miR-4776-5p	CLIP-seq
MIRT2348839	hsa-miR-4784	CLIP-seq
MIRT2348840	hsa-miR-4792	CLIP-seq
MIRT2348841	hsa-miR-4796-5p	CLIP-seq
MIRT2348842	hsa-miR-4799-5p	CLIP-seq
MIRT2348843	hsa-miR-490-3p	CLIP-seq
MIRT2348844	hsa-miR-498	CLIP-seq
MIRT1423703	hsa-miR-499-3p	CLIP-seq
MIRT1423704	hsa-miR-499a-3p	CLIP-seq
MIRT2348845	hsa-miR-509-3-5p	CLIP-seq
MIRT2348846	hsa-miR-509-5p	CLIP-seq
MIRT2348847	hsa-miR-511	CLIP-seq
MIRT2348848	hsa-miR-512-3p	CLIP-seq
MIRT2348849	hsa-miR-513a-3p	CLIP-seq
MIRT1423705	hsa-miR-513a-5p	CLIP-seq
MIRT2348850	hsa-miR-520f	CLIP-seq
MIRT2348851	hsa-miR-522	CLIP-seq
MIRT2348852	hsa-miR-545	CLIP-seq
MIRT2348853	hsa-miR-548k	CLIP-seq
MIRT2348854	hsa-miR-548m	CLIP-seq
MIRT2348855	hsa-miR-552	CLIP-seq
MIRT2348856	hsa-miR-580	CLIP-seq
MIRT2348857	hsa-miR-587	CLIP-seq
MIRT2348858	hsa-miR-590-5p	CLIP-seq
MIRT2348859	hsa-miR-595	CLIP-seq
MIRT2348860	hsa-miR-619	CLIP-seq
MIRT2348861	hsa-miR-639	CLIP-seq
MIRT2348862	hsa-miR-650	CLIP-seq
MIRT2348863	hsa-miR-657	CLIP-seq
MIRT2348864	hsa-miR-665	CLIP-seq
MIRT2348865	hsa-miR-708	CLIP-seq
MIRT2348866	hsa-miR-759	CLIP-seq
MIRT2348867	hsa-miR-762	CLIP-seq
MIRT2348868	hsa-miR-920	CLIP-seq
MIRT2348869	hsa-miR-922	CLIP-seq
MIRT2348870	hsa-miR-939	CLIP-seq
MIRT2348871	hsa-miR-940	CLIP-seq
MIRT2461445	hsa-miR-1208	CLIP-seq
MIRT2461446	hsa-miR-1285	CLIP-seq
MIRT2461447	hsa-miR-3187-5p	CLIP-seq
MIRT2348782	hsa-miR-378g	CLIP-seq
MIRT2461448	hsa-miR-4314	CLIP-seq
MIRT2461449	hsa-miR-4486	CLIP-seq
MIRT2461450	hsa-miR-452	CLIP-seq
MIRT2461451	hsa-miR-4676-3p	CLIP-seq
MIRT2461452	hsa-miR-597	CLIP-seq
MIRT2461453	hsa-miR-612	CLIP-seq
MIRT2461454	hsa-miR-668	CLIP-seq
MIRT2641903	hsa-miR-1205	CLIP-seq
MIRT2641904	hsa-miR-1206	CLIP-seq
MIRT2641905	hsa-miR-1228	CLIP-seq
MIRT2641906	hsa-miR-124	CLIP-seq
MIRT2641907	hsa-miR-1243	CLIP-seq
MIRT2348746	hsa-miR-125a-3p	CLIP-seq
MIRT2641908	hsa-miR-1264	CLIP-seq
MIRT2641909	hsa-miR-1286	CLIP-seq
MIRT2641910	hsa-miR-1290	CLIP-seq
MIRT2641911	hsa-miR-135a	CLIP-seq
MIRT2641912	hsa-miR-135b	CLIP-seq
MIRT2348752	hsa-miR-136	CLIP-seq
MIRT2641913	hsa-miR-139-3p	CLIP-seq
MIRT1423655	hsa-miR-146b-3p	CLIP-seq
MIRT2641914	hsa-miR-151-5p	CLIP-seq
MIRT2641915	hsa-miR-151b	CLIP-seq
MIRT2348755	hsa-miR-1587	CLIP-seq
MIRT2348756	hsa-miR-1827	CLIP-seq
MIRT2641916	hsa-miR-190	CLIP-seq
MIRT2641917	hsa-miR-190b	CLIP-seq
MIRT2641918	hsa-miR-204	CLIP-seq
MIRT2641919	hsa-miR-211	CLIP-seq
MIRT2641920	hsa-miR-2355-5p	CLIP-seq
MIRT2641921	hsa-miR-2682	CLIP-seq
MIRT2641922	hsa-miR-3065-5p	CLIP-seq
MIRT2641923	hsa-miR-3131	CLIP-seq
MIRT2641924	hsa-miR-3149	CLIP-seq
MIRT2641925	hsa-miR-3151	CLIP-seq
MIRT2641926	hsa-miR-3158-3p	CLIP-seq
MIRT2641927	hsa-miR-3167	CLIP-seq
MIRT1423660	hsa-miR-3173-5p	CLIP-seq
MIRT2641928	hsa-miR-3179	CLIP-seq
MIRT2641929	hsa-miR-3180-5p	CLIP-seq
MIRT2641930	hsa-miR-3183	CLIP-seq
MIRT2348774	hsa-miR-3184	CLIP-seq
MIRT2641931	hsa-miR-3189-3p	CLIP-seq
MIRT2641932	hsa-miR-34a	CLIP-seq
MIRT2641933	hsa-miR-34c-5p	CLIP-seq
MIRT2641934	hsa-miR-3591-5p	CLIP-seq
MIRT2348776	hsa-miR-3612	CLIP-seq
MIRT2348777	hsa-miR-3619-3p	CLIP-seq
MIRT2348779	hsa-miR-3665	CLIP-seq
MIRT1423689	hsa-miR-3667-3p	CLIP-seq
MIRT1423691	hsa-miR-3679-3p	CLIP-seq
MIRT2641935	hsa-miR-3686	CLIP-seq
MIRT2641936	hsa-miR-3714	CLIP-seq
MIRT2641937	hsa-miR-378	CLIP-seq
MIRT2641938	hsa-miR-378b	CLIP-seq
MIRT2641939	hsa-miR-378c	CLIP-seq
MIRT2641940	hsa-miR-378d	CLIP-seq
MIRT2641941	hsa-miR-378e	CLIP-seq
MIRT2641942	hsa-miR-378f	CLIP-seq
MIRT2348782	hsa-miR-378g	CLIP-seq
MIRT2641943	hsa-miR-378h	CLIP-seq
MIRT2641944	hsa-miR-378i	CLIP-seq
MIRT2348784	hsa-miR-3907	CLIP-seq
MIRT2641945	hsa-miR-3910	CLIP-seq
MIRT2126920	hsa-miR-3929	CLIP-seq
MIRT2641946	hsa-miR-3934	CLIP-seq
MIRT2641947	hsa-miR-3938	CLIP-seq
MIRT2641948	hsa-miR-3977	CLIP-seq
MIRT2641949	hsa-miR-3978	CLIP-seq
MIRT2641950	hsa-miR-421	CLIP-seq
MIRT2641951	hsa-miR-422a	CLIP-seq
MIRT2348792	hsa-miR-423-5p	CLIP-seq
MIRT2641952	hsa-miR-4287	CLIP-seq
MIRT1423694	hsa-miR-4297	CLIP-seq
MIRT2348799	hsa-miR-4300	CLIP-seq
MIRT2641953	hsa-miR-432	CLIP-seq
MIRT2641954	hsa-miR-4327	CLIP-seq
MIRT2126921	hsa-miR-4419b	CLIP-seq
MIRT2641955	hsa-miR-4443	CLIP-seq
MIRT1423696	hsa-miR-4446-5p	CLIP-seq
MIRT2641956	hsa-miR-4447	CLIP-seq
MIRT2641957	hsa-miR-4452	CLIP-seq
MIRT2641958	hsa-miR-4469	CLIP-seq
MIRT2641959	hsa-miR-4472	CLIP-seq
MIRT2126922	hsa-miR-4478	CLIP-seq
MIRT2348810	hsa-miR-4492	CLIP-seq
MIRT2641960	hsa-miR-4493	CLIP-seq
MIRT2348811	hsa-miR-4498	CLIP-seq
MIRT2641961	hsa-miR-449a	CLIP-seq
MIRT2641962	hsa-miR-449b	CLIP-seq
MIRT2641963	hsa-miR-449c	CLIP-seq
MIRT2641964	hsa-miR-450b-5p	CLIP-seq
MIRT2348814	hsa-miR-4532	CLIP-seq
MIRT2348815	hsa-miR-4535	CLIP-seq
MIRT1423698	hsa-miR-455-3p	CLIP-seq
MIRT2641965	hsa-miR-4638-3p	CLIP-seq
MIRT2348818	hsa-miR-4640-5p	CLIP-seq
MIRT2348819	hsa-miR-4649-3p	CLIP-seq
MIRT2641966	hsa-miR-4650-5p	CLIP-seq
MIRT2641967	hsa-miR-4651	CLIP-seq
MIRT2641968	hsa-miR-4652-3p	CLIP-seq
MIRT2348820	hsa-miR-4656	CLIP-seq
MIRT2348823	hsa-miR-4675	CLIP-seq
MIRT2641969	hsa-miR-4685-3p	CLIP-seq
MIRT2641970	hsa-miR-4685-5p	CLIP-seq
MIRT2641971	hsa-miR-4709-3p	CLIP-seq
MIRT2641972	hsa-miR-4709-5p	CLIP-seq
MIRT2348827	hsa-miR-4710	CLIP-seq
MIRT2641973	hsa-miR-4722-5p	CLIP-seq
MIRT2641974	hsa-miR-4723-3p	CLIP-seq
MIRT2641975	hsa-miR-4725-5p	CLIP-seq
MIRT2348832	hsa-miR-4726-5p	CLIP-seq
MIRT2348834	hsa-miR-4741	CLIP-seq
MIRT2641976	hsa-miR-4742-3p	CLIP-seq
MIRT2641977	hsa-miR-4755-5p	CLIP-seq
MIRT2641978	hsa-miR-4763-5p	CLIP-seq
MIRT2348838	hsa-miR-4776-5p	CLIP-seq
MIRT2641979	hsa-miR-4779	CLIP-seq
MIRT2641980	hsa-miR-4793-3p	CLIP-seq
MIRT2641981	hsa-miR-485-5p	CLIP-seq
MIRT2641982	hsa-miR-491-5p	CLIP-seq
MIRT2641983	hsa-miR-502-5p	CLIP-seq
MIRT2641984	hsa-miR-504	CLIP-seq
MIRT2641985	hsa-miR-506	CLIP-seq
MIRT2348854	hsa-miR-548m	CLIP-seq
MIRT2348855	hsa-miR-552	CLIP-seq
MIRT2641986	hsa-miR-568	CLIP-seq
MIRT2641987	hsa-miR-608	CLIP-seq
MIRT2641988	hsa-miR-611	CLIP-seq
MIRT2641989	hsa-miR-623	CLIP-seq
MIRT2641990	hsa-miR-627	CLIP-seq
MIRT2348861	hsa-miR-639	CLIP-seq
MIRT2348862	hsa-miR-650	CLIP-seq
MIRT2348864	hsa-miR-665	CLIP-seq
MIRT2348867	hsa-miR-762	CLIP-seq
MIRT1423676	hsa-miR-874	CLIP-seq
MIRT2641991	hsa-miR-876-5p	CLIP-seq
MIRT2348868	hsa-miR-920	CLIP-seq
MIRT2641992	hsa-miR-924	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001225	Function	RNA polymerase II transcription coactivator binding	IPI	9368056
GO:0002154	Process	Thyroid hormone mediated signaling pathway	IBA	21873635
GO:0003677	Function	DNA binding	TAS	1618799
GO:0003700	Function	DNA-binding transcription factor activity	NAS	1618799
GO:0004879	Function	Nuclear receptor activity	IBA	21873635
GO:0004879	Function	Nuclear receptor activity	IDA	15466465
GO:0005515	Function	Protein binding	IPI	7870181, 12904255, 15100213, 15625236
GO:0005634	Component	Nucleus	TAS	1618799
GO:0005654	Component	Nucleoplasm	TAS
GO:0006351	Process	Transcription, DNA-templated	TAS	1618799
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0007605	Process	Sensory perception of sound	IEA
GO:0007621	Process	Negative regulation of female receptivity	IEA
GO:0008016	Process	Regulation of heart contraction	IEA
GO:0008050	Process	Female courtship behavior	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009755	Process	Hormone-mediated signaling pathway	IBA	21873635
GO:0016604	Component	Nuclear body	IDA
GO:0019899	Function	Enzyme binding	IPI	12039952
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0031490	Function	Chromatin DNA binding	IEA
GO:0042480	Process	Negative regulation of eye photoreceptor cell development	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0046549	Process	Retinal cone cell development	IEA
GO:0060509	Process	Type I pneumocyte differentiation	IEA
GO:0070324	Function	Thyroid hormone binding	IDA	15466465
GO:0097067	Process	Cellular response to thyroid hormone stimulus	IDA	9368056
GO:0097474	Process	Retinal cone cell apoptotic process	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
190160	11799	ENSG00000151090

Protein

UniProt ID

P10828

Protein name

Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)

Protein function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100, ECO:0000269|Pub

PDB

1BSX , 1N46 , 1NAX , 1NQ0 , 1NQ1 , 1NQ2 , 1NUO , 1Q4X , 1R6G , 1XZX , 1Y0X , 2J4A , 2NLL , 2PIN , 3D57 , 3GWS , 3IMY , 3JZC , 4ZO1 , 6KKB , 6KKE , 6KNU , 6KNV , 6KNW , 7WLX , 7WMG , 7WMH , 7WMJ , 7WML , 7WMN , 7WMO , 8RQN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00105	zf-C4	105 → 176	Zinc finger, C4 type (two domains)	Domain
PF00104	Hormone_recep	264 → 445	Ligand-binding domain of nuclear hormone receptor	Domain

Sequence

MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED

Sequence length

461

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Hormone signaling Thyroid hormone signaling pathway		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors

Associated diseases

Show/Hide Causal Diseases (8)

Causal
Disease name	Disease term	dbSNP ID	References
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675	30061737, 29892015
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs120074176, rs786205019
Hearing loss	Sensorineural Hearing Loss (disorder)	rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359, rs180177151, rs180177154, rs180177153, rs35689081, rs35887622, rs80338944, rs104894396, rs104894398, rs80338947, rs80338948, rs80338942, rs104894402, rs104894403, rs80338945, rs28931594, rs80338940, rs80338941, rs80356590, rs80338950, rs387906706, rs387906707, rs387906708, rs398122848, rs387907016, rs587776894, rs387907088, rs397515411, rs370965183, rs398122930, rs199897298, rs111033187, rs111033448, rs199606180, rs111033284, rs397516413, rs111033305, rs111033220, rs111033256, rs111033297, rs111033253, rs104894408, rs111033295, rs397516874, rs76434661, rs111033335, rs397517323, rs111033247, rs367928692, rs374793617, rs143939430, rs397515605, rs80338939, rs200656442, rs779748859, rs587781261, rs587781262, rs143343083, rs200147906, rs730880338, rs797044491, rs146281367, rs756484720, rs869025593, rs201306709, rs540895576, rs777777359, rs879255246, rs1554358720, rs142498437, rs377145777, rs1057517519, rs779077039, rs952741388, rs1060499797, rs764139009, rs1060499590, rs1064794012, rs1064797115, rs756790858, rs775633137, rs1554952443, rs1554952193, rs782063761, rs1199012623, rs756147087, rs1555648043, rs1555661490, rs1553196233, rs781546107, rs111033190, rs775428246, rs782539587, rs537227442, rs148695069, rs1554835827, rs953422571, rs1554834186, rs1554834161, rs1554835103, rs1554577339, rs1554577402, rs768471577, rs782279338, rs781951909, rs998045226, rs375759781, rs755804651, rs1557458426, rs767797828, rs538027448, rs1559366084, rs367688416, rs1558480402, rs1558490542, rs1559870857, rs1560690591, rs1561299289, rs1562817224, rs1562817529, rs1562822565, rs1562835391, rs1564113368, rs1564554255, rs773851192, rs1564555240, rs761261855, rs1564805114, rs1565522273, rs1565127413, rs781790246, rs1565430886, rs1565469959, rs746667217, rs1565819402, rs1565855932, rs150529554, rs1567939793, rs201866631, rs754472294, rs1559372512, rs1558464965, rs1558488902, rs775062249, rs1226171550, rs1561590396, rs765574676, rs762876554, rs757327146, rs1564949059, rs1565519673, rs368050948, rs1565541888, rs781989117, rs1565402473, rs750358148, rs1386887007, rs1209665716, rs1567641234, rs1237955948, rs1569042782, rs752672077, rs146689036, rs1560070780, rs149712664, rs1564556995, rs762226905, rs773573968, rs1568528171, rs1198256157, rs377267777, rs370564476, rs1577876794, rs747787770, rs759432278, rs1043716893, rs1581138934, rs2033773650, rs1421964916, rs771766431, rs780917129, rs1895773215, rs1895769400, rs761543680, rs1565920060
Hyperthyroidism	Hyperthyroidism	rs121908861, rs121908864, rs121908874, rs121908875, rs121908876, rs121908877, rs121908873, rs121908880, rs121908883, rs121909258, rs6256, rs869312167
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605
Lung carcinoma	Squamous cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	29924316
Myopia	Myopia	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805, rs782555528, rs1554862601, rs1586620121, rs1387950081, rs2051026773, rs1422332023	27182965
Thyroid hormone resistance	Generalized Thyroid Hormone Resistance, THYROID HORMONE RESISTANCE, SELECTIVE PITUITARY, THYROID HORMONE RESISTANCE, GENERALIZED, AUTOSOMAL DOMINANT, Thyroid Hormone Resistance Syndrome, Thyroid Hormone Resistance, Generalized, Autosomal Recessive	rs121918686, rs121918688, rs121918687, rs387906515, rs121918690, rs28999971, rs121918691, rs28933408, rs121918692, rs121918693, rs121918694, rs121918695, rs121918696, rs121918697, rs121918698, rs121918703, rs121918704, rs121918705, rs121918706, rs121918707, rs121918708, rs1057519028, rs1060499695, rs1553610984, rs1553609185, rs1553609090, rs1553609119, rs1553609152, rs1553609179, rs1553610974, rs1553611038, rs1553611075, rs1553611083, rs750905761, rs1553609167, rs1553609210	24847459, 9349583, 10660344, 7528740, 8381821, 24847459, 1846005, 12511610, 16804041, 24847459, 1324420, 1619012, 8175986, 10660344, 19268523, 1587388, 2153155, 8664910, 12554782, 7833659, 8889584, 2510172, 1314846, 8514853, 1563081, 1661299, 9349583, 24847459, 10660344, 24847459, 24393243

Show/Hide Unknown Diseases (10)

Unknown
Disease name	Disease term	dbSNP ID	References
Congenital exomphalos	Congenital exomphalos
Congenital pectus carinatum	Congenital pectus carinatum
Dyssomnia	Dyssomnias
Follicular thyroid carcinoma	Follicular thyroid carcinoma		27440272
Macroglossia	Macroglossia
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	rs199865688, rs397515994, rs757096307	29892015, 30061737
Proptosis	Exophthalmos
Resistance to thyroid hormone	Resistance to thyroid hormone due to a mutation in thyroid hormone receptor beta
Sleep disorders	Sleep Disorders
Sprengel deformity	Sprengel deformity

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