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TAGLN (transgelin)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6876
Gene nameGene Name - the full gene name approved by the HGNC.
Transgelin
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TAGLN
SynonymsGene synonyms aliases
SM22, SM22-alpha, SMCC, TAGLN1, WS3-10
ChromosomeChromosome number
11
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q23.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT021406 hsa-miR-9-5p Microarray 17612493
MIRT022018 hsa-miR-128-3p Microarray 17612493
MIRT025891 hsa-miR-7-5p Microarray 17612493
MIRT030313 hsa-miR-26b-5p Microarray 19088304
MIRT496586 hsa-miR-6845-5p PAR-CLIP 22291592
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Transcription factor Regulation Reference
KLF4 Unknown 19486889
MKL1 Activation 14970199
SRF Activation 14970199
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21044950, 22245152, 32296183
GO:0005737 Component Cytoplasm IEA
GO:0007517 Process Muscle organ development TAS 9615232
GO:0030855 Process Epithelial cell differentiation IDA 21492153
GO:0051015 Function Actin filament binding IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Q01995
Protein name Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha)
Protein function Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00307 CH
24 → 139
Calponin homology (CH) domain
 Domain
PF00402 Calponin
175 → 199
Calponin family repeat
 Repeat
Sequence
Sequence length 201
Interactions View interactions
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Disease name Disease term References
Breast Carcinoma
Malignant tumor of colon
Colonic Neoplasms
Endometrioma
Endometriosis

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