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BTG1 (BTG anti-proliferation factor 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
694
Gene nameGene Name - the full gene name approved by the HGNC.
BTG anti-proliferation factor 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
BTG1
SynonymsGene synonyms aliases
APRO2
ChromosomeChromosome number
12
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q21.33
SummarySummary of gene provided in NCBI Entrez Gene.
This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein int
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028939 hsa-miR-26b-5p Microarray 19088304
MIRT041705 hsa-miR-484 CLASH 23622248
MIRT041705 hsa-miR-484 CLASH 23622248
MIRT053302 hsa-miR-372-3p Luciferase reporter assay, qRT-PCR, Western blot 22020335
MIRT053303 hsa-miR-373-3p Luciferase reporter assay, qRT-PCR, Western blot 22020335
Transcription factors
Transcription factor Regulation Reference
AR Repression 16281084
HLX Unknown 22897850
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003712 Function Transcription coregulator activity NAS 11420681
GO:0005515 Function Protein binding IPI 9712883, 9820826, 10617598, 11136725, 16189514, 21900206, 27107012, 31515488, 32296183
GO:0005634 Component Nucleus IBA 21873635
GO:0005634 Component Nucleus IDA 9820826, 11420681
GO:0005634 Component Nucleus IMP 11420681
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P62324
Protein name Protein BTG1 (B-cell translocation gene 1 protein)
Protein function Anti-proliferative protein.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07742 BTG
11 124
BTG family
Family
Sequence
Sequence length 171
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  RNA degradation   FOXO-mediated transcription of cell cycle genes
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Arthritis Juvenile arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 19565504
Multiple myeloma Multiple Myeloma rs11540652, rs78311289, rs121913482, rs397507340, rs121913343, rs121913240, rs121913529, rs730882018, rs1057517992, rs121913527, rs756183569, rs746646631, rs1574706907, rs372078034, rs745380962, rs751524927, rs1575079076, rs1575446356, rs1478603808, rs1578264146, rs1578673280, rs1579484570, rs1579491104, rs1171390403, rs1582867955, rs764264135, rs951047896, rs890521687, rs1581495906, rs1587941402, rs1003155450, rs1588299621, rs1591100766, rs1591693095, rs1029296641, rs1593107841, rs1208575764, rs1593835248, rs1594406727, rs1594966387, rs1595889508, rs1159294530, rs1597073318, rs1135402871, rs1599413207, rs1418268495, rs1212577459, rs1600394490, rs1455074519, rs1603113792, rs1603415028, rs1602247047, rs1603452612 16918137
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 16223876
Unknown
Disease name Disease term dbSNP ID References
Juvenile arthritis Juvenile psoriatic arthritis 19565504
Seronegative polyarthritis Polyarthritis, Juvenile, Rheumatoid Factor Negative 19565504
Polyarthritis, rheumatoid factor positive Polyarthritis, Juvenile, Rheumatoid Factor Positive 19565504
Still disease Juvenile-Onset Still Disease 19565504

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