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SURF4 (surfeit 4)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6836
Gene nameGene Name - the full gene name approved by the HGNC.
Surfeit 4
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SURF4
SynonymsGene synonyms aliases
ERV29
ChromosomeChromosome number
9
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Go
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001831 hsa-miR-124-3p Microarray, qRT-PCR 16549876
MIRT016415 hsa-miR-193b-3p Proteomics 21512034
MIRT001831 hsa-miR-124-3p qRT-PCR;Other 16549876
MIRT025424 hsa-miR-34a-5p Proteomics 21566225
MIRT050908 hsa-miR-17-5p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0005515 Function Protein binding IPI 18287528, 21903422, 29251827
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0005793 Component Endoplasmic reticulum-Golgi intermediate compartment IDA 15308636, 18287528
GO:0005829 Component Cytosol IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O15260
Protein name Surfeit locus protein 4
Protein function Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:29643117, PubMed:30251625, PubMed:33186557). Acts as a cargo receptor for lipoproteins b
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02077 SURF4
4 269
SURF4 family
Family
Sequence
Sequence length 269
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Neutrophil degranulation
COPI-dependent Golgi-to-ER retrograde traffic
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 17013881

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