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TBXA2R (thromboxane A2 receptor)
Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6915
Gene nameGene Name - the full gene name approved by the HGNC.
Thromboxane A2 receptor
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TBXA2R
SynonymsGene synonyms aliases
BDPLT13, TXA2-R
ChromosomeChromosome number
19
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants enc
SNPsSNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
SNP ID Visualize variation Clinical significance Consequence
rs387906691 C>T Risk-factor Coding sequence variant, missense variant
rs397514542 A>C Risk-factor Coding sequence variant, missense variant
rs1131691334 G>A Likely-pathogenic Coding sequence variant, missense variant
rs1599869510 T>C Likely-pathogenic Splice acceptor variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT022135 hsa-miR-124-3p Microarray 18668037
MIRT054726 hsa-miR-31-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 24558106
MIRT054726 hsa-miR-31-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 24558106
MIRT684264 hsa-miR-4432 HITS-CLIP 23313552
MIRT684263 hsa-miR-508-5p HITS-CLIP 23313552
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
EGR1 Unknown 18698092
ETS1 Activation 18698092
GATA1 Activation 18698092
NFE2 Unknown 18698092
SP1 Unknown 18698092
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0001669 Component Acrosomal vesicle IEA
GO:0004961 Function Thromboxane A2 receptor activity IBA 21873635
GO:0005085 Function Guanyl-nucleotide exchange factor activity TAS
GO:0005515 Function Protein binding IPI 17644091, 19464661
GO:0005886 Component Plasma membrane IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P21731
Protein name Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)
Protein function Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 t
PDB 8XJN , 8XJO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1
41 → 308
7 transmembrane receptor (rhodopsin family)
 Family
Sequence
Sequence length 343
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation 		  Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
Associated diseases
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Asthma Asthma, Aspirin-Induced rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 16502481, 20485159
Bleeding disorder Bleeding Disorder due to Defective Thromboxane A2 Receptor, Bleeding diathesis due to thromboxane synthesis deficiency rs121918444, rs387906691, rs397514542, rs398122372, rs398122373, rs773148506, rs1064797083, rs1064797085, rs1064797087, rs761749948
Platelet-type bleeding disorder Blood Platelet Disorders rs1560045738, rs70961716, rs142186404, rs121918035, rs121918444, rs760074158, rs2146873791, rs387907345, rs387907346, rs387907348, rs387907350, rs397989794, rs587777211, rs587777529, rs724159972, rs572295823, rs550565800, rs869320714, rs869320716, rs757188030, rs1057518838, rs1057518837, rs148051111, rs1555122100, rs1554724694, rs755459581, rs752492512, rs1592371840, rs747559032, rs778608263, rs148910227, rs3211901, rs1594755688, rs1594760036, rs1594760140, rs1594768463, rs1594771224, rs1594771270, rs551607784, rs774996406, rs200434813 7929844, 19828703
Unknown
Disease name Disease term dbSNP ID References
Hemorrhagic disorders Hemorrhagic Disorders 19828703
Pulmonary thromboembolism Pulmonary Thromboembolisms 7740511
Rhinitis Rhinitis 12167471

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