PRDX2 (peroxiredoxin 2)

Gene

• Entrez ID: 7001
• Gene name: Peroxiredoxin 2
• Gene symbol: PRDX2
• Synonyms: HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA
• Chromosome: 19
• Chromosome location: 19p13.13
• Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of C

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023992	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT047661	hsa-miR-10a-5p	CLASH	23622248
MIRT046023	hsa-miR-125b-5p	CLASH	23622248
MIRT042800	hsa-miR-339-5p	CLASH	23622248
MIRT039753	hsa-miR-615-3p	CLASH	23622248
MIRT1260410	hsa-miR-1228	CLIP-seq
MIRT1260411	hsa-miR-1245b-5p	CLIP-seq
MIRT1260412	hsa-miR-1253	CLIP-seq
MIRT1260413	hsa-miR-1275	CLIP-seq
MIRT1260414	hsa-miR-1293	CLIP-seq
MIRT1260415	hsa-miR-129-3p	CLIP-seq
MIRT1260416	hsa-miR-147b	CLIP-seq
MIRT1260417	hsa-miR-200b	CLIP-seq
MIRT1260418	hsa-miR-200c	CLIP-seq
MIRT1260419	hsa-miR-2682	CLIP-seq
MIRT1260420	hsa-miR-3138	CLIP-seq
MIRT1260421	hsa-miR-3142	CLIP-seq
MIRT1260422	hsa-miR-3176	CLIP-seq
MIRT1260423	hsa-miR-3184	CLIP-seq
MIRT1260424	hsa-miR-3612	CLIP-seq
MIRT1260425	hsa-miR-3922-3p	CLIP-seq
MIRT1260426	hsa-miR-409-5p	CLIP-seq
MIRT1260427	hsa-miR-423-5p	CLIP-seq
MIRT1260428	hsa-miR-4269	CLIP-seq
MIRT1260429	hsa-miR-429	CLIP-seq
MIRT1260430	hsa-miR-4290	CLIP-seq
MIRT1260431	hsa-miR-4310	CLIP-seq
MIRT1260432	hsa-miR-4318	CLIP-seq
MIRT1260433	hsa-miR-4417	CLIP-seq
MIRT1260434	hsa-miR-4436b-3p	CLIP-seq
MIRT1260435	hsa-miR-4443	CLIP-seq
MIRT1260436	hsa-miR-4446-5p	CLIP-seq
MIRT1260437	hsa-miR-4447	CLIP-seq
MIRT1260438	hsa-miR-4472	CLIP-seq
MIRT1260439	hsa-miR-4483	CLIP-seq
MIRT1260440	hsa-miR-4488	CLIP-seq
MIRT1260441	hsa-miR-4493	CLIP-seq
MIRT1260442	hsa-miR-449c	CLIP-seq
MIRT1260443	hsa-miR-4505	CLIP-seq
MIRT1260444	hsa-miR-4525	CLIP-seq
MIRT1260445	hsa-miR-4653-3p	CLIP-seq
MIRT1260446	hsa-miR-4665-5p	CLIP-seq
MIRT1260447	hsa-miR-4685-5p	CLIP-seq
MIRT1260448	hsa-miR-4687-5p	CLIP-seq
MIRT1260449	hsa-miR-4688	CLIP-seq
MIRT1260450	hsa-miR-4693-5p	CLIP-seq
MIRT1260451	hsa-miR-4697-5p	CLIP-seq
MIRT1260452	hsa-miR-4723-5p	CLIP-seq
MIRT1260453	hsa-miR-4726-3p	CLIP-seq
MIRT1260454	hsa-miR-4728-5p	CLIP-seq
MIRT1260455	hsa-miR-4736	CLIP-seq
MIRT1260456	hsa-miR-4755-5p	CLIP-seq
MIRT1260457	hsa-miR-4761-3p	CLIP-seq
MIRT1260458	hsa-miR-4777-3p	CLIP-seq
MIRT1260459	hsa-miR-486-3p	CLIP-seq
MIRT1260460	hsa-miR-541	CLIP-seq
MIRT1260461	hsa-miR-552	CLIP-seq
MIRT1260462	hsa-miR-625	CLIP-seq
MIRT1260463	hsa-miR-645	CLIP-seq
MIRT1260464	hsa-miR-650	CLIP-seq
MIRT1260465	hsa-miR-654-5p	CLIP-seq
MIRT1260466	hsa-miR-892a	CLIP-seq
MIRT1260467	hsa-miR-940	CLIP-seq
MIRT1260411	hsa-miR-1245b-5p	CLIP-seq
MIRT1260412	hsa-miR-1253	CLIP-seq
MIRT1260413	hsa-miR-1275	CLIP-seq
MIRT1260414	hsa-miR-1293	CLIP-seq
MIRT1260415	hsa-miR-129-3p	CLIP-seq
MIRT1260416	hsa-miR-147b	CLIP-seq
MIRT1260421	hsa-miR-3142	CLIP-seq
MIRT1260424	hsa-miR-3612	CLIP-seq
MIRT1260426	hsa-miR-409-5p	CLIP-seq
MIRT1260430	hsa-miR-4290	CLIP-seq
MIRT1260432	hsa-miR-4318	CLIP-seq
MIRT1260433	hsa-miR-4417	CLIP-seq
MIRT1260435	hsa-miR-4443	CLIP-seq
MIRT1260437	hsa-miR-4447	CLIP-seq
MIRT1260438	hsa-miR-4472	CLIP-seq
MIRT1260439	hsa-miR-4483	CLIP-seq
MIRT1260440	hsa-miR-4488	CLIP-seq
MIRT1260441	hsa-miR-4493	CLIP-seq
MIRT1260443	hsa-miR-4505	CLIP-seq
MIRT1260444	hsa-miR-4525	CLIP-seq
MIRT1260445	hsa-miR-4653-3p	CLIP-seq
MIRT1260446	hsa-miR-4665-5p	CLIP-seq
MIRT1260447	hsa-miR-4685-5p	CLIP-seq
MIRT1260448	hsa-miR-4687-5p	CLIP-seq
MIRT1260450	hsa-miR-4693-5p	CLIP-seq
MIRT1260451	hsa-miR-4697-5p	CLIP-seq
MIRT1260452	hsa-miR-4723-5p	CLIP-seq
MIRT1260453	hsa-miR-4726-3p	CLIP-seq
MIRT1260454	hsa-miR-4728-5p	CLIP-seq
MIRT1260458	hsa-miR-4777-3p	CLIP-seq
MIRT1260460	hsa-miR-541	CLIP-seq
MIRT1260461	hsa-miR-552	CLIP-seq
MIRT1260462	hsa-miR-625	CLIP-seq
MIRT1260463	hsa-miR-645	CLIP-seq
MIRT1260464	hsa-miR-650	CLIP-seq
MIRT1260465	hsa-miR-654-5p	CLIP-seq
MIRT1260466	hsa-miR-892a	CLIP-seq
MIRT2303376	hsa-miR-1207-5p	CLIP-seq
MIRT1260411	hsa-miR-1245b-5p	CLIP-seq
MIRT1260412	hsa-miR-1253	CLIP-seq
MIRT1260413	hsa-miR-1275	CLIP-seq
MIRT1260414	hsa-miR-1293	CLIP-seq
MIRT1260415	hsa-miR-129-3p	CLIP-seq
MIRT2303377	hsa-miR-1343	CLIP-seq
MIRT1260416	hsa-miR-147b	CLIP-seq
MIRT2303378	hsa-miR-1909	CLIP-seq
MIRT1260419	hsa-miR-2682	CLIP-seq
MIRT2303379	hsa-miR-3074-5p	CLIP-seq
MIRT2303380	hsa-miR-3124-3p	CLIP-seq
MIRT1260420	hsa-miR-3138	CLIP-seq
MIRT1260421	hsa-miR-3142	CLIP-seq
MIRT1260422	hsa-miR-3176	CLIP-seq
MIRT1260423	hsa-miR-3184	CLIP-seq
MIRT1260424	hsa-miR-3612	CLIP-seq
MIRT1260425	hsa-miR-3922-3p	CLIP-seq
MIRT1260426	hsa-miR-409-5p	CLIP-seq
MIRT1260427	hsa-miR-423-5p	CLIP-seq
MIRT1260428	hsa-miR-4269	CLIP-seq
MIRT1260430	hsa-miR-4290	CLIP-seq
MIRT1260431	hsa-miR-4310	CLIP-seq
MIRT1260432	hsa-miR-4318	CLIP-seq
MIRT1260433	hsa-miR-4417	CLIP-seq
MIRT1260434	hsa-miR-4436b-3p	CLIP-seq
MIRT1260435	hsa-miR-4443	CLIP-seq
MIRT1260437	hsa-miR-4447	CLIP-seq
MIRT1260438	hsa-miR-4472	CLIP-seq
MIRT1260439	hsa-miR-4483	CLIP-seq
MIRT1260440	hsa-miR-4488	CLIP-seq
MIRT1260441	hsa-miR-4493	CLIP-seq
MIRT1260442	hsa-miR-449c	CLIP-seq
MIRT1260443	hsa-miR-4505	CLIP-seq
MIRT1260444	hsa-miR-4525	CLIP-seq
MIRT1260445	hsa-miR-4653-3p	CLIP-seq
MIRT2303381	hsa-miR-4662a-5p	CLIP-seq
MIRT1260446	hsa-miR-4665-5p	CLIP-seq
MIRT2303382	hsa-miR-4676-5p	CLIP-seq
MIRT1260447	hsa-miR-4685-5p	CLIP-seq
MIRT1260448	hsa-miR-4687-5p	CLIP-seq
MIRT1260449	hsa-miR-4688	CLIP-seq
MIRT1260450	hsa-miR-4693-5p	CLIP-seq
MIRT1260451	hsa-miR-4697-5p	CLIP-seq
MIRT1260452	hsa-miR-4723-5p	CLIP-seq
MIRT1260453	hsa-miR-4726-3p	CLIP-seq
MIRT1260454	hsa-miR-4728-5p	CLIP-seq
MIRT1260455	hsa-miR-4736	CLIP-seq
MIRT1260457	hsa-miR-4761-3p	CLIP-seq
MIRT2303383	hsa-miR-4763-3p	CLIP-seq
MIRT1260458	hsa-miR-4777-3p	CLIP-seq
MIRT2303384	hsa-miR-4800-3p	CLIP-seq
MIRT1260459	hsa-miR-486-3p	CLIP-seq
MIRT1260460	hsa-miR-541	CLIP-seq
MIRT1260461	hsa-miR-552	CLIP-seq
MIRT2303385	hsa-miR-575	CLIP-seq
MIRT1260462	hsa-miR-625	CLIP-seq
MIRT1260463	hsa-miR-645	CLIP-seq
MIRT1260464	hsa-miR-650	CLIP-seq
MIRT1260465	hsa-miR-654-5p	CLIP-seq
MIRT1260466	hsa-miR-892a	CLIP-seq
MIRT1260467	hsa-miR-940	CLIP-seq
MIRT1260416	hsa-miR-147b	CLIP-seq
MIRT1260445	hsa-miR-4653-3p	CLIP-seq
MIRT1260411	hsa-miR-1245b-5p	CLIP-seq
MIRT1260412	hsa-miR-1253	CLIP-seq
MIRT1260413	hsa-miR-1275	CLIP-seq
MIRT1260414	hsa-miR-1293	CLIP-seq
MIRT1260415	hsa-miR-129-3p	CLIP-seq
MIRT2303377	hsa-miR-1343	CLIP-seq
MIRT1260416	hsa-miR-147b	CLIP-seq
MIRT1260417	hsa-miR-200b	CLIP-seq
MIRT1260418	hsa-miR-200c	CLIP-seq
MIRT2303379	hsa-miR-3074-5p	CLIP-seq
MIRT2303380	hsa-miR-3124-3p	CLIP-seq
MIRT1260421	hsa-miR-3142	CLIP-seq
MIRT1260422	hsa-miR-3176	CLIP-seq
MIRT1260423	hsa-miR-3184	CLIP-seq
MIRT1260424	hsa-miR-3612	CLIP-seq
MIRT1260425	hsa-miR-3922-3p	CLIP-seq
MIRT1260426	hsa-miR-409-5p	CLIP-seq
MIRT1260427	hsa-miR-423-5p	CLIP-seq
MIRT1260429	hsa-miR-429	CLIP-seq
MIRT1260430	hsa-miR-4290	CLIP-seq
MIRT1260431	hsa-miR-4310	CLIP-seq
MIRT1260432	hsa-miR-4318	CLIP-seq
MIRT1260433	hsa-miR-4417	CLIP-seq
MIRT1260434	hsa-miR-4436b-3p	CLIP-seq
MIRT1260435	hsa-miR-4443	CLIP-seq
MIRT1260436	hsa-miR-4446-5p	CLIP-seq
MIRT1260439	hsa-miR-4483	CLIP-seq
MIRT1260441	hsa-miR-4493	CLIP-seq
MIRT1260443	hsa-miR-4505	CLIP-seq
MIRT1260444	hsa-miR-4525	CLIP-seq
MIRT1260445	hsa-miR-4653-3p	CLIP-seq
MIRT1260446	hsa-miR-4665-5p	CLIP-seq
MIRT1260447	hsa-miR-4685-5p	CLIP-seq
MIRT1260448	hsa-miR-4687-5p	CLIP-seq
MIRT1260449	hsa-miR-4688	CLIP-seq
MIRT1260450	hsa-miR-4693-5p	CLIP-seq
MIRT1260452	hsa-miR-4723-5p	CLIP-seq
MIRT1260454	hsa-miR-4728-5p	CLIP-seq
MIRT1260455	hsa-miR-4736	CLIP-seq
MIRT1260456	hsa-miR-4755-5p	CLIP-seq
MIRT1260457	hsa-miR-4761-3p	CLIP-seq
MIRT1260458	hsa-miR-4777-3p	CLIP-seq
MIRT1260459	hsa-miR-486-3p	CLIP-seq
MIRT1260460	hsa-miR-541	CLIP-seq
MIRT1260462	hsa-miR-625	CLIP-seq
MIRT1260463	hsa-miR-645	CLIP-seq
MIRT1260464	hsa-miR-650	CLIP-seq
MIRT1260465	hsa-miR-654-5p	CLIP-seq
MIRT1260466	hsa-miR-892a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	IEA
GO:0002536	Process	Respiratory burst involved in inflammatory response	IEA
GO:0005515	Function	Protein binding	IPI	17557078, 25402766
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006979	Process	Response to oxidative stress	IBA	21873635
GO:0006979	Process	Response to oxidative stress	IMP	12943237
GO:0006979	Process	Response to oxidative stress	NAS	11904290
GO:0008379	Function	Thioredoxin peroxidase activity	IBA	21873635
GO:0008379	Function	Thioredoxin peroxidase activity	IDA	8144038
GO:0008379	Function	Thioredoxin peroxidase activity	TAS	18606987
GO:0010310	Process	Regulation of hydrogen peroxide metabolic process	IEA
GO:0016209	Function	Antioxidant activity	IDA	8144038
GO:0016209	Function	Antioxidant activity	NAS	12943237
GO:0019430	Process	Removal of superoxide radicals	IBA	21873635
GO:0019430	Process	Removal of superoxide radicals	IDA	20978343
GO:0030194	Process	Positive regulation of blood coagulation	IEA
GO:0031665	Process	Negative regulation of lipopolysaccharide-mediated signaling pathway	IEA
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0033554	Process	Cellular response to stress	IBA	21873635
GO:0034599	Process	Cellular response to oxidative stress	IDA	20978343
GO:0034599	Process	Cellular response to oxidative stress	TAS
GO:0042098	Process	T cell proliferation	IEA
GO:0042744	Process	Hydrogen peroxide catabolic process	IBA	21873635
GO:0042744	Process	Hydrogen peroxide catabolic process	TAS	18606987
GO:0042981	Process	Regulation of apoptotic process	IMP	12943237
GO:0043066	Process	Negative regulation of apoptotic process	TAS	16130169
GO:0045321	Process	Leukocyte activation	IBA	21873635
GO:0045454	Process	Cell redox homeostasis	IBA	21873635
GO:0045581	Process	Negative regulation of T cell differentiation	IEA
GO:0048538	Process	Thymus development	IEA
GO:0048872	Process	Homeostasis of number of cells	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708, 20458337, 23533145
GO:2001240	Process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA

Other IDs

• MIM: 600538
• HGNC: 9353
• e!Ensembl: ENSG00000167815

Protein

• UniProt ID: P32119
• Protein name: Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2)
• Protein function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrog
• PDB: 1QMV, 5B8A, 5B8B, 5IJT, 7KIZ, 7KJ0, 7KJ1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00578	AhpC-TSA	8 → 141	AhpC/TSA family	Domain
  PF10417	1-cysPrx_C	161 → 196	C-terminal domain of 1-Cys peroxiredoxin	Domain

• Sequence:

  MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSN
  RAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKT
  DEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGS
  DTIKPNVDDSKEYFSKHN

• Sequence length: 198

Pathways

Reactome:

Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	16316942
Esophagus neoplasm	Esophageal Neoplasms, Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	15986332
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	16778180
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17566973

Unknown
Disease name	Disease term	dbSNP ID	References
Anaplastic carcinoma	Anaplastic carcinoma		16316942
Asbestosis	Asbestosis		22537621
Down syndrome	Down Syndrome, Down Syndrome, Partial Trisomy 21		11771762
Liver carcinoma	Liver carcinoma		21472284
Monocytic leukemia	Leukemia, Monocytic, Chronic		16932348
Myeloid leukemia	Myeloid Leukemia		16932348
Osteosarcoma	Osteosarcoma		23911960
Prostatic neoplasms	Prostatic Neoplasms		17566973
Trisomy 21	Trisomy 21, Meiotic Nondisjunction, Trisomy 21, Mitotic Nondisjunction		11771762