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ADAM17 (ADAM metallopeptidase domain 17)

Gene

6868

ADAM metallopeptidase domain 17

ADAM17

ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE

2p25.1

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes i

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs387906866	GTCT>-	Pathogenic	5 prime UTR variant, coding sequence variant, frameshift variant

Show/Hide all(364)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003112	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT003112	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT003112	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT003112	hsa-miR-122-5p	Luciferase reporter assay, Review	19935707
MIRT003112	hsa-miR-122-5p	Review	20026422
MIRT003112	hsa-miR-122-5p	qRT-PCR	19726678
MIRT007275	hsa-miR-145-5p	Luciferase reporter assay	23441135
MIRT007275	hsa-miR-145-5p	Luciferase reporter assay	23441135
MIRT007275	hsa-miR-145-5p	Luciferase reporter assay, qRT-PCR, Western blot	23076445
0	hsa-miR-124-3p	ELISA, qRT-PCR, Immunoblot, Luciferase reporter assay	23979021
MIRT054717	hsa-miR-152-3p	ELISA, Luciferase reporter assay/qRT-PCR, Western blot	24813629
MIRT007275	hsa-miR-145-5p	Immunohistochemistry	23548270
MIRT054717	hsa-miR-152-3p	H157	24780186
MIRT054717	hsa-miR-152-3p	H157	24780186
MIRT438130	hsa-miR-26a-5p	Immunofluorescence, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24375761
MIRT438130	hsa-miR-26a-5p	Immunofluorescence, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24375761
MIRT438130	hsa-miR-26a-5p	Immunofluorescence, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24375761
MIRT438130	hsa-miR-26a-5p	Immunofluorescence, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24375761
MIRT715612	hsa-miR-302a-3p	HITS-CLIP	19536157
MIRT715611	hsa-miR-302b-3p	HITS-CLIP	19536157
MIRT715610	hsa-miR-302c-3p	HITS-CLIP	19536157
MIRT715609	hsa-miR-302d-3p	HITS-CLIP	19536157
MIRT715608	hsa-miR-302e	HITS-CLIP	19536157
MIRT715607	hsa-miR-372-3p	HITS-CLIP	19536157
MIRT715606	hsa-miR-373-3p	HITS-CLIP	19536157
MIRT715605	hsa-miR-520a-3p	HITS-CLIP	19536157
MIRT715604	hsa-miR-520b	HITS-CLIP	19536157
MIRT715603	hsa-miR-520c-3p	HITS-CLIP	19536157
MIRT715602	hsa-miR-520d-3p	HITS-CLIP	19536157
MIRT715601	hsa-miR-520e	HITS-CLIP	19536157
MIRT715600	hsa-miR-6819-3p	HITS-CLIP	19536157
MIRT715599	hsa-miR-6877-3p	HITS-CLIP	19536157
MIRT715598	hsa-miR-512-3p	HITS-CLIP	19536157
MIRT715597	hsa-miR-3691-3p	HITS-CLIP	19536157
MIRT715596	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT715595	hsa-miR-5695	HITS-CLIP	19536157
MIRT715594	hsa-miR-6722-5p	HITS-CLIP	19536157
MIRT715593	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT715592	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT705939	hsa-miR-649	HITS-CLIP	23313552
MIRT705938	hsa-miR-181a-5p	HITS-CLIP	23313552
MIRT705937	hsa-miR-181b-5p	HITS-CLIP	23313552
MIRT705936	hsa-miR-181c-5p	HITS-CLIP	23313552
MIRT705935	hsa-miR-181d-5p	HITS-CLIP	23313552
MIRT705934	hsa-miR-4262	HITS-CLIP	23313552
MIRT705933	hsa-miR-1323	HITS-CLIP	23313552
MIRT705932	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT705931	hsa-miR-149-5p	HITS-CLIP	23313552
MIRT705930	hsa-miR-3064-5p	HITS-CLIP	23313552
MIRT705929	hsa-miR-6504-5p	HITS-CLIP	23313552
MIRT705928	hsa-miR-5580-5p	HITS-CLIP	23313552
MIRT705926	hsa-miR-4284	HITS-CLIP	23313552
MIRT705927	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT705924	hsa-miR-3652	HITS-CLIP	23313552
MIRT705925	hsa-miR-4430	HITS-CLIP	23313552
MIRT705923	hsa-miR-4505	HITS-CLIP	23313552
MIRT705922	hsa-miR-5787	HITS-CLIP	23313552
MIRT705921	hsa-miR-130a-5p	HITS-CLIP	23313552
MIRT705920	hsa-miR-23a-3p	HITS-CLIP	23313552
MIRT705919	hsa-miR-23b-3p	HITS-CLIP	23313552
MIRT705918	hsa-miR-23c	HITS-CLIP	23313552
MIRT705917	hsa-miR-6842-3p	HITS-CLIP	23313552
MIRT705916	hsa-miR-129-5p	HITS-CLIP	23313552
MIRT007275	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT624817	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT624816	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT624815	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT624814	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT624813	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT624812	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT624811	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT624810	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT624809	hsa-miR-6731-3p	HITS-CLIP	23824327
MIRT007275	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT624817	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT624816	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT624815	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT624814	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT624813	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT624812	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT624811	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT624810	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT624809	hsa-miR-6731-3p	HITS-CLIP	23824327
MIRT503192	hsa-miR-4465	PAR-CLIP	24398324
MIRT503191	hsa-miR-1297	PAR-CLIP	24398324
MIRT438130	hsa-miR-26a-5p	PAR-CLIP	24398324
MIRT503190	hsa-miR-26b-5p	PAR-CLIP	24398324
MIRT503189	hsa-miR-6882-5p	PAR-CLIP	24398324
MIRT503188	hsa-miR-5697	PAR-CLIP	24398324
MIRT441264	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441264	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT732080	hsa-miR-338-3p	Luciferase reporter assay, qRT-PCR, Western blot	26617808
MIRT732080	hsa-miR-338-3p	Luciferase reporter assay, qRT-PCR, Western blot	26617808
MIRT715612	hsa-miR-302a-3p	HITS-CLIP	19536157
MIRT715611	hsa-miR-302b-3p	HITS-CLIP	19536157
MIRT715610	hsa-miR-302c-3p	HITS-CLIP	19536157
MIRT715609	hsa-miR-302d-3p	HITS-CLIP	19536157
MIRT715608	hsa-miR-302e	HITS-CLIP	19536157
MIRT715607	hsa-miR-372-3p	HITS-CLIP	19536157
MIRT715606	hsa-miR-373-3p	HITS-CLIP	19536157
MIRT715605	hsa-miR-520a-3p	HITS-CLIP	19536157
MIRT715604	hsa-miR-520b	HITS-CLIP	19536157
MIRT715603	hsa-miR-520c-3p	HITS-CLIP	19536157
MIRT715602	hsa-miR-520d-3p	HITS-CLIP	19536157
MIRT715601	hsa-miR-520e	HITS-CLIP	19536157
MIRT715600	hsa-miR-6819-3p	HITS-CLIP	19536157
MIRT715599	hsa-miR-6877-3p	HITS-CLIP	19536157
MIRT715598	hsa-miR-512-3p	HITS-CLIP	19536157
MIRT715597	hsa-miR-3691-3p	HITS-CLIP	19536157
MIRT715596	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT715595	hsa-miR-5695	HITS-CLIP	19536157
MIRT715594	hsa-miR-6722-5p	HITS-CLIP	19536157
MIRT715593	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT715592	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT705939	hsa-miR-649	HITS-CLIP	23313552
MIRT705938	hsa-miR-181a-5p	HITS-CLIP	23313552
MIRT705937	hsa-miR-181b-5p	HITS-CLIP	23313552
MIRT705936	hsa-miR-181c-5p	HITS-CLIP	23313552
MIRT705935	hsa-miR-181d-5p	HITS-CLIP	23313552
MIRT705934	hsa-miR-4262	HITS-CLIP	23313552
MIRT705933	hsa-miR-1323	HITS-CLIP	23313552
MIRT705932	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT705931	hsa-miR-149-5p	HITS-CLIP	23313552
MIRT705930	hsa-miR-3064-5p	HITS-CLIP	23313552
MIRT705929	hsa-miR-6504-5p	HITS-CLIP	23313552
MIRT705928	hsa-miR-5580-5p	HITS-CLIP	23313552
MIRT705926	hsa-miR-4284	HITS-CLIP	23313552
MIRT705927	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT705924	hsa-miR-3652	HITS-CLIP	23313552
MIRT705925	hsa-miR-4430	HITS-CLIP	23313552
MIRT705923	hsa-miR-4505	HITS-CLIP	23313552
MIRT705922	hsa-miR-5787	HITS-CLIP	23313552
MIRT705921	hsa-miR-130a-5p	HITS-CLIP	23313552
MIRT705920	hsa-miR-23a-3p	HITS-CLIP	23313552
MIRT705919	hsa-miR-23b-3p	HITS-CLIP	23313552
MIRT705918	hsa-miR-23c	HITS-CLIP	23313552
MIRT705917	hsa-miR-6842-3p	HITS-CLIP	23313552
MIRT705916	hsa-miR-129-5p	HITS-CLIP	23313552
MIRT007275	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT624817	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT624816	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT624815	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT624814	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT624813	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT624812	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT624811	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT624810	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT624809	hsa-miR-6731-3p	HITS-CLIP	23824327
MIRT007275	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT624817	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT624816	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT624815	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT624814	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT624813	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT624812	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT624811	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT624810	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT624809	hsa-miR-6731-3p	HITS-CLIP	23824327
MIRT503192	hsa-miR-4465	PAR-CLIP	24398324
MIRT503191	hsa-miR-1297	PAR-CLIP	24398324
MIRT438130	hsa-miR-26a-5p	PAR-CLIP	24398324
MIRT503190	hsa-miR-26b-5p	PAR-CLIP	24398324
MIRT503189	hsa-miR-6882-5p	PAR-CLIP	24398324
MIRT503188	hsa-miR-5697	PAR-CLIP	24398324
MIRT765968	hsa-miR-122	CLIP-seq
MIRT765969	hsa-miR-140-3p	CLIP-seq
MIRT765970	hsa-miR-142-3p	CLIP-seq
MIRT765971	hsa-miR-148a	CLIP-seq
MIRT765972	hsa-miR-148b	CLIP-seq
MIRT765973	hsa-miR-152	CLIP-seq
MIRT765974	hsa-miR-3135b	CLIP-seq
MIRT765975	hsa-miR-3140-3p	CLIP-seq
MIRT765976	hsa-miR-3163	CLIP-seq
MIRT765977	hsa-miR-3664-5p	CLIP-seq
MIRT765978	hsa-miR-3677-5p	CLIP-seq
MIRT765979	hsa-miR-4280	CLIP-seq
MIRT765980	hsa-miR-4446-5p	CLIP-seq
MIRT765981	hsa-miR-450b-5p	CLIP-seq
MIRT765982	hsa-miR-4639-3p	CLIP-seq
MIRT765983	hsa-miR-4697-3p	CLIP-seq
MIRT765984	hsa-miR-4755-5p	CLIP-seq
MIRT765985	hsa-miR-507	CLIP-seq
MIRT765986	hsa-miR-544	CLIP-seq
MIRT765987	hsa-miR-548a-3p	CLIP-seq
MIRT765988	hsa-miR-548ae	CLIP-seq
MIRT765989	hsa-miR-548aj	CLIP-seq
MIRT765990	hsa-miR-548am	CLIP-seq
MIRT765991	hsa-miR-548e	CLIP-seq
MIRT765992	hsa-miR-548f	CLIP-seq
MIRT765993	hsa-miR-548x	CLIP-seq
MIRT765994	hsa-miR-557	CLIP-seq
MIRT765995	hsa-miR-568	CLIP-seq
MIRT765996	hsa-miR-767-5p	CLIP-seq
MIRT765968	hsa-miR-122	CLIP-seq
MIRT765970	hsa-miR-142-3p	CLIP-seq
MIRT765974	hsa-miR-3135b	CLIP-seq
MIRT765978	hsa-miR-3677-5p	CLIP-seq
MIRT765979	hsa-miR-4280	CLIP-seq
MIRT1925698	hsa-miR-4474-5p	CLIP-seq
MIRT1925699	hsa-miR-4777-5p	CLIP-seq
MIRT1925700	hsa-miR-518d-5p	CLIP-seq
MIRT1925701	hsa-miR-519b-5p	CLIP-seq
MIRT1925702	hsa-miR-519c-5p	CLIP-seq
MIRT1925703	hsa-miR-520c-5p	CLIP-seq
MIRT1925704	hsa-miR-526a	CLIP-seq
MIRT1925705	hsa-miR-545	CLIP-seq
MIRT765987	hsa-miR-548a-3p	CLIP-seq
MIRT765988	hsa-miR-548ae	CLIP-seq
MIRT765989	hsa-miR-548aj	CLIP-seq
MIRT765990	hsa-miR-548am	CLIP-seq
MIRT765991	hsa-miR-548e	CLIP-seq
MIRT765992	hsa-miR-548f	CLIP-seq
MIRT765993	hsa-miR-548x	CLIP-seq
MIRT765968	hsa-miR-122	CLIP-seq
MIRT765970	hsa-miR-142-3p	CLIP-seq
MIRT765971	hsa-miR-148a	CLIP-seq
MIRT765972	hsa-miR-148b	CLIP-seq
MIRT765973	hsa-miR-152	CLIP-seq
MIRT765974	hsa-miR-3135b	CLIP-seq
MIRT765976	hsa-miR-3163	CLIP-seq
MIRT765977	hsa-miR-3664-5p	CLIP-seq
MIRT765978	hsa-miR-3677-5p	CLIP-seq
MIRT765979	hsa-miR-4280	CLIP-seq
MIRT765980	hsa-miR-4446-5p	CLIP-seq
MIRT1925698	hsa-miR-4474-5p	CLIP-seq
MIRT765982	hsa-miR-4639-3p	CLIP-seq
MIRT2167096	hsa-miR-4643	CLIP-seq
MIRT765983	hsa-miR-4697-3p	CLIP-seq
MIRT765984	hsa-miR-4755-5p	CLIP-seq
MIRT1925699	hsa-miR-4777-5p	CLIP-seq
MIRT1925700	hsa-miR-518d-5p	CLIP-seq
MIRT1925701	hsa-miR-519b-5p	CLIP-seq
MIRT1925702	hsa-miR-519c-5p	CLIP-seq
MIRT1925703	hsa-miR-520c-5p	CLIP-seq
MIRT1925704	hsa-miR-526a	CLIP-seq
MIRT2167097	hsa-miR-587	CLIP-seq
MIRT2167098	hsa-miR-634	CLIP-seq
MIRT765968	hsa-miR-122	CLIP-seq
MIRT765970	hsa-miR-142-3p	CLIP-seq
MIRT765974	hsa-miR-3135b	CLIP-seq
MIRT765978	hsa-miR-3677-5p	CLIP-seq
MIRT765979	hsa-miR-4280	CLIP-seq
MIRT2425929	hsa-miR-105	CLIP-seq
MIRT2425930	hsa-miR-1279	CLIP-seq
MIRT2425931	hsa-miR-145	CLIP-seq
MIRT765976	hsa-miR-3163	CLIP-seq
MIRT2425932	hsa-miR-4719	CLIP-seq
MIRT765995	hsa-miR-568	CLIP-seq
MIRT2425933	hsa-miR-582-5p	CLIP-seq
MIRT2469581	hsa-miR-1208	CLIP-seq
MIRT765968	hsa-miR-122	CLIP-seq
MIRT2469582	hsa-miR-129-3p	CLIP-seq
MIRT765970	hsa-miR-142-3p	CLIP-seq
MIRT2469583	hsa-miR-188-5p	CLIP-seq
MIRT2469584	hsa-miR-194	CLIP-seq
MIRT2469585	hsa-miR-302a	CLIP-seq
MIRT2469586	hsa-miR-302b	CLIP-seq
MIRT2469587	hsa-miR-302c	CLIP-seq
MIRT2469588	hsa-miR-302d	CLIP-seq
MIRT2469589	hsa-miR-3127-5p	CLIP-seq
MIRT765974	hsa-miR-3135b	CLIP-seq
MIRT765976	hsa-miR-3163	CLIP-seq
MIRT2469590	hsa-miR-340	CLIP-seq
MIRT2469591	hsa-miR-3529	CLIP-seq
MIRT2469592	hsa-miR-3606	CLIP-seq
MIRT2469593	hsa-miR-3651	CLIP-seq
MIRT765978	hsa-miR-3677-5p	CLIP-seq
MIRT2469594	hsa-miR-3713	CLIP-seq
MIRT2469595	hsa-miR-371b-5p	CLIP-seq
MIRT2469596	hsa-miR-372	CLIP-seq
MIRT2469597	hsa-miR-373	CLIP-seq
MIRT2469598	hsa-miR-379	CLIP-seq
MIRT2469599	hsa-miR-3918	CLIP-seq
MIRT2469600	hsa-miR-412	CLIP-seq
MIRT2469601	hsa-miR-4263	CLIP-seq
MIRT2469602	hsa-miR-4272	CLIP-seq
MIRT765979	hsa-miR-4280	CLIP-seq
MIRT2469603	hsa-miR-4438	CLIP-seq
MIRT2469604	hsa-miR-4451	CLIP-seq
MIRT2469605	hsa-miR-4464	CLIP-seq
MIRT1925698	hsa-miR-4474-5p	CLIP-seq
MIRT2469606	hsa-miR-4650-3p	CLIP-seq
MIRT2469607	hsa-miR-4687-5p	CLIP-seq
MIRT2469608	hsa-miR-4698	CLIP-seq
MIRT2469609	hsa-miR-4699-5p	CLIP-seq
MIRT2469610	hsa-miR-4724-3p	CLIP-seq
MIRT2469611	hsa-miR-4731-5p	CLIP-seq
MIRT2469612	hsa-miR-4748	CLIP-seq
MIRT2469613	hsa-miR-4766-5p	CLIP-seq
MIRT1925699	hsa-miR-4777-5p	CLIP-seq
MIRT2469614	hsa-miR-4794	CLIP-seq
MIRT2469615	hsa-miR-5095	CLIP-seq
MIRT1925700	hsa-miR-518d-5p	CLIP-seq
MIRT1925701	hsa-miR-519b-5p	CLIP-seq
MIRT1925702	hsa-miR-519c-5p	CLIP-seq
MIRT1925703	hsa-miR-520c-5p	CLIP-seq
MIRT1925704	hsa-miR-526a	CLIP-seq
MIRT1925705	hsa-miR-545	CLIP-seq
MIRT765987	hsa-miR-548a-3p	CLIP-seq
MIRT2469616	hsa-miR-548aa	CLIP-seq
MIRT765988	hsa-miR-548ae	CLIP-seq
MIRT2469617	hsa-miR-548ag	CLIP-seq
MIRT2469618	hsa-miR-548ai	CLIP-seq
MIRT765989	hsa-miR-548aj	CLIP-seq
MIRT765990	hsa-miR-548am	CLIP-seq
MIRT765991	hsa-miR-548e	CLIP-seq
MIRT765992	hsa-miR-548f	CLIP-seq
MIRT765993	hsa-miR-548x	CLIP-seq
MIRT2469619	hsa-miR-576-5p	CLIP-seq
MIRT2167097	hsa-miR-587	CLIP-seq
MIRT2469620	hsa-miR-802	CLIP-seq
MIRT2469621	hsa-miR-876-3p	CLIP-seq
MIRT2469622	hsa-miR-892b	CLIP-seq
MIRT2469581	hsa-miR-1208	CLIP-seq
MIRT765968	hsa-miR-122	CLIP-seq
MIRT2469582	hsa-miR-129-3p	CLIP-seq
MIRT765970	hsa-miR-142-3p	CLIP-seq
MIRT2469583	hsa-miR-188-5p	CLIP-seq
MIRT2469584	hsa-miR-194	CLIP-seq
MIRT2469585	hsa-miR-302a	CLIP-seq
MIRT2469586	hsa-miR-302b	CLIP-seq
MIRT2469587	hsa-miR-302c	CLIP-seq
MIRT2469588	hsa-miR-302d	CLIP-seq
MIRT2469589	hsa-miR-3127-5p	CLIP-seq
MIRT765974	hsa-miR-3135b	CLIP-seq
MIRT765976	hsa-miR-3163	CLIP-seq
MIRT2469590	hsa-miR-340	CLIP-seq
MIRT2469591	hsa-miR-3529	CLIP-seq
MIRT2469592	hsa-miR-3606	CLIP-seq
MIRT2469593	hsa-miR-3651	CLIP-seq
MIRT765978	hsa-miR-3677-5p	CLIP-seq
MIRT2469594	hsa-miR-3713	CLIP-seq
MIRT2469595	hsa-miR-371b-5p	CLIP-seq
MIRT2469596	hsa-miR-372	CLIP-seq
MIRT2469597	hsa-miR-373	CLIP-seq
MIRT2469598	hsa-miR-379	CLIP-seq
MIRT2469599	hsa-miR-3918	CLIP-seq
MIRT2469600	hsa-miR-412	CLIP-seq
MIRT2469601	hsa-miR-4263	CLIP-seq
MIRT2469602	hsa-miR-4272	CLIP-seq
MIRT765979	hsa-miR-4280	CLIP-seq
MIRT2469603	hsa-miR-4438	CLIP-seq
MIRT2469604	hsa-miR-4451	CLIP-seq
MIRT2469606	hsa-miR-4650-3p	CLIP-seq
MIRT2469607	hsa-miR-4687-5p	CLIP-seq
MIRT2469608	hsa-miR-4698	CLIP-seq
MIRT2469609	hsa-miR-4699-5p	CLIP-seq
MIRT2469611	hsa-miR-4731-5p	CLIP-seq
MIRT2469613	hsa-miR-4766-5p	CLIP-seq
MIRT2469614	hsa-miR-4794	CLIP-seq
MIRT2469615	hsa-miR-5095	CLIP-seq
MIRT1925705	hsa-miR-545	CLIP-seq
MIRT765987	hsa-miR-548a-3p	CLIP-seq
MIRT2469616	hsa-miR-548aa	CLIP-seq
MIRT765988	hsa-miR-548ae	CLIP-seq
MIRT765989	hsa-miR-548aj	CLIP-seq
MIRT765990	hsa-miR-548am	CLIP-seq
MIRT765991	hsa-miR-548e	CLIP-seq
MIRT765992	hsa-miR-548f	CLIP-seq
MIRT765993	hsa-miR-548x	CLIP-seq
MIRT2469619	hsa-miR-576-5p	CLIP-seq
MIRT2167097	hsa-miR-587	CLIP-seq
MIRT2469620	hsa-miR-802	CLIP-seq
MIRT2469622	hsa-miR-892b	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
SP1	Activation	22705645
SP1	Unknown	19772640

Show/Hide all(75)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IDA	18276953
GO:0001934	Process	Positive regulation of protein phosphorylation	IMP	18625725
GO:0002446	Process	Neutrophil mediated immunity	IC	16034137
GO:0002467	Process	Germinal center formation	ISS	10433800
GO:0002690	Process	Positive regulation of leukocyte chemotaxis	IC	16034137
GO:0004175	Function	Endopeptidase activity	IMP	24990881, 25049354
GO:0004222	Function	Metalloendopeptidase activity	IBA	21873635
GO:0004222	Function	Metalloendopeptidase activity	IDA	9774383, 9920899, 14625290, 15691827, 17010968, 24226769
GO:0004222	Function	Metalloendopeptidase activity	IMP	9034190, 9034191
GO:0004222	Function	Metalloendopeptidase activity	TAS
GO:0005112	Function	Notch binding	IDA	24226769
GO:0005138	Function	Interleukin-6 receptor binding	IPI	16034137
GO:0005178	Function	Integrin binding	IPI	14970227
GO:0005515	Function	Protein binding	IPI	9774383, 10527948, 12668732, 15280379, 18355445, 18625725, 18638486, 22246777, 22413019, 29897336, 30455686
GO:0005737	Component	Cytoplasm	IDA	25468996
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IDA	17786981
GO:0005911	Component	Cell-cell junction	IDA	14970227
GO:0005925	Component	Focal adhesion	IDA	14970227
GO:0006508	Process	Proteolysis	IDA	24227843
GO:0006509	Process	Membrane protein ectodomain proteolysis	IBA	21873635
GO:0006509	Process	Membrane protein ectodomain proteolysis	IDA	9034190, 9574564, 14625290, 15691827, 17010968, 17786981, 18676862
GO:0006509	Process	Membrane protein ectodomain proteolysis	IMP	9034191, 12743035, 16034137, 18373975, 21170088, 24990881
GO:0007155	Process	Cell adhesion	IDA	14970227
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IDA	12743035
GO:0007219	Process	Notch signaling pathway	IBA	21873635
GO:0007220	Process	Notch receptor processing	IDA	24226769
GO:0008233	Function	Peptidase activity	TAS	24966471
GO:0008237	Function	Metallopeptidase activity	IDA	12777399
GO:0008237	Function	Metallopeptidase activity	IMP	12535668
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	18373975
GO:0009986	Component	Cell surface	IDA	9034190, 18383040, 18625725
GO:0010820	Process	Positive regulation of T cell chemotaxis	IMP	18373975
GO:0015629	Component	Actin cytoskeleton	IDA	17010968
GO:0016020	Component	Membrane	HDA	19946888
GO:0016324	Component	Apical plasma membrane	IDA	16034137
GO:0016485	Process	Protein processing	IDA	9774383
GO:0017124	Function	SH3 domain binding	IEA
GO:0030165	Function	PDZ domain binding	IPI	12207026
GO:0030183	Process	B cell differentiation	ISS	10433800
GO:0030307	Process	Positive regulation of cell growth	IMP	18373975
GO:0030335	Process	Positive regulation of cell migration	IDA	26617808
GO:0030335	Process	Positive regulation of cell migration	IMP	18373975
GO:0030511	Process	Positive regulation of transforming growth factor beta receptor signaling pathway	ISS	10433800
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IMP	21170088
GO:0031293	Process	Membrane protein intracellular domain proteolysis	TAS
GO:0032496	Process	Response to lipopolysaccharide	IDA	18383040
GO:0032587	Component	Ruffle membrane	IDA	14970227
GO:0032722	Process	Positive regulation of chemokine production	IMP	16034137
GO:0033025	Process	Regulation of mast cell apoptotic process	ISS	10433800
GO:0033077	Process	T cell differentiation in thymus	ISS	10433800
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS
GO:0033627	Process	Cell adhesion mediated by integrin	IDA	14970227
GO:0035313	Process	Wound healing, spreading of epidermal cells	IEP	14970227
GO:0035624	Process	Receptor transactivation	IMP	17655843
GO:0042493	Process	Response to drug	ISS	10433800
GO:0042987	Process	Amyloid precursor protein catabolic process	IDA	9774383
GO:0043536	Process	Positive regulation of blood vessel endothelial cell migration	IDA	24813629
GO:0045121	Component	Membrane raft	IDA	17010968, 17786981
GO:0045737	Process	Positive regulation of cyclin-dependent protein serine/threonine kinase activity	IMP	18483258
GO:0045741	Process	Positive regulation of epidermal growth factor-activated receptor activity	IDA	18483258
GO:0045741	Process	Positive regulation of epidermal growth factor-activated receptor activity	IMP	17655843
GO:0046872	Function	Metal ion binding	IEA
GO:0048536	Process	Spleen development	ISS	10433800
GO:0048870	Process	Cell motility	ISS	10433800
GO:0050830	Process	Defense response to Gram-positive bacterium	IMP	16034137
GO:0051272	Process	Positive regulation of cellular component movement	ISS	10433800
GO:0071403	Process	Cellular response to high density lipoprotein particle stimulus	IDA	17786981
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	18687778
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IMP	18483258
GO:1902945	Function	Metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IDA	9774383
GO:1903265	Process	Positive regulation of tumor necrosis factor-mediated signaling pathway	IMP	24813629
GO:1905564	Process	Positive regulation of vascular endothelial cell proliferation	IDA	24813629

MIM	HGNC	e!Ensembl
603639	195	ENSG00000151694

Protein

UniProt ID

P78536

Protein name

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)

Protein function

Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:24226769, PubMed:24227

PDB

1BKC , 1ZXC , 2A8H , 2DDF , 2FV5 , 2FV9 , 2I47 , 2M2F , 2OI0 , 3B92 , 3CKI , 3E8R , 3EDZ , 3EWJ , 3G42 , 3KMC , 3KME , 3L0T , 3L0V , 3LE9 , 3LEA , 3LGP , 3O64 , 8CQY , 8SNL , 8SNN , 8SNO , 9E6K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01562	Pep_M12B_propep	31 → 167	Reprolysin family propeptide	Family
PF13688	Reprolysin_5	221 → 451		Family
PF00200	Disintegrin	484 → 558	Disintegrin	Domain
PF16698	ADAM17_MPD	581 → 642	Membrane-proximal domain, switch, for ADAM17	Domain

Sequence

MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL
QTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVV
GEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNM
AKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSC
KVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS
INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD
SASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKD
PFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC

Sequence length

824

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis Notch signaling pathway TNF signaling pathway Alzheimer disease Epithelial cell signaling in Helicobacter pylori infection Coronavirus disease - COVID-19		Regulated proteolysis of p75NTR Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants TNF signaling CD163 mediating an anti-inflammatory response

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Autoinflammatory disease	Autoinflammatory disorder	rs777759523, rs121434352, rs28940578, rs28940580, rs121908146, rs121908148, rs121908150, rs80338807, rs121908679, rs104895319, rs104894176, rs28933973, rs28933376, rs137854447, rs61736587, rs148755083, rs104895093, rs104895311, rs104895364, rs104895352, rs104895271, rs104895238, rs151344629, rs180177431, rs376785840, rs587777241, rs77563738, rs202134424, rs864321625, rs864321682, rs864321626, rs864321684, rs864321685, rs869312838, rs869312953, rs766657895, rs140148806, rs753966933, rs764196809, rs200956636, rs147035858, rs1274685768, rs1600700389, rs1776278098, rs754904956, rs1760720617, rs1760720924	20603312
Inflammatory skin and bowel disease	INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 1, Neonatal inflammatory skin and bowel disease	rs387906866, rs1572897958, rs1662434135, rs1662343008	22236242, 20603312, 22010916

Show/Hide Unknown Diseases (7)

Unknown
Disease name	Disease term	dbSNP ID	References
Colitis	Colitis		24548422
Eosinophilia	Eosinophilia
Exfoliative dermatitis	Exfoliative dermatitis
Immunodeficiency without anhidrotic ectodermal dysplasia	Immunodeficiency without anhidrotic ectodermal dysplasia
Onychogryposis	Onychogryposis
Otitis externa	Otitis Externa
Paronychia inflammation	Paronychia Inflammation

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