BTG1 (BTG anti-proliferation factor 1)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
694 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
BTG anti-proliferation factor 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
BTG1 |
SynonymsGene synonyms aliases
|
APRO2 |
ChromosomeChromosome number
|
12 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
12q21.33 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein int |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
AR |
Repression |
16281084 |
HLX |
Unknown |
22897850 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0003712 |
Function |
Transcription coregulator activity |
NAS |
11420681 |
GO:0005515 |
Function |
Protein binding |
IPI |
9712883, 9820826, 10617598, 11136725, 16189514, 21900206, 27107012, 31515488, 32296183 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005634 |
Component |
Nucleus |
IDA |
9820826, 11420681 |
GO:0005634 |
Component |
Nucleus |
IMP |
11420681 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
11420681 |
GO:0005737 |
Component |
Cytoplasm |
IMP |
11420681 |
GO:0006355 |
Process |
Regulation of transcription, DNA-templated |
NAS |
11420681 |
GO:0008285 |
Process |
Negative regulation of cell population proliferation |
IBA |
21873635 |
GO:0008285 |
Process |
Negative regulation of cell population proliferation |
IDA |
1373383, 11420681 |
GO:0016477 |
Process |
Cell migration |
NAS |
15033446 |
GO:0019899 |
Function |
Enzyme binding |
IPI |
8663146 |
GO:0019900 |
Function |
Kinase binding |
NAS |
9820826 |
GO:0030308 |
Process |
Negative regulation of cell growth |
NAS |
15033446 |
GO:0045603 |
Process |
Positive regulation of endothelial cell differentiation |
IMP |
15033446 |
GO:0045663 |
Process |
Positive regulation of myoblast differentiation |
IDA |
11420681 |
GO:0045663 |
Process |
Positive regulation of myoblast differentiation |
NAS |
15033446 |
GO:0045766 |
Process |
Positive regulation of angiogenesis |
IMP |
15033446 |
GO:0045930 |
Process |
Negative regulation of mitotic cell cycle |
IBA |
21873635 |
GO:2000271 |
Process |
Positive regulation of fibroblast apoptotic process |
IMP |
9690562 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P62324 |
Protein name |
Protein BTG1 (B-cell translocation gene 1 protein) |
Protein function |
Anti-proliferative protein. |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF07742 |
BTG |
11 → 124 |
BTG family |
Family |
|
Sequence |
|
Sequence length |
171 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
|
|
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Arthritis |
Juvenile arthritis |
rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 |
19565504 |
Multiple myeloma |
Multiple Myeloma |
rs11540652, rs78311289, rs121913482, rs397507340, rs121913343, rs121913240, rs121913529, rs730882018, rs1057517992, rs121913527, rs756183569, rs746646631, rs1574706907, rs372078034, rs745380962, rs751524927, rs1575079076, rs1575446356, rs1478603808, rs1578264146, rs1578673280, rs1579484570, rs1579491104, rs1171390403, rs1582867955, rs764264135, rs951047896, rs890521687, rs1581495906, rs1587941402, rs1003155450, rs1588299621, rs1591100766, rs1591693095, rs1029296641, rs1593107841, rs1208575764, rs1593835248, rs1594406727, rs1594966387, rs1595889508, rs1159294530, rs1597073318, rs1135402871, rs1599413207, rs1418268495, rs1212577459, rs1600394490, rs1455074519, rs1603113792, rs1603415028, rs1602247047, rs1603452612 |
16918137 |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
16223876 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Juvenile arthritis |
Juvenile psoriatic arthritis |
|
19565504 |
Seronegative polyarthritis |
Polyarthritis, Juvenile, Rheumatoid Factor Negative |
|
19565504 |
Polyarthritis, rheumatoid factor positive |
Polyarthritis, Juvenile, Rheumatoid Factor Positive |
|
19565504 |
Still disease |
Juvenile-Onset Still Disease |
|
19565504 |
|
|
|
| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412 |