TCP1 (t-complex 1)

Gene

• Entrez ID: 6950
• Gene name: T-complex 1
• Gene symbol: TCP1
• Synonyms: CCT-alpha, CCT1, CCTa, D6S230E, IDDPMGS, TCP-1-alpha
• Chromosome: 6
• Chromosome location: 6q25.3
• Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051234	hsa-miR-16-5p	CLASH	23622248
MIRT050683	hsa-miR-18a-5p	CLASH	23622248
MIRT050084	hsa-miR-26a-5p	CLASH	23622248
MIRT048447	hsa-miR-100-5p	CLASH	23622248
MIRT046434	hsa-miR-15b-5p	CLASH	23622248
MIRT046287	hsa-miR-23b-3p	CLASH	23622248
MIRT045307	hsa-miR-186-5p	CLASH	23622248
MIRT044438	hsa-miR-320a	CLASH	23622248
MIRT043872	hsa-miR-378a-3p	CLASH	23622248
MIRT043731	hsa-miR-342-3p	CLASH	23622248
MIRT043392	hsa-miR-331-3p	CLASH	23622248
MIRT039658	hsa-miR-615-3p	CLASH	23622248
MIRT039658	hsa-miR-615-3p	CLASH	23622248
MIRT039480	hsa-miR-652-3p	CLASH	23622248
MIRT732981	hsa-miR-34a-3p	Immunohistochemistry (IHC), Western blotting	33500737
MIRT1416722	hsa-miR-200b	CLIP-seq
MIRT1416723	hsa-miR-200c	CLIP-seq
MIRT1416724	hsa-miR-2054	CLIP-seq
MIRT1416725	hsa-miR-3143	CLIP-seq
MIRT1416726	hsa-miR-33a	CLIP-seq
MIRT1416727	hsa-miR-33b	CLIP-seq
MIRT1416728	hsa-miR-429	CLIP-seq
MIRT1416729	hsa-miR-4761-5p	CLIP-seq
MIRT1416730	hsa-miR-543	CLIP-seq
MIRT1416731	hsa-miR-888	CLIP-seq
MIRT1416722	hsa-miR-200b	CLIP-seq
MIRT1416723	hsa-miR-200c	CLIP-seq
MIRT1416724	hsa-miR-2054	CLIP-seq
MIRT1416725	hsa-miR-3143	CLIP-seq
MIRT1416726	hsa-miR-33a	CLIP-seq
MIRT1416727	hsa-miR-33b	CLIP-seq
MIRT2124963	hsa-miR-340	CLIP-seq
MIRT1416728	hsa-miR-429	CLIP-seq
MIRT1416729	hsa-miR-4761-5p	CLIP-seq
MIRT1416730	hsa-miR-543	CLIP-seq
MIRT1416731	hsa-miR-888	CLIP-seq
MIRT2347440	hsa-miR-3973	CLIP-seq
MIRT2347441	hsa-miR-4257	CLIP-seq
MIRT2347442	hsa-miR-4501	CLIP-seq
MIRT2347443	hsa-miR-4751	CLIP-seq
MIRT2347444	hsa-miR-548k	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000242	Component	Pericentriolar material	IEA
GO:0000792	Component	Heterochromatin	IEA
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0002199	Component	Zona pellucida receptor complex	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	14532270, 16085932, 16097032, 21098288, 24846140, 25416956, 25467444, 29477555, 30021884, 31470122, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005813	Component	Centrosome	IDA	20080638
GO:0005829	Component	Cytosol	TAS
GO:0005832	Component	Chaperonin-containing T-complex	IBA	21873635
GO:0005832	Component	Chaperonin-containing T-complex	IDA	23011926, 25467444, 30955883
GO:0005874	Component	Microtubule	IDA	21525035
GO:0006457	Process	Protein folding	IBA	21873635
GO:0006457	Process	Protein folding	IDA	30955883
GO:0006457	Process	Protein folding	TAS
GO:0007021	Process	Tubulin complex assembly	NAS	11532003
GO:0007339	Process	Binding of sperm to zona pellucida	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	21753002
GO:0032212	Process	Positive regulation of telomere maintenance via telomerase	IMP	25467444
GO:0035722	Process	Interleukin-12-mediated signaling pathway	TAS
GO:0044053	Process	Translocation of peptides or proteins into host cell cytoplasm	IEA
GO:0044183	Function	Protein folding chaperone	IDA	30955883
GO:0044297	Component	Cell body	IEA
GO:0050821	Process	Protein stabilization	IMP	25467444
GO:0051082	Function	Unfolded protein binding	IBA	21873635
GO:0051973	Process	Positive regulation of telomerase activity	IMP	25467444
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0090666	Process	ScaRNA localization to Cajal body	IMP	25467444
GO:1901998	Process	Toxin transport	IEA
GO:1904851	Process	Positive regulation of establishment of protein localization to telomere	IMP	25467444
GO:1904871	Process	Positive regulation of protein localization to Cajal body	HMP	25467444
GO:1904874	Process	Positive regulation of telomerase RNA localization to Cajal body	HMP	25467444
GO:1904874	Process	Positive regulation of telomerase RNA localization to Cajal body	IMP	25467444
GO:2000109	Process	Regulation of macrophage apoptotic process	IEA

Other IDs

• MIM: 186980
• HGNC: 11655
• e!Ensembl: ENSG00000120438

Protein

• UniProt ID: P17987
• Protein name: T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1)
• Protein function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TR
• PDB: 6NR8, 6NR9, 6NRA, 6NRB, 6NRC, 6NRD, 6QB8, 7LUM, 7LUP, 7NVL, 7NVM, 7NVN, 7NVO, 7TRG, 7TTN, 7TTT, 7TUB, 7WU7, 7WZ3, 7X0A, 7X0S, 7X0V, 7X3J, 7X3U, 7X6Q, 7X7Y, 8HKI, 8I1U, 8I9U, 8IB8, 8SFE, 8SFF, 8SG8, 8SG9, 8SGC, 8SGL, 8SGQ, 8SH9, 8SHA, 8SHD, 8SHE, 8SHF, 8SHG, 8SHL, 8SHN, 8SHO, 8SHP, 8SHQ, 8SHT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00118	Cpn60_TCP1	28 → 535	TCP-1/cpn60 chaperonin family	Family

• Sequence:

  MEGPLSVFGDRSTGETIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGAT
  ILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISG
  YRLACKEAVRYINENLIVNTDELGRDCLINAAKTSMSSKIIGINGDFFANMVVDAVLAIK
  YTDIRGQPRYPVNSVNILKAHGRSQMESMLISGYALNCVVGSQGMPKRIVNAKIACLDFS
  LQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYF
  VEAGAMAVRRVLKRDLKRIAKASGATILSTLANLEGEETFEAAMLGQAEEVVQERICDDE
  LILIKNTKARTSASIILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALS
  IYLENYATSMGSREQLAIAEFARSLLVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPER
  KNLKWIGLDLSNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKDD
  KHGSYEDAVHSGALND

• Sequence length: 556

Pathways

Reactome:

Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17566973

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17566973