TACR1 (tachykinin receptor 1)

Gene

• Entrez ID: 6869
• Gene name: Tachykinin receptor 1
• Gene symbol: TACR1
• Synonyms: NK1R, NKIR, SPR, TAC1R
• Chromosome: 2
• Chromosome location: 2p12
• Summary: This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, al

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT736804	hsa-miR-206	Western blotting, Immunofluorescence	31579977
MIRT1408484	hsa-miR-1245b-3p	CLIP-seq
MIRT1408485	hsa-miR-181a	CLIP-seq
MIRT1408486	hsa-miR-181b	CLIP-seq
MIRT1408487	hsa-miR-181c	CLIP-seq
MIRT1408488	hsa-miR-181d	CLIP-seq
MIRT1408489	hsa-miR-3179	CLIP-seq
MIRT1408490	hsa-miR-3180-5p	CLIP-seq
MIRT1408491	hsa-miR-3664-3p	CLIP-seq
MIRT1408492	hsa-miR-377	CLIP-seq
MIRT1408493	hsa-miR-4262	CLIP-seq
MIRT1408494	hsa-miR-4502	CLIP-seq
MIRT1408495	hsa-miR-4696	CLIP-seq
MIRT1408496	hsa-miR-4762-3p	CLIP-seq
MIRT1408497	hsa-miR-520a-5p	CLIP-seq
MIRT1408498	hsa-miR-520g	CLIP-seq
MIRT1408499	hsa-miR-520h	CLIP-seq
MIRT1408500	hsa-miR-525-5p	CLIP-seq
MIRT1408501	hsa-miR-609	CLIP-seq
MIRT1408502	hsa-miR-873	CLIP-seq
MIRT1408503	hsa-miR-297	CLIP-seq
MIRT1408504	hsa-miR-3187-3p	CLIP-seq
MIRT1408505	hsa-miR-3655	CLIP-seq
MIRT1408506	hsa-miR-3668	CLIP-seq
MIRT1408507	hsa-miR-4252	CLIP-seq
MIRT1408508	hsa-miR-4286	CLIP-seq
MIRT1408509	hsa-miR-4435	CLIP-seq
MIRT1408510	hsa-miR-4646-3p	CLIP-seq
MIRT1408511	hsa-miR-4701-5p	CLIP-seq
MIRT1408512	hsa-miR-548s	CLIP-seq
MIRT1408513	hsa-miR-567	CLIP-seq
MIRT1408514	hsa-miR-588	CLIP-seq
MIRT1408515	hsa-miR-642a	CLIP-seq
MIRT1408516	hsa-miR-892a	CLIP-seq
MIRT1408503	hsa-miR-297	CLIP-seq
MIRT1408504	hsa-miR-3187-3p	CLIP-seq
MIRT1408505	hsa-miR-3655	CLIP-seq
MIRT1408506	hsa-miR-3668	CLIP-seq
MIRT1408507	hsa-miR-4252	CLIP-seq
MIRT1408508	hsa-miR-4286	CLIP-seq
MIRT1408509	hsa-miR-4435	CLIP-seq
MIRT1408510	hsa-miR-4646-3p	CLIP-seq
MIRT1408511	hsa-miR-4701-5p	CLIP-seq
MIRT1408512	hsa-miR-548s	CLIP-seq
MIRT1408513	hsa-miR-567	CLIP-seq
MIRT1408514	hsa-miR-588	CLIP-seq
MIRT1408515	hsa-miR-642a	CLIP-seq
MIRT1408516	hsa-miR-892a	CLIP-seq
MIRT1408505	hsa-miR-3655	CLIP-seq
MIRT1408508	hsa-miR-4286	CLIP-seq
MIRT1408510	hsa-miR-4646-3p	CLIP-seq
MIRT1408515	hsa-miR-642a	CLIP-seq
MIRT1408503	hsa-miR-297	CLIP-seq
MIRT1408504	hsa-miR-3187-3p	CLIP-seq
MIRT1408505	hsa-miR-3655	CLIP-seq
MIRT1408506	hsa-miR-3668	CLIP-seq
MIRT1408507	hsa-miR-4252	CLIP-seq
MIRT1408508	hsa-miR-4286	CLIP-seq
MIRT1408509	hsa-miR-4435	CLIP-seq
MIRT1408510	hsa-miR-4646-3p	CLIP-seq
MIRT1408511	hsa-miR-4701-5p	CLIP-seq
MIRT1408512	hsa-miR-548s	CLIP-seq
MIRT1408513	hsa-miR-567	CLIP-seq
MIRT1408514	hsa-miR-588	CLIP-seq
MIRT1408515	hsa-miR-642a	CLIP-seq
MIRT1408516	hsa-miR-892a	CLIP-seq
MIRT1408503	hsa-miR-297	CLIP-seq
MIRT1408504	hsa-miR-3187-3p	CLIP-seq
MIRT1408505	hsa-miR-3655	CLIP-seq
MIRT1408506	hsa-miR-3668	CLIP-seq
MIRT1408507	hsa-miR-4252	CLIP-seq
MIRT1408509	hsa-miR-4435	CLIP-seq
MIRT1408511	hsa-miR-4701-5p	CLIP-seq
MIRT1408512	hsa-miR-548s	CLIP-seq
MIRT1408513	hsa-miR-567	CLIP-seq
MIRT1408514	hsa-miR-588	CLIP-seq
MIRT1408516	hsa-miR-892a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004995	Function	Tachykinin receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	12716968, 17986524, 23597562, 32296183
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	17986524
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	1657150
GO:0006954	Process	Inflammatory response	TAS	10854844
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	TAS	1657150
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IDA	12716968
GO:0007217	Process	Tachykinin receptor signaling pathway	IDA	17986524
GO:0007217	Process	Tachykinin receptor signaling pathway	IMP	12716968
GO:0009582	Process	Detection of abiotic stimulus	TAS	9537323
GO:0016496	Function	Substance P receptor activity	IBA	21873635
GO:0016496	Function	Substance P receptor activity	IMP	12716968
GO:0036126	Component	Sperm flagellum	IDA	17437961
GO:0048265	Process	Response to pain	IEA
GO:0061827	Component	Sperm head	IDA	17437961
GO:0070472	Process	Regulation of uterine smooth muscle contraction	IEA
GO:0097225	Component	Sperm midpiece	IBA	21873635
GO:0097225	Component	Sperm midpiece	IDA	17437961
GO:1902093	Process	Positive regulation of flagellated sperm motility	IBA	21873635
GO:1902093	Process	Positive regulation of flagellated sperm motility	IMP	17437961

Other IDs

• MIM: 162323
• HGNC: 11526
• e!Ensembl: ENSG00000115353

Protein

• UniProt ID: P25103
• Protein name: Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)
• Protein function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substa
• PDB: 2KS9, 2KSA, 2KSB, 6E59, 6HLL, 6HLO, 6HLP, 7P00, 7P02, 7RMG, 7RMH, 7RMI, 8U26
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	49 → 305	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
  KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
  YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
  MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
  SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
  NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
  VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS

• Sequence length: 407

Pathways

KEGG:

Calcium signaling pathway
Neuroactive ligand-receptor interaction

Reactome:

Tachykinin receptors bind tachykinins
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Attention deficit hyperactivity disorder	Attention Deficit Disorder, Attention deficit hyperactivity disorder	rs120074176, rs786205019	19204064
Hypertension	Hypertensive disease	rs13306026, rs13333226	21294877

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder, Depression, Bipolar		24817687, 19415819, 19204064, 19204064
Bronchial diseases	Bronchial Diseases		15774269
Manic disorder	Manic, Manic Disorder		19204064
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	16594257, 17974009, 24705689, 20112009, 12692775, 20112009, 12692775, 16594257, 17974009, 24705689
Minimal brain dysfunction	Minimal Brain Dysfunction		19204064
Mood disorder	Mood Disorders		12692775, 12562138, 24817687, 19415819, 10818257