VPS72 (vacuolar protein sorting 72 homolog)

Gene

• Entrez ID: 6944
• Gene name: Vacuolar protein sorting 72 homolog
• Gene symbol: VPS72
• Synonyms: CFL1, Swc2, TCFL1, YL-1, YL1
• Chromosome: 1
• Chromosome location: 1q21.3
• Summary: The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT039650	hsa-miR-615-3p	CLASH	23622248
MIRT479323	hsa-miR-4438	PAR-CLIP	23592263
MIRT479321	hsa-miR-4751	PAR-CLIP	23592263
MIRT479322	hsa-miR-6716-5p	PAR-CLIP	23592263
MIRT479320	hsa-miR-4271	PAR-CLIP	23592263
MIRT479319	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT479318	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT479317	hsa-miR-4450	PAR-CLIP	23592263
MIRT479316	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT479315	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT479314	hsa-miR-5095	PAR-CLIP	23592263
MIRT479313	hsa-miR-7151-3p	PAR-CLIP	23592263
MIRT479312	hsa-miR-2110	PAR-CLIP	23592263
MIRT479311	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT479310	hsa-miR-2053	PAR-CLIP	23592263
MIRT479323	hsa-miR-4438	PAR-CLIP	23592263
MIRT479321	hsa-miR-4751	PAR-CLIP	23592263
MIRT479322	hsa-miR-6716-5p	PAR-CLIP	23592263
MIRT479320	hsa-miR-4271	PAR-CLIP	23592263
MIRT479319	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT479318	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT479317	hsa-miR-4450	PAR-CLIP	23592263
MIRT479316	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT479315	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT479314	hsa-miR-5095	PAR-CLIP	23592263
MIRT479313	hsa-miR-7151-3p	PAR-CLIP	23592263
MIRT479312	hsa-miR-2110	PAR-CLIP	23592263
MIRT479311	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT479310	hsa-miR-2053	PAR-CLIP	23592263
MIRT1487383	hsa-miR-1224-5p	CLIP-seq
MIRT1487384	hsa-miR-1225-3p	CLIP-seq
MIRT1487385	hsa-miR-1253	CLIP-seq
MIRT1487386	hsa-miR-143	CLIP-seq
MIRT1487387	hsa-miR-191	CLIP-seq
MIRT1487388	hsa-miR-3120-3p	CLIP-seq
MIRT1487389	hsa-miR-3127-5p	CLIP-seq
MIRT1487390	hsa-miR-3148	CLIP-seq
MIRT1487391	hsa-miR-3175	CLIP-seq
MIRT1487392	hsa-miR-335	CLIP-seq
MIRT1487393	hsa-miR-383	CLIP-seq
MIRT1487394	hsa-miR-3918	CLIP-seq
MIRT1487395	hsa-miR-3919	CLIP-seq
MIRT1487396	hsa-miR-4270	CLIP-seq
MIRT1487397	hsa-miR-4303	CLIP-seq
MIRT1487398	hsa-miR-4305	CLIP-seq
MIRT1487399	hsa-miR-4323	CLIP-seq
MIRT1487400	hsa-miR-4423-3p	CLIP-seq
MIRT1487401	hsa-miR-4434	CLIP-seq
MIRT1487402	hsa-miR-4436b-3p	CLIP-seq
MIRT1487403	hsa-miR-4441	CLIP-seq
MIRT1487404	hsa-miR-4511	CLIP-seq
MIRT1487405	hsa-miR-4516	CLIP-seq
MIRT1487406	hsa-miR-451b	CLIP-seq
MIRT1487407	hsa-miR-4649-3p	CLIP-seq
MIRT1487408	hsa-miR-4668-5p	CLIP-seq
MIRT1487409	hsa-miR-4756-3p	CLIP-seq
MIRT1487410	hsa-miR-4759	CLIP-seq
MIRT1487411	hsa-miR-4762-3p	CLIP-seq
MIRT1487412	hsa-miR-4770	CLIP-seq
MIRT1487413	hsa-miR-548b-3p	CLIP-seq
MIRT1487414	hsa-miR-649	CLIP-seq
MIRT1487389	hsa-miR-3127-5p	CLIP-seq
MIRT1487394	hsa-miR-3918	CLIP-seq
MIRT1487402	hsa-miR-4436b-3p	CLIP-seq
MIRT1487386	hsa-miR-143	CLIP-seq
MIRT1487391	hsa-miR-3175	CLIP-seq
MIRT1487393	hsa-miR-383	CLIP-seq
MIRT1487395	hsa-miR-3919	CLIP-seq
MIRT1487409	hsa-miR-4756-3p	CLIP-seq
MIRT1487412	hsa-miR-4770	CLIP-seq
MIRT1487384	hsa-miR-1225-3p	CLIP-seq
MIRT1487385	hsa-miR-1253	CLIP-seq
MIRT1487387	hsa-miR-191	CLIP-seq
MIRT1487388	hsa-miR-3120-3p	CLIP-seq
MIRT1487391	hsa-miR-3175	CLIP-seq
MIRT1487392	hsa-miR-335	CLIP-seq
MIRT1487396	hsa-miR-4270	CLIP-seq
MIRT1487399	hsa-miR-4323	CLIP-seq
MIRT1487401	hsa-miR-4434	CLIP-seq
MIRT1487403	hsa-miR-4441	CLIP-seq
MIRT1487405	hsa-miR-4516	CLIP-seq
MIRT1487406	hsa-miR-451b	CLIP-seq
MIRT1487384	hsa-miR-1225-3p	CLIP-seq
MIRT1487385	hsa-miR-1253	CLIP-seq
MIRT1487387	hsa-miR-191	CLIP-seq
MIRT1487388	hsa-miR-3120-3p	CLIP-seq
MIRT1487391	hsa-miR-3175	CLIP-seq
MIRT1487392	hsa-miR-335	CLIP-seq
MIRT1487396	hsa-miR-4270	CLIP-seq
MIRT1487399	hsa-miR-4323	CLIP-seq
MIRT1487401	hsa-miR-4434	CLIP-seq
MIRT1487403	hsa-miR-4441	CLIP-seq
MIRT1487405	hsa-miR-4516	CLIP-seq
MIRT1487406	hsa-miR-451b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	TAS	7702631
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	15647280, 16189514, 16230350, 25416956, 28514442, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0016607	Component	Nuclear speck	IDA
GO:0032991	Component	Protein-containing complex	IDA	14966270
GO:0035019	Process	Somatic stem cell population maintenance	IEA
GO:0042393	Function	Histone binding	IPI	26974126
GO:0043486	Process	Histone exchange	IBA	21873635
GO:0043486	Process	Histone exchange	IMP	26974126

Other IDs

• MIM: 600607
• HGNC: 11644
• e!Ensembl: ENSG00000163159

Protein

• UniProt ID: Q15906
• Protein name: Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1)
• Protein function: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/
• PDB: 5FUG, 8QR1, 8X15, 8X19, 8X1C, 8XVG, 8XVT, 9C57, 9C62
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05764	YL1	7 → 216	YL1 nuclear protein	Family
  PF08265	YL1_C	291 → 319	YL1 nuclear protein C-terminal domain	Domain

• Sequence:

  MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD
  FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL
  ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
  ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA
  PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
  YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK
  IVIK

• Sequence length: 364

Pathways

KEGG:

ATP-dependent chromatin remodeling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243