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MAP3K7 (mitogen-activated protein kinase kinase kinase 7)

Gene

6885

Mitogen-activated protein kinase kinase kinase 7

MAP3K7

CSCF, FMD2, MEKK7, TAK1, TGF1a

6q15

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcripti

Show/Hide all(13)

SNP ID	Visualize variation	Clinical significance	Consequence
rs886039230	G>A,C,T	Pathogenic	Coding sequence variant, intron variant, missense variant
rs886039231	C>G	Pathogenic	5 prime UTR variant, coding sequence variant, missense variant
rs886039232	A>T	Pathogenic	5 prime UTR variant, coding sequence variant, missense variant
rs886039233	C>G	Pathogenic	Coding sequence variant, missense variant
rs886039234	TCTTCC>-	Pathogenic	5 prime UTR variant, inframe deletion, coding sequence variant
rs886039235	C>A	Pathogenic	5 prime UTR variant, coding sequence variant, missense variant
rs886039236	AAC>-	Pathogenic	5 prime UTR variant, inframe deletion, coding sequence variant
rs886039237	A>C,T	Pathogenic	Coding sequence variant, missense variant
rs1057517758	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1064795771	C>T	Likely-pathogenic	Coding sequence variant, 5 prime UTR variant, missense variant
rs1180249151	C>A,T	Likely-pathogenic	Splice acceptor variant
rs1554184177	T>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1582233787	AAC>-	Likely-pathogenic	Coding sequence variant, 5 prime UTR variant, inframe deletion

Show/Hide all(375)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005509	hsa-miR-10a-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	20624982
MIRT025316	hsa-miR-34a-5p	Sequencing	20371350
MIRT005509	hsa-miR-10a-5p	Reporter assay;Other	20624982
MIRT027011	hsa-miR-103a-3p	Sequencing	20371350
MIRT051235	hsa-miR-16-5p	CLASH	23622248
MIRT036539	hsa-miR-1226-5p	CLASH	23622248
MIRT053639	hsa-miR-143-3p	Microarray	22942087
MIRT616961	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616960	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616959	hsa-miR-3671	HITS-CLIP	23824327
MIRT616958	hsa-miR-5696	HITS-CLIP	23824327
MIRT616957	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT616956	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT616955	hsa-miR-607	HITS-CLIP	23824327
MIRT616954	hsa-miR-1305	HITS-CLIP	23824327
MIRT616953	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT566834	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT566833	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT051235	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT566832	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT566831	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT566830	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT566829	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT566828	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT566827	hsa-miR-646	PAR-CLIP	20371350
MIRT566826	hsa-miR-875-5p	PAR-CLIP	20371350
MIRT566825	hsa-miR-5589-3p	PAR-CLIP	20371350
MIRT566824	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT566823	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT566822	hsa-miR-599	PAR-CLIP	20371350
MIRT512946	hsa-miR-1910-3p	PAR-CLIP	20371350
MIRT512945	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT512944	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT512943	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT512942	hsa-miR-940	PAR-CLIP	20371350
MIRT512941	hsa-miR-2682-5p	PAR-CLIP	20371350
MIRT512940	hsa-miR-34b-5p	PAR-CLIP	20371350
MIRT512939	hsa-miR-449c-5p	PAR-CLIP	20371350
MIRT512938	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT512937	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT027011	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT512936	hsa-miR-107	PAR-CLIP	20371350
MIRT512935	hsa-miR-548au-3p	PAR-CLIP	20371350
MIRT512946	hsa-miR-1910-3p	PAR-CLIP	23446348
MIRT512945	hsa-miR-6511a-5p	PAR-CLIP	23446348
MIRT512944	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT512943	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT512942	hsa-miR-940	PAR-CLIP	23446348
MIRT512941	hsa-miR-2682-5p	PAR-CLIP	23446348
MIRT512940	hsa-miR-34b-5p	PAR-CLIP	23446348
MIRT512939	hsa-miR-449c-5p	PAR-CLIP	23446348
MIRT512938	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT512937	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT027011	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT512936	hsa-miR-107	PAR-CLIP	23446348
MIRT512935	hsa-miR-548au-3p	PAR-CLIP	23446348
MIRT449701	hsa-miR-3914	PAR-CLIP	22100165
MIRT445925	hsa-miR-4635	PAR-CLIP	22100165
MIRT445926	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT445925	hsa-miR-4635	PAR-CLIP	22100165
MIRT445926	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT735700	hsa-miR-129-5p	Luciferase reporter assay, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR	32048803
MIRT736428	hsa-miR-491-3p	qRT-PCR, Flow cytometry	33679688
MIRT616961	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616960	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616959	hsa-miR-3671	HITS-CLIP	23824327
MIRT616958	hsa-miR-5696	HITS-CLIP	23824327
MIRT616957	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT616956	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT616955	hsa-miR-607	HITS-CLIP	23824327
MIRT616954	hsa-miR-1305	HITS-CLIP	23824327
MIRT616953	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT566834	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT566833	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT051235	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT566832	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT566831	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT566830	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT566829	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT566828	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT566827	hsa-miR-646	PAR-CLIP	20371350
MIRT566826	hsa-miR-875-5p	PAR-CLIP	20371350
MIRT566825	hsa-miR-5589-3p	PAR-CLIP	20371350
MIRT566824	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT566823	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT566822	hsa-miR-599	PAR-CLIP	20371350
MIRT512946	hsa-miR-1910-3p	PAR-CLIP	20371350
MIRT512945	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT512944	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT512943	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT512942	hsa-miR-940	PAR-CLIP	20371350
MIRT512941	hsa-miR-2682-5p	PAR-CLIP	20371350
MIRT512940	hsa-miR-34b-5p	PAR-CLIP	20371350
MIRT512939	hsa-miR-449c-5p	PAR-CLIP	20371350
MIRT512938	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT512937	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT027011	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT512936	hsa-miR-107	PAR-CLIP	20371350
MIRT512935	hsa-miR-548au-3p	PAR-CLIP	20371350
MIRT512946	hsa-miR-1910-3p	PAR-CLIP	23446348
MIRT512945	hsa-miR-6511a-5p	PAR-CLIP	23446348
MIRT512944	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT512943	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT512942	hsa-miR-940	PAR-CLIP	23446348
MIRT512941	hsa-miR-2682-5p	PAR-CLIP	23446348
MIRT512940	hsa-miR-34b-5p	PAR-CLIP	23446348
MIRT512939	hsa-miR-449c-5p	PAR-CLIP	23446348
MIRT512938	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT512937	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT027011	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT512936	hsa-miR-107	PAR-CLIP	23446348
MIRT512935	hsa-miR-548au-3p	PAR-CLIP	23446348
MIRT449701	hsa-miR-3914	PAR-CLIP	22100165
MIRT445925	hsa-miR-4635	PAR-CLIP	22100165
MIRT445926	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT445925	hsa-miR-4635	PAR-CLIP	22100165
MIRT445926	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT1129023	hsa-miR-103a	CLIP-seq
MIRT1129024	hsa-miR-106a	CLIP-seq
MIRT1129025	hsa-miR-106b	CLIP-seq
MIRT1129026	hsa-miR-1256	CLIP-seq
MIRT1129027	hsa-miR-1297	CLIP-seq
MIRT1129028	hsa-miR-17	CLIP-seq
MIRT1129029	hsa-miR-20a	CLIP-seq
MIRT1129030	hsa-miR-20b	CLIP-seq
MIRT1129031	hsa-miR-224	CLIP-seq
MIRT1129032	hsa-miR-2682	CLIP-seq
MIRT1129033	hsa-miR-26a	CLIP-seq
MIRT1129034	hsa-miR-26b	CLIP-seq
MIRT1129035	hsa-miR-302a	CLIP-seq
MIRT1129036	hsa-miR-302b	CLIP-seq
MIRT1129037	hsa-miR-302c	CLIP-seq
MIRT1129038	hsa-miR-302d	CLIP-seq
MIRT1129039	hsa-miR-302e	CLIP-seq
MIRT1129040	hsa-miR-372	CLIP-seq
MIRT1129041	hsa-miR-373	CLIP-seq
MIRT1129042	hsa-miR-4465	CLIP-seq
MIRT1129043	hsa-miR-449c	CLIP-seq
MIRT1129044	hsa-miR-4642	CLIP-seq
MIRT1129045	hsa-miR-4684-3p	CLIP-seq
MIRT1129046	hsa-miR-4715-5p	CLIP-seq
MIRT1129047	hsa-miR-4716-5p	CLIP-seq
MIRT1129048	hsa-miR-494	CLIP-seq
MIRT1129049	hsa-miR-512-3p	CLIP-seq
MIRT1129050	hsa-miR-518a-5p	CLIP-seq
MIRT1129051	hsa-miR-519d	CLIP-seq
MIRT1129052	hsa-miR-520a-3p	CLIP-seq
MIRT1129053	hsa-miR-520b	CLIP-seq
MIRT1129054	hsa-miR-520c-3p	CLIP-seq
MIRT1129055	hsa-miR-520d-3p	CLIP-seq
MIRT1129056	hsa-miR-520e	CLIP-seq
MIRT1129057	hsa-miR-520g	CLIP-seq
MIRT1129058	hsa-miR-520h	CLIP-seq
MIRT1129059	hsa-miR-527	CLIP-seq
MIRT1129060	hsa-miR-545	CLIP-seq
MIRT1129061	hsa-miR-582-5p	CLIP-seq
MIRT1129062	hsa-miR-767-3p	CLIP-seq
MIRT1129063	hsa-miR-93	CLIP-seq
MIRT1129023	hsa-miR-103a	CLIP-seq
MIRT1129064	hsa-miR-1205	CLIP-seq
MIRT1129065	hsa-miR-1286	CLIP-seq
MIRT1129032	hsa-miR-2682	CLIP-seq
MIRT1129066	hsa-miR-34b	CLIP-seq
MIRT1129067	hsa-miR-4418	CLIP-seq
MIRT1129043	hsa-miR-449c	CLIP-seq
MIRT1129068	hsa-miR-4722-5p	CLIP-seq
MIRT1129069	hsa-miR-509-3-5p	CLIP-seq
MIRT1129070	hsa-miR-509-5p	CLIP-seq
MIRT1129060	hsa-miR-545	CLIP-seq
MIRT1129071	hsa-miR-1258	CLIP-seq
MIRT1129072	hsa-miR-1264	CLIP-seq
MIRT1129073	hsa-miR-15a	CLIP-seq
MIRT1129074	hsa-miR-15b	CLIP-seq
MIRT1129075	hsa-miR-16	CLIP-seq
MIRT1129076	hsa-miR-188-5p	CLIP-seq
MIRT1129077	hsa-miR-195	CLIP-seq
MIRT1129078	hsa-miR-3124-3p	CLIP-seq
MIRT1129079	hsa-miR-3614-3p	CLIP-seq
MIRT1129080	hsa-miR-377	CLIP-seq
MIRT1129081	hsa-miR-424	CLIP-seq
MIRT1129082	hsa-miR-4509	CLIP-seq
MIRT1129083	hsa-miR-4524	CLIP-seq
MIRT1129084	hsa-miR-4528	CLIP-seq
MIRT1129085	hsa-miR-4652-3p	CLIP-seq
MIRT1129086	hsa-miR-497	CLIP-seq
MIRT1129087	hsa-miR-503	CLIP-seq
MIRT1129088	hsa-miR-507	CLIP-seq
MIRT1129089	hsa-miR-548m	CLIP-seq
MIRT1129090	hsa-miR-557	CLIP-seq
MIRT1129091	hsa-miR-602	CLIP-seq
MIRT1551122	hsa-miR-590-3p	CLIP-seq
MIRT2036731	hsa-miR-448	CLIP-seq
MIRT1129023	hsa-miR-103a	CLIP-seq
MIRT1129026	hsa-miR-1256	CLIP-seq
MIRT1129071	hsa-miR-1258	CLIP-seq
MIRT2266921	hsa-miR-142-5p	CLIP-seq
MIRT1129032	hsa-miR-2682	CLIP-seq
MIRT2266922	hsa-miR-297	CLIP-seq
MIRT2266923	hsa-miR-3149	CLIP-seq
MIRT2266924	hsa-miR-329	CLIP-seq
MIRT1129066	hsa-miR-34b	CLIP-seq
MIRT1129079	hsa-miR-3614-3p	CLIP-seq
MIRT2266925	hsa-miR-362-3p	CLIP-seq
MIRT1129080	hsa-miR-377	CLIP-seq
MIRT2266926	hsa-miR-3941	CLIP-seq
MIRT2266927	hsa-miR-421	CLIP-seq
MIRT2266928	hsa-miR-4282	CLIP-seq
MIRT2266929	hsa-miR-4474-5p	CLIP-seq
MIRT1129043	hsa-miR-449c	CLIP-seq
MIRT2266930	hsa-miR-4517	CLIP-seq
MIRT1129044	hsa-miR-4642	CLIP-seq
MIRT1129085	hsa-miR-4652-3p	CLIP-seq
MIRT2266931	hsa-miR-4694-3p	CLIP-seq
MIRT2266932	hsa-miR-4705	CLIP-seq
MIRT1129046	hsa-miR-4715-5p	CLIP-seq
MIRT1129047	hsa-miR-4716-5p	CLIP-seq
MIRT2266933	hsa-miR-4789-3p	CLIP-seq
MIRT1129048	hsa-miR-494	CLIP-seq
MIRT2266934	hsa-miR-495	CLIP-seq
MIRT2266935	hsa-miR-526b	CLIP-seq
MIRT1129060	hsa-miR-545	CLIP-seq
MIRT1129061	hsa-miR-582-5p	CLIP-seq
MIRT1551122	hsa-miR-590-3p	CLIP-seq
MIRT1129091	hsa-miR-602	CLIP-seq
MIRT2266936	hsa-miR-603	CLIP-seq
MIRT1129064	hsa-miR-1205	CLIP-seq
MIRT1129066	hsa-miR-34b	CLIP-seq
MIRT1129067	hsa-miR-4418	CLIP-seq
MIRT1129069	hsa-miR-509-3-5p	CLIP-seq
MIRT1129070	hsa-miR-509-5p	CLIP-seq
MIRT2453690	hsa-miR-570	CLIP-seq
MIRT1129024	hsa-miR-106a	CLIP-seq
MIRT1129025	hsa-miR-106b	CLIP-seq
MIRT2566477	hsa-miR-10a	CLIP-seq
MIRT2566478	hsa-miR-10b	CLIP-seq
MIRT1129072	hsa-miR-1264	CLIP-seq
MIRT2566479	hsa-miR-1273f	CLIP-seq
MIRT2566480	hsa-miR-1278	CLIP-seq
MIRT2566481	hsa-miR-129-3p	CLIP-seq
MIRT1129027	hsa-miR-1297	CLIP-seq
MIRT2266921	hsa-miR-142-5p	CLIP-seq
MIRT2566482	hsa-miR-143	CLIP-seq
MIRT2566483	hsa-miR-153	CLIP-seq
MIRT1129028	hsa-miR-17	CLIP-seq
MIRT1129029	hsa-miR-20a	CLIP-seq
MIRT1129030	hsa-miR-20b	CLIP-seq
MIRT1129031	hsa-miR-224	CLIP-seq
MIRT1129033	hsa-miR-26a	CLIP-seq
MIRT1129034	hsa-miR-26b	CLIP-seq
MIRT2566484	hsa-miR-300	CLIP-seq
MIRT1129035	hsa-miR-302a	CLIP-seq
MIRT1129036	hsa-miR-302b	CLIP-seq
MIRT1129037	hsa-miR-302c	CLIP-seq
MIRT1129038	hsa-miR-302d	CLIP-seq
MIRT1129039	hsa-miR-302e	CLIP-seq
MIRT2566485	hsa-miR-3122	CLIP-seq
MIRT1129078	hsa-miR-3124-3p	CLIP-seq
MIRT2566486	hsa-miR-3148	CLIP-seq
MIRT2566487	hsa-miR-3153	CLIP-seq
MIRT2566488	hsa-miR-330-3p	CLIP-seq
MIRT2566489	hsa-miR-339-5p	CLIP-seq
MIRT1129066	hsa-miR-34b	CLIP-seq
MIRT2566490	hsa-miR-369-3p	CLIP-seq
MIRT1129040	hsa-miR-372	CLIP-seq
MIRT1129041	hsa-miR-373	CLIP-seq
MIRT2566491	hsa-miR-374a	CLIP-seq
MIRT2566492	hsa-miR-374b	CLIP-seq
MIRT2566493	hsa-miR-381	CLIP-seq
MIRT2566494	hsa-miR-3913-5p	CLIP-seq
MIRT2566495	hsa-miR-4421	CLIP-seq
MIRT1129042	hsa-miR-4465	CLIP-seq
MIRT2566496	hsa-miR-4477a	CLIP-seq
MIRT2036731	hsa-miR-448	CLIP-seq
MIRT2566497	hsa-miR-4639-3p	CLIP-seq
MIRT1129044	hsa-miR-4642	CLIP-seq
MIRT2566498	hsa-miR-4668-5p	CLIP-seq
MIRT2566499	hsa-miR-4682	CLIP-seq
MIRT1129045	hsa-miR-4684-3p	CLIP-seq
MIRT2566500	hsa-miR-4698	CLIP-seq
MIRT2266932	hsa-miR-4705	CLIP-seq
MIRT2566501	hsa-miR-4708-5p	CLIP-seq
MIRT2566502	hsa-miR-4720-5p	CLIP-seq
MIRT2566503	hsa-miR-4770	CLIP-seq
MIRT2566504	hsa-miR-4799-3p	CLIP-seq
MIRT2566505	hsa-miR-4799-5p	CLIP-seq
MIRT2566506	hsa-miR-511	CLIP-seq
MIRT1129049	hsa-miR-512-3p	CLIP-seq
MIRT2566507	hsa-miR-513a-3p	CLIP-seq
MIRT1129050	hsa-miR-518a-5p	CLIP-seq
MIRT1129051	hsa-miR-519d	CLIP-seq
MIRT1129052	hsa-miR-520a-3p	CLIP-seq
MIRT1129053	hsa-miR-520b	CLIP-seq
MIRT1129054	hsa-miR-520c-3p	CLIP-seq
MIRT1129055	hsa-miR-520d-3p	CLIP-seq
MIRT1129056	hsa-miR-520e	CLIP-seq
MIRT1129057	hsa-miR-520g	CLIP-seq
MIRT1129058	hsa-miR-520h	CLIP-seq
MIRT1129059	hsa-miR-527	CLIP-seq
MIRT2566508	hsa-miR-640	CLIP-seq
MIRT1129062	hsa-miR-767-3p	CLIP-seq
MIRT2566509	hsa-miR-889	CLIP-seq
MIRT1129063	hsa-miR-93	CLIP-seq
MIRT2566510	hsa-miR-938	CLIP-seq
MIRT2566511	hsa-miR-944	CLIP-seq
MIRT1129024	hsa-miR-106a	CLIP-seq
MIRT1129025	hsa-miR-106b	CLIP-seq
MIRT2566477	hsa-miR-10a	CLIP-seq
MIRT2566478	hsa-miR-10b	CLIP-seq
MIRT1129072	hsa-miR-1264	CLIP-seq
MIRT2566479	hsa-miR-1273f	CLIP-seq
MIRT2566480	hsa-miR-1278	CLIP-seq
MIRT2566481	hsa-miR-129-3p	CLIP-seq
MIRT1129027	hsa-miR-1297	CLIP-seq
MIRT2566482	hsa-miR-143	CLIP-seq
MIRT2566483	hsa-miR-153	CLIP-seq
MIRT1129028	hsa-miR-17	CLIP-seq
MIRT1129029	hsa-miR-20a	CLIP-seq
MIRT1129030	hsa-miR-20b	CLIP-seq
MIRT1129031	hsa-miR-224	CLIP-seq
MIRT1129033	hsa-miR-26a	CLIP-seq
MIRT1129034	hsa-miR-26b	CLIP-seq
MIRT1129035	hsa-miR-302a	CLIP-seq
MIRT1129036	hsa-miR-302b	CLIP-seq
MIRT1129037	hsa-miR-302c	CLIP-seq
MIRT1129038	hsa-miR-302d	CLIP-seq
MIRT1129039	hsa-miR-302e	CLIP-seq
MIRT2566485	hsa-miR-3122	CLIP-seq
MIRT1129078	hsa-miR-3124-3p	CLIP-seq
MIRT2566486	hsa-miR-3148	CLIP-seq
MIRT2566487	hsa-miR-3153	CLIP-seq
MIRT2566488	hsa-miR-330-3p	CLIP-seq
MIRT2566489	hsa-miR-339-5p	CLIP-seq
MIRT1129066	hsa-miR-34b	CLIP-seq
MIRT2566490	hsa-miR-369-3p	CLIP-seq
MIRT1129040	hsa-miR-372	CLIP-seq
MIRT1129041	hsa-miR-373	CLIP-seq
MIRT2566491	hsa-miR-374a	CLIP-seq
MIRT2566492	hsa-miR-374b	CLIP-seq
MIRT2566494	hsa-miR-3913-5p	CLIP-seq
MIRT2566495	hsa-miR-4421	CLIP-seq
MIRT1129042	hsa-miR-4465	CLIP-seq
MIRT2566496	hsa-miR-4477a	CLIP-seq
MIRT2036731	hsa-miR-448	CLIP-seq
MIRT2566497	hsa-miR-4639-3p	CLIP-seq
MIRT1129044	hsa-miR-4642	CLIP-seq
MIRT2566498	hsa-miR-4668-5p	CLIP-seq
MIRT2566499	hsa-miR-4682	CLIP-seq
MIRT1129045	hsa-miR-4684-3p	CLIP-seq
MIRT2566500	hsa-miR-4698	CLIP-seq
MIRT2266932	hsa-miR-4705	CLIP-seq
MIRT2566501	hsa-miR-4708-5p	CLIP-seq
MIRT2566502	hsa-miR-4720-5p	CLIP-seq
MIRT2566503	hsa-miR-4770	CLIP-seq
MIRT2566504	hsa-miR-4799-3p	CLIP-seq
MIRT2566505	hsa-miR-4799-5p	CLIP-seq
MIRT2566506	hsa-miR-511	CLIP-seq
MIRT1129049	hsa-miR-512-3p	CLIP-seq
MIRT2566507	hsa-miR-513a-3p	CLIP-seq
MIRT1129050	hsa-miR-518a-5p	CLIP-seq
MIRT1129051	hsa-miR-519d	CLIP-seq
MIRT1129052	hsa-miR-520a-3p	CLIP-seq
MIRT1129053	hsa-miR-520b	CLIP-seq
MIRT1129054	hsa-miR-520c-3p	CLIP-seq
MIRT1129055	hsa-miR-520d-3p	CLIP-seq
MIRT1129056	hsa-miR-520e	CLIP-seq
MIRT1129057	hsa-miR-520g	CLIP-seq
MIRT1129058	hsa-miR-520h	CLIP-seq
MIRT1129059	hsa-miR-527	CLIP-seq
MIRT1129091	hsa-miR-602	CLIP-seq
MIRT2566508	hsa-miR-640	CLIP-seq
MIRT1129062	hsa-miR-767-3p	CLIP-seq
MIRT2566509	hsa-miR-889	CLIP-seq
MIRT1129063	hsa-miR-93	CLIP-seq
MIRT2566510	hsa-miR-938	CLIP-seq
MIRT2566511	hsa-miR-944	CLIP-seq

Show/Hide all(50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000186	Process	Activation of MAPKK activity	IDA	8663074, 9079627
GO:0000187	Process	Activation of MAPK activity	IDA	9079627
GO:0000187	Process	Activation of MAPK activity	TAS
GO:0000287	Function	Magnesium ion binding	IEA
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002726	Process	Positive regulation of T cell cytokine production	IMP	15125833
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0004672	Function	Protein kinase activity	IDA	10094049
GO:0004674	Function	Protein serine/threonine kinase activity	EXP	10702308, 11460167, 20538596
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0004709	Function	MAP kinase kinase kinase activity	EXP	11460167
GO:0004709	Function	MAP kinase kinase kinase activity	IBA	21873635
GO:0004709	Function	MAP kinase kinase kinase activity	IDA	11460167
GO:0005515	Function	Protein binding	IPI	10094049, 11460167, 12496252, 15075345, 15764709, 16840345, 16845370, 17079228, 17110930, 17158449, 17449468, 17709393, 18286207, 18591963, 18758450, 19820695, 21512573, 21903422, 22081109, 22158122, 22904686, 25241761, 26334375, 27426733
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005671	Component	Ada2/Gcn5/Ada3 transcription activator complex	IDA	18838386
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	TAS	9466656
GO:0007223	Process	Wnt signaling pathway, calcium modulating pathway	TAS
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	TAS
GO:0007250	Process	Activation of NF-kappaB-inducing kinase activity	IMP	10094049, 15125833
GO:0007252	Process	I-kappaB phosphorylation	IDA	11460167
GO:0007254	Process	JNK cascade	IBA	21873635
GO:0007254	Process	JNK cascade	IDA	9079627
GO:0007254	Process	JNK cascade	TAS
GO:0008385	Component	IkappaB kinase complex	IPI	10094049
GO:0010008	Component	Endosome membrane	TAS
GO:0016032	Process	Viral process	IEA
GO:0016239	Process	Positive regulation of macroautophagy	ISS
GO:0016579	Process	Protein deubiquitination	TAS
GO:0030971	Function	Receptor tyrosine kinase binding	IPI	18762249
GO:0032743	Process	Positive regulation of interleukin-2 production	IMP	15125833
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0042802	Function	Identical protein binding	IPI	27426733
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	14982987
GO:0043276	Process	Anoikis	ISS
GO:0043507	Process	Positive regulation of JUN kinase activity	IDA	11460167
GO:0043507	Process	Positive regulation of JUN kinase activity	IMP	10094049
GO:0043966	Process	Histone H3 acetylation	IDA	18838386
GO:0050852	Process	T cell receptor signaling pathway	NAS	15125833
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	TAS
GO:0051403	Process	Stress-activated MAPK cascade	IDA	9079627
GO:0070423	Process	Nucleotide-binding oligomerization domain containing signaling pathway	TAS
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS
GO:0097110	Function	Scaffold protein binding	IDA	23776175

MIM	HGNC	e!Ensembl
602614	6859	ENSG00000135341

Protein

UniProt ID

O43318

Protein name

Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)

Protein function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Pl

PDB

2EVA , 2YIY , 4GS6 , 4L3P , 4L52 , 4L53 , 4O91 , 5E7R , 5GJD , 5GJF , 5GJG , 5J7S , 5J8I , 5J9L , 5JGA , 5JGB , 5JGD , 5JH6 , 5JK3 , 5V5N , 7NTH , 7NTI , 8GW3 , 9FPD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07714	PK_Tyr_Ser-Thr	36 → 284	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN
ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI
ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ
KRQGTS

Sequence length

606

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway NF-kappa B signaling pathway Autophagy - animal AMPK signaling pathway Wnt signaling pathway Osteoclast differentiation Adherens junction Neutrophil extracellular trap formation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway IL-17 signaling pathway T cell receptor signaling pathway TNF signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Leishmaniasis Toxoplasmosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Lipid and atherosclerosis Fluid shear stress and atherosclerosis		NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation Ca2+ pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Associated diseases

Show/Hide Causal Diseases (13)

Causal
Disease name	Disease term	dbSNP ID	References
Bicuspid aortic valve	Bicuspid aortic valve	rs1569484234, rs1569484208
Brachydactyly	Brachydactyly	rs121908949, rs28937580, rs121909082, rs104894122, rs863223289, rs863223290, rs104894121, rs1587657302, rs863223292, rs74315386, rs74315387, rs28936397, rs753691079, rs121909348, rs121917852, rs121917853, rs121917854, rs121917855, rs121917859, rs121917861, rs267606873, rs267606872, rs267606985, rs267606986, rs267606987, rs267606988, rs28933082, rs397514519, rs869025613, rs869025614, rs886039878, rs1553540620, rs1057518333, rs1948841937, rs1948868228, rs1948842030, rs1948842142
Cardiospondylocarpofacial syndrome	Cardiospondylocarpofacial syndrome	rs886039234, rs886039235, rs886039236, rs886039237, rs1582233787
Cholestasis	Cholestasis, Extrahepatic	rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039	28789951
Craniosynostosis	Craniosynostosis	rs104893895, rs587777006, rs587777007, rs587777008, rs587777010, rs281865153, rs281865154, rs864321680, rs864321681, rs1057517670, rs1085307122, rs1064794325, rs1884302, rs1555750816, rs1599823350
Frontometaphyseal dysplasia	Frontometaphyseal dysplasia, FRONTOMETAPHYSEAL DYSPLASIA 1, FRONTOMETAPHYSEAL DYSPLASIA 2	rs28935471, rs137853312, rs886039230, rs886039231, rs886039232, rs886039233, rs1180249151	27426733, 27426733, 30914295, 25899317
Hearing loss	Conductive hearing loss, Sensorineural Hearing Loss (disorder)	rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359, rs180177151, rs180177154, rs180177153, rs35689081, rs35887622, rs80338944, rs104894396, rs104894398, rs80338947, rs80338948, rs80338942, rs104894402, rs104894403, rs80338945, rs28931594, rs80338940, rs80338941, rs80356590, rs80338950, rs387906706, rs387906707, rs387906708, rs398122848, rs387907016, rs587776894, rs387907088, rs397515411, rs370965183, rs398122930, rs199897298, rs111033187, rs111033448, rs199606180, rs111033284, rs397516413, rs111033305, rs111033220, rs111033256, rs111033297, rs111033253, rs104894408, rs111033295, rs397516874, rs76434661, rs111033335, rs397517323, rs111033247, rs367928692, rs374793617, rs143939430, rs397515605, rs80338939, rs200656442, rs779748859, rs587781261, rs587781262, rs143343083, rs200147906, rs730880338, rs797044491, rs146281367, rs756484720, rs869025593, rs201306709, rs540895576, rs777777359, rs879255246, rs1554358720, rs142498437, rs377145777, rs1057517519, rs779077039, rs952741388, rs1060499797, rs764139009, rs1060499590, rs1064794012, rs1064797115, rs756790858, rs775633137, rs1554952443, rs1554952193, rs782063761, rs1199012623, rs756147087, rs1555648043, rs1555661490, rs1553196233, rs781546107, rs111033190, rs775428246, rs782539587, rs537227442, rs148695069, rs1554835827, rs953422571, rs1554834186, rs1554834161, rs1554835103, rs1554577339, rs1554577402, rs768471577, rs782279338, rs781951909, rs998045226, rs375759781, rs755804651, rs1557458426, rs767797828, rs538027448, rs1559366084, rs367688416, rs1558480402, rs1558490542, rs1559870857, rs1560690591, rs1561299289, rs1562817224, rs1562817529, rs1562822565, rs1562835391, rs1564113368, rs1564554255, rs773851192, rs1564555240, rs761261855, rs1564805114, rs1565522273, rs1565127413, rs781790246, rs1565430886, rs1565469959, rs746667217, rs1565819402, rs1565855932, rs150529554, rs1567939793, rs201866631, rs754472294, rs1559372512, rs1558464965, rs1558488902, rs775062249, rs1226171550, rs1561590396, rs765574676, rs762876554, rs757327146, rs1564949059, rs1565519673, rs368050948, rs1565541888, rs781989117, rs1565402473, rs750358148, rs1386887007, rs1209665716, rs1567641234, rs1237955948, rs1569042782, rs752672077, rs146689036, rs1560070780, rs149712664, rs1564556995, rs762226905, rs773573968, rs1568528171, rs1198256157, rs377267777, rs370564476, rs1577876794, rs747787770, rs759432278, rs1043716893, rs1581138934, rs2033773650, rs1421964916, rs771766431, rs780917129, rs1895773215, rs1895769400, rs761543680, rs1565920060
Mitral valve prolapse	Mitral Valve Prolapse Syndrome	rs768737101
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Patent ductus arteriosus	Patent ductus arteriosus	rs80338911, rs879253870, rs879253871, rs879255278, rs879255279, rs879253872
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17199135
Scoliosis	Scoliosis, unspecified	rs1057518828, rs147296805, rs758163506, rs1555613564, rs1596852902, rs1596853067, rs1596853085
Vesicoureteral reflux	Vesico-Ureteral Reflux	rs587777684, rs148731211

Show/Hide Unknown Diseases (22)

Unknown
Disease name	Disease term	dbSNP ID	References
Carpal synostosis	Carpal synostosis
Clinodactyly	Clinodactyly of fingers
Congenital camptodactyly	Congenital Camptodactyly
Congenital clubfoot	Congenital clubfoot
Dislocated radial head	Congenital dislocation of radial head
Developmental dysplasia of the hip	Congenital Dysplasia Of The Hip
Rib fusion	Congenital fusion of ribs
Congenital sensorineural hearing loss	Congenital sensorineural hearing loss
Dwarfism	Dwarfism
Gastroesophageal reflux disease	Gastroesophageal reflux disease
High palate	Byzanthine arch palate
Hip contracture	Hip Contracture
Hydronephrosis	Hydronephrosis
Micrognathism	Micrognathism
Otitis media	Recurrent otitis media	rs601338, rs1047781, rs1800028
Patent foramen ovale	Foramen Ovale, Patent
Posteriorly rotated ear	Posteriorly rotated ear
Prostatic neoplasms	Prostatic Neoplasms		17199135
Pulmonary stenosis	Pulmonary Stenosis
Strabismus	Strabismus
Tarsal coalition	Tarsal Coalition
Tracheal stenosis	Tracheal Stenosis

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