SULT2A1 (sulfotransferase family 2A member 1)

Gene

• Entrez ID: 6822
• Gene name: Sulfotransferase family 2A member 1
• Gene symbol: SULT2A1
• Synonyms: DHEA-ST, DHEA-ST8, DHEAS, HST, ST2, ST2A1, ST2A3, STD, SULT2A3, hSTa
• Chromosome: 19
• Chromosome location: 19q13.33
• Summary: This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This pr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017405	hsa-miR-335-5p	Microarray	18185580
MIRT030437	hsa-miR-24-3p	Microarray	19748357
MIRT736032	hsa-miR-486-5p	Luciferase reporter assay, Western blotting, qRT-PCR	31445882
MIRT1402899	hsa-miR-1183	CLIP-seq
MIRT1402900	hsa-miR-1193	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT1402902	hsa-miR-1208	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT1402904	hsa-miR-139-3p	CLIP-seq
MIRT1402905	hsa-miR-1976	CLIP-seq
MIRT1402906	hsa-miR-2392	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT1402908	hsa-miR-3137	CLIP-seq
MIRT1402909	hsa-miR-3152-3p	CLIP-seq
MIRT1402910	hsa-miR-3170	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT1402912	hsa-miR-3672	CLIP-seq
MIRT1402913	hsa-miR-4264	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402916	hsa-miR-4438	CLIP-seq
MIRT1402917	hsa-miR-4454	CLIP-seq
MIRT1402918	hsa-miR-4473	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402920	hsa-miR-4662a-5p	CLIP-seq
MIRT1402921	hsa-miR-4676-5p	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT1402923	hsa-miR-4731-5p	CLIP-seq
MIRT1402924	hsa-miR-4797-3p	CLIP-seq
MIRT1402925	hsa-miR-5095	CLIP-seq
MIRT1402926	hsa-miR-5096	CLIP-seq
MIRT1402927	hsa-miR-512-3p	CLIP-seq
MIRT1402928	hsa-miR-520f	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT1402930	hsa-miR-575	CLIP-seq
MIRT1402931	hsa-miR-622	CLIP-seq
MIRT1402932	hsa-miR-668	CLIP-seq
MIRT1402933	hsa-miR-720	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT2120784	hsa-miR-129-5p	CLIP-seq
MIRT2120785	hsa-miR-4279	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120787	hsa-miR-4740-3p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2120789	hsa-miR-4777-3p	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT1402900	hsa-miR-1193	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT1402905	hsa-miR-1976	CLIP-seq
MIRT1402906	hsa-miR-2392	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT1402913	hsa-miR-4264	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402924	hsa-miR-4797-3p	CLIP-seq
MIRT1402931	hsa-miR-622	CLIP-seq
MIRT1402933	hsa-miR-720	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT2395426	hsa-miR-24	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT2395427	hsa-miR-3186-5p	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT2395428	hsa-miR-4284	CLIP-seq
MIRT2395429	hsa-miR-4317	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT2395430	hsa-miR-767-5p	CLIP-seq
MIRT2460815	hsa-miR-296-3p	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT2120784	hsa-miR-129-5p	CLIP-seq
MIRT2395426	hsa-miR-24	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT2395427	hsa-miR-3186-5p	CLIP-seq
MIRT2636672	hsa-miR-3199	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2395428	hsa-miR-4284	CLIP-seq
MIRT2395429	hsa-miR-4317	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2636673	hsa-miR-4787-3p	CLIP-seq
MIRT2636674	hsa-miR-4794	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT2395430	hsa-miR-767-5p	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT2120784	hsa-miR-129-5p	CLIP-seq
MIRT2395426	hsa-miR-24	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2395428	hsa-miR-4284	CLIP-seq
MIRT2395429	hsa-miR-4317	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2636673	hsa-miR-4787-3p	CLIP-seq
MIRT2636674	hsa-miR-4794	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT2395430	hsa-miR-767-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
GATA6	Activation	15388788;19497978
MED1	Activation	19497978
PPARA	Unknown	20110263
SF1	Activation	15388788
SF1	Unknown	15878968

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004027	Function	Alcohol sulfotransferase activity	IDA	7854148, 19589875
GO:0005515	Function	Protein binding	IPI	21988832, 25416956, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IDA	2268288
GO:0005829	Component	Cytosol	TAS
GO:0006068	Process	Ethanol catabolic process	IDA	23207770
GO:0006805	Process	Xenobiotic metabolic process	IDA	7854148
GO:0008146	Function	Sulfotransferase activity	IBA	21873635
GO:0008146	Function	Sulfotransferase activity	IDA	19548878, 20056724
GO:0008202	Process	Steroid metabolic process	IDA	1588921, 23207770
GO:0008202	Process	Steroid metabolic process	IMP	29671343
GO:0008203	Process	Cholesterol metabolic process	IDA	19589875
GO:0016042	Process	Lipid catabolic process	IEA
GO:0019216	Process	Regulation of lipid metabolic process	TAS
GO:0030573	Process	Bile acid catabolic process	IEA
GO:0042403	Process	Thyroid hormone metabolic process	IDA	10199779
GO:0047704	Function	Bile-salt sulfotransferase activity	IDA	1588921, 2268288
GO:0050294	Function	Steroid sulfotransferase activity	IDA	23207770
GO:0050294	Function	Steroid sulfotransferase activity	IMP	29671343
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA	23207770
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	TAS
GO:0050656	Function	3'-phosphoadenosine 5'-phosphosulfate binding	IDA	10854859, 12471039
GO:0051923	Process	Sulfation	IBA	21873635
GO:0051923	Process	Sulfation	IDA	19548878, 20056724, 23207770

Other IDs

• MIM: 125263
• HGNC: 11458
• e!Ensembl: ENSG00000105398

Protein

• UniProt ID: Q06520
• Protein name: Sulfotransferase 2A1 (ST2A1) (EC 2.8.2.2) (Bile salt sulfotransferase) (EC 2.8.2.14) (Dehydroepiandrosterone sulfotransferase) (DHEA-ST) (DHEA-ST8) (Hydroxysteroid Sulfotransferase) (HST) (ST2) (SULT2A3)
• Protein function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, inclu
• PDB: 1EFH, 1J99, 1OV4, 2QP3, 2QP4, 3F3Y, 4IFB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00685	Sulfotransfer_1	34 → 278	Sulfotransferase domain	Domain

• Sequence:

  MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSK
  GDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLM
  RNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFL
  LLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVV
  DKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE

• Sequence length: 285

Pathways

KEGG:

Metabolism of xenobiotics by cytochrome P450
Bile secretion
Chemical carcinogenesis - DNA adducts

Reactome:

Cytosolic sulfonation of small molecules
PPARA activates gene expression

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	21716162

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		21716162