SUPV3L1 (Suv3 like RNA helicase)

Gene

• Entrez ID: 6832
• Gene name: Suv3 like RNA helicase
• Gene symbol: SUPV3L1
• Synonyms: SUV3
• Chromosome: 10
• Chromosome location: 10q22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027436	hsa-miR-98-5p	Microarray	19088304
MIRT046569	hsa-miR-200b-3p	CLASH	23622248
MIRT046174	hsa-miR-27b-3p	CLASH	23622248
MIRT044646	hsa-miR-320a	CLASH	23622248

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000958	Process	Mitochondrial mRNA catabolic process	IMP	19864255
GO:0000962	Process	Positive regulation of mitochondrial RNA catabolic process	IDA	19509288, 29967381
GO:0000962	Process	Positive regulation of mitochondrial RNA catabolic process	IMP	19864255
GO:0000965	Process	Mitochondrial RNA 3'-end processing	IBA	21873635
GO:0000965	Process	Mitochondrial RNA 3'-end processing	IMP	19864255
GO:0003677	Function	DNA binding	IMP	12466530
GO:0003678	Function	DNA helicase activity	IMP	12466530
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003724	Function	RNA helicase activity	IBA	21873635
GO:0003724	Function	RNA helicase activity	IDA	19509288
GO:0003725	Function	Double-stranded RNA binding	IDA	19509288
GO:0004386	Function	Helicase activity	TAS	9925937
GO:0005515	Function	Protein binding	IPI	17961633, 25416956, 29967381, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	17352692
GO:0005739	Component	Mitochondrion	IDA	17352692, 19864255
GO:0005759	Component	Mitochondrial matrix	IDA	12466530
GO:0006310	Process	DNA recombination	IMP	17961633
GO:0006401	Process	RNA catabolic process	IBA	21873635
GO:0006401	Process	RNA catabolic process	IMP	18678873
GO:0030307	Process	Positive regulation of cell growth	IMP	19864255
GO:0032508	Process	DNA duplex unwinding	IMP	12466530
GO:0034458	Function	3'-5' RNA helicase activity	IDA	19509288
GO:0035945	Process	Mitochondrial ncRNA surveillance	IMP	19864255
GO:0035946	Process	Mitochondrial mRNA surveillance	IMP	19864255
GO:0042645	Component	Mitochondrial nucleoid	IDA	18063578
GO:0042803	Function	Protein homodimerization activity	IPI	19509288
GO:0043066	Process	Negative regulation of apoptotic process	IMP	17352692
GO:0045025	Component	Mitochondrial degradosome	IBA	21873635
GO:0045025	Component	Mitochondrial degradosome	IDA	19509288, 29967381
GO:0070584	Process	Mitochondrion morphogenesis	IMP	19864255
GO:0070827	Process	Chromatin maintenance	IMP	17352692
GO:2000827	Process	Mitochondrial RNA surveillance	IMP	19864255

Other IDs

• MIM: 605122
• HGNC: 11471
• e!Ensembl: ENSG00000156502

Protein

• UniProt ID: Q8IYB8
• Protein name: ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1)
• Protein function: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradati
• PDB: 3RC3, 3RC8, 7W1R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF18114	Suv3_N	62 → 179	Suv3 helical N-terminal domain	Domain
  PF00271	Helicase_C	352 → 475	Helicase conserved C-terminal domain	Family
  PF18147	Suv3_C_1	556 → 598	Suv3 C-terminal domain 1	Domain
  PF12513	SUV3_C	625 → 672	Mitochondrial degradasome RNA helicase subunit C terminal	Family

• Sequence:

  MSFSRALLWARLPAGRQAGHRAAICSALRPHFGPFPGVLGQVSVLATASSSASGGSKIPN
  TSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKVLDKFYKRKEIQKLGADYGLDARLF
  HQAFISFRNYIMQSHSLDVDIHIVLNDICFGAAHADDLFPFFLRHAKQIFPVLDCKDDLR
  KISDLRIPPNWYPDARAMQRKIIFHSGPTNSGKTYHAIQKYFSAKSGVYCGPLKLLAHEI
  FEKSNAAGVPCDLVTGEERVTVQPNGKQASHVSCTVEMCSVTTPYEVAVIDEIQMIRDPA
  RGWAWTRALLGLCAEEVHLCGEPAAIDLVMELMYTTGEEVEVRDYKRLTPISVLDHALES
  LDNLRPGDCIVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNDPNDPCKI
  LVATDAIGMGLNLSIRRIIFYSLIKPSINEKGERELEPITTSQALQIAGRAGRFSSRFKE
  GEVTTMNHEDLSLLKEILKRPVDPIRAAGLHPTAEQIEMFAYHLPDATLSNLIDIFVDFS
  QVDGQYFVCNMDDFKFSAELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRN
  EPLTFAWLRRYIKWPLLPPKNIKDLMDLEAVHDVLDLYLWLSYRFMDMFPDASLIRDLQK
  ELDGIIQDGVHNITKLIKMSETHKLLNLEGFPSGSQSRLSGTLKSQARRTRGTKALGSKA
  TEPPSPDAGELSLASRLVQQGLLTPDMLKQLEKEWMTQQTEHNKEKTESGTHPKGTRRKK
  KEPDSD

• Sequence length: 786

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Ichthyosis	Ichthyoses	rs199766569, rs587776996, rs587777262, rs863223405, rs370031870, rs1569044747, rs200806519	19145458

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia		19145458
Alopecia, male pattern	Alopecia, Male Pattern		19145458
Androgenetic alopecia	Androgenetic Alopecia		19145458
Pseudopelade	Pseudopelade		19145458
Xeroderma	Xeroderma		19145458