Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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7029 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Transcription factor Dp-2 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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TFDP2 |
SynonymsGene synonyms aliases
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DP2 |
ChromosomeChromosome number
|
3 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
3q23 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcrip |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000083 |
Process |
Regulation of transcription involved in G1/S transition of mitotic cell cycle |
TAS |
|
GO:0000785 |
Component |
Chromatin |
ISA |
|
GO:0000977 |
Function |
RNA polymerase II transcription regulatory region sequence-specific DNA binding |
IBA |
21873635 |
GO:0000977 |
Function |
RNA polymerase II transcription regulatory region sequence-specific DNA binding |
IDA |
7739537, 9501179 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISA |
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GO:0001228 |
Function |
DNA-binding transcription activator activity, RNA polymerase II-specific |
IDA |
7739537 |
GO:0005515 |
Function |
Protein binding |
IPI |
16061792, 16189514, 20176812, 21516116, 22810586, 25416956, 27705803, 28514442 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005739 |
Component |
Mitochondrion |
IEA |
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GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0006977 |
Process |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
TAS |
|
GO:0007507 |
Process |
Heart development |
IEA |
|
GO:0008134 |
Function |
Transcription factor binding |
IPI |
7784053, 16360038 |
GO:0019904 |
Function |
Protein domain specific binding |
IPI |
16360038 |
GO:0045892 |
Process |
Negative regulation of transcription, DNA-templated |
IDA |
20176812 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IDA |
7739537 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
TAS |
|
GO:0070317 |
Process |
Negative regulation of G0 to G1 transition |
TAS |
|
GO:0072686 |
Component |
Mitotic spindle |
IDA |
|
GO:0090575 |
Component |
RNA polymerase II transcription regulator complex |
IDA |
7739537, 9501179 |
GO:1900740 |
Process |
Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
TAS |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q14188 |
Protein name |
Transcription factor Dp-2 (E2F dimerization partner 2) |
Protein function |
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation |
PDB |
1CF7
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF02319 |
E2F_TDP |
128 → 208 |
E2F/DP family winged-helix DNA-binding domain |
Domain |
PF08781 |
DP |
215 → 353 |
Transcription factor DP |
Domain |
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Sequence |
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Sequence length |
446 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Kidney failure |
Kidney Failure, Chronic |
|
20383146 |
Malignant mesothelioma |
Malignant mesothelioma |
|
25756049 |
Testicular germ cell tumor |
Testicular Germ Cell Tumor |
|
26503584, 28604728 |
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