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TEAD1 (TEA domain transcription factor 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7003
Gene nameGene Name - the full gene name approved by the HGNC.
TEA domain transcription factor 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TEAD1
SynonymsGene synonyms aliases
AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1
ChromosomeChromosome number
11
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs11567847 T>C Pathogenic Missense variant, coding sequence variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002701 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT002701 hsa-miR-124-3p Microarray 15685193
MIRT027571 hsa-miR-98-5p Microarray 19088304
MIRT044437 hsa-miR-320a CLASH 23622248
MIRT367734 hsa-miR-1324 HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IMP 26045994
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P28347
Protein name Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13)
Protein function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cas
PDB 2HZD , 3KYS , 4RE1 , 4Z8E , 5NNX , 6HIL , 6IM5 , 7CMM , 7ZJP , 8Q68 , 9FZA , 9GAX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01285 TEA
31 100
TEA/ATTS domain
Domain
PF17725 YBD
214 423
YAP binding domain
Domain
Sequence
Sequence length 426
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Hippo signaling pathway
Hippo signaling pathway - multiple species
  YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Helicoid peripapillary chorioretinal degeneration Helicoid peripapillary chorioretinal degeneration rs11567847, rs1249149946
Myopia Myopia rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805, rs782555528, rs1554862601, rs1586620121, rs1387950081, rs2051026773, rs1422332023
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 31374203
Unknown
Disease name Disease term dbSNP ID References
Astigmatism Astigmatism
Peripapillary chorioretinal atrophy Peripapillary chorioretinal atrophy
Sveinsson chorioretinal atrophy SVEINSSON CHORIORETINAL ATROPHY 15016762, 20123905, 18579750

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