TAGLN (transgelin)

Gene

• Entrez ID: 6876
• Gene name: Transgelin
• Gene symbol: TAGLN
• Synonyms: SM22, SM22-alpha, SMCC, TAGLN1, TGLN, WS3-10
• Chromosome: 11
• Chromosome location: 11q23.3
• Summary: This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The enc

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021406	hsa-miR-9-5p	Microarray	17612493
MIRT022018	hsa-miR-128-3p	Microarray	17612493
MIRT023899	hsa-miR-1-3p	Other	20458751
MIRT025891	hsa-miR-7-5p	Microarray	17612493
MIRT030313	hsa-miR-26b-5p	Microarray	19088304
MIRT496609	hsa-miR-3714	PAR-CLIP	22291592
MIRT496608	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT496607	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT496606	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT496605	hsa-miR-1321	PAR-CLIP	22291592
MIRT496604	hsa-miR-4739	PAR-CLIP	22291592
MIRT496603	hsa-miR-4756-5p	PAR-CLIP	22291592
MIRT496602	hsa-miR-4419a	PAR-CLIP	22291592
MIRT496601	hsa-miR-4510	PAR-CLIP	22291592
MIRT496600	hsa-miR-6127	PAR-CLIP	22291592
MIRT496599	hsa-miR-6129	PAR-CLIP	22291592
MIRT496598	hsa-miR-6130	PAR-CLIP	22291592
MIRT496597	hsa-miR-6133	PAR-CLIP	22291592
MIRT496596	hsa-miR-3184-5p	PAR-CLIP	22291592
MIRT496595	hsa-miR-423-5p	PAR-CLIP	22291592
MIRT496594	hsa-miR-1249-5p	PAR-CLIP	22291592
MIRT496593	hsa-miR-6797-5p	PAR-CLIP	22291592
MIRT496592	hsa-miR-149-3p	PAR-CLIP	22291592
MIRT496591	hsa-miR-4728-5p	PAR-CLIP	22291592
MIRT496590	hsa-miR-6785-5p	PAR-CLIP	22291592
MIRT496589	hsa-miR-6883-5p	PAR-CLIP	22291592
MIRT496588	hsa-miR-486-3p	PAR-CLIP	22291592
MIRT496587	hsa-miR-6762-5p	PAR-CLIP	22291592
MIRT496586	hsa-miR-6845-5p	PAR-CLIP	22291592
MIRT496609	hsa-miR-3714	PAR-CLIP	22291592
MIRT496608	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT496607	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT496606	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT496605	hsa-miR-1321	PAR-CLIP	22291592
MIRT496604	hsa-miR-4739	PAR-CLIP	22291592
MIRT496603	hsa-miR-4756-5p	PAR-CLIP	22291592
MIRT496602	hsa-miR-4419a	PAR-CLIP	22291592
MIRT496601	hsa-miR-4510	PAR-CLIP	22291592
MIRT496600	hsa-miR-6127	PAR-CLIP	22291592
MIRT496599	hsa-miR-6129	PAR-CLIP	22291592
MIRT496598	hsa-miR-6130	PAR-CLIP	22291592
MIRT496597	hsa-miR-6133	PAR-CLIP	22291592
MIRT496596	hsa-miR-3184-5p	PAR-CLIP	22291592
MIRT496595	hsa-miR-423-5p	PAR-CLIP	22291592
MIRT496594	hsa-miR-1249-5p	PAR-CLIP	22291592
MIRT496593	hsa-miR-6797-5p	PAR-CLIP	22291592
MIRT496592	hsa-miR-149-3p	PAR-CLIP	22291592
MIRT496591	hsa-miR-4728-5p	PAR-CLIP	22291592
MIRT496590	hsa-miR-6785-5p	PAR-CLIP	22291592
MIRT496589	hsa-miR-6883-5p	PAR-CLIP	22291592
MIRT496588	hsa-miR-486-3p	PAR-CLIP	22291592
MIRT496587	hsa-miR-6762-5p	PAR-CLIP	22291592
MIRT496586	hsa-miR-6845-5p	PAR-CLIP	22291592
MIRT1410153	hsa-miR-1275	CLIP-seq
MIRT1410154	hsa-miR-28-5p	CLIP-seq
MIRT1410155	hsa-miR-3139	CLIP-seq
MIRT1410156	hsa-miR-4487	CLIP-seq
MIRT1410157	hsa-miR-4525	CLIP-seq
MIRT1410158	hsa-miR-4665-5p	CLIP-seq
MIRT1410159	hsa-miR-4723-5p	CLIP-seq
MIRT1410160	hsa-miR-4731-5p	CLIP-seq
MIRT1410161	hsa-miR-625	CLIP-seq
MIRT1410162	hsa-miR-637	CLIP-seq
MIRT1410163	hsa-miR-708	CLIP-seq
MIRT1554407	hsa-miR-1184	CLIP-seq
MIRT1554408	hsa-miR-1262	CLIP-seq
MIRT1554409	hsa-miR-1827	CLIP-seq
MIRT1554410	hsa-miR-1915	CLIP-seq
MIRT1554411	hsa-miR-22	CLIP-seq
MIRT1554412	hsa-miR-2467-5p	CLIP-seq
MIRT1554413	hsa-miR-2682	CLIP-seq
MIRT1410154	hsa-miR-28-5p	CLIP-seq
MIRT1554414	hsa-miR-3136-3p	CLIP-seq
MIRT1410155	hsa-miR-3139	CLIP-seq
MIRT1554415	hsa-miR-3150b-3p	CLIP-seq
MIRT1554416	hsa-miR-3160-5p	CLIP-seq
MIRT1554417	hsa-miR-3173-3p	CLIP-seq
MIRT1554418	hsa-miR-3184	CLIP-seq
MIRT1554419	hsa-miR-3188	CLIP-seq
MIRT1554420	hsa-miR-328	CLIP-seq
MIRT1554421	hsa-miR-34a	CLIP-seq
MIRT1554422	hsa-miR-34c-5p	CLIP-seq
MIRT1554423	hsa-miR-361-3p	CLIP-seq
MIRT1554424	hsa-miR-3653	CLIP-seq
MIRT1554425	hsa-miR-3975	CLIP-seq
MIRT1554426	hsa-miR-4259	CLIP-seq
MIRT1554427	hsa-miR-4270	CLIP-seq
MIRT1554428	hsa-miR-4316	CLIP-seq
MIRT1554429	hsa-miR-4441	CLIP-seq
MIRT1554430	hsa-miR-4455	CLIP-seq
MIRT1554431	hsa-miR-4488	CLIP-seq
MIRT1554432	hsa-miR-449a	CLIP-seq
MIRT1554433	hsa-miR-449b	CLIP-seq
MIRT1554434	hsa-miR-449c	CLIP-seq
MIRT1554435	hsa-miR-4505	CLIP-seq
MIRT1554436	hsa-miR-4640-3p	CLIP-seq
MIRT1554437	hsa-miR-4649-3p	CLIP-seq
MIRT1554438	hsa-miR-4656	CLIP-seq
MIRT1554439	hsa-miR-4697-5p	CLIP-seq
MIRT1554440	hsa-miR-4701-3p	CLIP-seq
MIRT1554441	hsa-miR-4710	CLIP-seq
MIRT1554442	hsa-miR-4726-3p	CLIP-seq
MIRT1410160	hsa-miR-4731-5p	CLIP-seq
MIRT1554443	hsa-miR-4784	CLIP-seq
MIRT1554444	hsa-miR-485-5p	CLIP-seq
MIRT1554445	hsa-miR-555	CLIP-seq
MIRT1554446	hsa-miR-558	CLIP-seq
MIRT1554447	hsa-miR-604	CLIP-seq
MIRT1410162	hsa-miR-637	CLIP-seq
MIRT1554448	hsa-miR-647	CLIP-seq
MIRT1410163	hsa-miR-708	CLIP-seq
MIRT1554449	hsa-miR-764	CLIP-seq
MIRT1554450	hsa-miR-765	CLIP-seq
MIRT1554451	hsa-miR-935	CLIP-seq
MIRT1554452	hsa-miR-940	CLIP-seq
MIRT2433768	hsa-miR-1587	CLIP-seq
MIRT2433769	hsa-miR-4492	CLIP-seq
MIRT2433770	hsa-miR-4498	CLIP-seq
MIRT1554435	hsa-miR-4505	CLIP-seq
MIRT1554438	hsa-miR-4656	CLIP-seq
MIRT2433771	hsa-miR-762	CLIP-seq
MIRT2433768	hsa-miR-1587	CLIP-seq
MIRT2433769	hsa-miR-4492	CLIP-seq
MIRT2433770	hsa-miR-4498	CLIP-seq
MIRT1554435	hsa-miR-4505	CLIP-seq
MIRT1554438	hsa-miR-4656	CLIP-seq
MIRT2433771	hsa-miR-762	CLIP-seq
MIRT1554407	hsa-miR-1184	CLIP-seq
MIRT1554408	hsa-miR-1262	CLIP-seq
MIRT2638336	hsa-miR-140-3p	CLIP-seq
MIRT1554409	hsa-miR-1827	CLIP-seq
MIRT1410154	hsa-miR-28-5p	CLIP-seq
MIRT1410155	hsa-miR-3139	CLIP-seq
MIRT2638337	hsa-miR-3187-3p	CLIP-seq
MIRT2638338	hsa-miR-330-3p	CLIP-seq
MIRT1554428	hsa-miR-4316	CLIP-seq
MIRT2638339	hsa-miR-4435	CLIP-seq
MIRT2638340	hsa-miR-4446-3p	CLIP-seq
MIRT2638341	hsa-miR-4453	CLIP-seq
MIRT1554430	hsa-miR-4455	CLIP-seq
MIRT1410156	hsa-miR-4487	CLIP-seq
MIRT2638342	hsa-miR-4538	CLIP-seq
MIRT1554438	hsa-miR-4656	CLIP-seq
MIRT2638343	hsa-miR-4685-5p	CLIP-seq
MIRT1554440	hsa-miR-4701-3p	CLIP-seq
MIRT2638344	hsa-miR-4701-5p	CLIP-seq
MIRT1554441	hsa-miR-4710	CLIP-seq
MIRT1410160	hsa-miR-4731-5p	CLIP-seq
MIRT2638345	hsa-miR-493	CLIP-seq
MIRT2638346	hsa-miR-548s	CLIP-seq
MIRT2638347	hsa-miR-588	CLIP-seq
MIRT2638348	hsa-miR-602	CLIP-seq
MIRT1554447	hsa-miR-604	CLIP-seq
MIRT1410162	hsa-miR-637	CLIP-seq
MIRT1554448	hsa-miR-647	CLIP-seq
MIRT1410163	hsa-miR-708	CLIP-seq
MIRT1554452	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
KLF4	Unknown	19486889
MKL1	Activation	14970199
SRF	Activation	14970199

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21044950, 22245152, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0007517	Process	Muscle organ development	TAS	9615232
GO:0030855	Process	Epithelial cell differentiation	IDA	21492153
GO:0051015	Function	Actin filament binding	IEA

Other IDs

• MIM: 600818
• HGNC: 11553
• e!Ensembl: ENSG00000149591

Protein

• UniProt ID: Q01995
• Protein name: Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha)
• Protein function: Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	24 → 139	Calponin homology (CH) domain	Domain
  PF00402	Calponin	175 → 199	Calponin family repeat	Repeat

• Sequence:

  MANKGPSYGMSREVQSKIEKKYDEELEERLVEWIIVQCGPDVGRPDRGRLGFQVWLKNGV
  ILSKLVNSLYPDGSKPVKVPENPPSMVFKQMEQVAQFLKAAEDYGVIKTDMFQTVDLFEG
  KDMAAVQRTLMALGSLAVTKNDGHYRGDPNWFMKKAQEHKREFTESQLQEGKHVIGLQMG
  SNRGASQAGMTGYGRPRQIIS

• Sequence length: 201

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059430
Colonic neoplasms	Malignant tumor of colon, Colonic Neoplasms	rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483	15059925
Esophagus neoplasm	Squamous cell carcinoma of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21517111

Unknown
Disease name	Disease term	dbSNP ID	References
Endometrioma	Endometrioma		21063030
Endometriosis	Endometriosis	rs1800629, rs1143634	21063030
Lipoidosis	Lipoidosis		17175557, 15342952, 16919414
Malignant neoplasm	Malignant Childhood Neoplasm		29059430